The DOI matches its Crossref record; 86 of the 88 references it cites were found in a registry or an index.
Alternatives to in-feed antibiotics in pigs: Evaluation of probiotics, zinc or organic acids as protective agents for the intestinal mucosa. A comparison of in vitro and in vivo results
Open accessAbstract
Weaned pigs are susceptible to frequent infectious diseases.Antibiotics have been used over decades to reduce pathogen infections, but many microorganisms are becoming resistant to antibiotics.Thus, there is an urgent need to find alternatives to in-feed antibiotics.Up to now, various compounds have been used as alternatives, giving promising but sometimes contrasting results.In recent years, the in vitro models of cell culture have been proposed for the screening of various compounds and understanding their mechanisms of action.The intestine is a complex system with a continuous cross-talk among epithelial cells, the local immune system and microflora.Alternatives to in-feed antibiotics may interact with any of these constituents.This review presents data on the protective effects of probiotics, zinc salts and organic acids, used as alternatives to in-feed antibiotics, against pathogen induced damage and inflammatory processes in the intestinal cells and the underlying mechanisms, with an attempt to compare in vitro and in vivo results.All the alternatives tested resulted in effective protection against pathogens by a series of interactions with intestinal cells and pathogens, including the inhibition of adhesion and invasion of pathogens, interference in signalling pathways induced by pathogenic bacteria, maintenance of the epithelial cell cytoskeleton and junctional structure and modulation of the host immune response.antibiotic alternative / intestinal cell culture / probiotic / zinc oxide / organic acid Résumé -Alternatives aux antibiotiques additifs alimentaires chez le porc : évaluation des probiotiques, sels de zinc ou acides organiques comme agents protecteurs de la muqueuse intestinale.Comparaison des résultats in vitro avec les observations in vivo.Le porcelet est sensible aux infections gastro-intestinales au moment du sevrage.Les antibiotiques additifs alimentaires ont été utilisés pendant des décennies pour réduire ces infections, mais de nombreux
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“The survival of probiotic bacteria in gastrointestinal ecosystems and their adhesion to intestinal mucosa is considered to be preconditions for temporary colonization, stimulation of the immune system, and resistance to intestinal pathogens (Hudault et al., 1997; Roselli et al., 2005).”
From Adhesion and Colonization of the Probiotic Lactobacillus plantarum HC-2 in the Intestine of Litopenaeus Vannamei Are Associated With Bacterial Surface Proteins (2022) · cites this paper as Roselli et al., 2005
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Heo, J. M., Opapeju, F. O., Pluske, J. R., Kim, J.-C., Hampson, D. J., & Nyachoti, C. M. (2012) · Journal of Animal Physiology and Animal Nutrition · doi:10.1111/j.1439-0396.2012.01284.x · Cited by 828
Nutritional management of gut health in pigs around weaning
Lallès, J. P., Bosi, P., Smidt, H., & Stokes, C. R. (2007) · Proceedings of The Nutrition Society · doi:10.1017/s0029665107005484 · Cited by 609
Weaning — A challenge to gut physiologists
Lallès, J. P., Bosi, P., Smidt, H., & Stokes, C. R. (2007) · Livestock Science · doi:10.1016/j.livsci.2007.01.091 · Cited by 341
The use of probiotics as eco-friendly alternatives for antibiotics in poultry nutrition
Alagawany, M. M., El-Hack, M. E. A., Farag, M. R., Sachan, S., Karthik, K., & Dhama, K. (2018) · Environmental Science and Pollution Research · doi:10.1007/s11356-018-1687-x · Cited by 255
Chen, X., Xu, J., Shuai, J., Chen, J., Zhang, Z., & Fang, W. (2007) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2006.11.007 · Cited by 196
Metadata
- Authors
- Roselli, M., Finamore, A., Britti, M. S., Bosi, P., Oswald, I., & Mengheri, E.
- Affiliations
- Istituto Nazionale di Ricerca per gli Alimenti e la Nutrizione (IT)
- University of Bologna (IT)
- Institut National de la Recherche Agronomique (FR)
- Venue
- Animal Research
- Publisher
- EDP Sciences
- Published
- 2005-05
- Volume
- 54
- Issue
- 3
- Pages
- 203-218
- ISSN
- 1627-3583 (ISSN-L)
- 1627-3591
- OpenAlex
- W2151921633
- Cited by
- 97
- References
- 88
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 6 · 2023: 4 · 2022: 5 · 2021: 8 · 2020: 5 · 2019: 4 · 2018: 4 · 2017: 7 · 2016: 7 · 2015: 3 · 2014: 10 · 2013: 3 · 2012: 4
- FWCI
- 6.33
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Animal Research (publishedVersion)
- Springer Link (Chiba Institute of Technology) (submittedVersion)
- HAL (submittedVersion, other-oa)
- HAL (submittedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Health Sciences › Veterinary › Small Animals › Veterinary medicine and infectious diseases
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- weaned piglets, probiotics, zinc oxide, organic acids, intestinal mucosa protection, intestinal epithelial cells, epithelial cytoskeleton, tight junctions, host immune response, antibiotic resistance, in vitro cell culture model, inflammatory processes
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