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Cited by 97Animal Nutrition and PhysiologyVeterinary medicine and infectious diseasesProbiotics and Fermented Foods

The DOI matches its Crossref record; 86 of the 88 references it cites were found in a registry or an index.

Alternatives to in-feed antibiotics in pigs: Evaluation of probiotics, zinc or organic acids as protective agents for the intestinal mucosa. A comparison of in vitro and in vivo results

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Roselli, Marianna, Finamore, Alberto, Britti, Maria Serena, Bosi, Paolo, Oswald, Isabelle, Mengheri, Elena·2005·Animal Research
DOI 10.1051/animres:2005012
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Abstract

Weaned pigs are susceptible to frequent infectious diseases.Antibiotics have been used over decades to reduce pathogen infections, but many microorganisms are becoming resistant to antibiotics.Thus, there is an urgent need to find alternatives to in-feed antibiotics.Up to now, various compounds have been used as alternatives, giving promising but sometimes contrasting results.In recent years, the in vitro models of cell culture have been proposed for the screening of various compounds and understanding their mechanisms of action.The intestine is a complex system with a continuous cross-talk among epithelial cells, the local immune system and microflora.Alternatives to in-feed antibiotics may interact with any of these constituents.This review presents data on the protective effects of probiotics, zinc salts and organic acids, used as alternatives to in-feed antibiotics, against pathogen induced damage and inflammatory processes in the intestinal cells and the underlying mechanisms, with an attempt to compare in vitro and in vivo results.All the alternatives tested resulted in effective protection against pathogens by a series of interactions with intestinal cells and pathogens, including the inhibition of adhesion and invasion of pathogens, interference in signalling pathways induced by pathogenic bacteria, maintenance of the epithelial cell cytoskeleton and junctional structure and modulation of the host immune response.antibiotic alternative / intestinal cell culture / probiotic / zinc oxide / organic acid Résumé -Alternatives aux antibiotiques additifs alimentaires chez le porc : évaluation des probiotiques, sels de zinc ou acides organiques comme agents protecteurs de la muqueuse intestinale.Comparaison des résultats in vitro avec les observations in vivo.Le porcelet est sensible aux infections gastro-intestinales au moment du sevrage.Les antibiotiques additifs alimentaires ont été utilisés pendant des décennies pour réduire ces infections, mais de nombreux

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Research works printed but not linked: 2

  1. Hampson D.J., Postweaning Escherichia coli diarrhoea in pigs, in: Gyles C.L. (Ed.), Escherichia coli in domestic animals and humans, CAB International, Wallingford, UK, 1994, pp. 171-191.
  2. Roselli M., Finamore A., Britti M.S., Mengheri E., Protective effects and immunomodulation on intestinal cells by probiotics, Proceeding of the 2nd Probiotics and Prebiotics new foods, 2003, pp. 205-212.

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Metadata

Authors
Roselli, M., Finamore, A., Britti, M. S., Bosi, P., Oswald, I., & Mengheri, E.
Affiliations
  • Istituto Nazionale di Ricerca per gli Alimenti e la Nutrizione (IT)
  • University of Bologna (IT)
  • Institut National de la Recherche Agronomique (FR)
ORCID
Venue
Animal Research
Publisher
EDP Sciences
Published
2005-05
Volume
54
Issue
3
Pages
203-218
ISSN
  • 1627-3583 (ISSN-L)
  • 1627-3591
DOI
10.1051/animres:2005012
OpenAlex
W2151921633
Cited by
97
References
88
Citations by year
2026: 1 · 2025: 1 · 2024: 6 · 2023: 4 · 2022: 5 · 2021: 8 · 2020: 5 · 2019: 4 · 2018: 4 · 2017: 7 · 2016: 7 · 2015: 3 · 2014: 10 · 2013: 3 · 2012: 4
FWCI
6.33
Type
journal article
Language
en
Open access
Locations
  • Animal Research (publishedVersion)
  • Springer Link (Chiba Institute of Technology) (submittedVersion)
  • HAL (submittedVersion, other-oa)
  • HAL (submittedVersion)
  • Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
  • Health Sciences › Veterinary › Small Animals › Veterinary medicine and infectious diseases
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Keywords
weaned piglets, probiotics, zinc oxide, organic acids, intestinal mucosa protection, intestinal epithelial cells, epithelial cytoskeleton, tight junctions, host immune response, antibiotic resistance, in vitro cell culture model, inflammatory processes

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