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Cited by 293

The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.

Relative contributions of nutrition and inflammation to clinical outcome in dialysis patients

Open access
Kalantar-Zadeh, Kamyar, Kopple, Joel D.·2001·American Journal of Kidney Diseases

Abstract

Protein-energy malnutrition (PEM) is a common phenomenon in maintenance dialysis (MD) patients and a risk factor for poor quality of life and increased morbidity and mortality, including cardiovascular death, in these individuals. The association between undernutrition and adverse outcome in MD patients, which stands in contrast to that seen in the general population, has been referred to as reverse epidemiology. Measures of food intake, body composition tools, nutritional scoring systems, and laboratory values are used to assess the degree of severity of PEM, but no uniform approach is available for rating the overall severity of PEM. Epidemiologic studies suggest that inflammation is a missing link between PEM and poor clinical outcome in MD patients, and the existence of a malnutrition inflammation complex syndrome is suggested in these patients. Inflammation may be due to subclinical and clinically apparent illnesses. Some investigators suggest that PEM may predispose to illness and inflammation. There is a paucity of information concerning the effect of nutritional therapy on morbidity and mortality in MD patients. Interventional studies of the effect of nutritional support on outcome often are difficult to interpret because of small sample sizes, short duration of study, and other limitations. Large-scale, randomized, clinical trials of the effects of nutritional intake, nutritional status, and inflammation on clinical outcome are needed to define better the relationships between these factors in MD patients.

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Metadata

Authors
Kalantar-Zadeh, K., & Kopple, J. D.
Venue
American Journal of Kidney Diseases
Publisher
Elsevier BV
Published
2001-12
Volume
38
Issue
6
Pages
1343-1350
ISSN
0272-6386 (ISSN-L)
OpenAlex
W2130974939
Cited by
293
References
46
FWCI
6.71
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Relative contributions of nutrition and inflammation to clinical outcome in dialysis patients. https://app.cochat.ai/papers/10.1053/ajkd.2001.29250
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Kalantar-Zadeh, K., & Kopple, J. D. (2001). Relative contributions of nutrition and inflammation to clinical outcome in dialysis patients. American Journal of Kidney Diseases. https://doi.org/10.1053/ajkd.2001.29250

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.