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Chronic graft-versus-host disease
Open accessAbstract
Chronic graft-versus-host disease (GVHD) remains a vexing and dangerous complication of allogeneic stem cell transplantation. Mild forms of chronic GVHD are often manageable with local or low-dose systemic immunosuppression and do not affect long-term survival. In contrast, more severe forms of chronic GVHD require intensive medical management and adversely affect survival. This report reviews current concepts of the pathogenesis, clinical risk factors, classification systems, organ manifestations, and available treatments for chronic GVHD. It also provides a comprehensive listing of the published clinical trials aimed at prevention and primary treatment of chronic GVHD.
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Cited by
Socié, G., Schmoor, C., Bethge, W. A., Ottinger, H. D., Stelljes, M., Zander, A. R., Volin, L., Ruutu, T., Heim, D. A., Schwerdtfeger, R., et al. (2011) · Blood · doi:10.1182/blood-2011-01-329821 · Cited by 301
ROCK2 inhibition with belumosudil (KD025) for the treatment of chronic graft-versus-host disease
Jagasia, M., Lazaryan, A., Bachier, C. R., Salhotra, A., Weisdorf, D. J., Zoghi, B., Essell, J., Green, L., Schueller, O., Patel, J., et al. (2021) · Journal of Clinical Oncology · doi:10.1200/jco.20.02754 · Cited by 198
Self-citationBraamse, A. M. J., Gerrits, M. M. J. G., van Meijel, B., Visser, O., van Oppen, P., Boenink, A. D., Cuijpers, P., Huijgens, P. C., Beekman, A. T. F., & Dekker, J. (2012) · Bone Marrow Transplantation · doi:10.1038/bmt.2011.130 · Cited by 101
Chronic graft-versus-host disease. Part I: Epidemiology, pathogenesis, and clinical manifestations
Baumrin, E., Loren, A. W., Falk, S. J., Mays, J. W., & Cowen, E. W. (2024) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2022.12.024 · Cited by 59
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Metadata
- Authors
- Lee, S. J., Vogelsang, G., & Flowers, M. E. D.
- Venue
- Biology of Blood and Marrow Transplantation
- Publisher
- Elsevier BV
- Published
- 2003-04
- Volume
- 9
- Issue
- 4
- Pages
- 215-233
- ISSN
- 1083-8791 (ISSN-L)
- OpenAlex
- W2055313377
- Cited by
- 950
- References
- 0
- FWCI
- 13.56
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Lee, S. J., Vogelsang, G., & Flowers, M. E. D. (2003). Chronic graft-versus-host disease. Biology of Blood and Marrow Transplantation. https://doi.org/10.1053/bbmt.2003.50026
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
