Minimally invasive surgical management of primary venous ulcers vs. compression treatment: a randomized clinical trial
Open accessAbstract
Objectives to compare minimally invasive surgical haemodynamic correction of reflux (CHIVA) with compression in the treatment of venous ulceration.Design prospective randomised study.Materials and methods from a cohort of 80 patients with 87 venous leg ulcers, 47 were randomised to either surgery or compression.Results at a mean follow-up of 3 years, healing was 100% (31 days) in the surgical and 96% (63 days), in the compression group (p<0.02). The recurrence rate was 9% in the surgical and 38% in the compression group (p<0.05). In the surgical group, all plethysmographic parameters except ejection fraction, had improved significantly at 6 months in the surgical group, and at 3 years residual volume fraction remained in the normal range. Finally, quality of life significantly improved in the operated group.Conclusions this study supports the effectiveness of surgical therapy for leg ulceration secondary to superficial venous reflux.
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Hemochromatosis C282Y gene mutation increases the risk of venous leg ulceration
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Self-citation
- Authors
- Zamboni, P., Cisno, C., Marchetti, F., Mazza, P., Fogato, L., Carandina, S., De Palma, M., & Liboni, A.
- Affiliations
- University of Ferrara (IT)
- Venue
- European Journal of Vascular and Endovascular Surgery
- Publisher
- Elsevier BV
- Published
- 2003-04
- Volume
- 25
- Issue
- 4
- Pages
- 313-318
- ISSN
- 1078-5884 (ISSN-L)
- OpenAlex
- W2116246901
- Cited by
- 152
- References
- 37
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 2 · 2023: 7 · 2022: 4 · 2021: 2 · 2020: 5 · 2019: 6 · 2018: 9 · 2017: 1 · 2016: 12 · 2015: 12 · 2014: 9 · 2013: 10 · 2012: 4
- FWCI
- 7.37
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- European Journal of Vascular and Endovascular Surgery (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion)
- INFM-OAR (INFN Catania) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Surgery › Diagnosis and Treatment of Venous Diseases
- Health Sciences › Medicine › Internal Medicine › Venous Thromboembolism Diagnosis and Management
- Health Sciences › Medicine › Surgery › Vascular anomalies and interventions
- Keywords
- venous leg ulcers, CHIVA, minimally invasive surgery, compression therapy, superficial venous reflux, ulcer healing, ulcer recurrence, plethysmography, quality of life
- MeSH terms
- Aged, Bandages, Female, Follow-Up Studies, Hemodynamics, Humans, Male, Middle Aged, Prospective Studies, Time Factors, Varicose Ulcer, Cohort Studies, Outcome Assessment, Health Care, Minimally Invasive Surgical Procedures
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