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Cited by 256

The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.

Genetic polymorphism of alcohol dehydrogenase in europeans: The ADH2*2 allele decreases the risk for alcoholism and is associated with ADH3*1

Open access
Borràs, Emma, Coutelle, Christiane, Rosell, Albert, Fernández-Muixi, Fina, Broch, Montserrat, Crosas, Bernat, Hjelmqvist, Lars, Lorenzo, Alfons, Gutiérrez, Cristina, Santos, Mauro, Szczepanek, Malgorzata, Heilig, Markus, Quattrocchi, Pierrette, Farrés, Jaume, Vidal, Francesc, Richart, Cristóbal, Mach, Tomasz, Bogdal, Józef, Jörnvall, Hans, Seitz, Helmut K., Couzigou, Patrice, Parés, Xavier·2000·Hepatology
DOI 10.1053/he.2000.5978
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Abstract

Polymorphism at the ADH2 and ADH3 loci of alcohol dehydrogenase (ADH) has been shown to have an effect on the predisposition to alcoholism in Asian individuals. However, the results are not conclusive for white individuals. We have analyzed the ADH genotype of 876 white individuals from Spain (n = 251), France (n = 160), Germany (n = 184), Sweden (n = 88), and Poland (n = 193). Peripheral blood samples from healthy controls and groups of patients with viral cirrhosis and alcohol-induced cirrhosis, as well as alcoholics with no liver disease, were collected on filter paper. Genotyping of the ADH2 and ADH3 loci was performed using polymerase chain reaction-restriction fragment length polymorphism methods on white cell DNA. In healthy controls, ADH2*2 frequencies ranged from 0% (France) to 5.4% (Spain), whereas ADH3*1 frequencies ranged from 47.6% (Germany) to 62.5% (Sweden). Statistically significant differences were not found, however, between controls from different countries, nor between patients with alcoholism and/or liver disease. When all individuals were grouped in nonalcoholics (n = 451) and alcoholics (n = 425), ADH2*2 frequency was higher in nonalcoholics (3.8%) than in alcoholics (1.3%) (P = .0016), whereas the ADH3 alleles did not show differences. Linkage disequilibrium was found between ADH2 and ADH3, resulting in an association of the alleles ADH2*2 and ADH3*1, both coding for the most active enzymatic forms. In conclusion, the ADH2*2 allele decreases the risk for alcoholism, whereas the ADH2*2 and ADH3*1 alleles are found to be associated in the European population.

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Metadata

Authors
Borràs, E., Coutelle, C., Rosell, A., Fernández-Muixi, F., Broch, M., Crosas, B., Hjelmqvist, L., Lorenzo, A., Gutiérrez, C., Santos, M., Szczepanek, M., Heilig, M., Quattrocchi, P., Farrés, J., Vidal, F., Richart, C., Mach, T., Bogdal, J., Jörnvall, H., Seitz, H. K., Couzigou, P., & Parés, X.
Venue
Hepatology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2000-04
Volume
31
Issue
4
Pages
984-989
ISSN
0270-9139 (ISSN-L)
DOI
10.1053/he.2000.5978
OpenAlex
W2148911584
Cited by
256
References
51
FWCI
12.05
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Genetic polymorphism of alcohol dehydrogenase in europeans: The ADH2*2 allele decreases the risk for alcoholism and is associated with ADH3*1. https://app.cochat.ai/papers/10.1053/he.2000.5978
The paper
Borràs, E., Coutelle, C., Rosell, A., Fernández-Muixi, F., Broch, M., Crosas, B., Hjelmqvist, L., Lorenzo, A., Gutiérrez, C., Santos, M., Szczepanek, M., Heilig, M., Quattrocchi, P., Farrés, J., Vidal, F., Richart, C., Mach, T., Bogdal, J., Jörnvall, H., . . . Parés, X. (2000). Genetic polymorphism of alcohol dehydrogenase in europeans: The ADH2*2 allele decreases the risk for alcoholism and is associated with ADH3*1. Hepatology. https://doi.org/10.1053/he.2000.5978

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.