Pathogenesis of alcohol‐induced liver disease: Classical concepts and recent advances
Open accessAbstract
Alcoholic liver disease (ALD) is a primary consequence of heavy and prolonged drinking. ALD contributes to the bulk of liver disease burden worldwide. Progression of ALD is a multifactorial and multistep process that includes many genetic and environmental risk factors. The molecular pathogenesis of ALD involves alcohol metabolism and secondary mechanisms such as oxidative stress, endotoxin, cytokines and immune regulators. The histopathological manifestation of ALD occurs as an outcome of complex but controlled interactions between hepatic cell types. Hepatic stellate cells (HSCs) are the key drivers of fibrogenesis, but transformation of hepatocytes to myofibroblastoids also implicate parenchymal cells as playing an active role in hepatic fibrogenesis. Recent discoveries indicate that lipogenesis during the early stages of ALD is a risk for advancement to cirrhosis. Other recently identified novel molecules and physiological/cell signaling pathways include fibrinolysis, osteopontin, transforming growth factor‐β‐SMAD and hedgehog signaling, and involvement of novel cytokines in hepatic fibrogenesis. The observation that ALD and non‐alcoholic steatohepatitis share common pathways and genetic polymorphisms suggests operation of parallel pathogenic mechanisms. Future research involving genomics, epigenomics, deep sequencing and non‐coding regulatory elements holds promise to identify novel diagnostic and therapeutic targets for ALD. There is also a need for adequate animal models to study pathogenic mechanisms at the molecular level and targeted therapy.
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Nonoxidative pathway-derived metabolites, including PEth and FAEE, cause alcohol toxicity, but the mechanisms have not yet been determined.
“Nonoxidative pathway-derived metabolites, including PEth and FAEE, are also known to cause alcohol toxicity, but the mechanisms have not yet been determined [31,43].”
From Pathophysiological Aspects of Alcohol Metabolism in the Liver (2021) · cites this paper as [43]
Cites
Hayes, J. D., Flanagan, J. U., & Jowsey, I. R. (2004) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.45.120403.095857 · Cited by 3,565 · see citing works
Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
Romeo, S., Kozlitina, J., Xing, C., Pertsemlidis, A., Cox, D., Pennacchio, L. A., Boerwinkle, E., Cohen, J. C., & Hobbs, H. H. (2008) · Nature Genetics · doi:10.1038/ng.257 · Cited by 3,416 · see citing works
Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity.
MATTEONI, C., YOUNOSSI, Z., GRAMLICH, T., BOPARAI, N., LIU, Y., & MCCULLOUGH, A. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70506-8 · Cited by 3,345 · see citing works
Mechanisms of Hepatic Fibrogenesis
Friedman, S. L. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.03.003 · Cited by 2,640 · see citing works
Tanaka, Y., Nishida, N., Sugiyama, M., Kurosaki, M., Matsuura, K., Sakamoto, N., Nakagawa, M., Korenaga, M., Hino, K., Hige, S., et al. (2009) · Nature Genetics · doi:10.1038/ng.449 · Cited by 2,141 · see citing works
Medzhitov, R. M., & Janeway, C. A. (2000) · New England Journal of Medicine · doi:10.1056/nejm200008033430506 · Cited by 1,827 · see citing works
IL28B is associated with response to chronic hepatitis C interferon-α and ribavirin therapy
Study, F. T. H. C., Suppiah, V., Moldovan, M. V., Ahlenstiel, G., Berg, T., Weltman, M., Abate, M. L., Bassendine, M. F., Spengler, U., Dore, G. J., et al. (2009) · Nature Genetics · doi:10.1038/ng.447 · Cited by 1,807 · see citing works
Eta-1 (Osteopontin): An Early Component of Type-1 (Cell-Mediated) Immunity
Ashkar, S., Weber, G. F., Panoutsakopoulou, V., Sanchirico, M. E., Jansson, M., Zawaideh, S., Rittling, S. R., Denhardt, D. T., Glimcher, M. J., & Cantor, H. (2000) · Science · doi:10.1126/science.287.5454.860 · Cited by 1,125 · see citing works
Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis
Feldstein, A. E., Canbay, A., Angulo, P., Taniai, M., Burgart, L. J., Lindor, K. D., & Gores, G. J. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00907-7 · Cited by 1,085 · see citing works
A meta-analysis of alcohol consumption and the risk of 15 diseases
Corrao, G. (2004) · Preventive Medicine · doi:10.1016/j.ypmed.2003.11.027 · Cited by 1,077 · see citing works
Iredale, J. P., Benyon, R. C., Pickering, J., McCullen, M., Northrop, M., Pawley, S., Hovell, C., & Arthur, M. J. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1018 · Cited by 1,075 · see citing works
Denhardt, D. T., Noda, M., O'Regan, A. W., Pavlin, D., & Berman, J. S. (2001) · Journal of Clinical Investigation · doi:10.1172/jci12980 · Cited by 1,060 · see citing works
HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin
study, F. T. D., Daly, A. K., Donaldson, P. T., Bhatnagar, P., Shen, Y., Pe’er, I., Floratos, A., Daly, M. J., Goldstein, D. B., John, S., et al. (2009) · Nature Genetics · doi:10.1038/ng.379 · Cited by 1,041 · see citing works
Self-citationCytochrome P-4502E1: its physiological and pathological role
Lieber, C. S. (1997) · Physiological Reviews · doi:10.1152/physrev.1997.77.2.517 · Cited by 889 · see citing works
Prediction of risk of liver disease by alcohol intake, sex, and age: A prospective population study
Becker, U., Deis, A., Sørensen, T. I. A., Grønbæk, M., Borch‐Johnsen, K., Muller, C. F., Schnohr, P., & Jensen, G. B. (1996) · Hepatology · doi:10.1002/hep.510230513 · Cited by 847 · see citing works
Fibroblasts Derive from Hepatocytes in Liver Fibrosis via Epithelial to Mesenchymal Transition
Zeisberg, M., Yang, C., Martino, M., Duncan, M. B., Rieder, F., Tanjore, H., & Kalluri, R. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m700194200 · Cited by 838 · see citing works
Baldini, M., Lohman, I. C., Halonen, M. J., Erickson, R. P., Holt, P. G., & Martínez, F. D. (1999) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.20.5.3494 · Cited by 834 · see citing works
Oxidative stress-related molecules and liver fibrosis
Parola, M., & Robino, G. (2001) · Journal of Hepatology · doi:10.1016/s0168-8278(01)00142-8 · Cited by 781 · see citing works
Essential role of tumor necrosis factor α in alcohol-induced liver injury in mice
Yin, M., Wheeler, M. D., Kono, H., Bradford, B. U., Gallucci, R. M., Luster, M. I., & Thurman, R. G. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70354-9 · Cited by 699 · see citing works
Fracanzani, A., Valenti, L. N., Bugianesi, E., Andreoletti, M., Colli, A., Vanni, E., Bertelli, C., Fatta, E., Bignamini, D., Marchesini, G., et al. (2008) · Hepatology · doi:10.1002/hep.22429 · Cited by 692 · see citing works
Antibiotics prevent liver injury in rats following long-term exposure to ethanol
Adachi, Y., Moore, L. E., Bradford, B. U., Gao, W., & Thurman, R. G. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90027-6 · Cited by 692 · see citing works
Hayashi, S., Watanabe, J. A., & Kawajiri, K. (1991) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a123619 · Cited by 676 · see citing works
Wieckowska, A., Zein, N. N., Yerian, L. M., López, R., McCullough, A. J., & Feldstein, A. E. (2006) · Hepatology · doi:10.1002/hep.21223 · Cited by 668 · see citing works
Parlesak, A., Schäfer, C., Schütz, T., Bode, J. C., & Bode, C. (2000) · Journal of Hepatology · doi:10.1016/s0168-8278(00)80242-1 · Cited by 647 · see citing works
Drinking habits as cofactors of risk for alcohol induced liver damage
Bellentani, S., Saccoccio, G., Costa, G., Tiribelli, C., Manenti, F., Sodde, M., Croce’, L. S., Sasso, F., Pozzato, G., Cristianini, G., et al. (1997) · Gut · doi:10.1136/gut.41.6.845 · Cited by 630 · see citing works
Radaeva, S., Sun, R., Jaruga, B., Nguyen, V. T., Tian, Z., & Gao, B. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.10.055 · Cited by 610 · see citing works
Alcohol and Oxidative Liver Injury
Dey, A., & Cederbaum, A. I. (2006) · Hepatology · doi:10.1002/hep.20957 · Cited by 560 · see citing works
You, M., Fischer, M., Deeg, M. A., & Crabb, D. W. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202411200 · Cited by 543 · see citing works
Experimental liver cirrhosis induced by alcohol and iron.
Tsukamoto, H., Horne, W., Kamimura, S., Niemelä, O. J., Parkkila, S., Ylä‐Herttuala, S., & Brittenham, G. M. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118077 · Cited by 512 · see citing works
FASTSNP: an always up-to-date and extendable service for SNP function analysis and prioritization
Yuan, H., Chiou, J.-J., Tseng, W.-H., Liu, C.-H., Liu, C.-K., Lin, Y.-J., Wang, H.-H., Yao, A., Chen, Y., & Hsu, C. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl236 · Cited by 510 · see citing works
Signalling pathways in alcohol-induced liver inflammation
Mandrekar, P., & Szabó, G. (2009) · Journal of Hepatology · doi:10.1016/j.jhep.2009.03.007 · Cited by 500 · see citing works
Toll–Like Receptor 4 Is Involved in the Mechanism of Early Alcohol–Induced Liver Injury in Mice
Uesugi, T., Froh, M., Arteel, G. E., Bradford, B. U., & Thurman, R. G. (2001) · Hepatology · doi:10.1053/jhep.2001.25350 · Cited by 488 · see citing works
Mechanisms of Disease Progression in Nonalcoholic Fatty Liver Disease
Jou, J. H., Choi, S. S., & Diehl, A. M. (2008) · Seminars in Liver Disease · doi:10.1055/s-0028-1091981 · Cited by 482 · see citing works
Self-citationRichardson, M. M., Jonsson, J. R., Powell, E. E., Brunt, E. M., Neuschwander–Tetri, B. A., Bhathal, P. S., Dixon, J. B., Weltman, M. D., Tilg, H., Moschen, A. R., et al. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.05.012 · Cited by 482 · see citing works
Hrubec, Z., & Omenn, G. S. (1981) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1981.tb04890.x · Cited by 464 · see citing works
Mato, J. M., Cámara, J., de Paz, J. F., Caballería, L., Coll, S., Caballero, A., Garcı́a-Buey, L., Beltrán, J., Benita, V., Caballería, J., et al. (1999) · Journal of Hepatology · doi:10.1016/s0168-8278(99)80263-3 · Cited by 462 · see citing works
Small integrin-binding ligand N-linked glycoproteins (SIBLINGs): multifunctional proteins in cancer
Bellahcène, A., Castronovo, V., Ogbureke, K. U. E., Fisher, L. W., & Fedarko, N. S. (2008) · Nature reviews. Cancer · doi:10.1038/nrc2345 · Cited by 455 · see citing works
Yuan, X., Waterworth, D. M., Perry, J. R. B., Lim, N., Song, K. S., Chambers, J. C., Zhang, W., Vollenweider, P., Stirnadel-Farrant, H. A., Johnson, T., et al. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2008.09.012 · Cited by 449 · see citing works
CONSEQUENCES OF ALCOHOL CONSUMPTION ON HOST DEFENCE
Szabó, G. (1999) · Alcohol and Alcoholism · doi:10.1093/alcalc/34.6.830 · Cited by 449 · see citing works
Roskams, T., Yang, S. Q., Koteish, A., Durnez, A., DeVos, R., Huang, X., Achten, R., Verslype, C., & Diehl, A. M. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63489-x · Cited by 447 · see citing works
Self-citationInsulin Resistance in Nonalcoholic Fatty Liver Disease
Bugianesi, E., Moscatiello, S., Ciaravella, M. F., & Marchesini, G. (2010) · Current Pharmaceutical Design · doi:10.2174/138161210791208875 · Cited by 446 · see citing works
Variant in PNPLA3 is associated with alcoholic liver disease
Tian, C., Stokowski, R. P., Kershenobich, D., Ballinger, D. G., & Hinds, D. A. (2009) · Nature Genetics · doi:10.1038/ng.488 · Cited by 435 · see citing works
The interleukin-17 pathway is involved in human alcoholic liver disease # †
Lemmers, A., Moreno, C., Gustot, T., Maréchal, R., Degré, D., Demetter, P., de Nadai, P., Geerts, A., Quertinmont, E., Vercruysse, V., et al. (2009) · Hepatology · doi:10.1002/hep.22680 · Cited by 394 · see citing works
Current concepts in the pathogenesis of alcoholic liver injury
Tsukamoto, H., & Lu, S. C.-L. (2001) · The FASEB Journal · doi:10.1096/fj.00-0650rev · Cited by 381 · see citing works
II. Alcoholic liver injury involves activation of Kupffer cells by endotoxin
Thurman, R. G. (1998) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1998.275.4.g605 · Cited by 378 · see citing works
Steatosis: Co-factor in Other Liver Diseases *
Powell, E. E., Jonsson, J. R., & Clouston, A. D. (2005) · Hepatology · doi:10.1002/hep.20750 · Cited by 372 · see citing works
Zhang, J., Zhang, Z., Lin, F., Zou, Z., Xu, R., Jin, L., Fu, J., Shi, F., Shi, M., Wang, H., et al. (2009) · Hepatology · doi:10.1002/hep.23273 · Cited by 371 · see citing works
Genome-Wide Association Analysis in Primary Sclerosing Cholangitis
Karlsen, T. H., Franke, A., Melum, E., Kaser, A., Hov, J. R., Balschun, T. C., Lie, B. A., Bergquist, A. M., Schramm, C., Weismüller, T. J., et al. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.11.046 · Cited by 360 · see citing works
Bradham, C. A., Plümpe, J., Manns, M. P., Brenner, D. A., & Trautwein, C. (1998) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1998.275.3.g387 · Cited by 355 · see citing works
Kaimori, A., Potter, J. J., Kaimori, J.-Y., Wang, C., Mezey, E., & Koteish, A. A. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m700998200 · Cited by 354 · see citing works
Iron imports. IV. Hepcidin and regulation of body iron metabolism
Ganz, T., & Nemeth, E. (2006) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00412.2005 · Cited by 347 · see citing works
Omenetti, A., Porrello, A., Jung, Y., Yang, L., Popov, Y. V., Choi, S. S., Witek, R. P., Alpini, G. D., Venter, J., VanDongen, H. M. A., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci35875 · Cited by 342 · see citing works
Self-citationMathers, C. D., Stevenson, C., Vos, E. T., & Begg, S. J. (2000) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.2000.tb124125.x · Cited by 339 · see citing works
Liver fibrogenesis and the role of hepatic stellate cells: New insights and prospects for therapy
Li, D., & Friedman, S. L. (1999) · Journal of Gastroenterology and Hepatology · doi:10.1046/j.1440-1746.1999.01928.x · Cited by 337 · see citing works
Rockey, D. C. (1997) · Hepatology · doi:10.1002/hep.510250102 · Cited by 336 · see citing works
Fernández-Checa, J. C., Kaplowitz, N., García‐Ruiz, C., Colell, A., Miranda, M., Marı́, M., Ardite, E., & Morales, A. (1997) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1997.273.1.g7 · Cited by 332 · see citing works
Epithelial‐to‐mesenchymal transitions in the liver†
Choi, S. S., & Diehl, A. M. (2009) · Hepatology · doi:10.1002/hep.23196 · Cited by 305 · see citing works
Self-citationOxidative mechanisms in the pathogenesis of alcoholic liver disease
Albano, E. (2007) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2007.09.004 · Cited by 303 · see citing works
Role of Oxidative Stress and Antioxidant Therapy in Alcoholic and Nonalcoholic Liver Diseases
Lieber, C. S. (1996) · Advances in pharmacology · doi:10.1016/s1054-3589(08)61001-7 · Cited by 299 · see citing works
Yoshikawa, T., Ide, T., Shimano, H., Yahagi, N., Amemiya-Kudo, M., Matsuzaka, T., Yatoh, S., Kitamine, T., Okazaki, H., Tamura, Y., et al. (2003) · Molecular Endocrinology · doi:10.1210/me.2002-0190 · Cited by 299 · see citing works
Mori, R., Shaw, T. J., & Martin, P. B. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20071412 · Cited by 294 · see citing works
Genetic variation in the PNPLA3 gene is associated with alcoholic liver injury in caucasians
Stickel, F., Buch, S., Lau, K., zu Schwabedissen, H. E. M., Berg, T., Ridinger, M., Rietschel, M., Schafmayer, C., Braun, F., Hinrichsen, H. M., et al. (2010) · Hepatology · doi:10.1002/hep.24017 · Cited by 291 · see citing works
Fischer, M., You, M., Matsumoto, M., & Crabb, D. W. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302140200 · Cited by 291 · see citing works
Marra, F., DeFranco, R., Grappone, C., Milani, S., Pastacaldi, S., Pinzani, M., Romanelli, R. G., Laffi, G., & Geñtilini, P. (1998) · Europe PMC (PubMed Central) · Cited by 287 · see citing works
Wiese, J. G., Shlipak, M. G., & Browner, W. S. (2000) · Annals of Internal Medicine · doi:10.7326/0003-4819-132-11-200006060-00008 · Cited by 285 · see citing works
Accumulation of natural killer T cells in progressive nonalcoholic fatty liver disease
Syn, W.-K., Oo, Y. H., Pereira, T. A., Karaca, G. F., Jung, Y., Omenetti, A., Witek, R. P., Choi, S. S., Guy, C. D., Fearing, C. M., et al. (2010) · Hepatology · doi:10.1002/hep.23599 · Cited by 283 · see citing works
Self-citationAlcohol metabolism and cancer risk.
Seitz, H. K., & Becker, P. B. (2007) · PubMed · Cited by 281 · see citing works
Su, G. L., Klein, R., Aminlari, A., Zhang, H. Y., Steinstraesser, L., Alarcon, W. H., Remick, D., & Wang, S. C. (2000) · Hepatology · doi:10.1053/he.2000.5634 · Cited by 280 · see citing works
Dooley, S., Hamzavi, J., Ciuclan, L. I., Godoy, P., Ilkavets, I., Ehnert, S., Ueberham, E., Gebhardt, R., Kanzler, S., Geier, A., et al. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.04.038 · Cited by 280 · see citing works
Cytokines and Alcoholic Liver Disease
McClain, C. J., Hill, D. B., Schmidt, J., & Diehl, A. M. (1993) · Seminars in Liver Disease · doi:10.1055/s-2007-1007347 · Cited by 279 · see citing works
Self-citationPan, M., Cederbaum, A. I., Zhang, Y., Ginsberg, H. N., Williams, K. J., & Fisher, E. A. A. (2004) · Journal of Clinical Investigation · doi:10.1172/jci19197 · Cited by 278 · see citing works
Syn, W.-K., Choi, S. S., Liaskou, E., Karaca, G. F., Agboola, K. M., Oo, Y. H., Mi, Z., Pereira, T. A., Zdanowicz, M., Malladi, P., et al. (2011) · Hepatology · doi:10.1002/hep.23998 · Cited by 275 · see citing works
Self-citationAlcohol, host defence and society
Nelson, S., & Kolls, J. K. (2002) · Nature reviews. Immunology · doi:10.1038/nri744 · Cited by 268 · see citing works
Chakraborty, G., Jain, S., & Kundu, G. C. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-2126 · Cited by 267 · see citing works
You, M., Considine, R. V., Leone, T. C., Kelly, D. P., & Crabb, D. W. (2005) · Hepatology · doi:10.1002/hep.20821 · Cited by 259 · see citing works
Syn, W., Jung, Y., Omenetti, A., Abdelmalek, M. F., Guy, C. D., Yang, L., Wang, J., Witek, R. P., Fearing, C. M., Pereira, T. A., et al. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.06.051 · Cited by 257 · see citing works
Self-citationZhang, S., Fei, T., Zhang, L., Zhang, R., Chen, F., Ning, Y., Han, Y., Feng, X., Meng, A., & Chen, Y. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01636-06 · Cited by 257 · see citing works
Borràs, E., Coutelle, C., Rosell, A., Fernández-Muixí, F., Broch, M., Crosas, B., Hjelmqvist, L., Lorenzo, A., Gutiérrez, C., Mauro Santos, A., et al. (2000) · Hepatology · doi:10.1053/he.2000.5978 · Cited by 257 · see citing works
Sozio, M., & Crabb, D. (2008) · American Journal of Physiology. Endocrinology and Metabolism · doi:10.1152/ajpendo.00011.2008 · Cited by 256 · see citing works
McClain, C. J., Song, Z., Barve, S. S., Hill, D. B., & Deaciuc, I. V. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00171.2004 · Cited by 254 · see citing works
Baulande, S., Lasnier, F., Lucas, M., & Pairault, J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m105193200 · Cited by 252 · see citing works
Jeong, W., Park, O., & Gao, B. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.09.034 · Cited by 248 · see citing works
Disease Progression in Chronic Hepatitis C: Modifiable and Nonmodifiable Factors
Missiha, S. B., Ostrowski, M., & Heathcote, E. J. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.02.069 · Cited by 227 · see citing works
Osteopontin as a mediator of NKT cell function in T cell-mediated liver diseases.
Diao, H., Kon, S., Iwabuchi, K., Kimura, C., Morimoto, J., Ito, D., Segawa, T., Maeda, M., Hamuro, J., Nakayama, T., et al. (2004) · Immunity · doi:10.1016/j.immuni.2004.08.012 · Cited by 226 · see citing works
Motsinger‐Reif, A. A., Haas, D. W., Stanic, A. K., Kaer, L. V., Joyce, S., & Unutmaz, D. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20011712 · Cited by 218 · see citing works
Prognostic factors in alcoholic liver disease. VA Cooperative Study Group.
Chedid, A., Mendenhall, C. L., Gartside, P. S., French, S. W., Chen, T., & Rabin, L. (1991) · PubMed · Cited by 214 · see citing works
Peroxisome proliferator-activated receptor ? protects against alcohol-induced liver damage
Nakajima, T., Kamijo, Y., Tanaka, N., Sugiyama, E., Tanaka, E. I., Kiyosawa, K., Fukushima, Y., Peters, J. M., Gonzalez, F. J., & Aoyama, T. (2004) · Hepatology · doi:10.1002/hep.20399 · Cited by 214 · see citing works
Watanabe, J. A., Hayashi, S., & Kawajiri, K. (1994) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a124526 · Cited by 213 · see citing works
Hedgehog signaling maintains resident hepatic progenitors throughout life
Sicklick, J. K., Li, Y.-X., Melhem, A., Schmelzer, E., Zdanowicz, M., Huang, J., Caballero, M., Fair, J. H., Ludlow, J. W., McClelland, R., et al. (2005) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00456.2005 · Cited by 212 · see citing works
Self-citationBergheim, I., Guo, L., Davis, M. A., Lambert, J. C., Beier, J. I., Duveau, I., Luyendyk, J. P., Roth, R. A., & Arteel, G. E. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.03.020 · Cited by 205 · see citing works
Zintzaras, E., Stefanidis, I., Mauro Santos, A., & Vidal, F. (2006) · Hepatology · doi:10.1002/hep.21023 · Cited by 201 · see citing works
Hepatocyte CYP2E1 overexpression and steatohepatitis lead to impaired hepatic insulin signaling
Schattenberg, J. M., Wang, Y., Singh, R., Rigoli, R. M., & Czaja, M. J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m410310200 · Cited by 194 · see citing works
Review article: alcoholic liver disease – pathophysiological aspects and risk factors
Gramenzi, A., Caputo, F., Biselli, M., KURIA, F., Loggi, E., Andreoné, P., & Bernardi, M. (2006) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2006.03110.x · Cited by 191 · see citing works
Casini, A., Cunningham, M., Rojkind, M., & Lieber, C. S. (1991) · Hepatology · doi:10.1002/hep.1840130424 · Cited by 189 · see citing works
Inagaki, M., Moustakas, A., Lin, H. Y.-F., Lodish, H. F., & Carr, B. I. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.11.5359 · Cited by 188 · see citing works
Yamamoto, N., Sakai, F., Kon, S., Morimoto, J. O., Kimura, C., Yamazaki, H., Okazaki, I., Seki, N., Fujii, T., & Uede, T. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17778 · Cited by 187 · see citing works
Horiguchi, N., Wang, L., Mukhopadhyay, P., Park, O., Jeong, W.-I., Lafdil, F., Osei-Hyiaman, D., Moh, A., Fu, X.-Y., Pacher, P., et al. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.01.016 · Cited by 185 · see citing works
Pattern recognition receptors: A contemporary view on liver diseases
Szabó, G., Dolganiuc, A., & Mandrekar, P. (2006) · Hepatology · doi:10.1002/hep.21308 · Cited by 182 · see citing works
Distribution of ethanol-induced protein adducts in vivo: relationship to tissue injury,
Niemelä, O. J. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00744-4 · Cited by 181 · see citing works
Sahai, A., Malladi, P., Melin-Aldana, H., Green, R. M., & Whitington, P. F. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00002.2004 · Cited by 181 · see citing works
An osteopontin fragment is essential for tumor cell invasion in hepatocellular carcinoma
Takafuji, V., Forgues, M., Unsworth, E. J., Goldsmith, P. K., & Wang, X. W. (2007) · Oncogene · doi:10.1038/sj.onc.1210463 · Cited by 178 · see citing works
Choi, S. S., Syn, W., Karaca, G., Omenetti, A., Moylan, C. A., Witek, R. P., Agboola, K. M., Jung, Y., Michelotti, G. A., & Diehl, A. M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.168542 · Cited by 174 · see citing works
Self-citationGenetic Predisposition to Organ‐Specific Endpoints of Alcoholism
Reed, T., Page, W. F., Viken, R. J., & Christian, J. C. (1996) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1996.tb01695.x · Cited by 171 · see citing works
Acetate, the Key Modulator of Inflammatory Responses in Acute Alcoholic Hepatitis
Kendrick, S. F. W., O’Boyle, G., Mann, J., Zeybel, M., Palmer, J. M., Jones, D. E. J., & Day, C. (2010) · Hepatology · doi:10.1002/hep.23572 · Cited by 169 · see citing works
Self-citationJung, Y., Brown, K. D., Witek, R. P., Omenetti, A., Yang, L., Vandongen, M., Milton, R. J., Hines, I. N., Rippe, R. A., Spahr, L., et al. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.02.022 · Cited by 167 · see citing works
Self-citationInterleukin 10 promoter region polymorphisms and susceptibility to advanced alcoholic liver disease
Grove, J., Daly, A. K., Bassendine, M. F., Gilvarry, E., & Day, C. P. (2000) · Gut · doi:10.1136/gut.46.4.540 · Cited by 166 · see citing works
Self-citationDifferential gene expression between chronic hepatitis B and C hepatic lesion
Honda, M., Kaneko, S., Kawai, H. F., Shirota, Y., & KOBAYASHI, K. P. (2001) · Gastroenterology · doi:10.1053/gast.2001.22468 · Cited by 161 · see citing works
Signals from dying hepatocytes trigger growth of liver progenitors
Jung, Y., Witek, R. P., Syn, W., Choi, S. S., Omenetti, A., Premont, R. T., Guy, C. D., & Diehl, A. M. (2010) · Gut · doi:10.1136/gut.2009.204354 · Cited by 161 · see citing works
Self-citationAlcohol induced hepatic fibrosis: Role of acetaldehyde
Mello, T., Ceni, E., Surrenti, C., & Galli, A. (2008) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2007.10.001 · Cited by 160 · see citing works
Peroxisome proliferator-activated receptor α protects against alcohol-induced liver damage
Nakajima, T., Kamijo, Y., Tanaka, N., Sugiyama, E., Tanaka, E., Kiyosawa, K., Fukushima, Y., Peters, J. M., Gonzalez, F. J., & Aoyama, T. (2004) · Hepatology · doi:10.1002/hep.1840400428 · Cited by 158 · see citing works
Hines, I. N., & Wheeler, M. D. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00094.2004 · Cited by 158 · see citing works
[Cytokines in health and disease].
Fireman, L., & Qivity, S. (1996) · PubMed · Cited by 158 · see citing works
RNA Aptamer Blockade of Osteopontin Inhibits Growth and Metastasis of MDA-MB231 Breast Cancer Cells
Mi, Z., Guo, H., Russell, M. B., Liu, Y., Sullenger, B. A., & Kuo, P. C. (2008) · Molecular Therapy · doi:10.1038/mt.2008.235 · Cited by 157 · see citing works
Hepatic mitochondrial DNA deletion in alcoholics: Association with microvesicular steatosis
Fromenty, B., Grimbert, S., Mansouri, A., Beaugrand, M., Erlinger, S., Rötig, A., & Pessayre, D. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90024-1 · Cited by 150 · see citing works
Expression of Interleukin-10 by in Vitro and in Vivo Activated Hepatic Stellate Cells
Wang, S. C., Ohata, M., Schrum, L. W., Rippe, R. A., & Tsukamoto, H. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.1.302 · Cited by 150 · see citing works
Järveläinen, H. A., Orpana, A., Perola, M., Savolainen, V. T., Karhunen, P. J., & Lindros, K. O. (2001) · Hepatology · doi:10.1053/jhep.2001.24236 · Cited by 149 · see citing works
Kawashima, R., Mochida, S., Matsui, A., YouLuTuZ, Y., Ishikawa, K., Toshima, K., Yamanobe, F., Inao, M., Ikeda, H., Ohno, A., et al. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0372 · Cited by 148 · see citing works
Qin, X., Xie, X., Fan, Y., Tian, J., Guan, Y., Wang, X., Zhu, Y., & Wang, N. (2008) · Hepatology · doi:10.1002/hep.22334 · Cited by 147 · see citing works
Nagy, L. E. (2004) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.24.012003.132258 · Cited by 145 · see citing works
Adiponectin and alcoholic fatty liver disease
Rogers, C. Q., Ajmo, J. M., & You, M. (2008) · IUBMB Life · doi:10.1002/iub.124 · Cited by 138 · see citing works
Kishore, R., Hill, J. R., McMullen, M. R., Frenkel, J., & Nagy, L. E. (2002) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00328.2001 · Cited by 137 · see citing works
Poon, T. C. W., Hui, A., Chan, H. L., Ang, I. L., Chow, S. M., Wong, N., & Sung, J. J. �. (2005) · Clinical Chemistry · doi:10.1373/clinchem.2004.041764 · Cited by 131 · see citing works
Jung, Y., McCall, S. J., Li, Y., & Diehl, A. M. (2007) · Hepatology · doi:10.1002/hep.21660 · Cited by 122 · see citing works
Self-citationIdentification of Transcriptional Networks during Liver Regeneration
White, P., Brestelli, J. E., Kaestner, K. H., & Greenbaum, L. E. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m410844200 · Cited by 120 · see citing works
Degoul, F., Sutton, A., Mansouri, A., Cepanec, C., Valla, D. C., Pessayre, D., Fromenty, B., Degott, C., & Beaugrand, M. (2001) · Gastroenterology · doi:10.1053/gast.2001.24051 · Cited by 117 · see citing works
Anti‐TGF‐β Strategies for the Treatment of Chronic Liver Disease
Breitkopf, K., Haas, S., Wiercinska, E., Singer, M. V., & Dooley, S. (2005) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000189284.98684.22 · Cited by 116 · see citing works
Evidence for epithelial-mesenchymal transitions in adult liver cells
Sicklick, J. K., Choi, S. S., Bustamante, M., McCall, S. J., Pérez, E. H., Huang, J., Li, Y., Rojkind, M., & Diehl, A. M. (2006) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00102.2006 · Cited by 116 · see citing works
Self-citationMcMullen, M. R., Pritchard, M. T., Wang, Q., Millward, C. A., Croniger, C. M., & Nagy, L. E. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.02.065 · Cited by 116 · see citing works
THE ROLE OF GENETIC POLYMORPHISMS IN ALCOHOLIC LIVER DISEASE
Stickel, F., & Österreicher, C. (2006) · Alcohol and Alcoholism · doi:10.1093/alcalc/agl011 · Cited by 110 · see citing works
Omenetti, A., & Diehl, A. M. (2008) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00543.2007 · Cited by 109 · see citing works
Self-citationNanji, A. A., Dannenberg, A. J., Jokelainen, K., & Bass, N. M. (2004) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.064717 · Cited by 107 · see citing works
Structural Requirements for α9β1-Mediated Adhesion and Migration to Thrombin-Cleaved Osteopontin
Smith, L. L., & Giachelli, C. M. (1998) · Experimental Cell Research · doi:10.1006/excr.1998.4108 · Cited by 105 · see citing works
Hemochromatosis and alcoholic liver disease
Fletcher, L. M., & Powell, L. W. (2003) · Alcohol · doi:10.1016/s0741-8329(03)00128-9 · Cited by 104 · see citing works
AICAR, an AMPK Activator, Has Protective Effects on Alcohol‐Induced Fatty Liver in Rats
Tomita, K., Tamiya, G., Ando, S., Kitamura, N., Koizumi, H., Kato, S., Horie, Y., Kaneko, T., Azuma, T., Nagata, H., et al. (2005) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000191126.11479.69 · Cited by 102 · see citing works
Role of osteopontin in hepatic neutrophil infiltration during alcoholic steatohepatitis
Apte, U. M., Banerjee, A., Mcree, R., Wellberg, E. A., & Ramaiah, S. K. (2005) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2004.12.018 · Cited by 101 · see citing works
Repair‐related activation of hedgehog signaling promotes cholangiocyte chemokine production†
Omenetti, A., Syn, W., Jung, Y., Francis, H., Porrello, A., Witek, R. P., Choi, S. S., Yang, L., Mayo, M. J., Gershwin, M. E., et al. (2009) · Hepatology · doi:10.1002/hep.23019 · Cited by 100 · see citing works
Self-citationTransforming growth factor‐β and hepatocyte transdifferentiation in liver fibrogenesis
Meindl‐Beinker, N. M., & Dooley, S. (2008) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2007.05297.x · Cited by 100 · see citing works
Enomoto, N., Takei, Y., Hirose, M., Konno, A., Shibuya, T., Matsuyama, S., Suzuki, S., Ikejima, K., & Sato, N. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.047217 · Cited by 99 · see citing works
Interplay between oxidative stress and immunity in the progression of alcohol-mediated liver injury
Vidali, M., Stewart, S. F., & Albano, E. (2008) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2007.12.005 · Cited by 97 · see citing works
Li, T. (2008) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2007.05298.x · Cited by 95 · see citing works
Kohgo, Y. (2007) · World Journal of Gastroenterology · doi:10.3748/wjg.v13.i35.4699 · Cited by 91 · see citing works
Reuben, A. (2007) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e3280f27582 · Cited by 91 · see citing works
The liver: a model of organ-specific lymphocyte recruitment
Lalor, T., & Adams, D. (2002) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399402004155 · Cited by 90 · see citing works
Hanck, C., Rossol, S., BOCKER, U., TOKUS, M., & SINGER, M. V. (1998) · Alcohol and Alcoholism · doi:10.1093/alcalc/33.6.606 · Cited by 89 · see citing works
Ethanol‐Induced Liver Injury: Potential Roles for Egr‐1
Pritchard, M. T., & Nagy, L. E. (2005) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000189286.81943.51 · Cited by 88 · see citing works
Teramoto, H., Castellone, M. D., Malek, R. L., Letwin, N. E., Frank, B. C., Gutkind, J. S., & Lee, N. H. (2004) · Oncogene · doi:10.1038/sj.onc.1208209 · Cited by 88 · see citing works
Cook, R. T., Schlueter, A. J., Coleman, R. A., Tygrett, L. T., Ballas, Z. K., Jerrells, T. R., Nashelsky, M. B., Ray, N. B., Haugen, T. H., & Waldschmidt, T. J. (2007) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2007.00478.x · Cited by 84 · see citing works
Role of different dietary fatty acids in the pathogenesis of experimental alcoholic liver disease
Nanji, A. A. (2004) · Alcohol · doi:10.1016/j.alcohol.2004.08.005 · Cited by 84 · see citing works
ICAM-1 is involved in the mechanism of alcohol-induced liver injury: studies with knockout mice
Kono, H., Uesugi, T., Froh, M., Rusyn, I., Bradford, B. U., & Thurman, R. G. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.280.6.g1289 · Cited by 82 · see citing works
Signaling pathways activated by microorganisms
Takeuchi, O., & Akira, S. (2007) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2007.02.006 · Cited by 81 · see citing works
Chen, A. (2002) · Biochemical Journal · doi:10.1042/bj20020949 · Cited by 81 · see citing works
Nakamachi, T., Nomiyama, T., Gizard, F., Heywood, E. B., Jones, K. L., Zhao, Y., Fuentes, L., Takebayashi, K., Aso, Y., Staels, B., et al. (2007) · Diabetes · doi:10.2337/db06-1177 · Cited by 80 · see citing works
Helluin, O., Chan, C., Vilaire, G., Mousa, S. A., DeGrado, W. F., & BENNETT, J. S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001529200 · Cited by 79 · see citing works
Gene Expression Profiling of Alcoholic Liver Disease in the Baboon (Papio hamadryas) and Human Liver
Seth, D., Leo, M. A., McGuinness, P. H., Lieber, C. S., Brennan, Y., Williams, R. B. H., Wang, X. M., McCaughan, G. W., Gorrell, M. D., & Haber, P. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63587-0 · Cited by 78 · see citing works
Self-citationUlrich, R. G., Rockett, J. C., Gibson, G. G., & Pettit, S. D. (2004) · Environmental Health Perspectives · doi:10.1289/ehp.6675 · Cited by 78 · see citing works
Pathogenesis and management of alcoholic hepatitis
Haber, P., Warner, R. H., Seth, D., Gorrell, M. D., & McCaughan, G. W. (2003) · Journal of Gastroenterology and Hepatology · doi:10.1046/j.1440-1746.2003.03217.x · Cited by 77 · see citing works
Self-citationDas, R., Philip, S., Mahabeleshwar, G. H., Bulbule, A., & Kundu, G. C. (2005) · IUBMB Life · doi:10.1080/15216540500159424 · Cited by 77 · see citing works
Fatty acid ethyl esters: markers of alcohol abuse and alcoholism
Kaphalia, B. S., Cai, P., Khan, M. F., Okorodudu, A. O., & Ansari, G. A. S. (2004) · Alcohol · doi:10.1016/j.alcohol.2004.07.013 · Cited by 75 · see citing works
Takamatsu, M., Yamauchi, M., Maezawa, Y., Saitô, S., Maeyama, S., & Uchikoshi, T. (2000) · The American Journal of Gastroenterology · doi:10.1016/s0002-9270(00)00822-4 · Cited by 74 · see citing works
Lipid peroxidation and hepatic antioxidants in alcoholic liver disease.
Situnayake, R. D., Crump, B. J., Thurnham, D. I., Davies, J. A., Gearty, J., & Davis, M. (1990) · Gut · doi:10.1136/gut.31.11.1311 · Cited by 73 · see citing works
Fatty Liver Disease NASH and Related Disorders
Hughes, R. D. (2006) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-200606000-00020 · Cited by 71 · see citing works
Intrahepatic gene expression in human alcoholic hepatitis
Seth, D., Gorrell, M. D., Cordoba, S. P., McCaughan, G. W., & Haber, P. (2006) · Journal of Hepatology · doi:10.1016/j.jhep.2006.04.013 · Cited by 71 · see citing works
Self-citationA common variant in the adiponutrin gene influences liver enzyme values
Kollerits, B., Coassin, S., Zollner-Kiechl, S., Hunt, S. C., Paulweber, B., Willeit, J., Kloss‐Brandstätter, A., Lamina, C., Adams, T. D., & Kronenberg, F. (2009) · Journal of Medical Genetics · doi:10.1136/jmg.2009.066597 · Cited by 70 · see citing works
Hebbachi, A., Knight, B. L., Wiggins, D. K., Patel, D. D., & Gibbons, G. F. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m709471200 · Cited by 68 · see citing works
Norkina, O., Dolganiuc, A., Shapiro, T., Kodys, K., Mandrekar, P., & Szabó, G. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0207099 · Cited by 67 · see citing works
Seth, D., Gorrell, M. D., McGuinness, P. H., Leo, M. A., Lieber, C. S., McCaughan, G. W., & Haber, P. (2003) · Journal of Biochemical and Biophysical Methods · doi:10.1016/s0165-022x(02)00177-x · Cited by 64 · see citing works
Self-citationNath, B., & Szabó, G. (2009) · Seminars in Liver Disease · doi:10.1055/s-0029-1214372 · Cited by 61 · see citing works
New role of plasminogen activator inhibitor‐1 in alcohol‐induced liver injury
Arteel, G. E. (2008) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2007.05285.x · Cited by 61 · see citing works
Ladero, J. M., Martı́nez, C., García‐Martín, E., Fernández‐Arquero, M., López‐Alonso, G., de la Concha, E. G., Díaz‐Rubio, M., & Agúndez, J. A. G. (2005) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520510012109 · Cited by 61 · see citing works
Hepatic stellate cells and fibrosis progression in patients with nonalcoholic fatty liver disease
Feldstein, A. E., Papouchado, B. G., Angulo, P., Sanderson, S., Adams, L. A., & Gores, G. J. (2005) · Clinical Gastroenterology and Hepatology · doi:10.1016/s1542-3565(04)00616-0 · Cited by 60 · see citing works
Role for hedgehog pathway in regulating growth and function of invariant NKT cells
Syn, W., Witek, R. P., Curbishley, S. M., Jung, Y., Choi, S. S., Enrich, B., Omenetti, A., Agboola, K. M., Fearing, C. M., Tilg, H., et al. (2009) · European Journal of Immunology · doi:10.1002/eji.200838890 · Cited by 58 · see citing works
Self-citationStewart, S. F. (2002) · Hepatology · doi:10.1053/jhep.2002.36940 · Cited by 55 · see citing works
Direct effects of alcohol on hepatic fibrinolytic balance: Implications for alcoholic liver disease
Seth, D., Hogg, P. J., Gorrell, M. D., McCaughan, G. W., & Haber, P. (2008) · Journal of Hepatology · doi:10.1016/j.jhep.2007.12.015 · Cited by 55 · see citing works
Self-citationFatty Acid Ethyl Esters: Ethanol Metabolites That Reflect Ethanol Intake
Soderberg, B. L., Salem, R. O., Best-Popescu, C. A., Cluette‐Brown, J. E., & Laposata, M. (2003) · Pathology Patterns Reviews · doi:10.1309/6f39-ear2-l4gy-x5g6 · Cited by 55 · see citing works
Corrao, G., Ferrari, P. A., Zambon, A., & Torchio, P. (1997) · Journal of Studies on Alcohol · doi:10.15288/jsa.1997.58.486 · Cited by 54 · see citing works
Large-scale gene profiling of the liver in a mouse model of chronic, intragastric ethanol infusion.
Deaciuc, I., Doherty, D., Burikhanov, R., Lee, E. Y., Stromberg, A., Peng, X., & de Villiers, W. D. (2004) · Journal of Hepatology · doi:10.1016/j.jhep.2003.10.021 · Cited by 53 · see citing works
T-cell activation after chronic ethanol ingestion in mice
Cook, R. T., Zhu, X., Coleman, R. A., Ballas, Z. K., Waldschmidt, T. J., Ray, N. B., LaBrecque, D. R., & Cook, B. L. (2004) · Alcohol · doi:10.1016/j.alcohol.2004.06.007 · Cited by 52 · see citing works
Shackel, N. A., McGuinness, P. H., Abbott, C. A., Gorrell, M. D., & McCaughan, G. W. (2003) · Hepatology · doi:10.1053/jhep.2003.50376 · Cited by 51 · see citing works
Ethanol inhibits hepatocyte proliferation in insulin receptor substrate 1 transgenic mice
Mohr, L., Tanaka, S., & Wands, J. R. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70036-8 · Cited by 49 · see citing works
Leiper, K., Croll, A. M., Booth, N. A., Moore, N. R., Sinclair, T. S., & Bennett, B. (1994) · Journal of Clinical Pathology · doi:10.1136/jcp.47.3.214 · Cited by 49 · see citing works
Casini, A., Ceni, E., Salzano, R., Milani, S., Schuppan, D., & Surrenti, C. (1994) · Life Sciences · doi:10.1016/0024-3205(94)00763-2 · Cited by 47 · see citing works
Glutathione‐S‐Transferase GST M1 “Null” Genotype and the Risk of Alcoholic Liver Disease
Savolainen, V. T., Pajarinen, J., Perola, M., Penttilä, A., & Karhunen, P. J. (1996) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1996.tb01132.x · Cited by 46 · see citing works
Role of osteopontin in regulating hepatic inflammatory responses and toxic liver injury
Ramaiah, S. K., & Rittling, S. R. (2007) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425225.3.4.519 · Cited by 46 · see citing works
Per capita alcohol consumption in Australia: will the real trend please step forward?
Chikritzhs, T. N., ALLSOP, S. J., Moodie, R., & Hall, W. (2010) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.2010.tb04069.x · Cited by 45 · see citing works
Liang, W., Chikritzhs, T. N., Richard, P., & Binns, C. W. (2010) · Internal Medicine Journal · doi:10.1111/j.1445-5994.2010.02279.x · Cited by 44 · see citing works
Urokinase-type plasminogen activator supports liver repair independent of its cellular receptor
Shanmukhappa, K. S., Sabla, G. E., Degen, J. L., & Bezerra, J. A. (2006) · BMC Gastroenterology · doi:10.1186/1471-230x-6-40 · Cited by 44 · see citing works
Shao, R. (2005) · World Journal of Gastroenterology · doi:10.3748/wjg.v11.i13.1995 · Cited by 44 · see citing works
Brind, A. M., HURLSTONE, A., EDRISINGHE, D., Gilmore, I. T., Fisher, N. C., Pirmohamed, M., & Fryer, A. A. (2004) · Alcohol and Alcoholism · doi:10.1093/alcalc/agh105 · Cited by 44 · see citing works
Sieghart, W., Wang, X., Schmid, K., Pinter, M., König, F., Bodingbauer, M., Wrba, F., Rasoul‐Rockenschaub, S., & Peck‐Radosavljevic, M. (2010) · Journal of Hepatology · doi:10.1016/j.jhep.2010.06.030 · Cited by 43 · see citing works
Alcohol, Signaling, and ECM Turnover
Seth, D., D'Souza, N. B., Apte, M. V., Marı́, M., Dooley, S., Neuman, M. G., Haber, P., Kundu, G. C., Darwanto, A., de Villiers, W. J. S., et al. (2009) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2009.01060.x · Cited by 40 · see citing works
Self-citationDiscriminating two classes of toxicants through expression analysis of HepG2 cells with DNA arrays
Hong, Y., Müller, U. R., & Lai, F. (2003) · Toxicology in Vitro · doi:10.1016/s0887-2333(02)00122-4 · Cited by 38 · see citing works
Interleukin-12 Therapy Restores Cell-Mediated Immunity in Ethanol-Consuming Mice
Peterson, J. D., Vasquez, K. O., & Waltenbaugh, C. R. (1998) · Alcoholism Clinical and Experimental Research · doi:10.1097/00000374-199802000-00034 · Cited by 38 · see citing works
Schrum, L. W., Bird, M. A., Salcher, O., Burchardt, E. R., Grisham, J. W., Brenner, D. A., Rippe, R. A., & Behrns, K. E. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.280.1.g139 · Cited by 37 · see citing works
Fat paradox of steatohepatitis
Tsukamoto, H., She, H., Hazra, S., Cheng, J. H., & Wang, J. (2008) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2007.05294.x · Cited by 36 · see citing works
Mortality from liver disease in the West Midlands, 1993-2000: observational study
Fisher, N. C., Hanson, J., Phillips, A., Rao, J. N., & Swarbrick, E. T. (2002) · BMJ · doi:10.1136/bmj.325.7359.312 · Cited by 36 · see citing works
LEUCOCYTE ADHESION MOLECULES AND ALCOHOLIC LIVER DISEASE
Adams, D. (1994) · Alcohol and Alcoholism · doi:10.1093/oxfordjournals.alcalc.a045531 · Cited by 35 · see citing works
Osteopontin Small Interfering RNA Protects Mice from Fulminant Hepatitis
Saito, Y., Kon, S., Fujiwara, Y., Nakayama, Y., Kurotaki, D., Fukuda, N., Kimura, C., Kanayama, M., Ito, K., Diao, H., et al. (2007) · Human Gene Therapy · doi:10.1089/hum.2007.069 · Cited by 32 · see citing works
Sahai, A., Pan, X., Paul, R., Malladi, P., Kohli, R., & Whitington, P. F. (2006) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00360.2005 · Cited by 32 · see citing works
Patatin‐like phospholipase domain containing 3
Seth, D., Daly, A. K., Haber, P., & Day, C. P. (2010) · Hepatology · doi:10.1002/hep.23606 · Cited by 32 · see citing works
Self-citationValenti, L. V. C. (2004) · Alcohol and Alcoholism · doi:10.1093/alcalc/agh047 · Cited by 30 · see citing works
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Pathophysiological Aspects of Alcohol Metabolism in the Liver
Hyun, J., Han, J., Lee, C., Yoon, M., & Jung, Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115717 · Cited by 324 · see citing works
Alcoholic disease: Liver and beyond
Rocco, A. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i40.14652 · Cited by 260 · see citing works
Marshall, S. A., McClain, J. A., Kelso, M. L., Hopkins, D. M., Pauly, J. R., & Nixon, K. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.12.016 · Cited by 243 · see citing works
Baicalin and the liver-gut system: Pharmacological bases explaining its therapeutic effects
Hu, Q., Zhang, W., Wu, Z., Tian, X., Xiang, J., Li, L., Li, Z., Peng, X., Wei, S., Ma, X., et al. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105444 · Cited by 244 · see citing works
Animal models of chronic liver diseases
Liu, Y., Meyer, C., Xu, C., Weng, H., Hellerbrand, C., ten Dijke, P., & Dooley, S. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00199.2012 · Cited by 227 · see citing works
Pathogenesis, Early Diagnosis, and Therapeutic Management of Alcoholic Liver Disease
Kong, L.-Z., Chandimali, N., Han, Y., Lee, D., Kim, J., Kim, S., Kim, T., Jeong, D. K., Sun, H., Lee, D. S., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112712 · Cited by 205 · see citing works
Oxidative stress in alcohol-related liver disease
Tan, H. K., Yates, E., Lilly, K., & Dhanda, A. (2020) · World Journal of Hepatology · doi:10.4254/wjh.v12.i7.332 · Cited by 189 · see citing works
Longato, L., Ripp, K., Setshedi, M., Dostálek, M., Akhlaghi, F., Branda, M., Wands, J. R., & de la Monte, S. M. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/479348 · Cited by 133 · see citing works
Mechanisms of intrahepatic triglyceride accumulation
Ress, C. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i4.1664 · Cited by 133 · see citing works
Alcohol-associated liver disease: A review on its pathophysiology, diagnosis and drug therapy
Subramaniyan, V., Chakravarthi, S., Jegasothy, R., Wu, Y. S., Fuloria, N. K., Fuloria, S., Hazarika, I., & Das, A. (2021) · Toxicology Reports · doi:10.1016/j.toxrep.2021.02.010 · Cited by 132 · see citing works
Pathophysiology and Treatment Options for Hepatic Fibrosis: Can It Be Completely Cured?
Khanam, A., Saleeb, P. G., & Kottilil, S. (2021) · Cells · doi:10.3390/cells10051097 · Cited by 132 · see citing works
Ethanol and liver: Recent insights into the mechanisms of ethanol-induced fatty liver
Liu, J. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i40.14672 · Cited by 124 · see citing works
Impact of Alcohol Consumption on Male Fertility Potential: A Narrative Review
Finelli, R., Mottola, F., & Agarwal, A. K. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19010328 · Cited by 124 · see citing works
Natural Products for the Prevention and Treatment of Hangover and Alcohol Use Disorder
Wang, F., Li, Y., Zhang, Y.-J., Zhou, Y., Li, S., & Li, H. (2016) · Molecules · doi:10.3390/molecules21010064 · Cited by 116 · see citing works
Abdelmegeed, M. A., Ha, S.-K., Choi, Y., Akbar, M. D., & Song, B. (2017) · Current Molecular Pharmacology · doi:10.2174/1874467208666150817111114 · Cited by 102 · see citing works
la Tijera, F. H. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i16.4975 · Cited by 95 · see citing works
Maricic, I., Sheng, H., Marrero, I., Seki, E., Kisseleva, T., Chaturvedi, S., Molle, N., Mathews, S., Gao, B., & Kumar, V. (2014) · Hepatology · doi:10.1002/hep.27632 · Cited by 94 · see citing works
Alcohol and Substance Abuse in Solid-Organ Transplant Recipients
Parker, R., Armstrong, M. J., Corbett, C., Day, E., & Neuberger, J. (2013) · Transplantation · doi:10.1097/tp.0b013e31829f7579 · Cited by 88 · see citing works
Lee, H.-I., McGregor, R. A., Choi, M.-S., Seo, K.-I., Jung, U. J., Yeo, J., Kim, M.-J., & Lee, M.-K. (2013) · Life Sciences · doi:10.1016/j.lfs.2013.09.014 · Cited by 79 · see citing works
Guo, R., Xu, X., Babcock, S. A., Zhang, Y., & Ren, J. T. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2014.10.009 · Cited by 79 · see citing works
RetractedHong, M., Kim, S. W., Han, S. H., Kim, D. J., Suk, K. T., Kim, Y. S., Kim, M. J., Kim, M. Y., Baik, S. K., & Ham, Y. L. (2015) · PLoS ONE · doi:10.1371/journal.pone.0117451 · Cited by 78 · see citing works
Therapy for alcoholic liver disease
Jaurigue, M. M. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i9.2143 · Cited by 77 · see citing works
Protective effects of dioscin against alcohol-induced liver injury
Xu, T., Zheng, L., Xu, L., Yin, L., Qi, Y., Xu, Y., Han, X., & Peng, J. (2013) · Archives of Toxicology · doi:10.1007/s00204-013-1148-8 · Cited by 77 · see citing works
Lee, H.-I., Yun, K. W., Seo, K.-I., Kim, M., & Lee, M. (2014) · Metabolism · doi:10.1016/j.metabol.2014.01.003 · Cited by 64 · see citing works
Zhang, N., Hu, Y. W., Ding, C., Zeng, W., Shan, W., Fan, H. J., Zhao, Y., Shi, X., Gao, L., Xu, T., et al. (2016) · Toxicology Letters · doi:10.1016/j.toxlet.2016.12.010 · Cited by 64 · see citing works
Hollenbach, M. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18112466 · Cited by 62 · see citing works
Peng, J., Cui, T., Huang, F., Chen, L., Zhao, Y., Xu, L., Xu, L., Feng, Q., & Hu, Y. (2013) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.112.201137 · Cited by 59 · see citing works
Mitchell, T., Chacko, B., Ballinger, S. W., Bailey, S. M., Zhang, J., & Darley-Usmar, V. (2013) · Biochemical Society Transactions · doi:10.1042/bst20120231 · Cited by 57 · see citing works
Resveratrol Ameliorates Alcoholic Fatty Liver by Inducing Autophagy
Tang, L., Yang, F., Fang, Z., & Hu, C. (2016) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x16500671 · Cited by 52 · see citing works
Hepatoprotective Effect of Lactobacillus plantarum HFY09 on Ethanol-Induced Liver Injury in Mice
Gan, Y., Tong, J., Zhou, X., Long, X., Pan, Y., Liu, W., & Zhao, X. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.684588 · Cited by 50 · see citing works
Melatonin Upregulates the Activity of AMPK and Attenuates Lipid Accumulation in Alcohol-induced Rats
Rui, B.-B., Chen, H., Jang, L., Li, Z., Yang, J.-M., Xu, W., & Wei, W. (2015) · Alcohol and Alcoholism · doi:10.1093/alcalc/agv126 · Cited by 50 · see citing works
Dong, W., Xiong, Z., Wang, B., Tong, Q., & Li, Z. (2015) · Pharmacognosy Magazine · doi:10.4103/0973-1296.165556 · Cited by 49 · see citing works
Food and Nutrition in the Pathogenesis of Liver Damage
Mega, A., Marzi, L., Kob, M., Piccin, A., & Floreani, A. (2021) · Nutrients · doi:10.3390/nu13041326 · Cited by 48 · see citing works
Review article: the endocannabinoid system in liver disease, a potential therapeutic target
Basu, P. P., Aloysius, M. M., Shah, N. J., & Brown, R. S. (2014) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.12673 · Cited by 48 · see citing works
Wang, W., Shang, H., Li, J., Ma, Y., Xu, C., Ma, J., Hou, J., & Jiang, Z. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c06478 · Cited by 48 · see citing works
Brazilian Journal of Development
(2021) · doi:10.34117/25258761 · Cited by 46 · see citing works
Grasselli, E., Compalati, A. D., Voci, A., Vecchione, G., Ragazzoni, M., Gallo, G., Borro, P., Sumberaz, A., Testino, G., & Vergani, L. (2014) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2014.07.013 · Cited by 45 · see citing works
Decreased Peripheral Blood CD 4+/ CD 25+ Regulatory T Cells in Patients with Alcoholic Hepatitis
Almeida, J., Polvorosa, M. A., González‐Quintela, A., Marcos, M., Pastor, I., Cerceño, M. L. H., Órfão, A., & Laso, F. J. (2013) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12095 · Cited by 45 · see citing works
Lin, F., Taylor, N. J., Su, H., Huang, X., Hussain, M. J., Abeles, R. D., Blackmore, L., Zhou, Y., Ikbal, M. M., Heaton, N. D., et al. (2013) · Hepatology · doi:10.1002/hep.26334 · Cited by 44 · see citing works
Circadian Rhythms in Liver Physiology and Liver Diseases
Tong, X., & Yin, L. (2013) · Comprehensive physiology · doi:10.1002/cphy.c120017 · Cited by 48 · see citing works
Resveratrol Ameliorates Experimental Alcoholic Liver Disease by Modulating Oxidative Stress
He, P., Hou, Z., Chengjun, S., Wang, C., Li, B., & Imam, M. U. (2017) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2017/4287890 · Cited by 41 · see citing works
The Matrisome, Inflammation, and Liver Disease
Dolin, C. E., & Arteel, G. E. (2020) · Seminars in Liver Disease · doi:10.1055/s-0039-3402516 · Cited by 38 · see citing works
Qu, D., Chen, M., Zhu, H., Liu, X., Cui, Y., Zhou, W., & Zhang, M. (2023) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.149131 · Cited by 38 · see citing works
Stiuso, P., Bagarolo, M. L., Ilisso, C. P., Vanacore, D., Martino, E., Caraglia, M., Porcelli, M., & Cacciapuoti, G. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17050622 · Cited by 38 · see citing works
Fibrogenesis in alcoholic liver disease
Fujii, H. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i25.8048 · Cited by 37 · see citing works
Sun, Y., Kang, K., Li, Y., Sang, L.-X., & Chang, B. (2021) · Journal of Functional Foods · doi:10.1016/j.jff.2021.104865 · Cited by 36 · see citing works
Zabala, V., Tong, M., Yu, R., Ramirez, T., Yalcin, E. B., Balbo, S., Silbermann, E., Deochand, C., Nuñez, K. M., Hecht, S. S., et al. (2015) · Alcohol and Alcoholism · doi:10.1093/alcalc/agu083 · Cited by 35 · see citing works
Li, Z., Lian, Y., Wei, R., Jin, L., Cao, H., Zhao, T., Ma, X., Zhong, M., Gao, Y., & Zhang, K. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118546 · Cited by 35 · see citing works
Nguyen, V. L., Haber, P., & Seth, D. (2017) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13558 · Cited by 34 · see citing works
Self-citationLu, C., Jiang, Y., Zhang, F., Shao, J., Wu, L., Wu, X., Lian, N., Chen, L., Jin, H., Chen, Q., et al. (2015) · Life Sciences · doi:10.1016/j.lfs.2015.08.018 · Cited by 33 · see citing works
Telmisartan alleviates alcohol-induced liver injury by activation of PPAR-γ/ Nrf-2 crosstalk in mice
Abdelhamid, A. M., El‐Sheakh, A. R., Suddek, G. M., & Abdelaziz, R. R. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.107963 · Cited by 33 · see citing works
Transitional Remodeling of the Hepatic Extracellular Matrix in Alcohol-Induced Liver Injury
Poole, L. G., & Arteel, G. E. (2016) · BioMed Research International · doi:10.1155/2016/3162670 · Cited by 33 · see citing works
Ethanol sensitizes hepatocytes for TGF-β-triggered apoptosis
Gaitantzi, H., Meyer, C., Rakoczy, P., Thomas, M., Wahl, K., Wandrer, F., Bantel, H., Alborzinia, H., Wölfl, S., Ehnert, S., et al. (2018) · Cell Death and Disease · doi:10.1038/s41419-017-0071-y · Cited by 31 · see citing works
Effects of Ethanol Metabolites on Exocytosis of Pancreatic Acinar Cells in Rats
Dolai, S., Liang, T., Lam, P. P. L., Fernandez, N. A., Chidambaram, S., & Gaisano, H. Y. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.06.011 · Cited by 30 · see citing works
McMillin, M., Galindo, C., Pae, H. Y., Frampton, G. A., Patre, P. L. D., Quinn, M. A., Whittington, E., & DeMorrow, S. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2014.07.015 · Cited by 30 · see citing works
Hepatic mitochondrial dysfunction induced by fatty acids and ethanol
Gyamfi, D., Everitt, H., Tewfik, I., Clemens, D. L., & Patel, V. B. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.09.024 · Cited by 29 · see citing works
Yu, J. S., Li, C., Kwon, M., Oh, T., Lee, T. H., Kim, D. H., Ahn, J. S., Ko, S., Kim, C. S., Cao, S., et al. (2020) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2020.104397 · Cited by 28 · see citing works
Carvedilol Attenuates the Progression of Alcohol Fatty Liver Disease in Rats
Liu, J., Takase, I., Himemiya‐Hakucho, A., Okamura, N., & Fujimiya, T. (2012) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2012.01773.x · Cited by 28 · see citing works
Chronic ethanol consumption disrupts diurnal rhythms of hepatic glycogen metabolism in mice
Udoh, U. S., Swain, T. M., Filiano, A. N., Gamble, K. L., Young, M. E., & Bailey, S. M. (2015) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00081.2015 · Cited by 27 · see citing works
Emerging role of circadian clock disruption in alcohol-induced liver disease
Bailey, S. M. (2018) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00010.2018 · Cited by 25 · see citing works
Anti-Angiogenic Effects of Natural Compounds in Diet-Associated Hepatic Inflammation
Novi, S., Vestuto, V., Campiglia, P., Tecce, N., Bertamino, A., & Tecce, M. F. (2023) · Nutrients · doi:10.3390/nu15122748 · Cited by 26 · see citing works
Present and Future Perspectives in the Treatment of Liver Fibrosis
Cerrito, L., Galasso, L., Iaccarino, J., Pizzi, A., Termite, F., Esposto, G., Borriello, R., Ainora, M. E., Gasbarrini, A., & Zocco, M. A. (2025) · Pharmaceuticals · doi:10.3390/ph18091321 · Cited by 27 · see citing works
Papp-Peka, A., Tong, M., Kril, J. J., de la Monte, S. M., & Sutherland, G. T. (2016) · Alcohol and Alcoholism · doi:10.1093/alcalc/agw067 · Cited by 24 · see citing works
Hu, B., Zhang, J., Jiang, Y., Tong, W., Lai, S., & Ren, Y. (2020) · Food Chemistry · doi:10.1016/j.foodchem.2020.128489 · Cited by 23 · see citing works
Role of IRAK-M in Alcohol Induced Liver Injury
Wang, Y., Hu, Y., Chen, C., Yüksel, M., Colle, I. O., Flavell, R. A., Ma, Y., Yan, H., & Li, W. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057085 · Cited by 22 · see citing works
Yasmin, T., Menon, S. N., Pandey, A., Siddiqua, S., Kuddus, S. A., Alam, M. A., Khan, F., Hoque, N., Alam, M. A., Subhan, N., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-08450-z · Cited by 21 · see citing works
How much alcohol is consumed outside of the lifetime risk guidelines in Australia?
Callinan, S., Livingston, M., Room, R., & Dietze, P. (2017) · Drug and Alcohol Review · doi:10.1111/dar.12545 · Cited by 21 · see citing works
Promotion of Hepatocellular Carcinoma by Hepatitis C Virus
Bühler, S., & Bartenschlager, R. F. W. (2012) · Digestive Diseases · doi:10.1159/000341688 · Cited by 21 · see citing works
Cui, F., Hu, H. F., Guo, J., Sun, J. Y., & Shi, M. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00013 · Cited by 21 · see citing works
Betaine regulates the gut-liver axis: a therapeutic approach for chronic liver diseases
Perumal, S. K., Arumugam, M. K., Osna, N. A., Rasineni, K., & Kharbanda, K. K. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1478542 · Cited by 20 · see citing works
Siregar, A. S., Nyiramana, M. M., Kim, E., Shin, E., Woo, M. S., Kim, J.-M., Kim, J. H., Lee, D., Hahm, J. R., Kim, H. J., et al. (2020) · Marine Drugs · doi:10.3390/md18100512 · Cited by 20 · see citing works
Boye, A. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i1.50 · Cited by 20 · see citing works
Yang, Q., Luo, C., Zhang, X., Liu, Y., Wang, Z., Cacciamani, P., Shi, J., Cui, Y., Wang, C., Sinha, B., et al. (2020) · PubMed Central · Cited by 19 · see citing works
Peng, J., Cui, T., Sun, Z., Huang, F., Chen, L., Xu, L., Feng, Q., & Hu, Y. (2012) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2012/234987 · Cited by 19 · see citing works
Hao, Y., Fang, H., Yan, X. S., Shen, W., Liu, J., Han, P., Zhao, Y. M., Zhang, W., & Feng, Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043097 · Cited by 18 · see citing works
Serum lipid profile in alcoholic cirrhosis: A study in a teaching hospital of north-eastern India
Sinha, A., Phukan, J., & Deka, J. (2013) · Nigerian Medical Journal · doi:10.4103/0300-1652.108886 · Cited by 18 · see citing works
Wine, Polyphenols, and the Matrix Effect: Is Alcohol Always the Same?
Miraldi, E., Baini, G., Biagi, M., Cappellucci, G., Giordano, A., Vaccaro, F., & Bertelli, A. A. E. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25189796 · Cited by 17 · see citing works
Yao, R., Yasuoka, A., Kamei, A., Ushiama, S., Kitagawa, Y., Rogi, T., Shibata, H., Abe, K., & Misaka, T. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087142 · Cited by 17 · see citing works
Ketamine plus Alcohol: What We Know and What We Can Expect about This
Kobayashi, N. H. C., Farias, S. V., Luz, D. A., Ferraro, K. M. M. M., da Conceição, B. C., da Silveira, C. C. S. D. M., Fernandes, L. M. P., Cartágenes, S. D. C., Ferreira, V. M. M., Fontes-Júnior, E. A., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23147800 · Cited by 16 · see citing works
Peculiar characteristics of portal-hepatic hemodynamics of alcoholic cirrhosis
Bolognesi, M. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i25.8005 · Cited by 16 · see citing works
Hollenbach, M., Thonig, A., Pohl, S., Ripoll, C., Michel, M. S., & Zipprich, A. (2017) · PLoS ONE · doi:10.1371/journal.pone.0171260 · Cited by 16 · see citing works
Zhang, C., Yu, H., Tang, W., Sil, D., Jensen‐Smith, H. C., Bennett, R. G., McVicker, B. L., & Oupický, D. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14030669 · Cited by 15 · see citing works
Xu, H., Shi, J., Yu, W., Sun, S., Zhou, H., Wang, L., Ren, J. T., Gu, Z., Qi, L., & Zhang, Y. (2025) · Metabolism · doi:10.1016/j.metabol.2025.156290 · Cited by 16 · see citing works
Vidyashankar, S., Nandakumar, K. S., & Patki, P. S. (2012) · Toxicology · doi:10.1016/j.tox.2012.07.009 · Cited by 15 · see citing works
Asai, A., Malladi, S., Misch, J., Pan, X., Malladi, P., Diehl, A. M., & Whitington, P. F. (2014) · Human Pathology · doi:10.1016/j.humpath.2014.09.010 · Cited by 15 · see citing works
Self-citationMladenović, D. R., Ninković, M., Aleksić, V., Šljivančanin, T., Vučević, D. B., Todorović, V., Stanković, M. N., Stanojlović, O. P., & Radosavljević, T. S. (2013) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2013.04.002 · Cited by 15 · see citing works
Probiotics in treating with alcoholic liver disease and nonalcoholic fatty liver disease
Liu, L., Wang, Y., Zhang, J., Wang, C., Li, Y., Dai, W., Piao, C., Liu, J., Yu, H., Li, X., et al. (2021) · Food Reviews International · doi:10.1080/87559129.2021.1967380 · Cited by 14 · see citing works
Klein, J. D., Sherrill, J. B., Morello, G. M., Miguel, P. J. S., Ding, Z., Liangpunsakul, S., Liang, T., Muir, W. M., Lumeng, L., & Lossie, A. C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0110501 · Cited by 14 · see citing works
Long-term Management of Alcoholic Liver Disease
Woo, G. A., & O’Brien, C. (2012) · Clinics in Liver Disease · doi:10.1016/j.cld.2012.08.007 · Cited by 14 · see citing works
Dietary modulators of statin efficacy in cardiovascular disease and cognition
Wang, H., Blumberg, J. B., Chen, C. ‐. O., Choi, S., Corcoran, M. P., Harris, S. S., Jacques, P. F., Kristo, A. S., Lai, C., Lamon‐Fava, S., et al. (2014) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2014.04.001 · Cited by 14 · see citing works
Xu, J., Li, H.-D., Wu, M., Zhu, L., Du, X., Li, J., Li, Z., Meng, X., Huang, C., & Li, J. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.107471 · Cited by 13 · see citing works
Hu, C., Meng, X., Huang, C., Shen, C., & Li, J. (2016) · Journal of Leukocyte Biology · doi:10.1189/jlb.2hi1115-491r · Cited by 13 · see citing works
Shi, C., Wang, L., Zhou, K., Shao, M., Yifei, L. U., & Wu, T. (2020) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.66.536 · Cited by 12 · see citing works
Zhu, Y., Jia, Y., & Zhang, E. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1516603 · Cited by 15 · see citing works
Thapa, K., Grewal, A. S., Kanojia, N., Rani, L., Sharma, N., & Singh, S. (2020) · Current Drug Discovery Technologies · doi:10.2174/1570163817666200121143959 · Cited by 12 · see citing works
Salehi, E., Mashayekh, M., Taheri, F., Gholami, M., Motaghinejad, M., Safari, S., & Sepehr, A. (2021) · PubMed Central · doi:10.22037/ijpr.2020.112852.13985 · Cited by 11 · see citing works
Influence of aging on ethanol-induced oxidative stress in digestive tract of rats
Vučević, D. B., Mladenović, D. R., Ninković, M., Stanković, M., Jorgačević, B. Z., Stanković, M. N., Luka, S. R. D., & Radosavljević, T. S. (2012) · Human & Experimental Toxicology · doi:10.1177/0960327112467045 · Cited by 11 · see citing works
Sun, X., Ye, C., Deng, Q., Chen, J., & Guo, C. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118678 · Cited by 10 · see citing works
Wang, H. Y., Chi, C., Xu, Y. Q., Wang, C., Wang, T. Y., Lv, D., & Li, X. (2019) · Journal of Digestive Diseases · doi:10.1111/1751-2980.12800 · Cited by 9 · see citing works
Han, W., Li, H., Jiang, H., Xu, H., Lin, Y., Chen, J., Bi, C., & Liu, Z. (2023) · PeerJ · doi:10.7717/peerj.15977 · Cited by 10 · see citing works
- Authors
- Seth, D., Haber, P. S., Syn, W., Diehl, A. M., & Day, C. P.
- Affiliations
- The University of Sydney (AU)
- University of the Basque Country (ES)
- Duke Medical Center (US)
- Newcastle University (GB)
- Corresponding author
- Seth, Devanshi
- Venue
- Journal of Gastroenterology and Hepatology
- Publisher
- Wiley
- Published
- 2011-06-14
- Volume
- 26
- Issue
- 7
- Pages
- 1089-1105
- ISSN
- 0815-9319 (ISSN-L)
- 1440-1746
- OpenAlex
- W1574483226
- Cited by
- 166
- References
- 219
- Citations by year
- 2025: 10 · 2024: 3 · 2023: 10 · 2022: 6 · 2021: 16 · 2020: 22 · 2019: 4 · 2018: 4 · 2017: 8 · 2016: 12 · 2015: 16 · 2014: 21 · 2013: 17 · 2012: 15
- FWCI
- 2.18
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Gastroenterology and Hepatology (publishedVersion)
- PubMed (publishedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Funders
- National Institutes of Health (5r37aa010154-20)
- National Institute on Alcohol Abuse and Alcoholism (R37 AA-010154)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Keywords
- alcoholic liver disease, pathogenesis, alcohol metabolism, oxidative stress, endotoxin, cytokines, immune regulation, hepatic stellate cells, hepatic fibrogenesis, myofibroblast transformation, lipogenesis, liver cirrhosis, fibrinolysis, osteopontin, TGF-β/Smad signaling, Hedgehog signaling, nonalcoholic steatohepatitis, genetic polymorphism, epigenomics, animal models, therapeutic target
- MeSH terms
- Alcohol Drinking, Ethanol, Animals, Humans, Liver Diseases, Alcoholic, Risk Factors, Global Health, Prevalence, Oxidative Stress
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