Sleep Apnea, Coronary Artery Disease, and Antioxidant Status in Hemodialysis Patients
Abstract
Background It recently was suggested that sleep apnea syndrome (SAS) is associated with the cardiovascular complications and outcomes seen in patients with end-stage renal disease (ESRD). This study investigates the association of SAS with coronary artery disease and antioxidant status in patients with ESRD. Methods Twenty-six hemodialysis patients underwent overnight polysomnography to evaluate sleep parameters. We performed multirow spiral computed tomography to derive coronary artery calcification (CAC) scores as an indicator of the severity of coronary artery disease and measured predialysis serum total antioxidant status (TAS) as a marker of antioxidant defenses. Results Nine of 26 patients had normal to mild SAS with an apnea-hypopnea index (AHI) less than 15, 9 patients had moderate SAS with an AHI of 15 to 30, and the remaining 8 patients had severe SAS with an AHI greater than 30. AHI and oxygen desaturation index (ODI) were strongly interrelated (r = 0.754; P Conclusion These results suggest that frequent oxygen desaturation triggered by SAS is associated with severe coronary artery disease and decreased antioxidant status in patients with ESRD. However, conclusions from this study should be drawn with caution because of its methodological limitations (cross-sectional design, heterogeneity of study population, and small number of patients).
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Obstructive sleep apnea is a highly prevalent syndrome associated with substantial morbidity and increased mortality.
“OBSTRUCTIVE SLEEP APNEA (OSA) IS A HIGHLY PREV-ALENT SYNDROME THAT IS ASSOCIATED WITH SUB-STANTIAL MORBIDITY AND INCREASED MORTALITY. 1-10”
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- Authors
- Jung, H. H., Han, H., & Lee, J. H.
- Affiliations
- Kangwon National University (KR)
- Corresponding author
- Jung, Hae Hyuk
- Venue
- American Journal of Kidney Diseases
- Publisher
- Elsevier BV
- Published
- 2005-05
- Volume
- 45
- Issue
- 5
- Pages
- 875-882
- ISSN
- 0272-6386 (ISSN-L)
- OpenAlex
- W2012110747
- Cited by
- 60
- References
- 0
- Citations by year
- 2025: 1 · 2023: 2 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 4 · 2014: 2 · 2012: 5
- FWCI
- 4.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Kidney Diseases (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Health Sciences › Medicine › Pharmacology › Apelin-related biomedical research
- Keywords
- sleep apnea, coronary artery disease, antioxidant status, end-stage renal disease, hemodialysis patients, coronary artery calcification, apnea-hypopnea index, oxygen desaturation index, oxidative stress
- MeSH terms
- Hypoxia, Antioxidants, Calcinosis, Coronary Artery Disease, Cross-Sectional Studies, Female, Renal Dialysis, Humans, Hypertension, Kidney Failure, Chronic, Korea, Male, Middle Aged, Oxidation-Reduction, Oxygen, Severity of Illness Index, Sleep Apnea Syndromes, Smoking, Comorbidity, Polysomnography, Oxidative Stress, Tomography, Spiral Computed
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