Obstructive sleep apnoea syndrome – an oxidative stress disorder

Lavie, Lena

doi:10.1053/smrv.2002.0261

Cited by 993Obstructive Sleep Apnea ResearchNitric Oxide and Endothelin EffectsAntioxidant Activity and Oxidative Stress

Obstructive sleep apnoea syndrome – an oxidative stress disorder

Lavie, Lena·2003·Sleep Medicine Reviews

DOI 10.1053/smrv.2002.0261

Open this paper in CoChat — free account

Abstract

Obstructive sleep apnoea syndrome (OSA) is associated with increased cardiovascular morbidity and mortality. However, the underlying mechanisms are not entirely understood. This review will summarize the evidence that substantiates the notion that the repeated apnoea-related hypoxic events in OSA, similarly to hypoxia/reperfusion injury, initiate oxidative stress. Thus, affecting energy metabolism, redox-sensitive gene expression, and expression of adhesion molecules. A limited number of studies substantiate this hypothesis directly by demonstrating increased free radical production in OSA leukocytes and increased plasma-lipid peroxidation. A great number of studies, however, support this hypothesis indirectly. Increase in circulating levels of adenosine and urinary uric acid in OSA are implicated with increased production of reactive oxygen species (ROS). Activation of redox-sensitive gene expression is suggested by the increase in some protein products of these genes, including VEGF, erythropoietin, endothelin-1, inflammatory cytokines and adhesion molecules. These implicate the participation of redox-sensitive transcription factors as HIF-1 AP-1 and NFkappaB. Finally, adhesion molecule-dependent increased avidity of OSA monocytes to endothelial cells, combined with diminished NO bioavailability, lead to exaggerated endothelial cell damage and dysfunction. Cumulatively, these processes may exacerbate atherogenic sequelae in OSA.

Integrity signals

Registry

Crossref · 10.1053/smrv.2002.0261

Cites

130 of 130 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Long-term chronic hypoxia caused by OSA can lead to changes in NLR, PLR, C-reactive protein levels, and serum inflammation markers.
“Long-term chronic hypoxia caused by OSA can lead to several physiological and biochemical modifications, such as changes in the NLR, PLR, and levels of C-reactive proteins and markers of serum inflammation [33–37].”
From Airway morphology, hyoid position, and serum inflammatory markers of obstructive sleep apnea in children treated with modified twin-block appliances (2025) · cites this paper as [33]

Atherosclerosis--an inflammatory disease
Ross, R. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901143400207 · Cited by 21,725 · see citing works
Free Radicals in the Physiological Control of Cell Function
Dröge, W. (2002) · Physiological Reviews · doi:10.1152/physrev.00018.2001 · Cited by 9,855 · see citing works
Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly
Beckman, J. S., & Koppenol, W. H. (1996) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1996.271.5.c1424 · Cited by 5,513 · see citing works
Oxygen-Derived Free Radicals in Postischemic Tissue Injury
Epstein, F. H., & McCord, J. M. (1985) · New England Journal of Medicine · doi:10.1056/nejm198501173120305 · Cited by 5,399 · see citing works
[1] Role of free radicals and catalytic metal ions in human disease: An overview
Halliwell, B., & Gutteridge, J. M. C. (1990) · Methods in Enzymology · doi:10.1016/0076-6879(90)86093-b · Cited by 4,994 · see citing works
Prospective Study of the Association between Sleep-Disordered Breathing and Hypertension
Peppard, P. E., Young, T., Palta, M., & Skatrud, J. (2000) · New England Journal of Medicine · doi:10.1056/nejm200005113421901 · Cited by 4,973 · see citing works
Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis
Celermajer, D. S., Sorensen, K. E., Gooch, V. M., Spiegelhalter, D. J., Miller, O. I., Sullivan, I. D., Lloyd, J. K., & Deanfield, J. E. (1992) · The Lancet · doi:10.1016/0140-6736(92)93147-f · Cited by 4,742 · see citing works
A Quantitative Assessment of Plasma Homocysteine as a Risk Factor for Vascular Disease
Boushey, C. J. (1995) · JAMA · doi:10.1001/jama.1995.03530130055028 · Cited by 3,604 · see citing works
Association of Sleep-Disordered Breathing, Sleep Apnea, and Hypertension in a Large Community-Based Study
Nieto, F. J. (2000) · JAMA · doi:10.1001/jama.283.14.1829 · Cited by 3,369 · see citing works
Sleep-disordered Breathing and Cardiovascular Disease
SHAHAR, E., WHITNEY, C. W., REDLINE, S., LEE, E. T., NEWMAN, A. B., JAVIER NIETO, F., O'CONNOR, G. T., BOLAND, L. L., SCHWARTZ, J. E., & SAMET, J. M. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.163.1.2001008 · Cited by 2,901 · see citing works
NAD(P)H Oxidase: Role in Cardiovascular Biology and Disease
Griendling, K. K., Sorescu, D., & Ushio-Fukai, M. (2000) · Circulation Research · doi:10.1161/01.res.86.5.494 · Cited by 2,886 · see citing works
Sympathetic neural mechanisms in obstructive sleep apnea.
Somers, V. K., Dyken, M. E., Clary, M. P., & Abboud, F. M. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118235 · Cited by 2,527 · see citing works
Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone.
Rajagopalan, S., Kurz, S. D., Münzel, T. F., Tarpey, M. M., Freeman, B. Α., Griendling, K. K., & Harrison, D. G. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118623 · Cited by 2,441 · see citing works
Mitochondrial reactive oxygen species trigger hypoxia-induced transcription
Chandel, N. S., Maltepe, E., Goldwasser, E., Mathieu, C. E., Simon, M. C., & Schumacker, P. T. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.20.11715 · Cited by 1,926 · see citing works
Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis.
Ks, M. (1969) · PubMed · Cited by 1,824 · see citing works
Plasma Homocysteine Levels and Mortality in Patients with Coronary Artery Disease
Nygard, O. K., Nordrehaug, J. E., Refsum, H., Ueland, P. M., Farstad, M., & Vollset, S. E. (1997) · New England Journal of Medicine · doi:10.1056/nejm199707243370403 · Cited by 1,746 · see citing works
Plasma homocysteine as a risk factor for vascular disease. The European Concerted Action Project.
Graham, I. M., Daly, L. E., Refsum, H. M., Robinson, K., Brattström, L. E., Ueland, P. M., Palma-Reis, R. J., Boers, G. H., Sheahan, R. G., Israelsson, B., et al. (1997) · PubMed · doi:10.1001/jama.1997.03540460039030 · Cited by 1,738 · see citing works
Low Density Lipoprotein Oxidation and Its Pathobiological Significance
Steinberg, D. H. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.34.20963 · Cited by 1,643 · see citing works
Nitric Oxide Is Responsible for Flow-Dependent Dilatation of Human Peripheral Conduit Arteries In Vivo
Joannidès, R., Haefeli, W. E., Linder, L., Richard, V. J., Bakkali, E. H., Thuillez, C., & Lüscher, T. F. (1995) · Circulation · doi:10.1161/01.cir.91.5.1314 · Cited by 1,622 · see citing works
The evolution of free radicals and oxidative stress
McCord, J. M. (2000) · The American Journal of Medicine · doi:10.1016/s0002-9343(00)00412-5 · Cited by 1,396 · see citing works
Autoantibody against oxidised LDL and progression of carotid atherosclerosis
Salonen, J. T., Korpela, H., Salonen, R., Nyyssönen, K., Ylä‐Herttuala, S., Yamamoto, R., Butler, S., Palinski, W., & Witztum, J. L. (1992) · The Lancet · doi:10.1016/0140-6736(92)90926-t · Cited by 1,311 · see citing works
Association between Plasma Homocysteine Concentrations and Extracranial Carotid-Artery Stenosis
Selhub, J., Jacques, P. F., Bostom, A. G., D’Agostino, R. B., Wilson, P. W. F., Belanger, A. J., O’Leary, D. H., Wolf, P. A., Schaefer, E. J., & Rosenberg, I. H. (1995) · New England Journal of Medicine · doi:10.1056/nejm199502023320502 · Cited by 1,213 · see citing works
Sleep Apnea and Daytime Sleepiness and Fatigue: Relation to Visceral Obesity, Insulin Resistance, and Hypercytokinemia
Vgontzas, A. N., Papanicolaou, D. A., Bixler, E. O., Hopper, K. D., Lotsikas, A. J., LIN, H., Kales, A., & Chrousos, G. P. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.3.6484 · Cited by 1,196 · see citing works
Phagocytes and oxidative stress
Babior, B. M. (2000) · The American Journal of Medicine · doi:10.1016/s0002-9343(00)00481-2 · Cited by 1,061 · see citing works
Obstructive sleep apnoea syndrome as a risk factor for hypertension: population study
Lavie, P. (2000) · BMJ · doi:10.1136/bmj.320.7233.479 · Cited by 1,019 · see citing works
Elevation of Plasma Cytokines in Disorders of Excessive Daytime Sleepiness: Role of Sleep Disturbance and Obesity
Vgontzas, A. N., Papanicolaou, D. A., Bixler, E. O., Kales, A., Tyson, K., & Chrousos, G. P. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.5.3950 · Cited by 974 · see citing works
Population-Based Study of Sleep-Disordered Breathing as a Risk Factor for Hypertension
Young, T. B. (1997) · Archives of Internal Medicine · doi:10.1001/archinte.1997.00440360178019 · Cited by 967 · see citing works
Association of sleep apnoea with myocardial infarction in men
Hung, J., Whitford, E. G., Hillman, D. R., & Parsons, R. W. (1990) · The Lancet · doi:10.1016/0140-6736(90)91799-g · Cited by 905 · see citing works
Canine myocardial reperfusion injury. Its reduction by the combined administration of superoxide dismutase and catalase.
Jolly, S., Kane, W. J., Bailie, M. B., Abrams, G. D., & Lucchesi, B. R. (1984) · Circulation Research · doi:10.1161/01.res.54.3.277 · Cited by 900 · see citing works
A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes
Boushey, C. J. (1995) · JAMA · doi:10.1001/jama.274.13.1049 · Cited by 771 · see citing works
Increased Adhesion Molecules Expression and Production of Reactive Oxygen Species in Leukocytes of Sleep Apnea Patients
Dyugovskaya, L., Lavie, P., & Lavie, L. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.165.7.2104126 · Cited by 742 · see citing works
Self-citation
Impairment of Endothelium-Dependent Vasodilation of Resistance Vessels in Patients With Obstructive Sleep Apnea
Kato, M., Roberts‐Thomson, P., Phillips, B. G., Haynes, W. G., Winnicki, M., Accurso, V., & Somers, V. K. (2000) · Circulation · doi:10.1161/01.cir.102.21.2607 · Cited by 730 · see citing works
The oxidant stress of hyperhomocyst(e)inemia.
Loscalzo, J. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118776 · Cited by 724 · see citing works
The Yin and Yang of Oxidation in the Development of the Fatty Streak
Navab, M., Berliner, J. A., Watson, A. D., Hama, S. Y., Territo, M., Lusis, A. J., Shih, D. M., Lenten, B. J. V., Frank, J. S., Demer, L. L., et al. (1996) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.16.7.831 · Cited by 699 · see citing works
Hyperhomocyst(e)inemia Is Associated With Impaired Endothelium-Dependent Vasodilation in Humans
Tawakol, A. A., Omland, T., Gerhard, M. D., Wu, J. T., & Creager, M. A. (1997) · Circulation · doi:10.1161/01.cir.95.5.1119 · Cited by 683 · see citing works
Augmented Resting Sympathetic Activity in Awake Patients With Obstructive Sleep Apnea
Carlson, J. T., Hedner, J. A., Elam, M., Ejnell, H., Sellgren, J., & Wallin, B. G. (1993) · CHEST Journal · doi:10.1378/chest.103.6.1763 · Cited by 681 · see citing works
Intracellular Signaling by Reactive Oxygen Species during Hypoxia in Cardiomyocytes
Duranteau, J., Chandel, N. S., Kulisz, A., Shao, Z., & Schumacker, P. T. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.19.11619 · Cited by 679 · see citing works
Enhanced Release of Superoxide from Polymorphonuclear Neutrophils in Obstructive Sleep Apnea
Schulz, R., MAHMOUDI, S., Hattar, K., Sibelius, U., Olschewski, H., Mayer, K., Seeger, W., & Grimminger, F. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.162.2.9908091 · Cited by 639 · see citing works
Low density lipoprotein cytotoxicity induced by free radical peroxidation of lipid.
Morel, D. W., Hessler, J. R., & Chisolm, G. M. (1983) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37921-9 · Cited by 624 · see citing works
Marked reduction of free radical generation and contractile dysfunction by antioxidant therapy begun at the time of reperfusion. Evidence that myocardial "stunning" is a manifestation of reperfusion injury.
Bolli, R., Jeroudi, M. O., Patel, B. S., Aruoma, O. I., Halliwell, B. B., Lai, E. K., & McCay, P. B. (1989) · Circulation Research · doi:10.1161/01.res.65.3.607 · Cited by 579 · see citing works
Selective Potentiation of Peripheral Chemoreflex Sensitivity in Obstructive Sleep Apnea
Narkiewicz, K., van de Borne, P. J. H., Pesek, C. A., Dyken, M. E., Montano, N., & Somers, V. K. (1999) · Circulation · doi:10.1161/01.cir.99.9.1183 · Cited by 555 · see citing works
NADH oxidoreductase is a major source of superoxide anion in bovine coronary artery endothelium
Mohazzab, K. M., Kaminski, P. M., & Wolin, M. S. (1994) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1994.266.6.h2568 · Cited by 536 · see citing works
Vascular dysfunction in monkeys with diet-induced hyperhomocyst(e)inemia.
Lentz, S. R., Sobey, C. G., Piegors, D. J., Bhopatkar, M. Y., Faraci, F. M., Malinow, M. R., & Heistad, D. D. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118771 · Cited by 502 · see citing works
Circulating Nitric Oxide is Suppressed in Obstructive Sleep Apnea and is Reversed by Nasal Continuous Positive Airway Pressure
Ip, M., LAM, B. K., Chan, L., Zheng, L., TSANG, K. W. T., Fung, P. C. W., & Lam, W. K. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.162.6.2002126 · Cited by 479 · see citing works
Direct evidence that oxygen-derived free radicals contribute to postischemic myocardial dysfunction in the intact dog.
Bolli, R., Jeroudi, M. O., Patel, B. S., DuBose, C. M., Lai, E. K., Roberts, R., & McCay, P. B. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.12.4695 · Cited by 469 · see citing works
Effects of obstructive sleep apnea on endothelin-1 and blood pressure
Phillips, B. G., Narkiewicz, K., Pesek, C. A., Haynes, W. G., Dyken, M. E., & Somers, V. K. (1999) · Journal of Hypertension · doi:10.1097/00004872-199917010-00010 · Cited by 462 · see citing works
The role of sulfur-containing amino acids in superoxide production and modification of low density lipoprotein by arterial smooth muscle cells.
Heinecke, J. W., Rosen, H., Suzuki, L. A., & Chait, A. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)61082-8 · Cited by 459 · see citing works
Demonstration of Rapid Onset Vascular Endothelial Dysfunction After Hyperhomocysteinemia
Chambers, J. C., McGregor, A., Jean-Marie, J., Obeid, O., & Kooner, J. S. (1999) · Circulation · doi:10.1161/01.cir.99.9.1156 · Cited by 427 · see citing works
Plasma homocysteine as a risk factor for vascular disease. The European Concerted Action Project
Graham, I. M. (1997) · JAMA · doi:10.1001/jama.277.22.1775 · Cited by 409 · see citing works
Endothelial dysfunction in a murine model of mild hyperhomocyst(e)inemia
Eberhardt, R. T., Forgione, M. A., Cap, A., Leopold, J. A., Rudd, M. A., Trolliet, M. R., Heydrick, S. J., Stark, R., Klings, E. S., Moldovan, N. I., et al. (2000) · Journal of Clinical Investigation · doi:10.1172/jci8342 · Cited by 391 · see citing works
Invited Review: Physiological consequences of intermittent hypoxia: systemic blood pressure
Fletcher, E. C. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.90.4.1600 · Cited by 379 · see citing works
ENDOTHELIAL CELL RESPONSES TO HYPOXIC STRESS
Faller, D. V. (1999) · Clinical and Experimental Pharmacology and Physiology · doi:10.1046/j.1440-1681.1999.02992.x · Cited by 373 · see citing works
Leukocyte-endothelial cell interactions: Molecular mechanisms and implications in gastrointestinal disease☆☆☆
Panés, J., & Granger, D. N. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70328-2 · Cited by 369 · see citing works
Enhanced macrophage uptake of low density lipoprotein after self-aggregation.
Khoo, J. C., Miller, E. R., McLoughlin, P., & Steinberg, D. H. (1988) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.8.4.348 · Cited by 367 · see citing works
Redox Signaling and the Emerging Therapeutic Potential of Thiol Antioxidants
Sen, C. K. (1998) · Biochemical Pharmacology · doi:10.1016/s0006-2952(97)00672-2 · Cited by 358 · see citing works
Cellular thiols and redox-regulated signal transduction
Sen, C. K. (2001) · Current topics in cellular regulation · doi:10.1016/s0070-2137(01)80001-7 · Cited by 345 · see citing works
Hyperhomocysteinemia After an Oral Methionine Load Acutely Impairs Endothelial Function in Healthy Adults
Bellamy, M., McDowell, I., Ramsey, M. W., Brownlee, M., Bones, C., Newcombe, R. G., & LEWIS, M. J. (1998) · Circulation · doi:10.1161/01.cir.98.18.1848 · Cited by 336 · see citing works
Sleep-Disordered Breathing in Men With Coronary Artery Disease
Mooe, T., Rabben, T., Wiklund, U., Franklin, K. A., & Eriksson, P. (1996) · CHEST Journal · doi:10.1378/chest.109.3.659 · Cited by 333 · see citing works
Oxidative Stress and Cardiovascular Disease
Stanner, S., Coe, S., & Frayn, K. N. (2018) · doi:10.1002/9781118829875.ch9 · Cited by 330 · see citing works
Decreased plasma levels of nitric oxide derivatives in obstructive sleep apnoea: response to CPAP therapy
Schulz, R. (2000) · Thorax · doi:10.1136/thorax.55.12.1046 · Cited by 297 · see citing works
Modulation of leukocyte–endothelial interactions by reactive metabolites of oxygen and nitrogen: relevance to ischemic heart disease
Grisham, M. B., Granger, D. N., & Lefer, D. J. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00094-x · Cited by 293 · see citing works
Vascular Endothelial Growth Factor (VEGF) is Released from Platelets during Blood Clotting: Implications for Measurement of Circulating VEGF Levels in Clinical Disease
Webb, N. J. A., Bottomley, M. J., Watson, C. J., & Brenchley, P. E. (1998) · Clinical Science · doi:10.1042/cs0940395 · Cited by 285 · see citing works
Invited Review: Oxygen sensing during intermittent hypoxia: cellular and molecular mechanisms
Prabhakar, N. R. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.90.5.1986 · Cited by 281 · see citing works
Surges of muscle sympathetic nerve activity during obstructive apnea are linked to hypoxemia
Leuenberger, U. A., Jacob, E., Sweer, L., Waravdekar, N. V., Zwillich, C. W., & Sinoway, L. I. (1995) · Journal of Applied Physiology · doi:10.1152/jappl.1995.79.2.581 · Cited by 278 · see citing works
Attenuated endothelium-dependent vascular relaxation in patients with sleep apnoea
Carlson, J. T., ngemark, C. R., & Hedner, J. A. (1996) · Journal of Hypertension · doi:10.1097/00004872-199605000-00006 · Cited by 273 · see citing works
Increased levels of circulating ICAM-1, VCAM-1, and L-selectin in obstructive sleep apnea syndrome
Ohga, E., Nagase, T., Tomita, T., Teramoto, S., Matsuse, T., Katayama, H., & Ouchi, Y. (1999) · Journal of Applied Physiology · doi:10.1152/jappl.1999.87.1.10 · Cited by 265 · see citing works
Renin Activity and Blood Pressure in Response to Chronic Episodic Hypoxia
Fletcher, E. C., Bao, G., & Li, R. (1999) · Hypertension · doi:10.1161/01.hyp.34.2.309 · Cited by 261 · see citing works
Pulmonary Artery NADPH-Oxidase is Activated in Hypoxic Pulmonary Vasoconstriction
Marshall, C., Mamary, A. J., Verhoeven, A. J., & Marshall, B. E. (1996) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.15.5.8918370 · Cited by 257 · see citing works
Sleep apnea in patients with transient ischemic attack and stroke
Bassetti, C. L., Aldrich, M. S., Chervin, R. D., & Quint, D. J. (1996) · Neurology · doi:10.1212/wnl.47.5.1167 · Cited by 254 · see citing works
Obstructive Sleep Apnea Syndrome and Circadian Rhythms of Hormones and Cytokines
Entzian, P., Linnemann, K., Schlaak, M. S., & Zabel, P. (1996) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.153.3.8630548 · Cited by 248 · see citing works
Abnormal lipid peroxidation in patients with sleep apnoea
Barceló, A., Miralles, C., Barbé, F., Vila, M., Pons, S., & Agustí, A. G. N. (2000) · European Respiratory Journal · doi:10.1034/j.1399-3003.2000.16d13.x · Cited by 247 · see citing works
Impairment of Vascular Endothelial Function and Left Ventricular Filling
Kraiczi, H., Caidahl, K., Samuelsson, A., Peker, Y., & Hedner, J. A. (2001) · CHEST Journal · doi:10.1378/chest.119.4.1085 · Cited by 244 · see citing works
Effects of nasal continuous positive airway pressure on soluble cell adhesion molecules in patients with obstructive sleep apnea syndrome
Chin, K., Nakamura, T., Shimizu, K., Mishima, M., Nakamura, T., Miyasaka, M., & Ohi, M. (2000) · The American Journal of Medicine · doi:10.1016/s0002-9343(00)00580-5 · Cited by 229 · see citing works
Interindividual Heterogeneity in the Hypoxic Regulation of VEGF
Schultz, A., Lavie, L., Hochberg, I., Beyar, R., Stone, T., Skorecki, K. L., Lavie, P., Roguin, A., & Levy, A. P. (1999) · Circulation · doi:10.1161/01.cir.100.5.547 · Cited by 228 · see citing works
Self-citation
Serum Levels of Vascular Endothelial Growth Factor Are Elevated in Patients with Obstructive Sleep Apnea and Severe Nighttime Hypoxia
Schulz, R., Hummel, C., Heinemann, S., Seeger, W., & Grimminger, F. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.165.1.2101062 · Cited by 223 · see citing works
Cardiovascular effects of adenosine in man; possible clinical implications
Sollevi, A. (1986) · Progress in Neurobiology · doi:10.1016/0301-0082(86)90005-5 · Cited by 221 · see citing works
Hypoxia injures endothelial cells by increasing endogenous xanthine oxidase activity.
Terada, L. S., Guidot, D. M., Leff, J. A., Willingham, I. R., Hanley, M. E., Piermattei, D., & Repine, J. E. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.8.3362 · Cited by 207 · see citing works
Role of Endothelin in Intermittent Hypoxia-Induced Hypertension
Kanagy, N. L., Walker, B. R., & Nelin, L. D. (2001) · Hypertension · doi:10.1161/01.hyp.37.2.511 · Cited by 195 · see citing works
Oxidative stress and cardiovascular disease.
Rj, H. (1997) · PubMed · Cited by 189 · see citing works
Adhesion Molecules in Patients With Coronary Artery Disease and Moderate-to-Severe Obstructive Sleep Apnea
El-Solh, A., Mador, M. J., Sikka, P., Dhillon, R. S., Amsterdam, D., & Grant, B. J. B. (2002) · CHEST Journal · doi:10.1378/chest.121.5.1541 · Cited by 185 · see citing works
Sleep-related breathing disorder is an independent risk factor for uncontrolled hypertension
Grote, L., Hedner, J. A., & Peter, J. H. (2000) · Journal of Hypertension · doi:10.1097/00004872-200018060-00004 · Cited by 183 · see citing works
Erythropoietin response to acute normobaric hypoxia in humans
Knaupp, W., Khilnani, S., Sherwood, J. B., Scharf, S. M., & Steinberg, H. (1992) · Journal of Applied Physiology · doi:10.1152/jappl.1992.73.3.837 · Cited by 169 · see citing works
Plasma Vascular Endothelial Growth Factor in Sleep Apnea Syndrome: Effects of Nasal Continuous Positive Air Pressure Treatment
Lavie, L., Kraiczi, H., Hefetz, A., Ghandour, H., Perelman, A., Hedner, J. A., & Lavie, P. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.20110-040oc · Cited by 168 · see citing works
Self-citation
Blood pressure response to chronic episodic hypoxia: the renin-angiotensin system
Fletcher, E. C., Orolinova, N., & Bäder, M. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00152.2001 · Cited by 160 · see citing works
Oxygen-regulated transcription factors and their role in pulmonary disease
Semenza, G. L. (2000) · Respiratory Research · doi:10.1186/rr27 · Cited by 160 · see citing works
Airway effects of purine nucleosides and nucleotides and release with bronchial provocation in asthma
Mann, J. S., Holgate, S. T., Renwick, A. G. C., & Cushley, M. J. (1986) · Journal of Applied Physiology · doi:10.1152/jappl.1986.61.5.1667 · Cited by 158 · see citing works
Circulating Vascular Endothelial Growth Factor Levels in Patients with Obstructive Sleep Apnea
Gozal, D., Lipton, A. S., & Jones, K. (2002) · SLEEP · doi:10.1093/sleep/25.1.59 · Cited by 149 · see citing works
Selected Contribution: Altered vascular reactivity in arterioles of chronic intermittent hypoxic rats
Tahawi, Z., Orolinova, N., Joshua, I. G., Bäder, M., & Fletcher, E. C. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.90.5.2007 · Cited by 144 · see citing works
Possible Atherogenic Effects of Hypoxia During Obstructive Sleep Apnea
Dean, R. T., & Wilcox, I. (1993) · SLEEP · doi:10.1093/sleep/16.suppl_8.s15 · Cited by 142 · see citing works
Circulating xanthine oxidase mediates lung neutrophil sequestration after intestinal ischemia-reperfusion
Terada, L. S., Dormish, J. J., Shanley, P. F., Leff, J. A., Anderson, B. O., & Repine, J. E. (1992) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1992.263.3.l394 · Cited by 130 · see citing works
Obstructive Apnea during Sleep Is Associated with Peripheral Vasoconstriction
Imadojemu, V. A., Gleeson, K., Gray, K. S., Sinoway, L. I., & Leuenberger, U. A. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.165.1.2009062 · Cited by 115 · see citing works
Hyperoxic sheep pulmonary microvascular endothelial cells generate free radicals via mitochondrial electron transport.
Sanders, S. P., Zweier, J. L., Kuppusamy, P., Harrison, S. J., Bassett, D. J. P., Gabrielson, E. W., & SYLVESTER, J. T. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116198 · Cited by 110 · see citing works
Antagonism by theophylline of respiratory inhibition induced by adenosine
Eldridge, F. L., Millhorn, D. E., & Kiley, J. P. (1985) · Journal of Applied Physiology · doi:10.1152/jappl.1985.59.5.1428 · Cited by 110 · see citing works
Adhesion Molecules: The Path to a New Understanding of Acute Inflammation
Walzog, B., & Gaehtgens, P. A. L. (2000) · Physiology · doi:10.1152/physiologyonline.2000.15.3.107 · Cited by 109 · see citing works
Neurocirculatory consequences of intermittent asphyxia in humans
Xie, A., Skatrud, J. B., Crabtree, D. C., Puleo, D. S., Goodman, B., & Morgan, B. J. (2000) · Journal of Applied Physiology · doi:10.1152/jappl.2000.89.4.1333 · Cited by 108 · see citing works
Plasma Homocysteine Levels in Obstructive Sleep Apnea
Lavie, L., Perelman, A., & Lavie, P. (2001) · CHEST Journal · doi:10.1378/chest.120.3.900 · Cited by 100 · see citing works
Self-citation
Levels of vascular endothelial growth factor are elevated in patients with obstructive sleep apnea–hypopnea syndrome
Imagawa, S., Yamaguchi, Y., Higuchi, M., Neichi, T., Hasegawa, Y., Mukai, H. Y., Suzuki, N., Yamamoto, M., & Nagasawa, T. (2001) · Blood · doi:10.1182/blood.v98.4.1255 · Cited by 99 · see citing works
Angiotensin converting enzyme in patients with sleep apnoea syndrome: plasma activity and gene polymorphisms
Barceló, A., Elorza, M. Á., Barbé, F., Santos, C., Mayoralas, L. R., & Agustí, A. G. N. (2001) · European Respiratory Journal · doi:10.1183/09031936.01.17407280 · Cited by 99 · see citing works
Circulating Endothelin-1 in Obstructive Sleep Apnea
Saarelainen, S., Seppälä, E., Laasonen, K., & Hasan, J. (1997) · Endothelium · doi:10.3109/10623329709079869 · Cited by 97 · see citing works
Overnight Urinary Uric Acid: Creatinine Ratio for Detection of Sleep Hypoxemia: Validation Study in Chronic Obstructive Pulmonary Disease and Obstructive Sleep Apnea before and after Treatment with Nasal Continuous Positive Airway Pressure
Braghiroli, A., Sacco, C., Erbetta, M., Ruga, V., & Donner, C. F. (1993) · American Review of Respiratory Disease · doi:10.1164/ajrccm/148.1.173 · Cited by 89 · see citing works
Hypoxia‐induced upregulation of eNOS gene expression is redox‐sensitive: A comparison between hypoxia and inhibitors of cell metabolism
Hoffmann, A., GLOE, T. R., & Pohl, U. (2001) · Journal of Cellular Physiology · doi:10.1002/jcp.1092 · Cited by 89 · see citing works
Susceptibility of LDL to oxidative stress in obstructive sleep apnea.
Wali, S., BaHammam, A. S., Massaeli, H., Pierce, G. N., Iliskovic, N., Singal, P. K., & Kryger, M. H. (1998) · PubMed · Cited by 86 · see citing works
Endothelin-1 plasma levels are not elevated in patients with obstructive sleep apnoea
Grimpen, F., Kanne, P., Schulz, E. G., Hagenah, G. C., Hasenfuβ, G., & Andreas, S. (2000) · European Respiratory Journal · doi:10.1034/j.1399-3003.2000.15b17.x · Cited by 82 · see citing works
Disordered Breathing and Hypoxia during Sleep in Coronary Artery Disease
Olazabal, J. R. D., Miller, M. J., Cook, W. R., & Mithoefer, J. C. (1982) · CHEST Journal · doi:10.1378/chest.82.5.548 · Cited by 78 · see citing works
Changes in Urinary Uric Acid Excretion in Obstructive Sleep Apnea Before and After Therapy With Nasal Continuous Positive Airway Pressure
Sahebjami, H. (1998) · CHEST Journal · doi:10.1378/chest.113.6.1604 · Cited by 71 · see citing works
Role of inducible nitric oxide synthase in regulation of pulmonary vascular tone in the late gestation ovine fetus.
Rairigh, R. L., Cras, T. D. L., Ivy, D. D., Kinsella, J. P., Richter, G. T., Horan, M. P., Fan, I. X., & Abman, S. H. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1228 · Cited by 67 · see citing works
Sleep apnea in patients with acute myocardial infarction
Saito, T., Yoshikawa, T., Sakamoto, Y., Tanaka, K., Inoue, T., & Ogawa, R. (1991) · Critical Care Medicine · doi:10.1097/00003246-199107000-00019 · Cited by 65 · see citing works
Diurnal variations in serum erythropoietin levels in healthy subjects and sleep apnea patients
Cahan, C., Decker, M. J., Arnold, J. L., Washington, L. H., Veldhuis, J. D., Goldwasser, E., & Strohl, K. P. (1992) · Journal of Applied Physiology · doi:10.1152/jappl.1992.72.6.2112 · Cited by 64 · see citing works
Nocturnal increase of urinary uric acid:creatinine ratio. A biochemical correlate of sleep-associated hypoxemia.
Hasday, J. D., & Grum, C. M. (1987) · PubMed · doi:10.1164/arrd.1987.135.3.534 · Cited by 64 · see citing works
Cardiovascular effects of adenosine in man
Sollevi, A., Torssell, L., Öwall, A., Lagerkranser, M., EDLUND, A., & Kaijser, L. (1986) · The Japanese Journal of Pharmacology · doi:10.1016/s0021-5198(19)58913-2 · Cited by 60 · see citing works
Role of adhesion molecules in vascular regulation and damage
Tailor, A., & Granger, D. N. (2000) · Current Hypertension Reports · doi:10.1007/s11906-000-0063-6 · Cited by 56 · see citing works
The effects of calcium channel antagonist treatment and oxygen radical scavenging on infarct size and the no-reflow phenomenon in reperfused hearts
Villari, B., Ambrosio, G., Golino, P., Ragni, M., Focaccio, A., Tritto, I., Salvatore, M., & Massimo Chiariello, A. (1993) · American Heart Journal · doi:10.1016/0002-8703(93)90051-a · Cited by 51 · see citing works
Altered gene expression during hypoxia and reoxygenation of the heart
Piacentini, L., & Karliner, J. S. (1999) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(99)00010-8 · Cited by 47 · see citing works
Urinary Uric Acid:Creatinine Ratio, Serum Erythropoietin, and Blood 2,3-Diphosphoglycerate in Patients with Obstructive Sleep Apnea
McKeon, J. L., Saunders, N. A., Murree-Allen, K., Olson, L. G., Gyulay, S. G., Dickeson, J. E., Houghton, A., Wlodarczyk, J. H., & Hensley, M. (1990) · American Review of Respiratory Disease · doi:10.1164/ajrccm/142.1.8 · Cited by 46 · see citing works
Plasma adenosine and hypoxemia in patients with sleep apnea
Findley, L. J., Boykin, M. P., Fallon, T., & Belardinelli, L. (1988) · Journal of Applied Physiology · doi:10.1152/jappl.1988.64.2.556 · Cited by 46 · see citing works
Role of neuronal nitric oxide synthase in regulation of vascular and ductus arteriosus tone in the ovine fetus
Rairigh, R. L., Storme, L., Parker, T. A., Cras, T. D. L., Markham, N. E., Jakkula, M., & Abman, S. H. (2000) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.2000.278.1.l105 · Cited by 42 · see citing works
Susceptibility of LDL to Oxidative Stress in Obstructive Sleep Apnea
Wali, S. O., Bahammam, A. S., Massaeli, H., Pierce, G. N., Iliskovic, N., Singal, P. K., & Kryger, M. H. (1998) · SLEEP · doi:10.1093/sleep/21.3.290 · Cited by 42 · see citing works
Heat Shock Protein 72 Level Decreases During Sleep in Patients With Obstructive Sleep Apnea Syndrome
Noguchi, T., Chin, K., Ohi, M., Kita, H., Otsuka, N., Tsuboi, T., Satoh, M., Nakai, A., Kuno, K., & Nagata, K. (1997) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.155.4.9105073 · Cited by 35 · see citing works
Roles of endothelial dysfunction in coronary artery disease
Forgione, M. A., Leopold, J. A., & Loscalzo, J. (2000) · Current Opinion in Cardiology · doi:10.1097/00001573-200011000-00007 · Cited by 35 · see citing works
Increase in Bilirubin Levels of Patients with Obstructive Sleep Apnea in the Morning—A Possible Explanation of Induced Heme Oxygenase-1
Chin, K., Ohi, M., Shimizu, K., Nakamura, T., Miyaoka, F., Mishima, M., & Nakamura, T. (2001) · SLEEP · doi:10.1093/sleep/24.2.218 · Cited by 34 · see citing works
Erythropoietin levels with treatment of obstructive sleep apnea
Cahan, C., Decker, M. J., Arnold, J. L., Goldwasser, E., & Strohl, K. P. (1995) · Journal of Applied Physiology · doi:10.1152/jappl.1995.79.4.1278 · Cited by 33 · see citing works
Autoantibodies against Oxidised Low-Density Lipoprotein in Patients with Obstructive Sleep Apnoea
Saarelainen, S., Lehtimäki, T. J., Jaakkola, O., Poussa, T. A., Nikkilä, M. T., Solakivi, T., & Nieminen, M. M. (1999) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.1999.083 · Cited by 32 · see citing works
Mechanisms of Endothelin-1 Elevation in Chronic Obstructive Pulmonary Disease Patients with Nocturnal Oxyhemoglobin Desaturation
Trakada, G., Marangos, M. N., & Spiropoulos, K. V. (2001) · Respiration · doi:10.1159/000050482 · Cited by 27 · see citing works
Upregulation of molecular motor-encoding genes during hepatocyte growth factor-and epidermal growth factor-induced cell motility
Torok, N. J., Urrutia, R. A., Nakamura, T., & McNiven, M. A. (1996) · Journal of Cellular Physiology · doi:10.1002/(sici)1097-4652(199606)167:3 · Cited by 25 · see citing works
Secondary polycythaemia associated with nocturnal apnoea — a relationship not mediated by erythropoietin?
Carlson, J. T., Hedner, J. A., Fagerberg, B., Ejnell, H., Magnusson, B., & Fyhrquist, F. (1992) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.1992.tb00948.x · Cited by 24 · see citing works
Erythropoietin Response in Subjects with Obstructive Sleep Apnea
Pokala, P., Llanera, M., Sherwood, J. B., Scharf, S. M., & Steinberg, H. (1995) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.151.6.7767532 · Cited by 22 · see citing works
Mitochondrial respiratory chain as a new target for anti-ischemic molecules
Bouaziz, N., Redon, M., Quéré, L., Remacle, J., & Michiels, C. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)01490-5 · Cited by 21 · see citing works
Attempted antagonism of adenosine analogue induced depression of respiration
Mueller, R. A., Widerlöv, E., & Breese, G. R. (1984) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(84)90228-4 · Cited by 17 · see citing works
Circulating endothelin-1 and obstructive sleep apnoea
Saarelainen, S. K., & Hasan, J. (2000) · European Respiratory Journal · doi:10.1034/j.1399-3003.2000.16a32.x · Cited by 17 · see citing works
Blood levels of vascular endothelial growth factor in obstructive sleep apnea– hypopnea syndrome
Gunsilius, E., Petzer, A. L., & Gastl, G. A. (2002) · Blood · doi:10.1182/blood.v99.1.393 · Cited by 7 · see citing works

Flagged first, then by citations

4 of the 134 references couldn’t be matched to a known paper.

Sorted by citations

Sleep Apnea and Cardiovascular Disease
Somers, V. K., White, D. P., Amin, R. S., Abraham, W. T., Costa, F., Culebras, A., Daniels, S. R., Floras, J. S., Hunt, C. E., Olson, L. J., et al. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.05.002 · Cited by 1,510 · see citing works
“Some studies have reported increased levels of thiobarbituric acid reactive substances, isoprostanes, and oxidized low-density lipoprotein in OSA (100), although these changes have not been confirmed in other studies (101).”
Result
American Heart Association/American College of Cardiology Foundation/Heart Rhythm Society Scientific Statement on Noninvasive Risk Stratification Techniques for Identifying Patients at Risk for Sudden Cardiac Death: A Scientific Statement From the American Heart Association Council on Clinical Cardiology Committee on Electrocardiography and Arrhythmias and Council on Epidemiology and Prevention
Goldberger, J. J., Cain, M. E., Hohnloser, S. H., Kadish, A. H., Knight, B. P., Lauer, M. S., Maron, B. J., Page, R. L., Passman, R. S., Siscovick, D., et al. (2008) · Circulation · doi:10.1161/circulationaha.107.189375 · Cited by 1,450 · see citing works
Sleep Apnea and Cardiovascular Disease
Somers, V. K., White, D. P., Amin, R. S., Abraham, W. T., Costa, F., Culebras, A., Daniels, S. R., Floras, J. S., Hunt, C. E., Olson, L. J., et al. (2008) · Circulation · doi:10.1161/circulationaha.107.189420 · Cited by 1,301 · see citing works
Obstructive sleep apnoea syndrome
Lévy, P., Kohler, M., McNicholas, W. T., Barbé, F., McEvoy, R. D., Somers, V. K., Lavie, L., & Pépin, J.-L. (2015) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2015.15 · Cited by 1,235 · see citing works
Self-citation
Regulation of Oxygen Homeostasis by Hypoxia-Inducible Factor 1
Semenza, G. L. (2009) · Physiology · doi:10.1152/physiol.00045.2008 · Cited by 926 · see citing works
Sleep apnoea as an independent risk factor for cardiovascular disease: current evidence, basic mechanisms and research priorities: Fig. 1—
McNicholas, W. T., Bonsignore, M. R., & the Management Committee of EU COST ACTION B26 (2007) · European Respiratory Journal · doi:10.1183/09031936.00027406 · Cited by 911 · see citing works
Oxidative stress in obstructive sleep apnea and intermittent hypoxia – Revisited – The bad ugly and good: Implications to the heart and brain
Lavie, L. (2014) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2014.07.003 · Cited by 692 · see citing works
Self-citation
Obstructive Sleep Apnea and Cardiovascular Disease
Parish, J. M., & Somers, V. K. (2004) · Mayo Clinic Proceedings · doi:10.4065/79.8.1036 · Cited by 619 · see citing works
Endothelial Function in Obstructive Sleep Apnea and Response to Treatment
Ip, M. S. M., Tse, H.-F., Lam, B., Tsang, K. W. T., & Lam, W.-K. (2004) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200306-767oc · Cited by 615 · see citing works
“Other mechanisms for impaired nitric oxide–mediated endothelial function, including increased oxidant load, enhanced oxidation of low density lipoprotein, insulin resistance, and increased sympathetic activity (46, 47), have been demonstrated to be present in OSA ( 10 , 33, 48, 49).”
BackgroundInfluential
Obstructive sleep apnoea and cardiovascular disease
Sánchez‐de‐la‐Torre, M., Campos‐Rodríguez, F., & Barbé, F. (2012) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(12)70051-6 · Cited by 492 · see citing works
Long-term Effects of Nasal Continuous Positive Airway Pressure Therapy on Cardiovascular Outcomes in Sleep Apnea Syndrome
Doherty, L. S., Kiely, J. L., Swan, V., & McNicholas, W. T. (2005) · Chest · doi:10.1378/chest.127.6.2076 · Cited by 485 · see citing works
Pathophysiological mechanisms and therapeutic approaches in obstructive sleep apnea syndrome
Lv, R., Liu, X., Zhang, Y., Dong, N., Wang, X., He, Y., Yue, H., & Yin, Q. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01496-3 · Cited by 521 · see citing works
Therapeutic potential of intermittent hypoxia: a matter of dose
Navarrete-Opazo, A. A., & Mitchell, G. S. (2014) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00208.2014 · Cited by 469 · see citing works
“For instance, IH consisting of hypercapnic hypoxia (6 min of 8% O2, 7% CO2; 6 min normoxic/normocapnic intervals, 90 min) does not increase TNF- or CRP in male piglets (227).”
BackgroundMethodInfluential
Neurocognitive Impairment in Obstructive Sleep Apnea
Lal, C., Strange, C., & Bachman, D. (2012) · Chest · doi:10.1378/chest.11-2214 · Cited by 406 · see citing works
Cardiovascular Morbidity in Obstructive Sleep Apnea
Gozal, D., & Gozal, D. (2007) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200608-1190pp · Cited by 399 · see citing works
Association between Obstructive Sleep Apnea and Cancer Incidence in a Large Multicenter Spanish Cohort
Campos-Rodriguez, F., Martinez-Garcia, M. A., Martinez, M., Duran-Cantolla, J., Peña, M. D. L., Masdeu, M. J., Gonzalez, M., Campo, F. D., Gallego, I., Marin, J. M., et al. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201209-1671oc · Cited by 386 · see citing works
Increased oxidative stress is associated with chronic intermittent hypoxia-mediated brain cortical neuronal cell apoptosis in a mouse model of sleep apnea
Xu, W., Chi, L., Row, B. W., Xu, R., Ke, Y., Xu, B., Luo, C., Kheirandish, L., Gozal, D., & Liu, R. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.03.055 · Cited by 377 · see citing works
Obstructive Sleep Apnea and Type 2 Diabetes
Tasali, E., Mokhlesi, B., & Van Cauter, E. (2008) · Chest · doi:10.1378/chest.07-0828 · Cited by 371 · see citing works
Molecular mechanisms of cardiovascular disease in OSAHS: the oxidative stress link
Lavie, L., & Lavie, P. (2009) · European Respiratory Journal · doi:10.1183/09031936.00086608 · Cited by 370 · see citing works
Self-citation
Obstructive sleep apnea and type 2 diabetes
Rasche, K., Keller, T., Tautz, B., Hader, C., Hergenç, G., Antosiewicz, J., Giulio, C. D., & Pokorski, M. (2010) · European journal of medical research · doi:10.1186/2047-783x-15-s2-152 · Cited by 366 · see citing works
Obstructive Sleep Apnea and Metabolic Syndrome: Alterations in Glucose Metabolism and Inflammation
Tasali, E., & Ip, M. S. M. (2008) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200708-139mg · Cited by 365 · see citing works
Predictors of Elevated Nuclear Factor-κB–dependent Genes in Obstructive Sleep Apnea Syndrome
Ryan, S., Taylor, C. T., & McNicholas, W. T. (2006) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200601-066oc · Cited by 354 · see citing works
“There is growing evidence that sustained and intermittent hypoxia lead to significantly different molecular responses and different patterns of transcription factor activation (11, 28 , 29).”
Background
Molecular Signatures of Obstructive Sleep Apnea in Adults: A Review and Perspective
Arnardóttir, E. S., Mackiewicz, M., Gíslason, Þ., Teff, K. L., & Pack, A. I. (2009) · SLEEP · doi:10.1093/sleep/32.4.447 · Cited by 347 · see citing works
Systemic inflammation: a key factor in the pathogenesis of cardiovascular complications in obstructive sleep apnoea syndrome?
Ryan, S., Taylor, C. T., & McNicholas, W. T. (2009) · Postgraduate Medical Journal · doi:10.1136/thx.2008.105577 · Cited by 340 · see citing works
Sleep, sleep-disordered breathing and metabolic consequences
Levy, P. A., Bonsignore, M. R., & Eckel, J. (2009) · European Respiratory Journal · doi:10.1183/09031936.00166808 · Cited by 339 · see citing works
Obstructive Sleep Apnea is Linked to Depression and Cognitive Impairment: Evidence and Potential Mechanisms
Kerner, N. A., & Roose, S. P. (2016) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2016.01.134 · Cited by 338 · see citing works
Sleep and Cardiovascular Disease
Wolk, R. A., Gami, A. S., García‐Touchard, A., & Somers, V. K. (2005) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2005.07.002 · Cited by 327 · see citing works
Hypoxia and brain aging: Neurodegeneration or neuroprotection?
Burtscher, J., Mallet, R. T., Burtscher, M., & Millet, G. P. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101343 · Cited by 346 · see citing works
“resultant oxidative damage of biomolecules (Lavie, 2003), mitochondrial dysfunction (Duranteau et al.”
Background
Continuous Positive Airway Pressure Treatment of Mild to Moderate Obstructive Sleep Apnea Reduces Cardiovascular Risk
Buchner, N. J., Sanner, B. M., Borgel, J., & Rump, L. C. (2007) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200611-1588oc · Cited by 317 · see citing works
All-cause mortality in males with sleep apnoea syndrome: declining mortality rates with age
Lavie, P., Lavie, L., & Herer, P. (2005) · European Respiratory Journal · doi:10.1183/09031936.05.00051504 · Cited by 318 · see citing works
Self-citation
Obstructive Sleep Apnea and Cardiovascular Disease: Role of the Metabolic Syndrome and Its Components
Jean‐Louis, G., Zizi, F., Clark, L. T., Brown, C. D., & McFarlane, S. I. (2008) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.27191 · Cited by 303 · see citing works
Sleep-disordered breathing and type 2 diabetes
Shaw, J. E., Punjabi, N. M., Wilding, J. P. H., Alberti, K. G. M. M., & Zimmet, P. (2008) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2008.04.025 · Cited by 296 · see citing works
“leukin-6, tumour necrosis factor, C-reactive protein, and platelet activation and coagulation factors have been described in OSA [87,89–100].”
Background
Crossing the apnoeic threshold: causes and consequences
Dempsey, J. A. (2004) · Experimental Physiology · doi:10.1113/expphysiol.2004.028985 · Cited by 281 · see citing works
“These effects are likely to be mediated through intermittent hypoxia causing oxidative stress and endothelial dysfunction and increased sympathetic nerve activity, leading eventually to daytime hypertension (Fletcher, 2003; Lavie, 2003).”
Background
Mechanisms of cardiac dysfunction in obstructive sleep apnea
Baguet, J.-P., Barone‐Rochette, G., Tamisier, R., Levy, P. A., & Pépin, J. (2012) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2012.141 · Cited by 273 · see citing works
Sleep-disordered Breathing in Hispanic/Latino Individuals of Diverse Backgrounds. The Hispanic Community Health Study/Study of Latinos
Redline, S., Sotres-Alvarez, D., Loredo, J., Hall, M., Patel, S. R., Ramos, A., Shah, N., Ries, A., Arens, R., Barnhart, J., et al. (2014) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201309-1735oc · Cited by 270 · see citing works
Association of obstructive sleep apnea with hypertension: A systematic review and meta-analysis
Hou, H., Zhao, Y., Yu, W., Dong, H., Xue, X., Ding, J., Xing, W., & Wang, W. (2018) · Journal of Global Health · doi:10.7189/jogh.08.010405 · Cited by 346 · see citing works
Oxidative Stress—A Unifying Paradigm in Obstructive Sleep Apnea and Comorbidities
Lavie, L. (2008) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2008.08.003 · Cited by 266 · see citing works
Self-citation
Heavy Snoring as a Cause of Carotid Artery Atherosclerosis
Lee, S. A., Amis, T. C., Byth, K., Larcos, G., Kairaitis, K., Robinson, T. D., & Wheatley, J. R. (2008) · SLEEP · doi:10.5665/sleep/31.9.1207 · Cited by 265 · see citing works
Obstructive Sleep Apnea, Hypoxia, and Nonalcoholic Fatty Liver Disease
Mesarwi, O. A., Loomba, R. S., & Malhotra, A. (2018) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201806-1109tr · Cited by 265 · see citing works
Chronic intermittent hypoxia predisposes to liver injury†
Savransky, V., Nanayakkara, A., Vivero, A., Li, J., Bevans‐Fonti, S., Smith, P. L., Torbenson, M. S., & Polotsky, V. Y. (2007) · Hepatology · doi:10.1002/hep.21593 · Cited by 257 · see citing works
Chronic Obstructive Pulmonary Disease and Obstructive Sleep Apnea
McNicholas, W. T. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200903-0347pp · Cited by 249 · see citing works
Oxidative stress and oxidant signaling in obstructive sleep apnea and associated cardiovascular diseases
Suzuki, Y., Jain, V., Park, A.-M., & Day, R. M. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.01.008 · Cited by 239 · see citing works
“This reoxygenation/reperfusion phase is thought to result in the production of reactive oxygen species (ROS) and the promotion of oxidative stress [15-17].”
Background
Role of HIF-1α in the regulation ACE and ACE2 expression in hypoxic human pulmonary artery smooth muscle cells
Zhang, R., Wu, Y., Zhao, M. L., Liu, C., Zhou, L., Shen, S.-M., Liao, S., Yang, K., Li, Q. Y., & Wan, H. (2009) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.90415.2008 · Cited by 236 · see citing works
“Hypoxia is a complex physiological phenomenon, and many transcriptional regulators are activated during hypoxia (16, 37).”
Background
Oxidative Stress and Left Ventricular Function with Chronic Intermittent Hypoxia in Rats
Chen, L., Einbinder, E., Zhang, Q., Hasday, J. D., Balke, C. W., & Scharf, S. M. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200504-560oc · Cited by 237 · see citing works
Continuous positive airway pressure improves sleepiness but not calculated vascular risk in patients with minimally symptomatic obstructive sleep apnoea: the MOSAIC randomised controlled trial
Craig, S. E., Kohler, M., Nicoll, D., Bratton, D. J., Nunn, A., Davies, R., & Stradling, J. (2012) · Thorax · doi:10.1136/thoraxjnl-2012-202178 · Cited by 228 · see citing works
Obstructive Sleep Apnea and Cardiovascular Disease
Pack, A. I., & Gislason, T. (2009) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2009.01.002 · Cited by 228 · see citing works
The Severity of Oxygen Desaturation Is Predictive of Carotid Wall Thickening and Plaque Occurrence
Baguet, J.-P., Hammer, L., Leívy, P., Pierre, H., Launois, S. H., Mallion, J.-M., & Pépin, J. (2005) · CHEST Journal · doi:10.1378/chest.128.5.3407 · Cited by 227 · see citing works
The Relationship between Obstructive Sleep Apnea and Alzheimer’s Disease
Andrade, A. G., Bubu, O. M., Varga, A. W., & Osorio, R. S. (2018) · Journal of Alzheimer's Disease · doi:10.3233/jad-179936 · Cited by 216 · see citing works
“Mounting evidence suggests that repetitive cycles of intermittent hypoxia followed by reoxygenation, characteristicofOSA,promoteROSproduction[137, 138]andreducebloodantioxidantcapacity[165].”
Intermittent hypoxia and sleep-disordered breathing: current concepts and perspectives
Levy, P. A., Pépin, J., Arnaud, C., Tamisier, R., Borel, J., Demattéis, M., Godin‐Ribuot, D., & Ribuot, C. (2008) · European Respiratory Journal · doi:10.1183/09031936.00013308 · Cited by 208 · see citing works
Endothelial Dysfunction in Obstructive Sleep Apnea
Budhiraja, R., Parthasarathy, S., & Quan, S. F. (2007) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.26864 · Cited by 208 · see citing works
Sleep apnea: epidemiology, pathophysiology, and relation to cardiovascular risk
Parati, G., Lombardi, C., & Narkiewicz, K. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00400.2007 · Cited by 205 · see citing works
“preferential activation of inflammatory pathways may be a consequence of the intermittent reoxygenation that is characteristic of intermittent hypoxia and thus represents a variant of reperfusion injury (72).”
Background
Antioxidant status in patients with sleep apnoea and impact of continuous positive airway pressure treatment
Barceló, A., Barbé, F., de la Peña, M., Vila, M., Pérez, G., Piérola, J., Duran, J., & Agustí, A. G. N. (2006) · European Respiratory Journal · doi:10.1183/09031936.06.00067605 · Cited by 201 · see citing works
Sleep-Disordered Breathing and Cardiovascular Risk
Caples, S. M., García‐Touchard, A., & Somers, V. K. (2007) · SLEEP · doi:10.1093/sleep/30.3.291 · Cited by 201 · see citing works
Obesity, obstructive sleep apnoea and metabolic syndrome
LAM, J. C. M., MAK, J. C. W., & IP, M. S. M. (2012) · Respirology · doi:10.1111/j.1440-1843.2011.02081.x · Cited by 198 · see citing works
HDL dysfunction in obstructive sleep apnea
Tan, K. C. B., Chow, W.-S., Lam, J., LAM, B. K., Wong, W.-K., Tam, S., & Ip, M. (2005) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2005.04.024 · Cited by 200 · see citing works
Activation of nuclear factor κB in obstructive sleep apnea: a pathway leading to systemic inflammation
Htoo, A. K., Greenberg, H. E., Tongia, S., Chen, G., Henderson, T., Wilson, D., & Liu, S. F. (2006) · Sleep And Breathing · doi:10.1007/s11325-005-0046-6 · Cited by 200 · see citing works
“When cells are stimulated by various signals, including ROS, I-κB is rapidly phosphorylated by I-κB kinase.”
BackgroundInfluential
Carotid body chemoreceptors: physiology, pathology, and implications for health and disease
Iturriaga, R., Alcayaga, J., Chapleau, M. W., & Somers, V. K. (2021) · Physiological Reviews · doi:10.1152/physrev.00039.2019 · Cited by 199 · see citing works
Antioxidant defense responses to sleep loss and sleep recovery
Everson, C. A., Laatsch, C. D., & Hogg, N. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00565.2004 · Cited by 192 · see citing works
“injury, and in this way contributes to cardiovascular complications and inflammatory processes [e.g., (7, 39 , 55)].”
Background
Impact of obstructive sleep apnea treatment by continuous positive airway pressure on cardiometabolic biomarkers: A systematic review from sham CPAP randomized controlled trials
Jullian‐Desayes, I., Joyeux‐Faure, M., Tamisier, R., Launois, S. H., Borel, A., Levy, P. A., & Pépin, J. (2014) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2014.07.004 · Cited by 195 · see citing works
Advances in Sleep-disordered Breathing
Pack, A. I. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200509-1478oe · Cited by 188 · see citing works
Relationship of Metabolic Syndrome and Obstructive Sleep Apnea
Parish, J. M., Adam, T. J., & Facchiano, L. (2007) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.26910 · Cited by 188 · see citing works
“(15-89) (31-90) (15-75) (31-83) (29-51) (25-85) (29-80) (25-85)”
Obstructive Sleep Apnea
López-Jiménez, F. A., Kuniyoshi, F. H. S., Gami, A. S., & Somers, V. K. (2008) · CHEST Journal · doi:10.1378/chest.07-0800 · Cited by 186 · see citing works
Unexpected survival advantage in elderly people with moderate sleep apnoea
Lavie, P., & Lavie, L. (2009) · Journal of Sleep Research · doi:10.1111/j.1365-2869.2009.00754.x · Cited by 183 · see citing works
“Although ischaemic preconditioning is elicited largely by exposure to up to five sublethal ischaemic events, chronic intermittent hypoxia resembling sleep apnoea also confers cardioprotection; furthermore, oxidative stress that is associated closely with sleep apnoea (Lavie, 2003) was implicated specifically in these…”
BackgroundSelf-citation
Chronic intermittent hypoxia and obstructive sleep apnea: an experimental and clinical approach
Sforza, E. A., & Roche, F. (2016) · Hypoxia · doi:10.2147/hp.s103091 · Cited by 184 · see citing works
Sleep-Disordered Breathing in Down Syndrome
Lal, C., White, D. R., Joseph, J. E., van Bakergem, K., & LaRosa, A. (2015) · CHEST Journal · doi:10.1378/chest.14-0266 · Cited by 182 · see citing works
Intermittent hypoxia and vascular function: implications for obstructive sleep apnoea
Foster, G. E., Poulin, M. J., & Hanly, P. J. (2006) · Experimental Physiology · doi:10.1113/expphysiol.2006.035204 · Cited by 178 · see citing works
“Although the mechanism by which intermittent hypoxia leads to vascular disease in OSA is unknown, it has been proposed that sympathetic nervous system overactivity (Fletcher, 2001), oxidative stress (Lavie, 2003) and endothelial dysfunction (Lavie, 2003) contribute to it.”
BackgroundInfluential
Statin therapy reduces plasma endothelin-1 concentrations: A meta-analysis of 15 randomized controlled trials
Sahebkar, A., Kotani, K., Șerban, M.-C., Ursoniu, S., Mikhailidis, D. P., Jones, S. R., Ray, K. K., Blaha, M. J., Rysz, J., Toth, P. P., et al. (2015) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2015.05.022 · Cited by 178 · see citing works
Non-arteritic anterior ischaemic optic neuropathy is nearly systematically associated with obstructive sleep apnoea
Palombi, K., Renard, E., Levy, P. A., Chiquet, C., Deschaux, C., Romanet, J. P., & Pépin, J. (2006) · British Journal of Ophthalmology · doi:10.1136/bjo.2005.087452 · Cited by 174 · see citing works
Effects of different acute hypoxic regimens on tissue oxygen profiles and metabolic outcomes
Reinke, C., Bevans‐Fonti, S., Drager, L. F., Shin, M., & Polotsky, V. Y. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00492.2011 · Cited by 174 · see citing works
“There was a general assumption that the pathogenesis of intermittent hypoxia and sleep apnea is similar to ischemiareperfusion injury (22, 23, 31).”
Background
The Effects of 1-Year Treatment With a Herbst Mandibular Advancement Splint on Obstructive Sleep Apnea, Oxidative Stress, and Endothelial Function
Itzhaki, S., Dorchin, H., Clark, G., Lavie, L., Lavie, P., & Pillar, G. (2007) · Chest · doi:10.1378/chest.06-0965 · Cited by 172 · see citing works
Self-citation
Obstructive Sleep Apnea and Inflammation
McNicholas, W. T. (2009) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2008.10.005 · Cited by 171 · see citing works
Major Role for Hypoxia Inducible Factor-1 and the Endothelin System in Promoting Myocardial Infarction and Hypertension in an Animal Model of Obstructive Sleep Apnea
Belaïdi, E., Joyeux‐Faure, M., Ribuot, C., Launois, S. H., Levy, P. A., & Godin‐Ribuot, D. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.12.050 · Cited by 169 · see citing works
Intermittent Hypoxia: Cause of or Therapy for Systemic Hypertension?
Serebrovskaya, T. V., Manukhina, E. B., Smith, M. L., Downey, H. F., & Mallet, R. T. (2008) · Experimental Biology and Medicine · doi:10.3181/0710-mr-267 · Cited by 168 · see citing works
“The pro-inflammatory factors NF-jB (228, 230, 264, 265) and iNOS (233, 234) are activated in the OSA setting in response to ROS.”
Background
Obstructive sleep apnea and the metabolic syndrome in community-based Chinese adults in Hong Kong
Lam, J., LAM, B. K., Lam, C.-L., Fong, D., Wang, J. K. L., Tse, H., Lam, K. S. L., & Ip, M. (2005) · Respiratory Medicine · doi:10.1016/j.rmed.2005.10.003 · Cited by 165 · see citing works
Hypoxia, energy balance and obesity: from pathophysiological mechanisms to new treatment strategies
Kayser, B., & Vergès, S. (2013) · Obesity Reviews · doi:10.1111/obr.12034 · Cited by 165 · see citing works
“The desaturation-reoxygenation sequence typical of OSA leads to oxidative stress, with production of reactive oxygen species (95), contributing to the development of systemic inflammation (96).”
Background
Ischemic preconditioning as a possible explanation for the age decline relative mortality in sleep apnea
Lavie, L., & Lavie, P. (2006) · Medical Hypotheses · doi:10.1016/j.mehy.2005.10.033 · Cited by 164 · see citing works
Self-citation
Effect of sleep apnea on cognition and mood
El-Ad, B., & Lavie, P. (2005) · International Review of Psychiatry · doi:10.1080/09540260500104508 · Cited by 166 · see citing works
“Sleep apnea has been linked to development of hypertension, increased cardiovascular morbidity, and, on cellular and molecular levels, to an increased oxidative stress leading to endothelial damage by activation of cytokines and a decrease in plasma levels of nitric oxide (Lavie, 2003).”
Background
Continuous Positive Airway Pressure in Patients With Obstructive Sleep Apnea and Resistant Hypertension: A Meta‐Analysis of Randomized Controlled Trials
Liu, L., Cao, Q., Guo, Z., & Dai, Q. (2016) · The Journal of Clinical Hypertension · doi:10.1111/jch.12639 · Cited by 160 · see citing works
Inflammation, Oxidative Stress, and the Vascular Endothelium in Obstructive Sleep Apnea
Jelić, S., & Jemtel, T. H. L. (2008) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2008.11.008 · Cited by 162 · see citing works
Cardiovascular Drugs and Serum Uric Acid
Reyes, A. J. (2003) · Cardiovascular Drugs and Therapy · doi:10.1023/b:card.0000015855.02485.e3 · Cited by 163 · see citing works
“Oxidative stress could also mediate part of the increase in cardiovascular risk caused by sleep apnoea [217].”
Background
Sleep-Disordered Breathing
Pack, A. I. (2004) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.2401008 · Cited by 161 · see citing works
Obstructive sleep apnea and cardiovascular disease
Butt, M., Dwivedi, G., Khair, O. A., & Lip, G. Y. H. (2009) · International Journal of Cardiology · doi:10.1016/j.ijcard.2009.05.021 · Cited by 161 · see citing works
Chronic Intermittent Hypoxia/Reoxygenation Facilitate Amyloid-β Generation in Mice
Shiota, S., Takekawa, H., Matsumoto, S., Takeda, K., Nurwidya, F., Yoshioka, Y., Takahashi, F., Hattori, N., Tabira, T., Mochizuki, H., et al. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-130419 · Cited by 155 · see citing works
“A numbers of studies have produced supportive evidence for the presence of oxidative stress in OSA patients [41] [42] [43] [44] [45]; some studies went on to show reversible oxidative stress after treatment of continuous positive airway pressure therapy [41] [42] [44] [45].”
Background
Phenotypic and Functional Characterization of Blood γδ T Cells in Sleep Apnea
Dyugovskaya, L., Lavie, P., & Lavie, L. (2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200210-1226oc · Cited by 160 · see citing works
“Sleep apnea–related oxidative stress and a state of inflammatory cell activation resulting in endothelial cell injury have been proposed as one of the underlying mechanisms responsible for atherogenesis in this syndrome (4, 5 ).”
BackgroundInfluentialSelf-citation
Obstructive sleep apnoea and stroke
Yaggi, H. K., & Mohsenin, V. (2004) · The Lancet Neurology · doi:10.1016/s1474-4422(04)00766-5 · Cited by 157 · see citing works
Hypoxia: The Force that Drives Chronic Kidney Disease
Fu, Q., Colgan, S. P., & Shelley, C. S. (2016) · Clinical Medicine & Research · doi:10.3121/cmr.2015.1282 · Cited by 154 · see citing works
Cardiovascular Consequences of Sleep Apnea
Selim, B. J., Won, C. H. J., & Yaggi, H. K. (2010) · Clinics in Chest Medicine · doi:10.1016/j.ccm.2010.02.010 · Cited by 152 · see citing works
Obstructive sleep apnea and cognitive impairment: Addressing the blood–brain barrier
Lim, D. C., & Pack, A. I. (2013) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2012.12.003 · Cited by 149 · see citing works
Sleep and Cardiovascular Disease: An Overview
Malhotra, A., & Loscalzo, J. (2008) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2008.10.004 · Cited by 147 · see citing works
Mechanisms and Clinical Consequences of Untreated Central Sleep Apnea in Heart Failure
Costanzo, M. R., Khayat, R., Ponikowski, P. P., Augostini, R. S., Stellbrink, C., Mianulli, M. J., & Abraham, W. T. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.10.025 · Cited by 150 · see citing works
Endothelial Cell Apoptosis in Obstructive Sleep Apnea
Solh, A. A. E., Akinnusi, M. E., Baddoura, F. H., & Mankowski, C. R. (2007) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200611-1598oc · Cited by 147 · see citing works
“These mechanisms include the phenomenon of hypoxia reoxygenation (30), oxidative stress ( 31 ), and release of proinflammatory markers (32), all of which have been described to cause endothelial cell apopto-”
Background
Obstructive Sleep Apnea, Cardiovascular Disease, and Pulmonary Hypertension
Golbin, J. M., Somers, V. K., & Caples, S. M. (2008) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200708-143mg · Cited by 145 · see citing works
“Each acute oxyhemoglobin desaturation is coupled to an episode of reoxygenation, a process thought to promote oxidative stress through formation of reactive oxygen species (6, 7 ), a cascade that may be associated with heightened inflammation (8, 9) and mitochondrial dysfunction (10).”
Background
Interactions of Obstructive Sleep Apnea With the Pathophysiology of Cardiovascular Disease, Part 1
Javaheri, S., Javaheri, S., Somers, V. K., Gozal, D., Mokhlesi, B., Mehra, R., McNicholas, W. T., Zee, P. C., Campos‐Rodríguez, F., Martínez‐García, M. Á., et al. (2024) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2024.02.059 · Cited by 157 · see citing works
Does obstructive sleep apnea cause endothelial dysfunction? A critical review of the literature
Hoyos, C. M., Melehan, K. L., Liu, P. Y., Grunstein, R. R., & Phillips, C. L. (2015) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2014.06.003 · Cited by 142 · see citing works
Coordinated Metabolic Transitions During Drosophila Embryogenesis and the Onset of Aerobic Glycolysis
Tennessen, J. M., Bertagnolli, N. M., Evans, J. M., Sieber, M., Cox, J. E., & Thummel, C. S. (2014) · G3 Genes Genomes Genetics · doi:10.1534/g3.114.010652 · Cited by 141 · see citing works
“…acid production in humans is commonly associated with disorders in which oxidative metabolism is disrupted, such as cardiac failure, acute stroke, sleep apnea, and the onset of type 2 diabetes (Fessel 1980; Leyva et al. 1998; Fang and Alderman 2000; Lavie 2003; Weir et al. 2003; Bhole et al. 2010).”
Cognitive-behavioral therapy for sleep disturbance decreases inflammatory cytokines and oxidative stress in hemodialysis patients
Chen, H.-Y., Cheng, I.-C., Pan, Y.-J., Chiu, Y.-L., Hsu, S.-P., Pai, M.-F., Yang, J.-Y., Peng, Y.-S., Tsai, T.-J., & Wu, K.-D. (2011) · Kidney International · doi:10.1038/ki.2011.151 · Cited by 140 · see citing works
Obstructive sleep apnea, pain, and opioids
Lam, K. K., Kunder, S., Wong, J., Doufas, A. G., & Chung, F. F. (2015) · Current Opinion in Anaesthesiology · doi:10.1097/aco.0000000000000265 · Cited by 141 · see citing works
Oxidative stress inflammation and endothelial dysfunction in obstructive sleep apnea
Lavie, L. (2012) · Frontiers in Bioscience-Elite · doi:10.2741/e469 · Cited by 139 · see citing works
Self-citation
Hypoxic Conditioning as a New Therapeutic Modality
Vergès, S., Chacaroun, S., Godin‐Ribuot, D., & Baillieul, S. (2015) · Frontiers in Pediatrics · doi:10.3389/fped.2015.00058 · Cited by 134 · see citing works
“Desaturation–reoxygenation sequences lead to oxidative stress and the production of reactive oxygen species (ROS) (1).”
BackgroundInfluential
The relationship between obstructive sleep apnea syndrome and obesity: A new perspective on the pathogenesis in terms of organ crosstalk
Kuvat, N., Tanrıverdi, H., & Armutçu, F. (2020) · The Clinical Respiratory Journal · doi:10.1111/crj.13175 · Cited by 136 · see citing works

Oxidative Stress in Obstructive Sleep Apnea: Putative Pathways to the Cardiovascular Complications
Yamauchi, M., & Kimura, H. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1946 · Cited by 107 · see citing works
From Oxidative Stress to Cardiovascular Risk in Obstructive Sleep Apnoea. Vom oxidativen Stress zum kardiovaskularen Risiko bei obstruktiver Schlafapnoe
Lavie, L. (2006) · Somnologie - Schlafforschung und Schlafmedizin · doi:10.1111/j.1439-054x.2006.00090.x · Cited by 1 · see citing works
Self-citation
Molecular mechanisms of cardiovascular disease in OSAHS: the oxidative stress link
Lavie, L., & Lavie, P. (2009) · European Respiratory Journal · doi:10.1183/09031936.00086608 · Cited by 370 · see citing works
Self-citation
Oxidative stress and oxidant signaling in obstructive sleep apnea and associated cardiovascular diseases
Suzuki, Y., Jain, V., Park, A.-M., & Day, R. M. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.01.008 · Cited by 239 · see citing works
Oxidative stress inflammation and endothelial dysfunction in obstructive sleep apnea
Lavie, L. (2012) · Frontiers in Bioscience-Elite · doi:10.2741/e469 · Cited by 139 · see citing works
Self-citation

Authors: Lavie, L.
Affiliations: Technion – Israel Institute of Technology (IL)
Corresponding author: Lavie, Lena
Venue: Sleep Medicine Reviews
Publisher: Elsevier BV
Published: 2003-02
Volume: 7
Issue: 1
Pages: 35-51
ISSN: 1087-0792 (ISSN-L)
DOI: 10.1053/smrv.2002.0261
OpenAlex: W1988114644
Cited by: 993
References: 134
Citations by year: 2026: 17 · 2025: 44 · 2024: 28 · 2023: 30 · 2022: 33 · 2021: 43 · 2020: 42 · 2019: 31 · 2018: 38 · 2017: 37 · 2016: 44 · 2015: 51 · 2014: 58 · 2013: 48 · 2012: 51
FWCI: 4.50
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Sleep Medicine Reviews (publishedVersion)
PubMed (publishedVersion)
Funders: Ministry of Health, State of Israel
Topics: Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Keywords: obstructive sleep apnea, oxidative stress, hypoxia/reoxygenation injury, reactive oxygen species, lipoprotein oxidation, adhesion molecules, adenosine, uric acid, HIF-1, NF-κB, AP-1, endothelial dysfunction, monocyte adhesion, nitric oxide bioavailability, atherosclerosis, cardiovascular risk
MeSH terms: Cardiovascular Diseases, Free Radicals, Humans, Leukocytes, Lymphokines, Nitric Oxide, Lipid Peroxidation, Endothelial Growth Factors, Oxidative Stress, Hyperhomocysteinemia, Sleep Apnea, Obstructive, Intercellular Signaling Peptides and Proteins, Vascular Endothelial Growth Factors, Vascular Endothelial Growth Factor A

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Obstructive sleep apnoea syndrome – an oxidative stress disorder

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks