The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Pathogenesis of hepatitis B virus—related hepatocellular carcinoma: Old and new paradigms
Open accessAbstract
Chronic infection with the hepatitis B virus (HBV) is a major risk factor for development of hepatocellular carcinoma (HCC). The pathogenesis of cancer in HBV infection has been extensively analyzed, and multiple factors appear to play a role. A major factor is chronic inflammation and the effects of cytokines in the development of fibrosis and liver cell proliferation. Also important is the role of integration of HBV DNA into host cellular DNA, which, in some situations, acts to disrupt or promote expression of cellular genes that are important in cell growth and differentiation. In addition, expression of HBV proteins may have a direct effect on cellular functions, and some of these gene products can favor malignant transformation. Several HBV genes have been found in infected tissues more frequently than others, including truncated pre-S2/S, hepatitis B X gene, and a novel spliced transcript of HBV, referred to as the hepatitis B spliced protein. The proteins expressed from these integrated genes have been shown to have intracellular activities that may account for their association with HCC, including effects on cellular growth and apoptosis. Finally, some patients with HCC have no detectable hepatitis B surface antigen in serum but do have low levels of HBV DNA in serum and integrated molecules of HBV DNA in tissue. Occult HBV infection may account for a proportion of cases of HCC that occur in patients without serologic markers for hepatitis B and C and may be a cofactor in HCC in patients with chronic hepatitis C who have coexistent occult HBV infection.
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Ye, Q.-H., Qin, L.-X., Forgues, M., He, P., Kim, J. W., Peng, A. C., Simon, R., Li, Y., Robles, A. I., Chen, Y., et al. (2003) · Nature Medicine · doi:10.1038/nm843 · Cited by 850
Bréchot, C., Thiers, V., Kremsdorf, D., Nalpas, B., Pol, S., & Paterlini-Bréchot, P. (2001) · Hepatology · doi:10.1053/jhep.2001.25172 · Cited by 560
Self-citationTorbenson, M., & Thomas, D. L. (2002) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(02)00345-6 · Cited by 533
Hepatitis B virus maintains its pro-oncogenic properties in the case of occult HBV infection
Pollicino, T., Squadrito, G., Cerenzia, G., Cacciola, I., Raffa, G., Craxı̀, A., Farinati, F., Missale, G., Smedile, A., Tiribelli, C., et al. (2004) · Gastroenterology · doi:10.1053/j.gastro.2003.10.048 · Cited by 427
Calcium Signaling by HBx Protein in Hepatitis B Virus DNA Replication
Bouchard, M. J., Wang, L.-H., & Schneider, R. J. (2001) · Science · doi:10.1126/science.294.5550.2376 · Cited by 385
Paterlini-Bréchot, P., Saigo, K., Murakami, Y., Chami, M., Gozuacik, D., Mugnier, C., Lagorce, D., & Bréchot, C. (2003) · Oncogene · doi:10.1038/sj.onc.1206492 · Cited by 354
Self-citationRahmani, Z., Huh, K.-W., Lasher, R., & Siddiqui, A. (2000) · Journal of Virology · doi:10.1128/jvi.74.6.2840-2846.2000 · Cited by 319
Viruses, Immunity, and Cancer: Lessons from Hepatitis B
Chisari, F. V. (2000) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64980-2 · Cited by 304
Bréchot, C., Gozuacik, D., Murakami, Y., & Paterlini-Bréchot, P. (2000) · Seminars in Cancer Biology · doi:10.1006/scbi.2000.0321 · Cited by 276
Self-citationTu, H., Bonura, C., Giannini, C., Mouly, H., Soussan, P., Kew, M. C., Paterlini-Bréchot, P., Bréchot, C., & Kremsdorf, D. (2001) · PubMed · Cited by 185
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Transcriptome classification of HCC is related to gene alterations and to new therapeutic targets
Boyault, S., Rickman, D. S., de Reyniès, A., Balabaud, C., Rebouissou, S., Jeannot, E., Hérault, A., Saric, J., Belghiti, J., Franco, D., et al. (2007) · Hepatology · doi:10.1002/hep.21467 · Cited by 1,258
Update of the statements on biology and clinical impact of occult hepatitis B virus infection
Raimondo, G., Locarnini, S., Pollicino, T., Levrero, M., Zoulim, F., Lok, A. S., Allain, J.-P., Berg, T., Bertoletti, A., Brunetto, M. R., et al. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2019.03.034 · Cited by 572
Pathogenesis of hepatitis B virus infection
Chisari, F. V., Isogawa, M., & Wieland., S. F. (2010) · Pathologie Biologie · doi:10.1016/j.patbio.2009.11.001 · Cited by 414
Mak, L.-Y., Wong, D. K.-H., Pollicino, T., Raimondo, G., Hollinger, F. B., & Yuen, M.-F. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2020.05.042 · Cited by 223
Leptin in hepatocellular carcinoma
Wang, S.-N. (2010) · World Journal of Gastroenterology · doi:10.3748/wjg.v16.i46.5801 · Cited by 59
Metadata
- Authors
- Bréchot, C.
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2004-11
- Volume
- 127
- Issue
- 5
- Pages
- S56-S61
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W2071019693
- Cited by
- 438
- References
- 21
- FWCI
- 17.56
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
