The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
The Vagus Nerve and Nicotinic Receptors Modulate Experimental Pancreatitis Severity in Mice
Abstract
Background & aims The nervous system, through the vagus nerve, controls inflammation by decreasing the release of tumor necrosis factor-alpha from endotoxin stimulated macrophages. This anti-inflammatory effect is mediated by an interaction of acetylcholine, the principal neurotransmitter of the vagus nerve, with macrophage cholinergic nicotinic receptors expressing the alpha7 subunit.Methods To determine the role of this "nicotinic anti-inflammatory pathway" in experimental pancreatitis, we induced pancreatitis in mice by 12 hourly intraperitoneal injections of cerulein. Pancreatitis was preceded by unilateral left cervical vagotomy or pretreatment with the nicotinic receptor antagonist mecamylamine or by pretreatment with the selective alpha7 nicotinic receptor agonist 3-(2,4-dimethoxybenzylidene) anabaseine (GTS-21).Results Vagotomy or pretreatment with mecamylamine resulted in an enhanced severity of pancreatitis, as reflected by histology, edema, plasma hydrolases, and interleukin-6 levels. Furthermore, the number of neutrophils migrated to the pancreas was increased in these mice, as shown by myeloperoxidase content and intrapancreatic staining of neutrophils. Conversely, GTS-21 pretreatment strongly decreased the severity of pancreatitis. Pancreatitis-associated pulmonary inflammation was independent of the integrity of the vagus nerve and nicotinic receptors.Conclusions This study provides the first evidence for a therapeutic potential of the vagus nerve and the "nicotinic anti-inflammatory pathway" in attenuating inflammation and injury during experimental pancreatitis.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“This occurred even when the vagus nerves had been cut, indicating that a pharmacological approach to therapy may be useful even when the basal activity of the vagus nerve during the disease is insufficient to suppress cytokines.”
From Physiology and immunology of the cholinergic antiinflammatory pathway (2007) · cites this paper as [24]
In the citing paper
“Administration of GTS-21, an α7 nAChR receptor agonist, significantly decreased pancreati-tis severity and attenuated pulmonary inflammation (24).”
From Physiology and immunology of the cholinergic antiinflammatory pathway (2007) · cites this paper as [24]
Citations
Cites
Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin
Borovikova, L. V., Ivanova, S., Zhang, M., Yang, H., Botchkina, G. I., Watkins, L. R., Wang, H., Abumrad, N., Eaton, J. W., & Tracey, K. J. (2000) · Nature · doi:10.1038/35013070 · Cited by 4,211
Self-citationTracey, K. J. (2002) · Nature · doi:10.1038/nature01321 · Cited by 3,728
Self-citationNicotinic acetylcholine receptor α7 subunit is an essential regulator of inflammation
Wang, H., Yu, M., Ochani, M., Amella, C. A., Tanovic, M., Susarla, S., Li, J. H., Wang, H., Yang, H., Ulloa, L., et al. (2003) · Nature · doi:10.1038/nature01339 · Cited by 3,228
Self-citationFadok, V. A., Bratton, D. L., Konowal, A., Freed, P. W., Westcott, J. Y., & Henson, P. M. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1112 · Cited by 3,166
Cytochemical Identification of Monocytes and Granulocytes
Yam, L. T., LI, C. Y., & Crosby, W. H. (1971) · American Journal of Clinical Pathology · doi:10.1093/ajcp/55.3.283 · Cited by 2,694
Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis
Wang, H., Liao, H., Ochani, M., Justiniani, M., Lin, X., Yang, L., Al-Abed, Y., Wang, H., Metz, C., Miller, E. J., et al. (2004) · Nature Medicine · doi:10.1038/nm1124 · Cited by 1,170
Self-citationThe Role of Cytokines in the Pathogenesis of Acute Pancreatitis
Norman, J. (1998) · The American Journal of Surgery · doi:10.1016/s0002-9610(97)00240-7 · Cited by 709
Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis
Halangk, W., Lerch, M. M., Brandt-Nedelev, B., Roth, W., Ruthenbürger, M., Reinheckel, T., Domschke, W., Lippert, H., Peters, C., & Deussing, J. M. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9411 · Cited by 564
Pharmacological stimulation of the cholinergic antiinflammatory pathway
Bernik, T. R., Friedman, S. G., Ochani, M., DiRaimo, R., Ulloa, L., Yang, H., Sudan, S., Czura, C. J., Ivanova, S. M., & Tracey, K. J. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20011714 · Cited by 529
Self-citationThe Pancreas : biology, pathobiology, and disease
Go, V. L. W. (1993) · Raven Press eBooks · Cited by 526
Flagged first, then by citations
Cited by
Sorted by citations
Acetylcholine-Synthesizing T Cells Relay Neural Signals in a Vagus Nerve Circuit
Rosas-Ballina, M., Olofsson, P. S., Ochani, M., Valdés-Ferrer, S. I., Levine, Y. A., Reardon, C., Tusche, M. W., Pavlov, V. A., Andersson, U., Chavan, S., et al. (2011) · Science · doi:10.1126/science.1209985 · Cited by 1,551
Self-citationPhysiology and immunology of the cholinergic antiinflammatory pathway
Tracey, K. J. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30555 · Cited by 1,563
Self-citationSepsis: pathophysiology and clinical management
Gotts, J. E., & Matthay, M. A. (2016) · BMJ · doi:10.1136/bmj.i1585 · Cited by 1,308
Tracey, K. J. (2009) · Nature Reviews Immunology · doi:10.1038/nri2566 · Cited by 1,154
Self-citationSplenic nerve is required for cholinergic antiinflammatory pathway control of TNF in endotoxemia
Rosas‐Ballina, M., Ochani, M., Parrish, W. R., Ochani, K., Harris, Y., Huston, J. M., Chavan, S. S., & Tracey, K. J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803237105 · Cited by 762
Self-citation
Metadata
- Authors
- van Westerloo, D. J., Giebelen, I. A., Florquin, S., Bruno, M. J., LaRosa, G. J., Ulloa, L., Tracey, K. J., & van der Poll, T.
- Affiliations
- Amsterdam UMC Location University of Amsterdam (NL)
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2006-05
- Volume
- 130
- Issue
- 6
- Pages
- 1822-1830
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W2156897641
- Cited by
- 377
- References
- 37
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 6 · 2023: 11 · 2022: 24 · 2021: 20 · 2020: 26 · 2019: 9 · 2018: 20 · 2017: 18 · 2016: 18 · 2015: 18 · 2014: 23 · 2013: 26 · 2012: 23
- FWCI
- 19.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Funders
- National Institute of General Medical Sciences (R01GM084125, R01GM057226)
- Topics
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Keywords
- vagus nerve, nicotinic acetylcholine receptors, alpha7 nicotinic acetylcholine receptor, experimental pancreatitis, cerulein-induced pancreatitis, vagotomy, mecamylamine, GTS-21, cholinergic anti-inflammatory pathway, neutrophil migration, interleukin-6, lung inflammation, pancreatitis severity
- MeSH terms
- Animals, Biopsy, Needle, Ceruletide, Disease Models, Animal, Female, Immunohistochemistry, Mice, Inbred C57BL, Pancreatitis, Probability, Receptors, Nicotinic, Risk Factors, Sensitivity and Specificity, Severity of Illness Index, Vagotomy, Vagus Nerve, Nicotinic Antagonists, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
