The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
The Vagus Nerve and Nicotinic Receptors Modulate Experimental Pancreatitis Severity in Mice
Abstract
Background & aims The nervous system, through the vagus nerve, controls inflammation by decreasing the release of tumor necrosis factor-alpha from endotoxin stimulated macrophages. This anti-inflammatory effect is mediated by an interaction of acetylcholine, the principal neurotransmitter of the vagus nerve, with macrophage cholinergic nicotinic receptors expressing the alpha7 subunit.Methods To determine the role of this "nicotinic anti-inflammatory pathway" in experimental pancreatitis, we induced pancreatitis in mice by 12 hourly intraperitoneal injections of cerulein. Pancreatitis was preceded by unilateral left cervical vagotomy or pretreatment with the nicotinic receptor antagonist mecamylamine or by pretreatment with the selective alpha7 nicotinic receptor agonist 3-(2,4-dimethoxybenzylidene) anabaseine (GTS-21).Results Vagotomy or pretreatment with mecamylamine resulted in an enhanced severity of pancreatitis, as reflected by histology, edema, plasma hydrolases, and interleukin-6 levels. Furthermore, the number of neutrophils migrated to the pancreas was increased in these mice, as shown by myeloperoxidase content and intrapancreatic staining of neutrophils. Conversely, GTS-21 pretreatment strongly decreased the severity of pancreatitis. Pancreatitis-associated pulmonary inflammation was independent of the integrity of the vagus nerve and nicotinic receptors.Conclusions This study provides the first evidence for a therapeutic potential of the vagus nerve and the "nicotinic anti-inflammatory pathway" in attenuating inflammation and injury during experimental pancreatitis.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“This occurred even when the vagus nerves had been cut, indicating that a pharmacological approach to therapy may be useful even when the basal activity of the vagus nerve during the disease is insufficient to suppress cytokines.”
From Physiology and immunology of the cholinergic antiinflammatory pathway (2007) · cites this paper as [24]
In the citing paper
“Administration of GTS-21, an α7 nAChR receptor agonist, significantly decreased pancreati-tis severity and attenuated pulmonary inflammation (24).”
From Physiology and immunology of the cholinergic antiinflammatory pathway (2007) · cites this paper as [24]
Citations
Cites
Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin
Borovikova, L. V., Ivanova, S., Zhang, M., Yang, H., Botchkina, G. I., Watkins, L. R., Wang, H., Abumrad, N., Eaton, J. W., & Tracey, K. J. (2000) · Nature · doi:10.1038/35013070 · Cited by 4,211
Self-citationTracey, K. J. (2002) · Nature · doi:10.1038/nature01321 · Cited by 3,728
Self-citationNicotinic acetylcholine receptor α7 subunit is an essential regulator of inflammation
Wang, H., Yu, M., Ochani, M., Amella, C. A., Tanovic, M., Susarla, S., Li, J. H., Wang, H., Yang, H., Ulloa, L., et al. (2003) · Nature · doi:10.1038/nature01339 · Cited by 3,228
Self-citationFadok, V. A., Bratton, D. L., Konowal, A., Freed, P. W., Westcott, J. Y., & Henson, P. M. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1112 · Cited by 3,166
Cytochemical Identification of Monocytes and Granulocytes
Yam, L. T., LI, C. Y., & Crosby, W. H. (1971) · American Journal of Clinical Pathology · doi:10.1093/ajcp/55.3.283 · Cited by 2,694
Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis
Wang, H., Liao, H., Ochani, M., Justiniani, M., Lin, X., Yang, L., Al-Abed, Y., Wang, H., Metz, C., Miller, E. J., et al. (2004) · Nature Medicine · doi:10.1038/nm1124 · Cited by 1,170
Self-citationThe Role of Cytokines in the Pathogenesis of Acute Pancreatitis
Norman, J. (1998) · The American Journal of Surgery · doi:10.1016/s0002-9610(97)00240-7 · Cited by 709
Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis
Halangk, W., Lerch, M. M., Brandt-Nedelev, B., Roth, W., Ruthenbürger, M., Reinheckel, T., Domschke, W., Lippert, H., Peters, C., & Deussing, J. M. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9411 · Cited by 564
Pharmacological stimulation of the cholinergic antiinflammatory pathway
Bernik, T. R., Friedman, S. G., Ochani, M., DiRaimo, R., Ulloa, L., Yang, H., Sudan, S., Czura, C. J., Ivanova, S. M., & Tracey, K. J. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20011714 · Cited by 529
Self-citationThe Pancreas : biology, pathobiology, and disease
Go, V. L. W. (1993) · Raven Press eBooks · Cited by 526
Flagged first, then by citations
Cited by
Sorted by citations
Acetylcholine-Synthesizing T Cells Relay Neural Signals in a Vagus Nerve Circuit
Rosas-Ballina, M., Olofsson, P. S., Ochani, M., Valdés-Ferrer, S. I., Levine, Y. A., Reardon, C., Tusche, M. W., Pavlov, V. A., Andersson, U., Chavan, S., et al. (2011) · Science · doi:10.1126/science.1209985 · Cited by 1,551
Self-citationPhysiology and immunology of the cholinergic antiinflammatory pathway
Tracey, K. J. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30555 · Cited by 1,563
Self-citationSepsis: pathophysiology and clinical management
Gotts, J. E., & Matthay, M. A. (2016) · BMJ · doi:10.1136/bmj.i1585 · Cited by 1,308
Tracey, K. J. (2009) · Nature Reviews Immunology · doi:10.1038/nri2566 · Cited by 1,154
Self-citationSplenic nerve is required for cholinergic antiinflammatory pathway control of TNF in endotoxemia
Rosas‐Ballina, M., Ochani, M., Parrish, W. R., Ochani, K., Harris, Y., Huston, J. M., Chavan, S. S., & Tracey, K. J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803237105 · Cited by 762
Self-citationBrain–Gut Interactions in Inflammatory Bowel Disease
Bonaz, B. L., & Bernstein, C. N. (2013) · Gastroenterology · doi:10.1053/j.gastro.2012.10.003 · Cited by 667
Mechanisms and Therapeutic Relevance of Neuro-immune Communication
Chavan, S. S., Pavlov, V. A., & Tracey, K. J. (2017) · Immunity · doi:10.1016/j.immuni.2017.06.008 · Cited by 678
Self-citationDopamine mediates vagal modulation of the immune system by electroacupuncture
Rosas, R. T., Yehia, G., Peña, G., Mishra, P., Thompson-Bonilla, M. D. R., Moreno‐Eutímio, M. A., Arriaga‐Pizano, L., Isibasi, A., & Ulloa, L. (2014) · Nature Medicine · doi:10.1038/nm.3479 · Cited by 633
Self-citationThe alpha7 nicotinic acetylcholine receptor as a pharmacological target for inflammation
de Jonge, W. J., & Ulloa, L. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707264 · Cited by 634
Self-citationCholinergic control of inflammation
Rosas‐Ballina, M., & Tracey, K. J. (2009) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2009.02098.x · Cited by 592
Self-citationBonaz, B., Sinniger, V., & Pellissier, S. (2016) · The Journal of Physiology · doi:10.1113/jp271539 · Cited by 561
Neural regulation of immunity: molecular mechanisms and clinical translation
Pavlov, V. A., & Tracey, K. J. (2017) · Nature Neuroscience · doi:10.1038/nn.4477 · Cited by 552
Self-citationReflex principles of immunological homeostasis
Andersson, U., & Tracey, K. J. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075015 · Cited by 414
Self-citationMicroRNA-132 Potentiates Cholinergic Anti-Inflammatory Signaling by Targeting Acetylcholinesterase
Shaked, I., Meerson, A., Wolf, Y., Avni, R., Greenberg, D., Gilboa-Geffen, A., & Soreq, H. (2009) · Immunity · doi:10.1016/j.immuni.2009.09.019 · Cited by 366
Bonaz, B., Sinniger, V., & Pellissier, S. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01452 · Cited by 405
Rethinking inflammation: neural circuits in the regulation of immunity
Olofsson, P. S., Rosas‐Ballina, M., Levine, Y. A., & Tracey, K. J. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01138.x · Cited by 393
Self-citationPavlov, V. A., Ochani, M., Yang, L., Gallowitsch‐Puerta, M., Ochani, K., Lin, X., Levi, J., Parrish, W. R., Rosas‐Ballina, M., Czura, C. J., et al. (2007) · Critical Care Medicine · doi:10.1097/01.ccm.0000259381.56526.96 · Cited by 357
Self-citationHuston, J. M., & Tracey, K. J. (2010) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2010.02321.x · Cited by 345
Self-citationParrish, W. R., Rosas‐Ballina, M., Gallowitsch‐Puerta, M., Ochani, M., Ochani, K., Yang, L., Hudson, L., Lin, X., Patel, N. B., Johnson, S. M., et al. (2008) · Molecular Medicine · doi:10.2119/2008-00079.parrish · Cited by 335
Self-citationAnti-inflammatory effect of vagus nerve stimulation in a rat model of inflammatory bowel disease
Meregnani, J., Clarençon, D., Vivier, M., Peinnequin, A., Mouret, C., Sinniger, V., Picq, C., Job, A., Canini, F., Jacquier-Sarlin, M., et al. (2011) · Autonomic Neuroscience · doi:10.1016/j.autneu.2010.10.007 · Cited by 310
Vagus nerve stimulation: from epilepsy to the cholinergic anti‐inflammatory pathway
Bonaz, B., Picq, C., Sinniger, V., Mayol, J., & Clarencon, D. (2013) · Neurogastroenterology and Motility · doi:10.1111/nmo.12076 · Cited by 302
Anti-inflammatory role of microglial alpha7 nAChRs and its role in neuroprotection.
Egea, J., Buendía, I., Parada, E., Navarro, E., León, R., & López, M. G. (2015) · Biochemical Pharmacology · doi:10.1016/j.bcp.2015.07.032 · Cited by 292
Psychosocial stress in pregnancy and preterm birth: associations and mechanisms
Shapiro, G. D., Fraser, W., Frasch, M. G., & Séguin, J. (2013) · Journal of Perinatal Medicine · doi:10.1515/jpm-2012-0295 · Cited by 278
A nicotinic hypothesis for Covid-19 with preventive and therapeutic implications
Changeux, J., Amoura, Z., Rey, F. A., & Miyara, M. (2020) · Comptes Rendus Biologies · doi:10.5802/crbiol.8 · Cited by 316
The relationship between heart rate variability and inflammatory markers in cardiovascular diseases
Haensel, A., Mills, P. J., Nelesen, R. A., Ziegler, M. G., & Dimsdale, J. E. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.08.007 · Cited by 291
The vagal innervation of the gut and immune homeostasis
Matteoli, G., & Boeckxstaens, G. E. (2013) · Gut · doi:10.1136/gutjnl-2012-302550 · Cited by 276
Stimulation of nicotinic acetylcholine receptors attenuates collagen‐induced arthritis in mice
van Maanen, M. A., Lebre, M. C., van der Poll, T., LaRosa, G. J., Elbaum, D., Vervoordeldonk, M. J., & Tak, P. P. (2008) · Arthritis & Rheumatism · doi:10.1002/art.24177 · Cited by 276
Self-citationα7-Cholinergic Receptor Mediates Vagal Induction of Splenic Norepinephrine
Vida, G., Peña, G., Deitch, E. A., & Ulloa, L. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003722 · Cited by 262
Self-citationPavlov, V. A., & Tracey, K. J. (2015) · Immunologic Research · doi:10.1007/s12026-015-8718-1 · Cited by 254
Self-citationNeutrophils in Periodontal Inflammation
Scott, D. A., & Krauss, J. L. (2011) · Frontiers of oral physiology/Frontiers of oral biology · doi:10.1159/000329672 · Cited by 254
Neuro–Immune Cell Units: A New Paradigm in Physiology
Godinho‐Silva, C., Cardoso, F., & Veiga‐Fernandes, H. (2018) · Annual Review of Immunology · doi:10.1146/annurev-immunol-042718-041812 · Cited by 250
Somatosensory and autonomic neuronal regulation of the immune response
Udit, S., Blake, K. J., & Chiu, I. M. (2022) · Nature reviews. Neuroscience · doi:10.1038/s41583-021-00555-4 · Cited by 238
THE ROLE OF THE INTESTINAL BARRIER IN THE PATHOGENESIS OF NECROTIZING ENTEROCOLITIS
Anand, R., Leaphart, C. L., Mollen, K. P., & Hackam, D. J. (2007) · Shock · doi:10.1097/01.shk.0000239774.02904.65 · Cited by 232
The Spectrum of Achalasia: Lessons From Studies of Pathophysiology and High-Resolution Manometry
Kahrilas, P. J., & Boeckxstaens, G. E. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.08.038 · Cited by 236
Vincler, M., Wittenauer, S., Parker, R., Ellison, M., Olivera, B., & Mcintosh, J. (2006) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0608715103 · Cited by 222
The Neurology of the Immune System: Neural Reflexes Regulate Immunity
Rosas‐Ballina, M., & Tracey, K. J. (2009) · Neuron · doi:10.1016/j.neuron.2009.09.039 · Cited by 226
Self-citationActivation of the Cholinergic Anti-Inflammatory Pathway Ameliorates Postoperative Ileus in Mice
The, F. O., Boeckxstaens, G. E., Snoek, S. A., Cash, J. L., Bennink, R. J., LaRosa, G. J., van den Wijngaard, R. M., Greaves, D. R., & de Jonge, W. J. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.07.022 · Cited by 226
Self-citationControlling inflammation: the cholinergic anti-inflammatory pathway
Pavlov, V. A., & Tracey, K. J. (2006) · Biochemical Society Transactions · doi:10.1042/bst0341037 · Cited by 226
Self-citationCentral cholinergic activation of a vagus nerve-to-spleen circuit alleviates experimental colitis
Ji, H. L., Rabbi, M. F., Labis, B., Pavlov, V. A., Tracey, K. J., & Ghia, J. (2013) · Mucosal Immunology · doi:10.1038/mi.2013.52 · Cited by 212
Self-citationYang, M., Tao, L., Jiang, Y., Yang, J., Huo, Y., Liu, D., Li, J., Fu, X., He, R., Lin, C., et al. (2020) · Cancer Research · doi:10.1158/0008-5472.can-19-2689 · Cited by 208
Alpha7 nicotinic receptors as novel therapeutic targets for inflammation-based diseases
Bencherif, M., Lippiello, P. M., Lucas, R., & Marrero, M. B. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0525-1 · Cited by 207
LOCAL STIMULATION OF α7 CHOLINERGIC RECEPTORS INHIBITS LPS-INDUCED TNF-α RELEASE IN THE MOUSE LUNG
Giebelen, I. A. J., van Westerloo, D. J., LaRosa, G. J., de Vos, A. F., & van der Poll, T. (2007) · Shock · doi:10.1097/shk.0b013e318054dd89 · Cited by 200
Self-citationRosas‐Ballina, M., Goldstein, R. S., Gallowitsch‐Puerta, M., Yang, L., Valdés‐Ferrer, S. I., Patel, N. B., Chavan, S. S., Al‐Abed, Y., Yang, H., & Tracey, K. J. (2009) · Molecular Medicine · doi:10.2119/molmed.2009.00039 · Cited by 200
Self-citationCholinergic System and Its Therapeutic Importance in Inflammation and Autoimmunity
Halder, N., & Lal, G. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.660342 · Cited by 190
Manipulation of the inflammatory reflex as a therapeutic strategy
Kelly, M. J., Breathnach, C., Tracey, K. J., & Donnelly, S. C. (2022) · Cell Reports Medicine · doi:10.1016/j.xcrm.2022.100696 · Cited by 196
Self-citationReactivation of Inflammatory Bowel Disease in a Mouse Model of Depression
Ghia, J., Blennerhassett, P. A., Deng, Y., Verdu, E. F., Khan, W. I., & Collins, S. M. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.02.069 · Cited by 182
Activation of the α7 nAChR Reduces Acid-Induced Acute Lung Injury in Mice and Rats
Su, X., Lee, J. W., Matthay, Z. A., Mednick, G., Uchida, T., Fang, X., Gupta, N., & Matthay, M. A. (2007) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2006-0240oc · Cited by 176
Su, X., Matthay, M. A., & Malik, A. B. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901808 · Cited by 176
Immune privilege in corneal transplantation
Hori, J., Yamaguchi, T., Keino, H., Hamrah, P., & Maruyama, K. (2019) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2019.04.002 · Cited by 173
Corradi, J., & Bouzat, C. (2016) · Molecular Pharmacology · doi:10.1124/mol.116.104240 · Cited by 163
Vida, G., Peña, G., Kanashiro, A., Thompson-Bonilla, M. D. R., Palange, D., Deitch, E. A., & Ulloa, L. (2011) · The FASEB Journal · doi:10.1096/fj.11-191007 · Cited by 173
Self-citationDexmedetomidine Controls Systemic Cytokine Levels through the Cholinergic Anti-inflammatory Pathway
Xiang, H., Hu, B., Li, Z., & Li, J. (2014) · Inflammation · doi:10.1007/s10753-014-9906-1 · Cited by 162
Therapeutic Potential of Vagus Nerve Stimulation for Inflammatory Bowel Diseases
Bonaz, B. L., Sinniger, V., & Sonia Pellissier, A. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.650971 · Cited by 168
Balancing the autonomic nervous system to reduce inflammation in rheumatoid arthritis
Koopman, F. A., van Maanen, M. A., Vervoordeldonk, M. J., & Tak, P. P. (2017) · Journal of Internal Medicine · doi:10.1111/joim.12626 · Cited by 163
Pharmacologic cholinesterase inhibition improves survival in experimental sepsis*
Hofer, S., Eisenbach, C., Lukić, I. K., Schneider, L., Bode, K. A., Brueckmann, M., Mautner, S., Wente, M. N., Encke, J., Werner, J. M., et al. (2008) · Critical Care Medicine · doi:10.1097/01.ccm.0b013e31816208b3 · Cited by 153
Koopman, F. A., Stoof, S. P., Straub, R. H., van Maanen, M. A., Vervoordeldonk, M. J., & Tak, P. P. (2011) · Molecular Medicine · doi:10.2119/molmed.2011.00065 · Cited by 159
The vagus nerve as a modulator of intestinal inflammation
van der Zanden, E. P., Boeckxstaens, G. E., & de Jonge, W. J. (2008) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2008.01252.x · Cited by 155
Cholinergic agonists attenuate renal ischemia–reperfusion injury in rats
Yeboah, M. M., Xue, X., Duan, B., Ochani, M., Tracey, K. J., Susin, M., & Metz, C. N. (2008) · Kidney International · doi:10.1038/ki.2008.94 · Cited by 150
Self-citationThe cholinergic anti-inflammatory pathway: towards innovative treatment of rheumatoid arthritis
van Maanen, M. A., Vervoordeldonk, M. J., & Tak, P. P. (2009) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2009.31 · Cited by 140
Sadis, C., Teske, G. J., Stokman, G., Kubjak, C., Claessen, N., Moore, F., Loi, P., Diallo, B., Barvais, L., Goldman, M., et al. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000469 · Cited by 141
Self-citationEssential Neuroscience in Immunology
Chavan, S. S., & Tracey, K. J. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601613 · Cited by 140
Self-citationvan Maanen, M. A., Stoof, S. P., LaRosa, G. J., Vervoordeldonk, M. J., & Tak, P. P. (2010) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2009.118554 · Cited by 137
Self-citationZhao, M. F., He, X., Bi, X., Yu, X., Wier, W. G., & Zang, W. (2013) · Basic Research in Cardiology · doi:10.1007/s00395-013-0345-1 · Cited by 134
Jiang, Y., Li, L., Liu, B., Zhang, Y., Chen, Q., & Li, C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0102342 · Cited by 128
Cailotto, C., Gomez‐Pinilla, P. J., Costes, L. M. M., van der Vliet, J., Giovangiulio, M. D., Némethova, A., Matteoli, G., & Boeckxstaens, G. E. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087785 · Cited by 126
Function of Partially Duplicated Human α7 Nicotinic Receptor Subunit CHRFAM7A Gene
de Lucas‐Cerrillo, A. M., Maldifassi, M. C., Arnalich, F., Renart, J., Atienza, G., Serantes, R., Cruces, J., Sánchez‐Pacheco, A., Andrés‐Mateos, E., & Montiel, C. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.180067 · Cited by 123
Nicotinic acetylcholine receptors: Conventional and unconventional ligands and signaling
Papke, R. L., & Lindstrom, J. M. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108021 · Cited by 128
Partecke, L. I., Käding, A., Trung, D. N., Diedrich, S., Sendler, M., Weiß, F. U., Kühn, J., Mayerle, J. V., Beyer, K., von Bernstorff, W., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.15019 · Cited by 117
Lieb, D. C., Parson, H. K., Mamikunian, G., & Vinik, A. I. (2011) · Experimental Diabetes Research · doi:10.1155/2012/878760 · Cited by 114
The Involvement of Parasympathetic and Sympathetic Nerve in the Inflammatory Reflex
Pereira, M. R., & Leite, P. E. C. (2016) · Journal of Cellular Physiology · doi:10.1002/jcp.25307 · Cited by 115
Vagus nerve integrity and experimental colitis
Ghia, J., Blennerhassett, P. A., & Collins, S. M. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00098.2007 · Cited by 113
The intestinal cholinergic anti-inflammatory pathway
Goverse, G., Stakenborg, M., & Matteoli, G. (2016) · The Journal of Physiology · doi:10.1113/jp271537 · Cited by 109
Dysfunction of the Cholinergic Anti-Inflammatory Pathway Mediates Organ Damage in Hypertension
Li, D., Evans, R. G., Yang, Z., Song, S., Wang, P., Ma, X., Liu, C., Xi, T., Su, D., & Shen, F. (2010) · Hypertension · doi:10.1161/hypertensionaha.110.160077 · Cited by 108
Lung innervation in the eye of a cytokine storm: neuroimmune interactions and COVID-19
Virgiliis, F. D., & Giovanni, S. D. (2020) · Nature Reviews Neurology · doi:10.1038/s41582-020-0402-y · Cited by 107
Vagus nerve stimulation: A new bioelectronics approach to treat rheumatoid arthritis?
Koopman, F. A., Schuurman, P. R., Vervoordeldonk, M. J., & Tak, P. P. (2014) · Best Practice & Research Clinical Rheumatology · doi:10.1016/j.berh.2014.10.015 · Cited by 99
Mueller, B. R., Figueroa, A., & Robinson‐Papp, J. (2022) · Neurological Sciences · doi:10.1007/s10072-021-05810-1 · Cited by 127
Neuro-Immune Circuits Regulate Immune Responses in Tissues and Organ Homeostasis
Jakob, M. O., Murugan, S., & Klose, C. S. N. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00308 · Cited by 97
Ren, C., Tong, Y., Li, J., Lu, Z., & Yao, Y.-M. (2016) · International Journal of Biological Sciences · doi:10.7150/ijbs.16404 · Cited by 93
Caravaca, A. S., Gallina, A. L., Tarnawski, L., Shavva, V. S., Colas, R. A., Dalli, J., Malin, S., Hult, H., Arnardottir, H. H., & Olofsson, P. S. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2023285119 · Cited by 94
The, F., Cailotto, C., van der Vliet, J., de Jonge, W. J., Bennink, R. J., Buijs, R. M., & Boeckxstaens, G. E. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01296.x · Cited by 89
Hong, G., Zillekens, A., Schneiker, B., Pantelis, D., de Jonge, W. J., Schaefer, N., Kalff, J. C., & Wehner, S. (2018) · Neurogastroenterology & Motility · doi:10.1111/nmo.13501 · Cited by 88
Therapeutic Targeting of α7 Nicotinic Acetylcholine Receptors
Papke, R. L., & Horenstein, N. A. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000097 · Cited by 92
The Role of the Vagus Nerve in Cancer Prognosis: A Systematic and a Comprehensive Review
Couck, M., Caers, R., Spiegel, D., & Gidron, Y. (2018) · Journal of Oncology · doi:10.1155/2018/1236787 · Cited by 87
Huston, J. M. (2012) · Surgical Infections · doi:10.1089/sur.2012.126 · Cited by 87
Kox, M., van Velzen, J. F., Pompe, J. C., Hoedemaekers, C., van der Hoeven, J. G., & Pickkers, P. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.06.096 · Cited by 85
VAN WESTERLOO, D. J., GIEBELEN, I. A. J., MEIJERS, J. C. M., DAALHUISEN, J., DE VOS, A. F., LEVI, M., & VAN DER POLL, T. (2006) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2006.02112.x · Cited by 84
Self-citationvan Maanen, M. A., Stoof, S. P., van der Zanden, E. P., de Jonge, W. J., Janssen, R. A. J., Fischer, D. F., Vandeghinste, N., Brys, R., Vervoordeldonk, M. J., & Tak, P. P. (2009) · Arthritis & Rheumatism · doi:10.1002/art.24470 · Cited by 84
Targeting neural reflex circuits in immunity to treat kidney disease
Okusa, M. D., Rosin, D. L., & Tracey, K. J. (2017) · Nature Reviews Nephrology · doi:10.1038/nrneph.2017.132 · Cited by 85
Self-citationHeart rate and microinflammation in men: a relevant atherothrombotic link
Rogowski, O., Shapira, I., Shirom, A., Melamed, S., Toker, S., & Berliner, S. (2007) · Heart · doi:10.1136/hrt.2006.101949 · Cited by 83
Anatomical and clinical implications of vagal modulation of the spleen
Bassi, G. S., Kanashiro, A., Coimbra, N. C., Terrando, N., Maixner, W. D., & Ulloa, L. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.02.011 · Cited by 80
Self-citationThe vagus nerve modulates CD4+ T cell activity
Karimi, K., Bienenstock, J., Wang, L., & Forsythe, P. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.10.016 · Cited by 81
Park, J., Kang, J., & Lee, S. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.03.026 · Cited by 79
Zhu, Y., Peng, K., Meng, X., & Ji, F. (2016) · Brain Research · doi:10.1016/j.brainres.2016.04.074 · Cited by 77
Chatterjee, P. K., Yeboah, M. M., Dowling, O., Xue, X., Powell, S. R., Al‐Abed, Y., & Metz, C. N. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035361 · Cited by 78
The Effect of the Cholinergic Anti‐Inflammatory Pathway on Experimental Colitis
Bai, A., Guo, Y., & Lü, N. (2007) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.2007.02011.x · Cited by 72
Modulation of inflammatory response via α2-adrenoceptor blockade in acute murine colitis
Bai, A., Lü, N., Guo, Y., Chen, J., & Liu, Z. (2009) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2009.03894.x · Cited by 71
Invited review: Deterioration of the immune system after trauma: signals and cellular mechanisms
Flohé, S. B., Flohé, S., & Schade, F. U. (2008) · Innate Immunity · doi:10.1177/1753425908100016 · Cited by 72
Experimental Therapeutic Strategies for Severe Sepsis
Parrish, W. R., Gallowitsch‐Puerta, M., Czura, C. J., & Tracey, K. J. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1418.011 · Cited by 68
Self-citationKox, M., Pompe, J. C., Peters, T. A., Vaneker, M., van der Laak, J. A. W. M., van der Hoeven, J. G., Scheffer, G. J., Hoedemaekers, C., & Pickkers, P. (2011) · British Journal of Anaesthesia · doi:10.1093/bja/aer202 · Cited by 72
An Effective Method for Acute Vagus Nerve Stimulation in Experimental Inflammation
Caravaca, A. S., Gallina, A. L., Tarnawski, L., Tracey, K. J., Pavlov, V. A., Levine, Y. A., & Olofsson, P. S. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00877 · Cited by 66
Self-citation
Metadata
- Authors
- van Westerloo, D. J., Giebelen, I. A., Florquin, S., Bruno, M. J., LaRosa, G. J., Ulloa, L., Tracey, K. J., & van der Poll, T.
- Affiliations
- Amsterdam UMC Location University of Amsterdam (NL)
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2006-05
- Volume
- 130
- Issue
- 6
- Pages
- 1822-1830
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W2156897641
- Cited by
- 377
- References
- 37
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 6 · 2023: 11 · 2022: 24 · 2021: 20 · 2020: 26 · 2019: 9 · 2018: 20 · 2017: 18 · 2016: 18 · 2015: 18 · 2014: 23 · 2013: 26 · 2012: 23
- FWCI
- 19.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Funders
- National Institute of General Medical Sciences (R01GM084125, R01GM057226)
- Topics
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Keywords
- vagus nerve, nicotinic acetylcholine receptors, alpha7 nicotinic acetylcholine receptor, experimental pancreatitis, cerulein-induced pancreatitis, vagotomy, mecamylamine, GTS-21, cholinergic anti-inflammatory pathway, neutrophil migration, interleukin-6, lung inflammation, pancreatitis severity
- MeSH terms
- Animals, Biopsy, Needle, Ceruletide, Disease Models, Animal, Female, Immunohistochemistry, Mice, Inbred C57BL, Pancreatitis, Probability, Receptors, Nicotinic, Risk Factors, Sensitivity and Specificity, Severity of Illness Index, Vagotomy, Vagus Nerve, Nicotinic Antagonists, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review