American Gastroenterological Association Consensus Development Conference on the Use of Biologics in the Treatment of Inflammatory Bowel Disease, June 21–23, 2006
Open accessAbstract
The American Gastroenterological Association (AGA) convened a panel of gastroenterologists expert in the area of inflammatory bowel disease (IBD) that developed this consensus statement based on expert presentations of current scientific knowledge about IBD and through subsequent group discussion. This statement reflects the panel's assessment of medical knowledge available when written. Thus, readers should view this statement in the context of data that will accumulate after its creation. The opinions, conclusions, and recommendations expressed in this report are those of the consensus panel members and may or may not reflect the official opinion of the American Gastroenterological Association Institute. The conference upon which this report is based was funded through an unrestricted educational grant from Abbott Laboratories. Abbott Laboratories representatives did not attend the conference, nor did they participate in any way in the development of this report.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Infliximab has been proven to have utility to maintain remission, but its persistent use implies that the patient at one time had sufficiently active disease to warrant prescription.
“Infliximab has been proven to have utility to maintain remission 20 but its persistent use implies that the patient at one time had sufficiently active disease to warrant prescription.”
From The Manitoba IBD Index: Evidence for a New and Simple Indicator of IBD Activity (2009) · cites this paper as [20]
Recent initiation of infliximab can identify recently active disease even though long-term usage does not.
“Hence recent initiation of infliximab can identify recently active disease even though long term usage does not 20 .”
From The Manitoba IBD Index: Evidence for a New and Simple Indicator of IBD Activity (2009) · cites this paper as [20]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Maintenance infliximab for Crohn's disease: the ACCENT I randomised trial
Hanauer, S. B., Feagan, B. G., Lichtenstein, G. R., Mayer, L., Schreiber, S., Colombel, J., Rachmilewitz, D., Wolf, D. C., Olson, A. D., Bao, W., et al. (2002) · The Lancet · doi:10.1016/s0140-6736(02)08512-4 · Cited by 4,164 · see citing works
Self-citationInfliximab for Induction and Maintenance Therapy for Ulcerative Colitis
Rutgeerts, P. J., Sandborn, W. J., Feagan, B. G., Reinisch, W., Olson, A. D., Johanns, J., Travers, S., Rachmilewitz, D., Hanauer, S. B., Lichtenstein, G. R., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa050516 · Cited by 3,910 · see citing works
Self-citationDevelopment of a Crohn's Disease Activity Index
Best, W. R., Becktel, J. M., Singleton, J. W., & Kern, F. (1976) · Gastroenterology · doi:10.1016/s0016-5085(76)80163-1 · Cited by 3,152 · see citing works
Development of a Crohn's disease activity index. National Cooperative Crohn's Disease Study.
Best, W. R., Becktel, J. M., Singleton, J. W., & Kern, F. (1976) · PubMed · Cited by 3,147 · see citing works
Targan, S. R., Hanauer, S. B., van Deventer, S. J. H., Mayer, L., Present, D. H., Braakman, T., DeWoody, K. L., Schaible, T. F., & Rutgeerts, P. J. (1997) · New England Journal of Medicine · doi:10.1056/nejm199710093371502 · Cited by 3,135 · see citing works
Self-citationCoated Oral 5-Aminosalicylic Acid Therapy for Mildly to Moderately Active Ulcerative Colitis
Schroeder, K. W., Tremaine, W. J., & Ilstrup, D. M. (1987) · New England Journal of Medicine · doi:10.1056/nejm198712243172603 · Cited by 3,037 · see citing works
A SIMPLE INDEX OF CROHN'S-DISEASE ACTIVITY
Harvey, R. F., & Bradshaw, J. M. (1980) · The Lancet · doi:10.1016/s0140-6736(80)92767-1 · Cited by 2,974 · see citing works
Infliximab for the Treatment of Fistulas in Patients with Crohn's Disease
Present, D. H., Rutgeerts, P., Targan, S., Hanauer, S. B., Mayer, L., van Hogezand, R. A., Podolsky, D. K., Sands, B. E., Braakman, T., DeWoody, K. L., et al. (1999) · New England Journal of Medicine · doi:10.1056/nejm199905063401804 · Cited by 2,748 · see citing works
Self-citationBongartz, T., Sutton, A. J., Sweeting, M. J., Buchan, I. E., Matteson, E. L., & Montori, V. M. (2006) · JAMA · doi:10.1001/jama.295.19.2275 · Cited by 2,470 · see citing works
Colombel, J., Sandborn, W. J., Rutgeerts, P. J., Enns, R. A., Hanauer, S. B., Panaccione, R., Schreiber, S., Byczkowski, D., Li, J., Kent, J. D., et al. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.11.041 · Cited by 2,239 · see citing works
Self-citationInfliximab Maintenance Therapy for Fistulizing Crohn's Disease
Sands, B. E., Anderson, F., Bernstein, C. N., Chey, W. Y., Feagan, B. G., Fedorak, R. N., Kamm, M. A., Korzenik, J. R., Lashner, B. A., Onken, J. E., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa030815 · Cited by 2,222 · see citing works
Self-citationInfluence of Immunogenicity on the Long-Term Efficacy of Infliximab in Crohn's Disease
Baert, F., Noman, M., Vermeire, S., Assche, G. V., Haens, G. D., Carbonez, A., & Rutgeerts, P. J. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa020888 · Cited by 2,012 · see citing works
Self-citationPredictability of the postoperative course of Crohn's disease
Rutgeerts, P., Geboes, K., Vantrappen, G., Beyls, J., Kerremans, R., & Hiele, M. I. (1990) · Gastroenterology · doi:10.1016/0016-5085(90)90613-6 · Cited by 1,814 · see citing works
Self-citationDaperno, M., D’Haens, G., Assche, G. V., Baert, F., Bulois, P., Maunoury, V., Sostegni, R., Rocca, R., Pera, A., Gevers, A., et al. (2004) · Gastrointestinal Endoscopy · doi:10.1016/s0016-5107(04)01878-4 · Cited by 1,779 · see citing works
Self-citationHanauer, S. B., Sandborn, W. J., Rutgeerts, P. J., Fedorak, R. N., Lukáš, M., MacIntosh, D. G., Panaccione, R., Wolf, D. C., & Pollack, P. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.11.030 · Cited by 1,711 · see citing works
Self-citationGoekoop-Ruiterman, Y. P. M., Vries-Bouwstra, J. K. D., Allaart, C. F., van Zeben, D., Kerstens, P. J. S. M., Hazes, J. M. W., Zwinderman, A. H., Ronday, H. K., Han, K. H., Westedt, M. L., et al. (2005) · Arthritis & Rheumatism · doi:10.1002/art.21405 · Cited by 1,447 · see citing works
D’Haens, G., Sandborn, W. J., Feagan, B. G., Geboes, K., Hanauer, S. B., Irvine, E. J., Lémann, M., Marteau, P. R., Rutgeerts, P. J., Schölmerich, J., et al. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.12.038 · Cited by 1,205 · see citing works
Self-citationManagement of Crohn's Disease in Adults
Lichtenstein, G. R., Hanauer, S. B., & Sandborn, W. J. (2009) · The American Journal of Gastroenterology · doi:10.1038/ajg.2008.168 · Cited by 1,184 · see citing works
Self-citationJärnerot, G., Hertervig, E., Friis–Liby, I., Blomquist, L., Karlén, P., Grännö, C., VILIEN, M., Ström, M., Danielsson, Å., Verbaan, H., et al. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.03.003 · Cited by 1,092 · see citing works
Rutgeerts, P. J., D’Haens, G., Targan, S. R., Vasiliauskas, E. A., Hanauer, S. B., Present, D. H., Mayer, L., van Hogezand, R. A., Braakman, T., DeWoody, K. L., et al. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70332-x · Cited by 1,078 · see citing works
Self-citationKleinschmidt-DeMasters, B. K., & Tyler, K. L. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa051782 · Cited by 1,073 · see citing works
Progressive Multifocal Leukoencephalopathy after Natalizumab Therapy for Crohn's Disease
Assche, G. V., Ranst, M. A. V., Sciot, R., Dubois, B., Vermeire, S., Noman, M., Verbeeck, J., Geboes, K., Robberecht, W., & Rutgeerts, P. J. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa051586 · Cited by 1,058 · see citing works
Self-citationRachmilewitz, D. (1989) · BMJ · doi:10.1136/bmj.298.6666.82 · Cited by 1,038 · see citing works
Progressive Multifocal Leukoencephalopathy in a Patient Treated with Natalizumab
Langer-Gould, A. M., Atlas, S. W., Green, A., Bollen, A. W., & Pelletier, D. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa051847 · Cited by 1,032 · see citing works
Treatment of Crohn's Disease with 6-Mercaptopurine
Present, D. H., Korelitz, B. I., Wisch, N., Glass, J. L., Sachar, D. B., & Pasternack, B. S. (1980) · New England Journal of Medicine · doi:10.1056/nejm198005013021801 · Cited by 1,024 · see citing works
Timing of new black box warnings and withdrawals for prescription medications
Lasser, K. E. (2002) · JAMA · doi:10.1001/jama.287.17.2215 · Cited by 1,005 · see citing works
Natalizumab Induction and Maintenance Therapy for Crohn's Disease
Sandborn, W. J., Colombel, J., Enns, R., Feagan, B. G., Hanauer, S. B., Lawrance, I. C., Panaccione, R., Sanders, M. E., Schreiber, S., Targan, S. R., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043335 · Cited by 925 · see citing works
Self-citationEtanercept for active Crohn's disease: A randomized, double-blind, placebo-controlled trial
Sandborn, W. J., Hanauer, S. B., Katz, S., Safdi, M. A., Wolf, D. G., Baerg, R. D., Tremaine, W. J., Johnson, T., Diehl, N. N., & ZINSMEISTER, A. R. (2001) · Gastroenterology · doi:10.1053/gast.2001.28674 · Cited by 906 · see citing works
Self-citationSerious Infections and Mortality in Association With Therapies for Crohn’s Disease: TREAT Registry
Lichtenstein, G. R., Feagan, B. G., Cohen, R. D., Salzberg, B. A., Diamond, R. H., Chen, D. M., Pritchard, M. L., & Sandborn, W. J. (2006) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2006.03.002 · Cited by 902 · see citing works
Self-citationColombel, J., Loftus, E. V., Tremaine, W. J., Egan, L. J., Harmsen, W. S., Schleck, C. D., Zinsmeister, A. R., & Sandborn, W. J. (2003) · Gastroenterology · doi:10.1053/j.gastro.2003.10.047 · Cited by 898 · see citing works
Self-citationMary, J. Y., & Modigliani, R. (1989) · Gut · doi:10.1136/gut.30.7.983 · Cited by 887 · see citing works
Hyams, J. S., Crandall, W., Kugathasan, S., Griffiths, A. M., Olson, A. D., Johanns, J., Liu, G., Travers, S., Heuschkel, R. B., Markowitz, J. F., et al. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.12.003 · Cited by 876 · see citing works
Bégaud, B., Evreux, J. C., Jouglard, J., et al. (1985) · PubMed · Cited by 840 · see citing works
Natalizumab for Active Crohn's Disease
Ghosh, S. K., Goldin, E., Gordon, F. H., Malchow, H. A., Rask-Madsen, J., Rutgeerts, P. J., Vyhnálek, P., Zádorová, Z., Palmer, T., & Donoghue, S. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa020732 · Cited by 811 · see citing works
Self-citationEvaluation of Patients Treated with Natalizumab for Progressive Multifocal Leukoencephalopathy
Yousry, T. A., Major, E. O., Ryschkewitsch, C. F., Fahle, G. A., Fischer, S. H., Hou, J., Curfman, B. L., Miszkiel, K., Mueller‐Lenke, N., Sánchez, E., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa054693 · Cited by 789 · see citing works
Predicting outcome in severe ulcerative colitis.
Travis, S. P. L., Farrant, J. M., Ricketts, C., Nolan, D. J., Mortensen, N. M., Kettlewell, M. G. W., & Jewell, D. P. (1996) · Gut · doi:10.1136/gut.38.6.905 · Cited by 788 · see citing works
Self-citationvan den Brande, J. M. H., Braat, H., BRINK, G. R. V. D., Versteeg, H. H., Bauer, C. A., Hoedemaeker, I., van Montfrans, C., Hommes, D. W., Peppelenbosch, M. P., & van Deventer, S. J. H. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00382-2 · Cited by 722 · see citing works
Sandborn, W. J., Feagan, B. G., Hanauer, S. B., Lochs, H. H., Löfberg, R., Modigliani, R., Present, D. H., Rutgeerts, P. J., Schölmerich, J., Stange, E. F., et al. (2002) · Gastroenterology · doi:10.1053/gast.2002.31072 · Cited by 687 · see citing works
Self-citationCenter for Drug Evaluation and Research
National Cancer Institute (2020) · Definitions · doi:10.32388/doq9wu · Cited by 682 · see citing works
Scallon, B. J. (1995) · Cytokine · doi:10.1006/cyto.1995.0029 · Cited by 681 · see citing works
Brooklyn, T., Dunnill, M. G. S., Shetty, A., Bowden, J. J., Williams, J. D. L., Griffiths, C. E. M., Forbes, A., Greenwood, R., & Probert, C. S. (2005) · Gut · doi:10.1136/gut.2005.074815 · Cited by 642 · see citing works
Elliott, M. J., Maini, R. N., Feldmann, M., Long-Fox, A., Charles, P. J., Bijl, J. A., & Woody, J. N. (1994) · The Lancet · doi:10.1016/s0140-6736(94)90632-7 · Cited by 638 · see citing works
Variation Between Observers in Describing Mucosal Appearances in Proctocolitis
Baron, J. H., Connell, A. M., & Lennard-Jones, J. E. (1964) · BMJ · doi:10.1136/bmj.1.5375.89 · Cited by 614 · see citing works
Lügering, A., Schmidt, M., Lügering, N., Pauels, H., Domschke, W., & Kucharzik, T. F. (2001) · Gastroenterology · doi:10.1053/gast.2001.28702 · Cited by 588 · see citing works
Centre for Evidence Based Medicine
Badenoch, D., & Mbe (2003) · Cited by 586 · see citing works
Schreiber, S., Rutgeerts, P. J., Fedorak, R. N., Khaliq–Kareemi, M., Kamm, M. A., Boivin, M., Bernstein, C. N., Staun, M., Thomsen, O. Ø., & Innes, A. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.06.064 · Cited by 578 · see citing works
Self-citationInfliximab treatment induces apoptosis of lamina propria T lymphocytes in Crohn's disease
ten Hove, T. (2002) · Gut · doi:10.1136/gut.50.2.206 · Cited by 545 · see citing works
Cellier, C., Sahmoud, T., Froguel, E., Adenis, A., Belaiche, J., Bretagne, J. F., Florent, C., Bouvry, M., Mary, J. Y., & Modigliani, R. (1994) · Gut · doi:10.1136/gut.35.2.231 · Cited by 430 · see citing works
Sands, B. E., Blank, M. A., Patel, K., & van Deventer, S. J. H. (2004) · Clinical Gastroenterology and Hepatology · doi:10.1016/s1542-3565(04)00414-8 · Cited by 359 · see citing works
Self-citationSargramostim for Active Crohn's Disease
Korzenik, J. R., Dieckgraefe, B. K., Valentine, J. F., Hausman, D. F., & Gilbert, M. J. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa041109 · Cited by 338 · see citing works
An index of inflammatory activity in patients with Crohn's disease.
van Hees, P. A., van Elteren, P., van Lier, H. J. J., & van Tongeren, J. H. (1980) · Gut · doi:10.1136/gut.21.4.279 · Cited by 330 · see citing works
Vermeire, S., Noman, M., Van Assche, G., Baert, F., Van Steen, K., Esters, N., Joossens, S., Bossuyt, X., & Rutgeerts, P. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00701-7 · Cited by 327 · see citing works
Self-citationBinder, V., Hendriksen, C., & Kreiner, S. (1985) · Gut · doi:10.1136/gut.26.2.146 · Cited by 291 · see citing works
Infections and anti–tumor necrosis factor α therapy
Ellerin, T. B., Rubin, R. H., & Weinblatt, M. E. (2003) · Arthritis & Rheumatism · doi:10.1002/art.11301 · Cited by 284 · see citing works
Wolfe, F., & Sharp, J. T. (1998) · Arthritis & Rheumatism · doi:10.1002/1529-0131(199809)41:9 · Cited by 274 · see citing works
Lindgren, S. C., Flood, L., Kilander, A. F., Löfberg, R., Persson, T., & Sjödahl, R. I. (1998) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-199810000-00003 · Cited by 274 · see citing works
Louis, E. J., Vermeire, S., Rutgeerts, P., Vos, M. D., Gossum, A. V., Pescatore, P., Fiasse, R., Pelckmans, P. A., Reynaert, H., D’Haens, G., et al. (2002) · Scandinavian Journal of Gastroenterology · doi:10.1080/713786515 · Cited by 269 · see citing works
Self-citationManagement of Crohn's disease in adults
Hanauer, S. B., & Sandborn, W. J. (2001) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2001.03671.x · Cited by 261 · see citing works
Self-citationPredictors of response to infliximab in patients with Crohn's disease
Parsi, M. A., Achkar, J., Richardson, S., Katz, J., Hammel, J., Lashner, B. A., & Brzezinski, A. (2002) · Gastroenterology · doi:10.1053/gast.2002.35390 · Cited by 251 · see citing works
Prolonged duration of response to infliximab in early but not late pediatric Crohn's disease
Kugathasan, S., Werlin, S. L., Martinez, A., Rivera, M. T., Heikenen, J. B., & Binion, D. G. (2000) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2000.03263.x · Cited by 228 · see citing works
Vermeire, S. A. R. A., Louis, E. J., Carbonez, A., et al. (2002) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2002.05991.x · Cited by 227 · see citing works
Self-citationLouis, E. J., Vermeire, S. A. R. A., Rutgeerts, P., et al. (2002) · Scandinavian Journal of Gastroenterology · doi:10.1080/gas.37.7.818.824 · Cited by 225 · see citing works
Self-citationLouis, E. J., Ghoul, Z. E., Vermeire, S., Dall’Ozzo, S., Rutgeerts, P., Paintaud, G., Bélaïche, J., Vos, M. D., Gossum, A. V., Colombel, J. F., et al. (2004) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2004.01871.x · Cited by 224 · see citing works
Self-citationTaylor, K. D., Yang, H., Landers, C. J., Rotter, J. I., Targan, S. R., Plevy, S. E., & Barry, M. J. (2001) · Gastroenterology · doi:10.1053/gast.2001.23966 · Cited by 221 · see citing works
Self-citationSu, C., Lichtenstein, G. R., Krok, K., Brensinger, C. M., & Lewis, J. D. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.01.024 · Cited by 212 · see citing works
NOD2/CARD15 does not influence response to infliximab in Crohn's disease
Vermeire, S. A. R. A., Louis, E. J., Rutgeerts, P. J., et al. (2002) · Gastroenterology · doi:10.1053/gast.2002.34172 · Cited by 208 · see citing works
Self-citationSands, B. E., Kozarek, R. A., Spainhour, J. B., Barish, C. F., Becker, S., Goldberg, L., Katz, S., Goldblum, R., Harrigan, R., Hilton, D., et al. (2006) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20014 · Cited by 206 · see citing works
Self-citationSafety of Tumour Necrosis Factor-?? Antagonists
Khanna, D., McMahon, M. A., & Fürst, D. E. (2004) · Drug Safety · doi:10.2165/00002018-200427050-00003 · Cited by 205 · see citing works
Arnott, I. D., McNeill, G., & Satsangi, J. (2003) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2003.01574.x · Cited by 196 · see citing works
Hlavatý, T., Pierik, M. J., Henckaerts, L., Ferrante, M., Joossens, S. B. A., Schuerbeek, N. V., Noman, M., Rutgeerts, P. J., & Vermeire, S. (2005) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2005.02635.x · Cited by 195 · see citing works
Self-citationSabatino, A. D. (2003) · Gut · doi:10.1136/gut.53.1.70 · Cited by 190 · see citing works
Powell-Tuck, J., Day, D. W., Buckell, N. A., Wadsworth, J., & Lennard‐Jones, J. E. (1982) · Digestive Diseases and Sciences · doi:10.1007/bf01296733 · Cited by 181 · see citing works
Pierik, M. J., Vermeire, S., Steen, K. V., Joossens, S. B. A., Claessens, G., VLIETINCK, R. F., & Rutgeerts, P. (2004) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2004.01946.x · Cited by 149 · see citing works
Self-citationMascheretti, S., Hampe, J., Croucher, P. J. P., Nikolaus, S., Andus, T., Schubert, S., Olson, A. D., Bao, W., Fölsch, U. R., & Schreiber, S. (2002) · Pharmacogenetics · doi:10.1097/00008571-200210000-00002 · Cited by 147 · see citing works
Self-citationResponse to infliximab is related to disease duration in paediatric Crohn's disease
Lionetti, P., Bronzini, F., Salvestrini, C., Bascietto, C., Canani, R. B., Angelis, G. L. D., Guariso, G., Martelossi, S., Papadatou, B., & Barabino, A. V. (2003) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2003.01672.x · Cited by 144 · see citing works
Esters, N., Vermeire, S., Joossens, S. B. A., Noman, M., Louis, E., Bélaïche, J., Vos, M. D., Gossum, A. M. V., Pescatore, P., Fiasse, R., et al. (2002) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2002.05689.x · Cited by 143 · see citing works
Self-citationGenerini, S., Giacomelli, R., Fedi, R., Fulminis, A., Pignone, A. M., Frieri, G., Rosso, A. D., Viscido, A., Galletti, B., Fazzi, M., et al. (2004) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2003.012450 · Cited by 142 · see citing works
Risk of Early Surgery for Crohn's Disease: Implications for Early Treatment Strategies
Sands, B. E., Arsenault, J. E., Rosen, M. J., Alsahli, M., Bailen, L. S., Banks, P. A., Bensen, S. P., Bousvaros, A., Cave, D. R., Cooley, J. S., et al. (2003) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2003.08674.x · Cited by 141 · see citing works
Self-citationAn evaluation of utility measurement in Crohn's disease
Gregor, J. C., McDonald, J. W., Klar, N. S., Wall, R., Atkinson, K., Lamba, B., & Feagan, B. G. (1997) · Inflammatory Bowel Diseases · doi:10.1002/ibd.3780030405 · Cited by 140 · see citing works
Self-citationMass Screening for Colorectal Cancer
Kronborg, O. (1984) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365521.1984.12005675 · Cited by 129 · see citing works
Markowitz, J. F., Hyams, J. S., Mack, D. R., LeLeiko, N. S., Evans, J., Kugathasan, S., Pfefferkorn, M. D., Mezoff, A. G., Rosh, J. R., Tolia, V. K., et al. (2006) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2006.05.011 · Cited by 119 · see citing works
Myren, J., Bouchier, I. A. D., Watkinson, G., Softley, A., Clamp, S. E., & de Dombal, F. T. (1984) · PubMed · Cited by 115 · see citing works
Has disease outcome in Crohn's disease changed during the last four decades?
Wolters, F. J., Rüssel, M. G., & Stockbrügger, R. W. (2004) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2004.02123.x · Cited by 112 · see citing works
Herfarth, H. H., Obermeier, F., Andus, T., et al. (2002) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2002.06064.x · Cited by 110 · see citing works
Treatment of fistulizing Crohn's disease
Lichtenstein, G. R. (2000) · Gastroenterology · doi:10.1053/gast.2000.18165 · Cited by 110 · see citing works
B cells in rheumatoid arthritis: from hypothesis to the clinic
Keystone, E. C. (2005) · Lara D. Veeken · doi:10.1093/rheumatology/keh617 · Cited by 108 · see citing works
Antibodies to tumour necrosis factor α as treatment for Crohn's disease
Bell, S., & Kamm, M. A. (2000) · The Lancet · doi:10.1016/s0140-6736(99)00442-0 · Cited by 101 · see citing works
Self-citationKavanaugh, A. F., Schulze‐Koops, H., Davis, L. S., & Lipsky, P. E. (1997) · Arthritis & Rheumatism · doi:10.1002/art.1780400511 · Cited by 97 · see citing works
Clinical and biological consequences of immunization to infliximab in pediatric Crohn's disease
Candon, S., Mosca, A., Ruemmele, F. M., Goulet, O., Chatenoud, L., & Cézard, J. (2005) · Clinical Immunology · doi:10.1016/j.clim.2005.07.010 · Cited by 95 · see citing works
The O.M.G.E. Multinational Inflammatory Bowel Disease Survey 1976-1982
Myren, J., Bouchier, I. A. D., Watkinson, G., Softley, A., Se, C., & de Dombal, F. T. (1984) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365521.1984.12199901 · Cited by 93 · see citing works
Drug interaction between infliximab and azathioprine in patients with Crohn's disease
Roblin, X., Serre-Debeauvais, F., Phelip, J., Bessard, G., & Bonaz, B. L. (2003) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2003.01778.x · Cited by 91 · see citing works
Safety of biologic therapies--an update.
Keystone, E. C. (2005) · PubMed · Cited by 85 · see citing works
Treatment of acute uveitis associated with Crohn's disease and sacroileitis with infliximab
Fries, W., Giofré, M. R., Catanoso, M., et al. (2002) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2002.05514.x · Cited by 84 · see citing works
Seo, M., Okada, M., Yao, T., et al. (2002) · Journal of Gastroenterology · doi:10.1007/s535-002-8129-2 · Cited by 74 · see citing works
Siegel, C. A., Levy, C. L., MacKenzie, T. A., et al. (2007) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20283 · Cited by 72 · see citing works
Schreiber, S., Reinisch, W., Colombel, J. F., et al. (2007) · Journal of Crohn s and Colitis Supplements · doi:10.1016/s1873-9954(07)70190-8 · Cited by 67 · see citing works
Self-citationRutgeerts, P., Sandborn, W. J., Fedorak, R. N., et al. (2006) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2006.04.022 · Cited by 66 · see citing works
Self-citationHommes, D. W., Baert, F., Assche, G. V., et al. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.05.064 · Cited by 57 · see citing works
A simple clinical index of Crohn's disease activity--the Cape Town index.
Jp, W., In, M., & PARFITT, A. M. (1985) · PubMed · Cited by 50 · see citing works
Predictors of response to infliximab in luminal Crohn's disease
Laharie, D., Salzmann, M., Boubekeur, H., et al. (2005) · Gastroentérologie Clinique et Biologique · doi:10.1016/s0399-8320(05)80718-3 · Cited by 48 · see citing works
Fossati, G., & Nesbitt, A. M. (2005) · The American Journal of Gastroenterology · doi:10.14309/00000434-200509001-00806 · Cited by 33 · see citing works
Sandborn, W. J., Rutgeerts, P., Enns, R. A., et al. (2006) · The American Journal of Gastroenterology · doi:10.14309/00000434-200609001-01147 · Cited by 29 · see citing works
Self-citationHanauer, S. B. (2005) · Nature Clinical Practice Gastroenterology & Hepatology · doi:10.1038/ncpgasthep0318 · Cited by 25 · see citing works
Self-citationNesbitt, A. M., & Henry, A. J. (2004) · The American Journal of Gastroenterology · doi:10.14309/00000434-200410001-00777 · Cited by 18 · see citing works
Reshaping antibodies for therapy
Routledge, E. G., Gorman, S. D., & Clark, M. (1993) · Cited by 17 · see citing works
Self-citationSandborn, W. J., Colombel, J., Panés, J., et al. (2006) · The American Journal of Gastroenterology · doi:10.14309/00000434-200609001-01109 · Cited by 15 · see citing works
Self-citationMaintenance of Remission over 1 Year in Patients with Active Crohnʼs Disease Treated with Adalimumab
Sandborn, W. J., Hanauer, S., Lukas, M., et al. (2005) · The American Journal of Gastroenterology · doi:10.14309/00000434-200509001-00843 · Cited by 14 · see citing works
Self-citationMetz, D., Amer, F., & Hunt, B. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.05.063 · Cited by 11 · see citing works
Optimal Crohn's disease activity index (CDAI) response criteria is defined by decreaseȦ100 points
Sands, B. E., Steinhart, A. H., Lewis, J. D., Hanauer, S., Persson, T., & Sandborn, W. J. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)81034-x · Cited by 10 · see citing works
Self-citationNikolaus, S., Freitag, S., Krawczak, M., & Schreiber, S. (2008) · Inflammatory Bowel Diseases · doi:10.1097/00054725-200801001-00004 · Cited by 10 · see citing works
Self-citationSchreiber, S. (2007) · Gastroenterology · Cited by 10 · see citing works
Self-citationSchreiber, S. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.068 · Cited by 10 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 4
- Scallon BJ, Moore MA, Trinh H, Knight DM, Ghrayeb J. Chimeric anti-TNF monoclonal effector functions. Cytokine 1995;7:251- 259.
- Maini RN, Breedveld FC, Kalden JR, Smolen JS, Davis D, Mac- farlane JD, Antoni C, Leeb B, Elliott MJ, Woody JN, Schaible TF, Feldmann M. Therapeutic efficacy of multiple intravenous infu- sions of anti-tumor necrosis factor alpha monoclonal antibody combined with low-dose weekly methotrexate in rheumatoid arthritis. Arthritis Rheum 1998;41:1552-1563.
- Hanauer SB, Rutgeerts P, D'Haens G, et al. Delayed hypersensi- tivity to infliximab (Remicade) re-infusion after a 2-4 year interval without treatment (abstr). Gastroenterology 1999;116:A731.
- Stephen B. Hanauer, MD, and Paul Rutgeerts, MD, C/O of the AGA Institute National Office, 4930 Del Ray Avenue, Bethesda, Maryland 20814. e-mail: ktwomey@gastro.org; Fax: (301) 654-5920. Participants in the conference have indicated they have the follow- ing financial relationships with companies that market drugs and devices to gastroenterologists:
Cited by
Sorted by citations
Dignass, A., Lindsay, J. O., Sturm, A., Windsor, A., Colombel, J.-F., Allez, M., D'Haens, G., D'Hoore, A., Mantzaris, G., Novacek, G., et al. (2012) · Journal of Crohn's and Colitis · doi:10.1016/j.crohns.2012.09.002 · Cited by 1,548 · see citing works
Self-citationThe Manitoba IBD Index: Evidence for a New and Simple Indicator of IBD Activity
Clara, I., Lix, L. M., Walker, J. R., Graff, L. A., Miller, N., Rogala, L., Rawsthorne, P., & Bernstein, C. N. (2009) · The American Journal of Gastroenterology · doi:10.1038/ajg.2009.197 · Cited by 119 · see citing works
- Authors
- Clark, M., Colombel, J.-F., Feagan, B. C., Fedorak, R. N., Hanauer, S. B., Kamm, M. A., Mayer, L., Regueiro, C., Rutgeerts, P., Sandborn, W. J., Sands, B. E., Schreiber, S., Targan, S., Travis, S., & Vermeire, S.
- Affiliations
- Robarts Clinical Trials (CA)
- University of Alberta (CA)
- University of Chicago (US)
- St Mark's Hospital (GB)
- Icahn School of Medicine at Mount Sinai (US)
- Universitair Ziekenhuis Leuven (BE)
- Mayo Clinic (US)
- Massachusetts General Hospital (US)
- Christian-Albrechts-Universität zu Kiel (DE)
- Cedars-Sinai Medical Center (US)
- John Radcliffe Hospital (GB)
- Corresponding author
- Hanauer, Stephen B.
- ORCID
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2007-07
- Volume
- 133
- Issue
- 1
- Pages
- 312-339
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W2072711218
- Cited by
- 224
- References
- 112
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 1 · 2023: 4 · 2022: 4 · 2021: 8 · 2020: 3 · 2019: 4 · 2018: 6 · 2017: 7 · 2016: 11 · 2015: 12 · 2014: 12 · 2013: 10 · 2012: 25
- FWCI
- 15.53
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Abbott Laboratories
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Keywords
- inflammatory bowel disease, biologic therapy, Crohn's disease, ulcerative colitis, treatment guidelines, consensus statement
- MeSH terms
- Antibodies, Monoclonal, Biological Factors, Humans, Inflammatory Bowel Diseases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
