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Cited by 139Inflammatory mediators and NSAID effectsColorectal Cancer Screening and DetectionEsophageal Cancer Research and Treatment

Proton Pump Inhibitor Use and Risk of Colorectal Cancer: A Population-Based, Case–Control Study

Robertson, Douglas J., Larsson, Heidi, Friis, Søren, Pedersen, Lars, Baron, John A., Sørensen, Henrik T.·2007·Gastroenterology
DOI 10.1053/j.gastro.2007.06.014
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Abstract

Background & aims Use of proton pump inhibitors (PPIs) has been associated with elevated levels of serum gastrin. Because hypergastrinemia increases colorectal mucosa proliferation and has been associated with risk of colorectal cancer (CRC) in human beings, we conducted a large population-based study in Denmark to assess whether PPI use is associated with CRC risk.Methods We conducted the study in North Jutland County, Denmark. From the County Hospital Discharge Registry we identified incident cases of CRC during the period 1989-2005. Using risk set sampling we selected approximately 10 controls from the Danish Civil Registration System, with matching for sex and birth year. PPI use was ascertained in the Prescription Database of North Jutland (and so recorded before CRC diagnosis) and analyzed with conditional logistic regression adjusted for multiple covariates.Results We identified 5589 cases of CRC which were compared with 55,890 controls. In a comparison of ever to never or rare users (< or =30 pills during observation period), no evidence was observed of increased risk (adjusted odds ratio [OR], 1.11; 95% confidence interval [CI], 0.97-1.27). When we compared the most intense users of PPI (more than every other day) with never or rare users, we found that no increased cancer risk was shown in either short-term users (adjusted OR, 1.07; 95% CI, 0.86-1.34) or long-term users (>7 years; adjusted OR = 1.09; 95% CI, 0.58-2.06).Conclusions The use of PPIs in clinical practice does not measurably increase the risk of CRC.

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Crossref · 10.1053/j.gastro.2007.06.014

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  • Many studies over the years have not found a direct correlation between PPI use in clinical practice and an increased risk of CRC.

    “Nevertheless, it is fundamental to highlight that many studies over the years have not found a direct correlation between PPI use in clinical practice and an increased risk of CRC[154-156].”

    From Proton pump inhibitors and dysbiosis: current knowledge and aspects to be clarified (2019) · cites this paper as [156]

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Authors
Robertson, D. J., Larsson, H., Friis, S., Pedersen, L., Baron, J. A., & Sørensen, H. T.
Affiliations
  • Dartmouth–Hitchcock Medical Center (US)
  • Aarhus University Hospital (DK)
  • Danish Cancer Society (DK)
Corresponding author
Robertson, Douglas J.
ORCID
Venue
Gastroenterology
Publisher
Elsevier BV
Published
2007-09
Volume
133
Issue
3
Pages
755-760
ISSN
0016-5085 (ISSN-L)
DOI
10.1053/j.gastro.2007.06.014
OpenAlex
W1977659216
Cited by
139
References
51
Citations by year
2026: 3 · 2025: 2 · 2024: 3 · 2023: 5 · 2022: 1 · 2021: 9 · 2020: 17 · 2019: 3 · 2018: 7 · 2017: 10 · 2016: 5 · 2015: 5 · 2014: 3 · 2013: 7 · 2012: 8
FWCI
8.86
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Gastroenterology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
  • Health Sciences › Medicine › Oncology › Colorectal Cancer Screening and Detection
  • Health Sciences › Medicine › Surgery › Esophageal Cancer Research and Treatment
Keywords
proton pump inhibitors, colorectal cancer, hypergastrinemia, serum gastrin, cancer risk, drug use, long-term PPI use
MeSH terms
Aged, Anti-Inflammatory Agents, Non-Steroidal, Aspirin, Denmark, Dose-Response Relationship, Drug, Female, Gastrins, Histamine H2 Antagonists, Humans, Hypoglycemic Agents, Intestinal Mucosa, Male, Risk Factors, Time Factors, Colorectal Neoplasms, Logistic Models, Case-Control Studies, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Cell Proliferation, Proton Pump Inhibitors

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