C/EBPα Is Up-regulated in a Subset of Hepatocellular Carcinomas and Plays a Role in Cell Growth and Proliferation
Open accessAbstract
Background & aims C/EBPalpha (cebpa) is a putative tumor suppressor. However, initial results indicated that cebpa was up-regulated in a subset of human hepatocellular carcinomas (HCCs). The regulation and function of C/EBPalpha was investigated in HCC cell lines to clarify its role in liver carcinogenesis. Methods The regulation of C/EBPalpha expression was studied by quantitative reverse transcription-polymerase chain reaction (qRT-PCR), Western blotting, immunohistochemistry, methylation-specific PCR, and chromatin immunoprecipitation assays. C/EBPalpha expression was knocked-down by small interfering RNA or short hairpin RNA. Functional assays included colony formation, methylthiotetrazole, bromodeoxyuridine incorporation, and luciferase-reporter assays. Results Cebpa was up-regulated at least 2-fold in a subset (approximately 55%) of human HCCs compared with adjacent nontumor tissues. None of the up-regulated samples were positive for hepatitis C infection. The HCC cell lines Hep3B and Huh7 expressed high, PLC/PRF/5 intermediate, HepG2 and HCC-M low levels of C/EBPalpha, recapitulating the pattern of expression observed in HCCs. No mutations were detected in the CEBPA gene in HCCs and cell lines. C/EBPalpha was localized to the nucleus and functional in Hep3B and Huh7 cells; knocking-down its expression reduced target-gene expression, colony formation, and cell growth, associated with a decrease in cyclin A and CDK4 concentrations and E2F transcriptional activity. Epigenetic mechanisms including DNA methylation, and the binding of acetylated histone H3 to the CEBPA promoter-regulated cebpa expression in the HCC cells. Conclusions C/EBPalpha is up-regulated in a subset of HCCs and has growth-promoting activities in HCC cells. Novel oncogenic mechanisms involving C/EBPalpha may be amenable to epigenetic regulation to improve treatment outcomes.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Five candidate TFs (ARID3A, C/EBPα, FOXA3, MYBL2, SOX13) are identified by overlapping TF enrichment and co-expression with GPC3.
“By overlapping these lists, we identified five candidate TFs: ARID3A, C/EBPα, FOXA3, MYBL2, and SOX13, most of which are overexpressed in HCC and are implicated in hepatocarcinogenesis (Supplementary Fig. 6b, c)69–73.”
From Multi-omic analysis of hepatocellular carcinoma reveals aberrant cis-regulatory changes and dysregulated retrotransposons with prognostic potential (2025) · cites this paper as [73]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Hepatocellular Carcinoma: Epidemiology and Molecular Carcinogenesis
El‐Serag, H. B., & Rudolph, K. L. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.04.061 · Cited by 5,401 · see citing works
Sherr, C. J. (1996) · Science · doi:10.1126/science.274.5293.1672 · Cited by 5,379 · see citing works
Pabst, T., Mueller, B. U., Zhang, P., Radomska, H. S., Narravula, S., Schnittger, S., Behre, G., Hiddemann, W., & Tenen, D. G. (2001) · Nature Genetics · doi:10.1038/85820 · Cited by 901 · see citing works
Plumb, J. A., Finn, P. W., Williams, R. J., Bandara, M. J., Romero, M., Watkins, C. J., Thangue, N. B. L., & Brown, R. E. (2003) · PubMed · Cited by 312 · see citing works
Marcucci, G., Maharry, K. S., Radmacher, M. D., Mrózek, K., Vukosavljevic, T., Paschka, P., Whitman, S. P., Langer, C., Baldus, C. D., Liu, C., et al. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2008.17.5554 · Cited by 304 · see citing works
C/EBPα mutations in acute myeloid leukaemias
Nerlov, C. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1363 · Cited by 277 · see citing works
Resnitzky, D., Hengst, L., & Reed, S. I. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.8.4347 · Cited by 248 · see citing works
Natural history of hepatitis-related hepatocellular carcinoma
But, D. Y. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.1652 · Cited by 234 · see citing works
Identification of a Novel Small-Molecule Inhibitor of the Hypoxia-Inducible Factor 1 Pathway
Tan, C., de Noronha, R. G., Roecker, A. J., Pyrzyńska, B., Khwaja, F. W., Zhang, Z., Zhang, H., Teng, Q., Nicholson, A. C., Giannakakou, P., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.605.65.2 · Cited by 225 · see citing works
Self-citationWang, G., Iakova, P. A., Wilde, M., Awad, S. S., & Timchenko, N. A. (2004) · Genes & Development · doi:10.1101/gad.1183304 · Cited by 140 · see citing works
Datta, J., Majumder, S., Kutay, H., Motiwala, T., Frankel, W. L., Costa, R. H., Cha, H. C., MacDougald, O. A., Jacob, S. T., & Ghoshal, K. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-4433 · Cited by 132 · see citing works
Epigenetic Modulation of Tumor Suppressor CCAAT/Enhancer Binding Protein α Activity in Lung Cancer
Tada, Y., Brena, R. M., Hackanson, B. W., Morrison, C., Otterson, G. A., & Plass, C. (2006) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djj093 · Cited by 114 · see citing works
De-regulation of common housekeeping genes in hepatocellular carcinoma
Waxman, S., & Wurmbach, E. (2007) · BMC Genomics · doi:10.1186/1471-2164-8-243 · Cited by 110 · see citing works
Positive and negative regulatory elements in the mouse albumin enhancer.
Herbst, R. S., Friedman, N., Darnell, J. E., Jr., & Babiss, L. E. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.5.1553 · Cited by 102 · see citing works
C/EBPα: A tumour suppressor in multiple tissues?
Schuster, M. B., & Porse, B. T. (2006) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2006.02.003 · Cited by 96 · see citing works
Bennett, K. L., Hackanson, B. W., Smith, L. T., Morris, Q., Lang, J. C., Schuller, D. E., Weber, F., Eng, C., & Plass, C. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-4793 · Cited by 85 · see citing works
Chapiro, É., Russell, L. J., Radford‐Weiss, I., Bastard, C., Lessard, M., Struski, S., Cavé, H., Fert‐Ferrer, S., Barin, C., Maarek, O., et al. (2006) · Blood · doi:10.1182/blood-2006-03-010835 · Cited by 72 · see citing works
Dephosphorylated C/EBPα Accelerates Cell Proliferation through Sequestering Retinoblastoma Protein
Wang, G., & Timchenko, N. A. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.4.1325-1338.2005 · Cited by 65 · see citing works
Qiu, G., Xie, H., Wheelhouse, N., Harrison, D. J., Chen, G. G., Salto‐Tellez, M., Lai, P. B. S., Ross, J. A., & Hooi, S. C. (2006) · Journal of Hepatology · doi:10.1016/j.jhep.2006.11.012 · Cited by 57 · see citing works
Self-citationHistone deacetylase inhibition is associated with transcriptional repression of the Hmga2 gene
Ferguson, M. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg403 · Cited by 52 · see citing works
Establishment of a cell line (HCC‐M) from a human hepatocellular carcinoma
Watanabe, T., Morizane, T., Tsuchimoto, K., Inagaki, Y., Munakata, Y., Nakamura, T., Kumagai, N., & Tsuchiya, M. (1983) · International Journal of Cancer · doi:10.1002/ijc.2910320202 · Cited by 52 · see citing works
TSA downregulates Wilms tumor gene 1 (Wt1) expression at multiple levels
Makki, M. S., Heinzel, T., & Englert, C. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn356 · Cited by 47 · see citing works
Tseng, H. H., Hwang, Y., Yeh, K., Chang, J., Chen, Y., & Yu, H. (2008) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-008-0448-5 · Cited by 41 · see citing works
Tomizawa, M., Watanabe, K., Saisho, H., Nakagawara, A., & Tagawa, M. (2003) · PubMed · Cited by 37 · see citing works
Anticancer effects of aloe‐emodin on HepG2 cells: Cellular and proteomic studies
Lu, G., Shen, H., Ong, C. N., & Chung, M. C. M. (2007) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.200600798 · Cited by 35 · see citing works
Self-citationYin, H., Lowery, M. N., & Glass, J. (2009) · The Prostate · doi:10.1002/pros.20947 · Cited by 20 · see citing works
Identification of CCAAT enhancer binding protein α binding sites on the human α-fetoprotein gene
Li, H. M., Ikeda, H., Nakabayashi, H., Nishi, S., & Sakai, M. (2006) · Gene · doi:10.1016/j.gene.2006.10.024 · Cited by 7 · see citing works
Flagged first, then by citations
1 of the 28 references couldn’t be matched to a known paper.
Research works printed but not linked: 3
- Tan EH, Hooi SC, Laban M, et al. CCAAT/enhancer binding pro- tein alpha knock-in mice exhibit early liver glycogen storage and reduced susceptibility to hepatocellular carcinoma. Cancer Res 2005;65:10330 -10337.
- Resnitzky D, Hengst L, Reed SI. Cyclin A-associated kinase ac- tivity is rate limiting for entrance into S phase and is negatively regulated in G1 by p27Kip1. Mol Cell Biol 1995;15:4347-4352.
- Wang GL, Timchenko NA. Dephosphorylated C/EBPalpha accel- erates cell proliferation through sequestering retinoblastoma pro- tein. Mol Cell Biol 2005;25:1325-1338.
Cited by
Sorted by citations
ACSL4 is a predictive biomarker of sorafenib sensitivity in hepatocellular carcinoma
Ji, F., Lu, P.-Z., Zhu, G., Hooi, S. C., Wu, Y., Huang, X., Dai, H.-Q., Chen, P.-H., Li, Z., Su, W., et al. (2020) · Acta Pharmacologica Sinica · doi:10.1038/s41401-020-0439-x · Cited by 170 · see citing works
Self-citationPIWIL3/OIP5-AS1/miR-367-3p/CEBPA feedback loop regulates the biological behavior of glioma cells
Liu, X., Zheng, J., Xue, Y., Yu, H., Gong, W., Wang, P., Li, Z., & Liu, Y. (2018) · Theranostics · doi:10.7150/thno.21740 · Cited by 145 · see citing works
Boss, I. W., Nadeau, P. E., Abbott, J. R., Yang, Y., Mergia, A., & Renne, R. (2011) · Journal of Virology · doi:10.1128/jvi.05558-11 · Cited by 123 · see citing works
Yamamoto, K., Tateishi, K., Kudo, Y., Sato, T., Yamamoto, S., Miyabayashi, K., Matsusaka, K., Asaoka, Y., Ijichi, H., Hirata, Y., et al. (2014) · Carcinogenesis · doi:10.1093/carcin/bgu136 · Cited by 104 · see citing works
The Role of Autophagy in Hepatocellular Carcinoma
Lee, Y. J., & Jang, B. K. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161125984 · Cited by 104 · see citing works
Reebye, V., Huang, K., Lin, V., Jarvis, S., Cutillas, P. R., Dorman, S., Ciriello, S., Andrikakou, P., Voutila, J., Sætrom, P., et al. (2018) · Oncogene · doi:10.1038/s41388-018-0126-2 · Cited by 104 · see citing works
A tumor suppressor role for C/EBPα in solid tumors: more than fat and blood
Lourenço, A. R., & Coffer, P. J. (2017) · Oncogene · doi:10.1038/onc.2017.151 · Cited by 101 · see citing works
Zhao, Y., Wang, J., Xu, C., Li, Y., Sun, B., & Yang, L. (2019) · Clinical Science · doi:10.1042/cs20190225 · Cited by 90 · see citing works
Lu, G., Ang, Y. H., Zhou, J., Jegadeesan, T., Yan, B., Lim, Y. C., Srivastava, S., Salto‐Tellez, M., Hui, K. M., Shen, H., et al. (2014) · Hepatology · doi:10.1002/hep.27593 · Cited by 84 · see citing works
Self-citationEpigenetic Mechanisms Involved in HCV-Induced Hepatocellular Carcinoma (HCC)
Zhao, P., Malik, S., & Xing, S. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.677926 · Cited by 73 · see citing works
Naboulsi, W., Megger, D. A., Bracht, T., Kohl, M., Turewicz, M., Eisenacher, M., Voss, D. M., Schlaak, J., Hoffmann, A.-C., Weber, F., et al. (2015) · Journal of Proteome Research · doi:10.1021/acs.jproteome.5b00420 · Cited by 70 · see citing works
Sarma, N. J., Tiriveedhi, V., Subramanian, V., Shenoy, S., Crippin, J. S., Chapman, W. C., & Mohanakumar, T. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050826 · Cited by 67 · see citing works
Sarma, N. J., Tiriveedhi, V., Crippin, J. S., Chapman, W. C., & Mohanakumar, T. (2014) · Journal of Virology · doi:10.1128/jvi.03060-13 · Cited by 62 · see citing works
Development of MTL-CEBPA: Small Activating RNA Drug for Hepatocellular Carcinoma
Setten, R. L., Lightfoot, H. L., Habib, N., & Rossi, J. J. (2018) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201019666180611093428 · Cited by 48 · see citing works
Sun, Y., Tan, Y.-J., Lu, Z.-Z., Li, B., Sun, C., Li, T., Zhao, L., Liu, Z., Zhang, G., Yao, J., et al. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00268 · Cited by 42 · see citing works
Wang, Z., Xie, Q., Zhang, Y., Zhou, H., Huang, Y., Bi, X., Wang, Y., Shi, W., Sun, H., Gu, P., et al. (2015) · Scientific Reports · doi:10.1038/srep15280 · Cited by 36 · see citing works
Stefañska, B., Suderman, M. J., Machnes, Z. M., Bhattacharyya, B., Hallett, M. T., & Moshe Szyf, A. (2013) · Carcinogenesis · doi:10.1093/carcin/bgt273 · Cited by 35 · see citing works
Qiao, X., Liu, J., Zhu, L., Song, R., Zhong, M., & Guo, Y. (2021) · International Journal of Medical Sciences · doi:10.7150/ijms.64253 · Cited by 27 · see citing works
Zhao, T., Coutts, A. J., Xu, L., Yu, J., Ohshima, K., & Matsuoka, M. (2013) · Retrovirology · doi:10.1186/1742-4690-10-159 · Cited by 25 · see citing works
C/EBPα mediates the growth inhibitory effect of progestins on breast cancer cells
Nacht, A. S., Ferrari, R., Zaurín, R., Scabia, V., Carbonell‐Caballero, J., Dily, F. L., Quilez, J., Leopoldi, A., Brisken, C., Beato, M., et al. (2019) · The EMBO Journal · doi:10.15252/embj.2018101426 · Cited by 23 · see citing works
Su, Y., Li, Z., Li, Q., Guo, X., Zhang, H., Li, Y., Meng, Z., Huang, S., & Hu, Z. (2024) · Theranostics · doi:10.7150/thno.99633 · Cited by 22 · see citing works
Liu, G., Lu, J.-Y., Zhang, Y., Zhang, L.-X., Lu, G., Xie, Z., Cheng, M.-B., Shen, Y.-F., & Zhang, Y. (2015) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2015.12.004 · Cited by 21 · see citing works
Self-citationLiu, X., Chen, X., Xiao, M., Zhu, Y., Gong, R., Liu, J., Zeng, Q., Xu, C., Chen, X., Wang, F. W., et al. (2021) · Cancers · doi:10.3390/cancers13143475 · Cited by 20 · see citing works
Konopka, B., Szafron, L. M., Kwiatkowska, E., Podgórska, A., Zołocińska, A., Pieńkowska‐Grela, B., Dansonka‐Mieszkowska, A., Balcerak, A., Łukasik, M., Stachurska, A., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.11822 · Cited by 18 · see citing works
Berger, E., Véga, N., Vidal, H., & Géloën, A. (2012) · Biotechnology Journal · doi:10.1002/biot.201200188 · Cited by 17 · see citing works
HCV and HCC Tango—Deciphering the Intricate Dance of Disease: A Review Article
Milošević, I., Todorović, N., Filipović, A., Simić, J., Marković, M., Stevanović, O., Malinić, J., Katanić, N., Mitrović, N., & Nikolic, N. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242216048 · Cited by 15 · see citing works
Wang, C., Dong, D., Zhao, N., Liu, Y., Bai, C., Hua, J., Cui, R., Wei, X. C., Zhao, T., Ji, N., et al. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.217420 · Cited by 12 · see citing works
CRED9: a differentially expressed elncRNA regulates expression of transcription factor CEBPA
Setten, R. L., Chomchan, P., Epps, E. W., Burnett, J. C., & Rossi, J. J. (2021) · RNA · doi:10.1261/rna.078752.121 · Cited by 11 · see citing works
The Spectrum of E2F in Liver Disease-Mediated Regulation in Biology and Cancer
Huntington, J. T., Tang, X., Kent, L. N., Schmidt, C. R., & Leone, G. W. (2015) · Journal of Cellular Physiology · doi:10.1002/jcp.25242 · Cited by 12 · see citing works
Li, H., He, Y., Jiang, J., Liu, Z., Liu, Y., Shi, Q., Ding, J., Li, H., Sun, W., Hu, X., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-62743-5 · Cited by 11 · see citing works
C/EBPα inhibits hepatocellular carcinoma by reducing Notch3/Hes1/p27 cascades
Shi, Y., Zhao, H., Yin, C., Zeng, X. Y., Zhang, Q. H., Xu, W., Wei, J., Chen, F., & Xie, W.-F. (2013) · Digestive and Liver Disease · doi:10.1016/j.dld.2013.03.013 · Cited by 11 · see citing works
Xu, Z., Meng, S., Bai, J., Sun, C., Zhao, L., Tang, R., Yin, Z., Ji, J., Yang, W., & Ma, G. (2019) · Current Cancer Drug Targets · doi:10.2174/1568009619666190912161003 · Cited by 10 · see citing works
Okumura, N., Ikeda, M., Satoh, S., Dansako, H., Sugiyama, M., Mizokami, M., & Kato, N. (2015) · FEBS Letters · doi:10.1016/j.febslet.2015.03.022 · Cited by 10 · see citing works
Aberrant expression of alternative isoforms of transcription factors in hepatocellular carcinoma
Кривцова, О. М., Makarova, A. S., & Lazarevich, N. L. (2018) · World Journal of Hepatology · doi:10.4254/wjh.v10.i10.645 · Cited by 10 · see citing works
Assi, M., Kenawi, M., ROPARS, M., & Rébillard, A. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.06.158 · Cited by 9 · see citing works
Wang, X., Liao, X., Zhou, X., Han, C., Chen, Z., Yang, C., Huang, J., Wang, J., Liu, J., Huang, H.-S., et al. (2020) · PubMed Central · Cited by 9 · see citing works
Transcriptomic screening of novel targets of sericin in human hepatocellular carcinoma cells
Jantaravinid, J., Tirawanchai, N., Ampawong, S., Kengkoom, K., Somkasetrin, A., Nakhonsri, V., & Aramwit, P. (2024) · Scientific Reports · doi:10.1038/s41598-024-56179-y · Cited by 8 · see citing works
Stoyanov, E., Mizrahi, L., Olam, D., Perlman, T. S., Galun, E., & Goldenberg, D. (2017) · Oncotarget · doi:10.18632/oncotarget.18300 · Cited by 8 · see citing works
Satoh, S., Onomura, D., Ueda, Y., Dansako, H., Honda, M., Kaneko, S., & Kato, N. (2018) · Biochemical Journal · doi:10.1042/bcj20180680 · Cited by 8 · see citing works
Hu, X., Ji, F., Huang, X., Lu, P.-Z., Wang, Z., Dai, H.-Q., Deng, J.-H., Xin-pin, Y., Peng, T., Hooi, S. C., et al. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.05.024 · Cited by 8 · see citing works
Self-citationZhou, J., Tang, Y., Xie, Z., Lu, J., Deng, J.-H., Huang, X., Hooi, S. C., He, M. Y., & Lu, G. (2017) · Anti-Cancer Drugs · doi:10.1097/cad.0000000000000475 · Cited by 8 · see citing works
Self-citationNie, Y., Su, L., Li, W., & Gao, S. (2021) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2021.103379 · Cited by 8 · see citing works
Bai, R., Kusama, K., Matsuno, Y., Bai, H., Sakurai, T., Kimura, K., & Imakawa, K. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1075030 · Cited by 7 · see citing works
Shu-fang, M., Zhang, L., Li, M., Dong, Z., Tian, C., & Fu, M. (2022) · Frontiers in Surgery · doi:10.3389/fsurg.2022.842823 · Cited by 7 · see citing works
Mi, L., Hu, K., Wen, X., Sun, J. P., Wu, A., Wang, M., Zheng, M., Zang, L., & Ji, J. (2018) · Europe PMC (PubMed Central) · Cited by 6 · see citing works
Liu, Z., Yang, J. C., Ge, C., Zhao, F., Li, H., Yao, M., Li, J., & Tian, H. (2018) · Europe PMC (PubMed Central) · Cited by 6 · see citing works
Brettfeld, C., Englert, S., Aumueller, E., & Haslberger, A. G. (2012) · Italian Journal of Public Health · doi:10.2427/8694 · Cited by 5 · see citing works
A review of C/EBP α: a potential novel target for solid tumor intervention
Li, X., Dai, T., Zhao, J., Liang, Y., Chen, L., Chen, C., Guo, M., Han, Y., Xu, L., & Zhao, J. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06884-7 · Cited by 4 · see citing works
Zhu, Y., Lu, H., Hao, X., Chang, M., Wang, Q.-X., Wan, F.-Y., & Wan, X. (2018) · PubMed Central · doi:10.7499/j.issn.1008-8830.2018.05.013 · Cited by 4 · see citing works
Cheng, C. C. Y., Cheung, M. F., Lee, A. Y., Wu, Q., Chow, S. H.-C., Ang, J. Y. J., Riquelme Medina, I., Lo, G., Wu, H., Yang, W., et al. (2025) · Communications Biology · doi:10.1038/s42003-025-09154-w · Cited by 3 · see citing works
MAFB-mediated CEBPA regulated human urothelium growth through Wnt/β-catenin signaling pathway
Liu, Z., Luo, X., Zhang, Z., Zhang, Q., Wang, C., Chen, H., Long, C., Liu, X., & Wei, G. (2024) · Genes & Diseases · doi:10.1016/j.gendis.2024.101432 · Cited by 3 · see citing works
Naik, K. A. P., Kethavath, S. N., Rosangzula, K., Saikrishna, J., Sangeetha, R., Patlolla, R. R., Chandgude, A. H., & Banoth, L. (2026) · Springer eBooks · doi:10.1007/978-981-95-5071-5_12 · Cited by 3 · see citing works
Computational modeling of chromatin accessibility identified important epigenomic regulators
Zhao, Y., Dong, Y., Wei, H., Jiang, C., Yao, K., & Cheng, C. (2022) · BMC Genomics · doi:10.1186/s12864-021-08234-5 · Cited by 3 · see citing works
Cao, H., Wen, Y., Xu, X., Liu, K., Liu, H., Tan, Y., Zhou, W. M., Mao, H., Dong, X., Xu, N., et al. (2020) · Animal Biotechnology · doi:10.1080/10495398.2020.1803343 · Cited by 3 · see citing works
The current progress of histone deacetylase SIRT7
Zhan, J., Xiong, J., Huang, J., Zhu, W., & Wang, H. (2020) · Scientia Sinica Vitae · doi:10.1360/ssv-2019-0132 · Cited by 3 · see citing works
Transcriptional Regulation of the Human MGP Promoter: Identification of Downstream Repressors
Caiado, H., Cancela, M. L., & Conceição, N. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252312597 · Cited by 1 · see citing works
Zhao, Y., Dong, Y., Hong, W., Jiang, C., Yao, K., & Cheng, C. (2022) · Figshare · doi:10.6084/m9.figshare.18071071
Shafi, O., Rajpar, R., Zafar, S., Irfan, S., Ashar, M., Jafry, S. H., Virk, L. N., & Raveena (2024) · Research Square · doi:10.21203/rs.3.rs-4360926/v1
Zhao, Y., Dong, Y., Hong, W., Jiang, C., Yao, K., & Cheng, C. (2022) · Figshare · doi:10.6084/m9.figshare.18071059
Zhao, Y., Dong, Y., Hong, W., Jiang, C., Yao, K., & Cheng, C. (2022) · Figshare · doi:10.6084/m9.figshare.18071062
Zhao, Y., Dong, Y., Hong, W., Jiang, C., Yao, K., & Cheng, C. (2022) · Figshare · doi:10.6084/m9.figshare.18071056
Zhao, Y., Dong, Y., Hong, W., Jiang, C., Yao, K., & Cheng, C. (2022) · Figshare · doi:10.6084/m9.figshare.18071068
Zhao, Y., Dong, Y., Hong, W., Jiang, C., Yao, K., & Cheng, C. (2022) · Figshare · doi:10.6084/m9.figshare.18071065
- Authors
- Lu, G., Leung, C. H., Yan, B., Tan, C. M., Low, S. Y., Aung, M. O., Salto–Tellez, M., Lim, S. G., & Hooi, S. C.
- Affiliations
- National University of Singapore (SG)
- National University Hospital (SG)
- Corresponding author
- Hooi, Shing Chuan
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2010-08
- Volume
- 139
- Issue
- 2
- Pages
- 632-643.e4
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W2088354340
- Cited by
- 62
- References
- 28
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 6 · 2023: 2 · 2022: 7 · 2021: 5 · 2020: 4 · 2019: 4 · 2018: 9 · 2017: 4 · 2016: 1 · 2015: 6 · 2014: 3 · 2013: 3 · 2012: 3
- FWCI
- 1.47
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- National University of Singapore (submittedVersion)
- Research Portal (Queen's University Belfast) (submittedVersion)
- Funders
- National University of Singapore
- Medical Research Council
- National Medical Research Council (NMRC/1211/2009)
- National Cancer Institute
- Topics
- Health Sciences › Medicine › Hepatology › Hepatocellular Carcinoma Treatment and Prognosis
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Keywords
- C/EBPα, hepatocellular carcinoma, oncogenes, tumor suppressor, cell proliferation, cell growth, epigenetic regulation, DNA methylation, histone H3 acetylation, cyclin A, CDK4, E2F transcription, hepatocarcinogenesis, gene expression regulation
- MeSH terms
- Cell Nucleus, Carcinoma, Hepatocellular, Histones, Humans, Immunohistochemistry, Liver Neoplasms, Blotting, Western, Up-Regulation, Gene Expression Regulation, Neoplastic, DNA Methylation, Cyclin A, Reverse Transcriptase Polymerase Chain Reaction, CCAAT-Enhancer-Binding Proteins, RNA Interference, Epigenesis, Genetic, Chromatin Immunoprecipitation, Cell Proliferation, Cyclin-Dependent Kinase 4, Hep G2 Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
