The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
MicroRNA Regulation of Intestinal Epithelial Tight Junction Permeability
Open accessAbstract
Background & Aims Defects in the intestinal epithelial tight junction (TJ) barrier contribute to intestinal inflammation. Tumor necrosis factor (TNF)-α induced increase in intestinal TJ permeability contributes to the intestinal TJ barrier defect in inflammatory disorders. We investigated the mechanisms by which TNF-α induces occludin depletion and increase in intestinal TJ permeability. Methods We assessed intestinal TJ barrier function using intestinal epithelial model systems: filter-grown Caco-2 monolayers and recycling perfusion studies of mouse small intestine. Results TNF-α caused a rapid increase in expression of miR-122a in enterocytes, in cultured cells and intestinal tissue. The over-expressed miR-122a bound to a binding motif at the 3′-untranslated region of occludin mRNA to induce its degradation; mRNA degradation depleted occludin from enterocytes, resulting in increased intestinal TJ permeability. Transfection of enterocytes with an anti-sense oligoribonucleotide against miR-122a blocked the TNF-α-induced increase in enterocyte expression of miR-122a, degradation of occludin mRNA, and increase in intestinal permeability. Overexpression of miR-122a in enterocytes using pre-miR-122a was sufficient to induce degradation of occludin mRNA and increase in intestinal permeability. Conclusions TNF-α regulates intestinal permeability by inducing miR-122a-mediated degradation of occludin mRNA. These studies demonstrate the feasibility of therapeutically targeting miR-122a in-vivo to preserve the intestinal barrier.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Intestinal mucosal barrier function in health and disease
Turner, J. R. (2009) · Nature reviews. Immunology · doi:10.1038/nri2653 · Cited by 3,952
Infliximab for Induction and Maintenance Therapy for Ulcerative Colitis
Rutgeerts, P., Sandborn, W. J., Feagan, B. G., Reinisch, W., Olson, A., Johanns, J., Travers, S., Rachmilewitz, D., Hanauer, S. B., Lichtenstein, G. R., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa050516 · Cited by 3,902
Targan, S. R., Hanauer, S. B., van Deventer, S. J. H., Mayer, L., Present, D. H., Braakman, T., DeWoody, K. L., Schaible, T. F., & Rutgeerts, P. J. (1997) · New England Journal of Medicine · doi:10.1056/nejm199710093371502 · Cited by 3,135
Occludin: a novel integral membrane protein localizing at tight junctions.
Furuse, M., Hirase, T., Itoh, M., Nagafuchi, A., Yonemura, S., Tsukita, S., & Tsukita, S. (1993) · The Journal of cell biology · doi:10.1083/jcb.123.6.1777 · Cited by 2,580
Multifunctional strands in tight junctions
Tsukita, S., Furuse, M., & Itoh, M. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35067088 · Cited by 2,509
Zeissig, S., Bürgel, N., Günzel, D., Richter, J., Mankertz, J., Wahnschaffe, U., Kroesen, A. J., Zeitz, M., Fromm, M., & Schulzke, J.-D. (2007) · Gut · doi:10.1136/gut.2006.094375 · Cited by 1,223
microRNA target predictions in animals
Rajewsky, N. (2006) · Nature Genetics · doi:10.1038/ng1798 · Cited by 1,091
Ma, T. Y., Iwamoto, G. K., Hoa, N. T., Akotia, V., Pedram, A., Boivin, M. A., & Said, H. M. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00173.2003 · Cited by 909
Self-citationTumour necrosis factor alpha in stool as a marker of intestinal inflammation
Braegger, C. P., Nicholls, S., Murch, S. H., MacDonald, T. T., & Stephens, S. (1992) · The Lancet · doi:10.1016/0140-6736(92)90999-j · Cited by 683
Occludin is a functional component of the tight junction
McCarthy, K. M., Skare, I. B., Stankewich, M. C., Furuse, M., Tsukita, S., Rogers, R. A., Lynch, R. D., & Schneeberger, E. E. (1996) · Journal of Cell Science · doi:10.1242/jcs.109.9.2287 · Cited by 645
Cited by
Guo, S., Al-Sadi, R., Said, H. M., & Ma, T. Y. (2013) · The American Journal of Pathology · doi:10.1016/j.ajpath.2012.10.014 · Cited by 719
Self-citationIL-1β and the Intestinal Epithelial Tight Junction Barrier
Kaminsky, L. W., Al-Sadi, R., & Ma, T. Y. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.767456 · Cited by 432
Self-citationGuo, S., Nighot, M., Al-Sadi, R., Alhmoud, T., Nighot, P., & Ma, T. Y. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402598 · Cited by 417
Self-citationAge-Associated Remodeling of the Intestinal Epithelial Barrier
Tran, L., & Greenwood-Van Meerveld, B. (2013) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glt106 · Cited by 320
Al-Sadi, R., Ye, D., Boivin, M., Guo, S., Hashimi, M., Ereifej, L., & Ma, T. Y. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085345 · Cited by 280
Self-citation
Metadata
- Authors
- Ye, D., Guo, S., Al–Sadi, R., & Ma, T. Y.
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2011-10
- Volume
- 141
- Issue
- 4
- Pages
- 1323-1333
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W2064964362
- Cited by
- 306
- References
- 34
- FWCI
- 5.00
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: MicroRNA Regulation of Intestinal Epithelial Tight Junction Permeability. https://app.cochat.ai/papers/10.1053/j.gastro.2011.07.005
- The paper
- Ye, D., Guo, S., Al–Sadi, R., & Ma, T. Y. (2011). MicroRNA Regulation of Intestinal Epithelial Tight Junction Permeability. Gastroenterology. https://doi.org/10.1053/j.gastro.2011.07.005
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
