Intestinal mucosal barrier function in health and disease

Turner, Jerrold R.

doi:10.1038/nri2653

Cited by 3,952Gastrointestinal motility and disordersGut microbiota and healthInflammatory Bowel Disease

Intestinal mucosal barrier function in health and disease

Turner, Jerrold R.·2009·Nature reviews. Immunology

DOI 10.1038/nri2653

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Abstract

Mucosal surfaces are lined by epithelial cells. These cells establish a barrier between sometimes hostile external environments and the internal milieu. However, mucosae are also responsible for nutrient absorption and waste secretion, which require a selectively permeable barrier. These functions place the mucosal epithelium at the centre of interactions between the mucosal immune system and luminal contents, including dietary antigens and microbial products. Recent advances have uncovered mechanisms by which the intestinal mucosal barrier is regulated in response to physiological and immunological stimuli. Here I discuss these discoveries along with evidence that this regulation shapes mucosal immune responses in the gut and, when dysfunctional, may contribute to disease.

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Solutes and water cross tight junctions through 2 distinct pathways based on their size and charge selectivity: the pore pathway and the leak pathway.
“It was reported that solutes and water cross TJs through 2 distinct pathways based on their size and charge selectivity: the pore pathway48, 49, 50 and the leak pathway.48,51”
From Regulation of Intestinal Barrier Function by Microbial Metabolites (2021) · cites this paper as [49]

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Metagenomic biomarker discovery and explanation
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Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus
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The intestinal epithelial barrier: a therapeutic target?
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Symbiotic bacterial metabolites regulate gastrointestinal barrier function via the xenobiotic sensor PXR and Toll-like receptor 4
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Edible ginger-derived nanoparticles: A novel therapeutic approach for the prevention and treatment of inflammatory bowel disease and colitis-associated cancer
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Zonulin and its regulation of intestinal barrier function: the biological door to inflammation, autoimmunity, and cancer.
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The Blood-Testis Barrier and Its Implications for Male Contraception
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Tight Junction Pore and Leak Pathways: A Dynamic Duo
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Akkermansia muciniphila-derived extracellular vesicles influence gut permeability through the regulation of tight junctions
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Gut-liver axis: Pathophysiological concepts and clinical implications
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Regulation of Intestinal Barrier Function by Microbial Metabolites
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New developments in goblet cell mucus secretion and function
Birchenough, G. M. H., Johansson, M., Gustafsson, J. K., Bergström, J. H., & Hansson, G. C. (2015) · Mucosal Immunology · doi:10.1038/mi.2015.32 · Cited by 820 · see citing works
Intestinal Permeability Regulation by Tight Junction: Implication on Inflammatory Bowel Diseases
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The microbiome in infectious disease and inflammation
Honda, K., & Littman, D. R. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-074937 · Cited by 791 · see citing works
Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe −/− Mice
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Interleukin-23-Independent IL-17 Production Regulates Intestinal Epithelial Permeability
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Basics and Recent Advances in Peptide and Protein Drug Delivery
Bruno, B. J., Miller, G. D., & Lim, C. S. (2013) · Therapeutic Delivery · doi:10.4155/tde.13.104 · Cited by 760 · see citing works
Cell Biology of Tight Junction Barrier Regulation and Mucosal DiseasePreprint
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The gut–liver axis and gut microbiota in health and liver disease
Hsu, C. L., & Schnabl, B. (2023) · Nature Reviews Microbiology · doi:10.1038/s41579-023-00904-3 · Cited by 737 · see citing works
Lipopolysaccharide Causes an Increase in Intestinal Tight Junction Permeability in Vitro and in Vivo by Inducing Enterocyte Membrane Expression and Localization of TLR-4 and CD14
Guo, S., Al–Sadi, R., Said, H. M., & Ma, T. Y. (2012) · American Journal Of Pathology · doi:10.1016/j.ajpath.2012.10.014 · Cited by 722 · see citing works
Hyaluronic acid–bilirubin nanomedicine for targeted modulation of dysregulated intestinal barrier, microbiome and immune responses in colitis
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Interactions of commensal and pathogenic microorganisms with the intestinal mucosal barrier
Martens, E. C., Neumann, M., & Desai, M. S. (2018) · Nature Reviews Microbiology · doi:10.1038/s41579-018-0036-x · Cited by 711 · see citing works
Programmable probiotics modulate inflammation and gut microbiota for inflammatory bowel disease treatment after effective oral delivery
Zhou, J., Li, M., Chen, Q., Li, X., Chen, L., Dong, Z., Zhu, W., Yang, Y., Liu, Z., & Chen, Q. (2022) · Nature Communications · doi:10.1038/s41467-022-31171-0 · Cited by 717 · see citing works
Paracellular permeability and tight junction regulation in gut health and disease
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The role of gut microbiota (commensal bacteria) and the mucosal barrier in the pathogenesis of inflammatory and autoimmune diseases and cancer: contribution of germ-free and gnotobiotic animal models of human diseases
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Authors: Turner, J. R.
Affiliations: University of Chicago (US)
Corresponding author: Turner, Jerrold R.
ORCID: Turner, Jerrold R.
Venue: Nature reviews. Immunology
Publisher: Springer Science and Business Media LLC
Published: 2009-11
Volume: 9
Issue: 11
Pages: 799-809
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri2653
OpenAlex: W2145189896
Cited by: 3,952
References: 120
Citations by year: 2026: 404 · 2025: 298 · 2024: 341 · 2023: 313 · 2022: 356 · 2021: 302 · 2020: 303 · 2019: 262 · 2018: 210 · 2017: 212 · 2016: 183 · 2015: 178 · 2014: 161 · 2013: 126 · 2012: 139
FWCI: 15.07
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: National Heart, Lung, and Blood Institute (R01HL091889, HL091889)
National Cancer Institute (CA 14599, P30CA014599)
National Institute of Diabetes and Digestive and Kidney Diseases (DK068271, DK061931, P01DK067887, DK042086, DK-67887, P30DK042086, R01DK068271, R01DK061931)
Topics: Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
Keywords: intestinal barrier, intestinal epithelium, mucosal immunity, nutrient absorption, selective permeability, dietary antigens, microbial products, barrier dysfunction, intestinal diseases
MeSH terms: Animals, Cell Membrane Permeability, Cytoskeleton, Epithelial Cells, Homeostasis, Humans, Intestinal Diseases, Intestinal Mucosa, Membrane Proteins, Cytokines, Immunity, Mucosal, Tight Junctions, Gastrointestinal Tract

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Intestinal mucosal barrier function in health and disease

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