CoChat
Sign Up
Cited by 257

Next-Generation Stool DNA Test Accurately Detects Colorectal Cancer and Large Adenomas

Ahlquist, David A., Zou, Hongzhi, Domanico, Michael, Mahoney, Douglas W., Yab, Tracy C., Taylor, William R., Butz, Malinda L., Thibodeau, Stephen N. +9 more·2012·Gastroenterology
DOI 10.1053/j.gastro.2011.10.031PMC PMC4017869
Open this paper in CoChat — free account

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1053/j.gastro.2011.10.031

Cites

3 of 3 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Combining FIT with assay of exfoliated molecular markers in stool expands sensitivity of stool testing for colorectal neoplasia.

    “Combining a FIT application with assay of exfoliated molecular markers in stool has proven to be a rational and effective approach to further expand the sensitivity of stool testing for detection of colorectal neoplasia [8–11].”

    From Novel Approach to Fecal Occult Blood Testing by Assay of Erythrocyte-Specific microRNA Markers (2017) · cites this paper as [8]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 48

  1. [2]Center MM Jemal A Ward E International trends in colorectal cancer incidence rates Cancer Epidemiol Biomarkers Prev 2009 18 1688 1694 19505900
  2. [3]Morikawa T Kato J Yamaji Y A comparison of the immunochemical fecal occult blood test and total colonoscopy in the asymptomatic population Gastroenterology 2005 129 422 428 16083699
  3. [4]Ahlquist DA Sargent DJ Loprinzi CL Stool DNA and occult blood testing for screen detection of colorectal neoplasia Ann Intern Med 2008 149 441 450 W81 18838724 PMC4016975
  4. [5]Imperiale TF Ransohoff DF Itzkowitz SH Fecal DNA versus fecal occult blood for colorectal-cancer screening in an average-risk population N Engl J Med 2004 351 2704 2714 15616205
  5. [6]Atkin WS Edwards R Kralj-Hans I Once-only flexible sigmoidoscopy screening in prevention of colorectal cancer: a multicentre randomised controlled trial Lancet 2010 375 1624 1633 20430429
  6. [7]Selby JV Friedman GD Quesenberry CP Jr A case-control study of screening sigmoidoscopy and mortality from colorectal cancer N Engl J Med 1992 326 653 657 1736103
  7. [8]Baxter NN Goldwasser MA Paszat LF Association of colonoscopy and death from colorectal cancer Ann Intern Med 2009 150 1 8 19075198
  8. [9]Brenner H Hoffmeister M Arndt V Protection from right- and left-sided colorectal neoplasms after colonoscopy: population-based study J Natl Cancer Inst 2009 102 89 95 20042716
  9. [10]Brenner H Chang-Claude J Seiler CM Protection from colorectal cancer after colonoscopy: a population-based, case-control study Ann Intern Med 2011 154 22 30 21200035
  10. [11]Ahlquist DA Wieand HS Moertel CG Accuracy of fecal occult blood screening for colorectal neoplasia. A prospective study using Hemoccult and HemoQuant tests JAMA 1993 269 1262 1267 8437303
  11. [12]Heresbach D Manfredi S D’Halluin PN Review in depth and meta-analysis of controlled trials on colorectal cancer screening by faecal occult blood test Eur J Gastroenterol Hepatol 2006 18 427 433 16538116
  12. [13]Ahlquist DA Molecular detection of colorectal neoplasia Gastroenterology 2010 138 2127 2139 20420950
  13. [14]Sidransky D Tokino T Hamilton SR Identification of ras oncogene mutations in the stool of patients with curable colorectal tumors Science 1992 256 102 105 1566048
  14. [15]Ahlquist DA Skoletsky JE Boynton KA Colorectal cancer screening by detection of altered human DNA in stool: feasibility of a multitarget assay panel Gastroenterology 2000 119 1219 1227 11054379
  15. [16]Ahlquist DA Next-generation stool DNA testing: expanding the scope Gastroenterology 2009 136 2068 2073 19379748
  16. [17]Olson J Whitney DH Durkee K DNA stabilization is critical for maximizing performance of fecal DNA-based colorectal cancer tests Diagn Mol Pathol 2005 14 183 191 16106201
  17. [18]Zou H Harrington JJ Klatt KK A sensitive method to quantify human long DNA in stool: relevance to colorectal cancer screening Cancer Epidemiol Biomarkers Prev 2006 15 1115 1119 16775168
  18. [19]Zou H Cao X Dominico M Sensitive quantification of methylated markers with a novel methylation specific technology Clin Chem 2010 56 A199 22194633
  19. [21]Zou H Taylor WR Harrington JJ High detection rates of colorectal neoplasia by stool DNA testing with a novel digital melt curve assay Gastroenterology 2009 136 459 470 19026650
  20. [22]Diehl F Schmidt K Durkee KH Analysis of mutations in DNA isolated from plasma and stool of colorectal cancer patients Gastroenterology 2008 135 489 498 18602395 PMC2820386
  21. [26]Stone BB Cohen SP Breton GL Detection of rRNA from four respiratory pathogens using an automated Q beta replicase assay Mol Cell Probes 1996 10 359 370 8910891
  22. [27]Ahlquist DA McGill DB Schwartz S HemoQuant, a new quantitative assay for fecal hemoglobin. Comparison with Hemoccult Ann Intern Med 1984 101 297 302 6465700
  23. [28]Ahlquist DA McGill DB Schwartz S Fecal blood levels in health and disease. A study using HemoQuant N Engl J Med 1985 312 1422 1428 3873009
  24. [29]McIntosh MW Pepe MS Combining several screening tests: optimality of the risk score Biometrics 2002 58 657 664 12230001
  25. [31]Lin LI A concordance correlation coefficient to evaluate reproducibility Biometrics 1989 45 255 268 2720055
  26. [32]Huang Z Li L Wang J Hypermethylation of SFRP2 as a potential marker for stool-based detection of colorectal cancer and precancerous lesions Dig Dis Sci 2007 52 2287 2291 17410438
  27. [33]Itzkowitz SH Jandorf L Brand R Improved fecal DNA test for colorectal cancer screening Clin Gastroenterol Hepatol 2007 5 111 117 17161655
  28. [35]Nagasaka T Tanaka N Cullings HM Analysis of fecal DNA methylation to detect gastrointestinal neoplasia J Natl Cancer Inst 2009 101 1244 1258 19700653 PMC2762745
  29. [36]Baek YH Chang E Kim YJ Stool methylation-specific polymerase chain reaction assay for the detection of colorectal neoplasia in Korean patients Dis Colon Rectum 2009 52 1452 1459 discussion 1459–1463 19617759
  30. [37]Ehrlich M DNA methylation in cancer: too much, but also too little Oncogene 2002 21 5400 5413 12154403
  31. [38]Grutzmann R Molnar B Pilarsky C Sensitive detection of colorectal cancer in peripheral blood by septin 9 DNA methylation assay PLoS One 2008 3 e3759 19018278 PMC2582436
  32. [39]Tanzer M Balluff B Distler J Performance of epigenetic markers SEPT9 and ALX4 in plasma for detection of colorectal precancerous lesions PLoS One 2010 5 e9061 20140221 PMC2816214
  33. [41]Muto T Bussey HJ Morson BC The evolution of cancer of the colon and rectum Cancer 1975 36 2251 2270 1203876
  34. [42]Pickhardt PJ The natural history of colorectal polyps and masses: rediscovered truths from the barium enema era Am J Roentgenol 2007 188 619 621 17312044
  35. [43]Welin S Youker J Spratt JS Jr The rates and patterns of growth of 375 tumors of the large intestine and rectum observed serially by double contrast enema study (Malmoe technique) Am J Roentgenol Radium Ther Nucl Med 1963 90 673 687 14068399
  36. [44]Stryker SJ Wolff BG Culp CE Natural history of untreated colonic polyps Gastroenterology 1987 93 1009 1013 3653628
  37. [45]Hofstad B Vatn M Larsen S Growth of colorectal polyps: recovery and evaluation of unresected polyps of less than 10 mm, 1 year after detection Scand J Gastroenterol 1994 29 640 645 7939401
  38. [46]Knoernschild HE Growth rate and malignant potential of colonic polyps: early results Surg Forum 1963 14 137 138 14064485
  39. [47]Loeve F Boer R Zauber AG National Polyp Study data: evidence for regression of adenomas Int J Cancer 2004 111 633 639 15239144
  40. [48]Hisabe T Tsuda S Matsui T Natural history of small colorectal protuberant adenomas Dig Endosc 2010 22 Suppl 1 S43 S46 20590771
  41. [49]Noffsinger AE Serrated polyps and colorectal cancer: new pathway to malignancy Annu Rev Pathol 2009 4 343 364 19400693
  42. [51]Gupta AK Melton LJ 3rd Petersen GM Changing trends in the incidence, stage, survival, and screen-detection of colorectal cancer: a population-based study Clin Gastroenterol Hepatol 2005 3 150 158 15704049
  43. [52]Cucino C Buchner AM Sonnenberg A Continued rightward shift of colorectal cancer Dis Colon Rectum 2002 45 1035 1040 12195187
  44. [53]Fenoglio L Castagna E Comino A A shift from distal to proximal neoplasia in the colon: a decade of polyps and CRC in Italy BMC Gastroenterol 2010 10 139 21108823 PMC3001711
  45. [54]Kahi CJ Hewett DG Norton DL Prevalence and variable detection of proximal colon serrated polyps during screening colonoscopy Clin Gastroenterol Hepatol 2011 9 42 46 20888435
  46. [55]Schoen RE Gerber LD Margulies C The pathologic measurement of polyp size is preferable to the endoscopic estimate Gastroin-test Endosc 1997 46 492 496 9434214
  47. [56]Ahlquist DAYG Yamada T Approach to the patient with occult gastrointestinal bleeding Principles of clinical gastroenterology Chichester; Hoboken Wiley-Blackwell 2008 152 169
  48. [57]Harewood GC McConnell JP Harrington JJ Detection of occult upper gastrointestinal tract bleeding: performance differences in fecal occult blood tests Mayo Clin Proc 2002 77 23 28 11794453

Cited by

Sorted by citations

Authors
Ahlquist, D. A., Zou, H., Domanico, M., Mahoney, D. W., Yab, T. C., Taylor, W. R., Butz, M. L., Thibodeau, S. N., Rabeneck, L., Paszat, L. F., Kinzler, K. W., Vogelstein, B., Bjerregaard, N. C., Laurberg, S., Sørensen, H. T., Berger, B. M., & Lidgard, G. P.
Venue
Gastroenterology
Publisher
Elsevier BV
Published
2012-02
Volume
142
Issue
2
Pages
248-256
ISSN
0016-5085
DOI
10.1053/j.gastro.2011.10.031
PMC
PMC4017869
Cited by
257
References
3
Language
en
Licence
Funders
National Institutes of Health (CA 62924)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review