Cited by 1,069Liver Disease Diagnosis and TreatmentLipid metabolism and biosynthesisLipid metabolism and disorders

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Increased De Novo Lipogenesis Is a Distinct Characteristic of Individuals With Nonalcoholic Fatty Liver Disease

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Lambert, Jennifer E., Ramos–Roman, Maria A., Browning, Jeffrey D., Parks, Elizabeth J.·2014·Gastroenterology

DOI 10.1053/j.gastro.2013.11.049PMC PMC6276362

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Abstract

Background & aims There have been few studies of the role of de novo lipogenesis in the development of nonalcoholic fatty liver disease (NAFLD). We used isotope analyses to compare de novo lipogenesis and fatty acid flux between subjects with NAFLD and those without, matched for metabolic factors (controls).Methods We studied subjects with metabolic syndrome and/or levels of alanine aminotransferase and aspartate aminotransferase >30 mU/L, using magnetic resonance spectroscopy to identify those with high levels (HighLF, n = 13) or low levels (LowLF, n = 11) of liver fat. Clinical and demographic information was collected from all participants, and insulin sensitivity was measured using the insulin-modified intravenous glucose tolerance test. Stable isotopes were administered and gas chromatography with mass spectrometry was used to analyze free (nonesterified) fatty acid (FFA) and triacylglycerol flux and lipogenesis.Results Subjects with HighLF (18.4% ± 3.6%) had higher plasma levels of FFAs during the nighttime and higher concentrations of insulin than subjects with LowLF (3.1% ± 2.7%; P = .04 and P < .001, respectively). No differences were observed between groups in adipose flux of FFAs (414 ± 195 μmol/min for HighLF vs 358 ± 105 μmol/min for LowLF; P = .41) or production of very-low-density lipoprotein triacylglycerol from FFAs (4.06 ± 2.57 μmol/min vs 4.34 ± 1.82 μmol/min; P = .77). In contrast, subjects with HighLF had more than 3-fold higher rates of de novo fatty acid synthesis than subjects with LowLF (2.57 ± 1.53 μmol/min vs 0.78 ± 0.42 μmol/min; P = .001). As a percentage of triacylglycerol palmitate, de novo lipogenesis was 2-fold higher in subjects with HighLF (23.2% ± 7.9% vs 10.1% ± 6.7%; P < .001); this level was independently associated with the level of intrahepatic triacylglycerol (r = 0.53; P = .007).Conclusions By administering isotopes to subjects with NAFLD and control subjects, we confirmed that those with NAFLD have increased synthesis of fatty acids. Subjects with NAFLD also had higher nocturnal plasma levels of FFAs and did not suppress the contribution from de novo lipogenesis on fasting. These findings indicate that lipogenesis might be a therapeutic target for NAFLD.

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“Of note, DNL rates are twice as high in patients with MASLD compared to the reference rates [46].”
Association of insulin resistance-related indicators with cardiovascular disease and cardiovascular disease mortality in individuals with MASLD: a population-based study
Yang, X., & Peng, W. J. (2026) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/20420188261435033 · Cited by 6
“62,63 Concurrently, IR enhances the generation of advanced glycation products and free radicals, leading to reduced endothelial nitric oxide production and increased reactive oxygen species, which collectively impair vascular relaxation and contraction, producing peripheral endothelial dysfunction.”
Gkongensin A, an HSP90β inhibitor, improves hyperlipidemia, hepatic steatosis, and insulin resistance
Miao, K., Zhao, Y., & Xue, N. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e29367 · Cited by 7
“These findings align with the evidence that DNL also rises in individuals with NAFLD and type 2 diabetes [33].”
Result
Activation of hepatic acetyl-CoA carboxylase by S-nitrosylation in response to diet
Venetos, N. M., Stomberski, C. T., Qian, Z., Premont, R. T., & Stamler, J. S. (2024) · Journal of Lipid Research · doi:10.1016/j.jlr.2024.100542 · Cited by 6
“Our observation that stimulatory ACC S-nitrosylation is reduced by over-nutrition may serve to reconcile these opposing Aberrantly elevated lipogenesis is a hallmark of he-patic steatosis (29) and inhibitors of ACC ameliorate steatosis (30).”
Background
FABP1 induces lipogenesis by regulating the processing of SREBP1 in hepatocytes of large yellow croaker ( Larimichthys crocea )
Chen, F., Hao, T., Chen, Q., Sun, Y., Shen, Y., Zhao, Z., Du, J., Li, Y., Mai, K., & Ai, Q. (2024) · The FASEB Journal · doi:10.1096/fj.202401087rr · Cited by 6
Sex Hormone: A Potential Target at Treating Female Metabolic Dysfunction-Associated Steatotic Liver Disease?
Duan, H., Gong, M., Yuan, G., & Wang, Z. (2024) · Journal of Clinical and Experimental Hepatology · doi:10.1016/j.jceh.2024.102459 · Cited by 7
Aurantio‐Obtusin Regulates Gut Microbiota and Serum Metabolism to Alleviate High‐Fat Diet‐Induced Obesity‐Associated Non‐Alcoholic Fatty Liver Disease in Mice
Li, Z., Jin, Y., Zhao, H.-S., Gu, Y., Zhang, Y., Cheng, S., Zhang, L., He, P., Liu, X., & Jia, Y. (2025) · Phytotherapy Research · doi:10.1002/ptr.8459 · Cited by 7
“Hyperglycemia and hyperlipidemia stimulate hepatic DNL, converting carbohydrates into fatty acids (Smith et al. 2020), with hepatic DNL being significantly higher in patients with than without NAFLD (Lambert, Ramos-Roman, Browning, & Parks, Lambert et al. 2014).”
Aging Liver: Can Exercise be a Better Way to Delay the Process than Nutritional and Pharmacological Intervention? Focus on Lipid Metabolism
Su, H., Liu, D., Shao, J., Li, Y., Wang, X., & Gao, Q. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666200605111232 · Cited by 6
Molecular Advances in MAFLD—A Link between Sphingolipids and Extracellular Matrix in Development and Progression to Fibrosis
Kołakowski, A., Dziemitko, S., Chmielecka, A., Żywno, H., Bzdęga, W., Charytoniuk, T., Chabowski, A., & Konstantynowicz-Nowicka, K. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911380 · Cited by 6
“Moreover, the presence of insulin resistance also affects glucose metabolism in tissues other than the liver such as skeletal muscles which result in glucose uptake by this tissue causing hyperglycemia which as a vicious circle enhances insulin resistance [15,16].”
Background
Fibroblast Growth Factor 21: A More Effective Biomarker Than Free Fatty Acids and Other Insulin Sensitivity Measures for Predicting Non-alcoholic Fatty Liver Disease in Saudi Arabian Type 2 Diabetes Patients
Bahijri, S., Eldakhakhny, B. M., Enani, S. M., Ajabnoor, G., Al-Mowallad, A. S., Alsheikh, L., Alhozali, A. M., Alamoudi, A. A., Borai, A., & Tuomilehto, J. O. (2023) · Cureus · doi:10.7759/cureus.50524 · Cited by 6
“…triglycerides in the liver in people with NAFLD has been reported to be associated with various causes, including increased de novo lipogenesis [21,22], increased lipolysis in the adipocytes, increased delivery of free fatty acids (FFAs) to the liver [21,23], and decreased lipid clearance…”
Background
Observational and genetic association of non-alcoholic fatty liver disease and calcific aortic valve disease
Hao, Q.-Y., Zeng, Y.-H., Lin, Y., Guo, J., Li, S., Yang, P., Gao, J., & Li, Z. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1421642 · Cited by 7
“In addition to considering the horizontal pleiotropy, we also excluded these IVs based on the biological reasons (42, 43).”
BackgroundMethod
Does Nutrition Matter in Liver Disease?
Ramos‐Tovar, E., & Muriel, P. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804274-8.00053-9 · Cited by 6
Regulation of lipid droplet (LD) formation in hepatocytes via regulation of SREBP1c by non-coding RNAs
Sobky, S. A. E., Aboud, N. K., assaly, N. M. E., Fawzy, I. O., El-Ekiaby, N. M., & Abdelaziz, A. I. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.903856 · Cited by 6
“Accordingly, this treatment fulfills the following criteria: (1) it simulates fasting levels of free FAs in patients with NASH, (2) it is not toxic to the cells and (3) it induces LD formation.”
Background
Hígado graso (parte 1): aspectos generales, epidemiología, fisiopatología e historia natural
Ortíz, J. E. P., Luque, C. B. S., & Quiróz, R. J. O. (2022) · Revista Colombiana de Gastroenterología · doi:10.22516/25007440.952 · Cited by 9
Pathogenesis of nonalcoholic fatty liver disease (NAFLD)
Yki‐Järvinen, H. (2015) · doi:10.1002/9781118387658.ch19 · Cited by 6
Hepatic de novo lipogenesis is suppressed and fat oxidation is increased by omega-3 fatty acids at the expense of glucose metabolism
Green, C., Pramfalk, C., Charlton, C. A., Gunn, P. J., Cornfield, T., Pavalides, M., Karpe, F., & Hodson, L. (2019) · Endocrine Abstracts · doi:10.1530/endoabs.65.oc1.2 · Cited by 6
Rap1 Activation Protects Against Fatty Liver and Non-Alcoholic Steatohepatitis DevelopmentPreprint
Agarwal, H., Wang, Y., & Özcan, L. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.10.24.563728 · Cited by 10
Changes in alanine aminotransferase in adults with severe and complicated obesity during a milk-based meal replacement programme
Abdalgwad, R., Rafey, M. F., Murphy, C., Ioana, I., O’Shea, P. M., Slattery, E., Davenport, C., O’Keeffe, D. T., & Finucane, F. M. (2020) · Nutrition & Metabolism · doi:10.1186/s12986-020-00512-5 · Cited by 6
Sensitive Profiling of Mouse Liver Membrane Proteome Dysregulation Following a High‐Fat and Alcohol Diet Treatment
Antony, F., Brough, Z., Orangi, M., Al‐Seragi, M., Aoki, H., Babu, M., & Duong, F. (2024) · PROTEOMICS · doi:10.1002/pmic.202300599 · Cited by 8
Novel Choline-Deficient and 0.1%-Methionine-Added High-Fat Diet Induces Burned-Out Metabolic-Dysfunction-Associated Steatohepatitis with Inflammation by Rapid Immune Cell Infiltration on Male Mice
Sakaguchi, T., Nagahama, Y., Hamada, N., Singh, S. K., Mikami, H., Maeda, K., & Akira, S. (2024) · Nutrients · doi:10.3390/nu16234151 · Cited by 5
Growth Hormone Promotes Hepatic Triglyceride Export in Humans
Baumgartner, C., Metz, M., Beghini, M., Pfleger, L., Tosin, A., Koldyka, O., Beiglböck, H., Fellinger, P., Vila, G., Luger, A., et al. (2025) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaf155 · Cited by 6
Induction of Fructose Mediated De Novo Lipogenesis Coexists with the Upregulation of Mitochondrial Oxidative Function in Mice Livers
Bhattacharjee, P., Fadlaoui, A., Ryan, C. E., Carlson, C. B., Zhang, D., & Sunny, N. E. (2025) · Journal of Nutrition · doi:10.1016/j.tjnut.2025.04.030 · Cited by 5
“Metabolic dysfunction-associated steatotic liver disease (MASLD) [1] is characterized by high rates of lipid accumulation and dysfunctional mitochondrial oxidative function [2 – 7] and is a highly prevalent comorbidity of obesity [8,9] and type-2 diabetes mellitus [10 – 12].”
Influential
Zhuru extracts ameliorate lipid accumulation of MASLD via suppressing the mTORC1/SREBPs pathway
Sun, Z., Wei, Y., Ma, S., Xu, Y., Zhang, Y., Li, C., Zhang, J., Duan, F., Jiao, J., & Duan, X. (2025) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2025.120246 · Cited by 5
Adipose tissue-derived PRXL2A suppresses hepatic lipogenesis in a study with male mice
Li, Z., Tian, Z., Shi, X., Long, A., Wang, Y., Yang, Y., Wang, Y., Zhang, J., & Wang, Y. (2025) · Nature Communications · doi:10.1038/s41467-025-61963-z · Cited by 6
Histone Deacetylase 9 Deletion Inhibits Hepatic Steatosis and Adipose Tissue Inflammation in Male Diet‐Induced Obese Mice
Hu, S., Kang, H., Bae, M., Kim, M., Jang, H., Corvino, O., Pham, T. X., Lee, Y., Smyth, J. A., Park, Y., et al. (2024) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.16856 · Cited by 6
“Among patients with metabolic syndrome, patients with high hepatic TG levels have higher DNL rates than those with low he-patic TG levels [25].”
Nonalcoholic Fatty Liver Disease and the Gut Microbiota: Exploring the Connection
Oldfield, E. C., & Dong, R. (2014) · Journal of Gastrointestinal & Digestive System · doi:10.4172/2161-069x.1000245 · Cited by 5
A Prediction Model of the Incidence of Nonalcoholic Fatty Liver Disease With Visceral Fatty Obesity: A General Population-Based Study
Zhou, Y., Chai, X., Guo, T., Pu, Y., Zeng, M., Zhong, A., Yang, G., & Cai, J. (2022) · Frontiers in Public Health · doi:10.3389/fpubh.2022.895045 · Cited by 5
“Recent accumulating evidence has indicated that body weight gain in overweight individuals increased the hyperlipidemia that induces NAFLD (33, 34).”
Background
gp130 Activates Mitochondrial Dynamics for Hepatocyte Survival in a Model of Steatohepatitis
Shunkina, D., Dakhnevich, A. Y., Shunkin, E. O., Хазиахматова, О. Г., Shupletsova, V. V., Vulf, M. A., Komar, A., Кириенкова, Е. В., & Litvinova, L. S. (2023) · Biomedicines · doi:10.3390/biomedicines11020396 · Cited by 5
“It is known that NAFLD is a multicomponent disease, including disorders of lipid, carbohydrate, and energy metabolism.”
BackgroundInfluential
Fumigaclavine C ameliorates liver steatosis by attenuating hepatic de novo lipogenesis via modulation of the RhoA/ROCK signaling pathway
Yu, W., Gao, Y., Zhao, Z., Long, X., Yi, Y., & Ai, S. (2023) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-023-04110-9 · Cited by 5
“Substantial evidences have revealed that the level of hepatic TG depended on de novo lipogenesis , β-oxidation, FFA uptake, and very low density lipoprotein (VLDL) export [36, 37].”
BackgroundResult
Emerging Drug Therapies for Metabolic Dysfunction-Associated Steatotic Liver Disease: A Glimpse into the Horizon
Arnold, J., Idalsoaga, F. J., Díaz, L. A., Cabrera, D., Francisco Barrera, M., Arab, J. P., & Arrese, M. A. (2024) · Current Hepatology Reports · doi:10.1007/s11901-023-00629-0 · Cited by 5
“As mentioned above, de novo lipogenesis is upregulated by 30% in patients with MILD compared to healthy controls [106].”
Postnatal Consumption of Black Bean Powder Protects against Obesity and Dyslipidemia in Male Adult Rat Offspring from Obese Pregnancies
Choudhary, D., Andreani, G. A., Mahmood, S., Wen, X., Patel, M. S., & Rideout, T. C. (2024) · Nutrients · doi:10.3390/nu16071029 · Cited by 5
“Although these results suggest a potential role of BBP in improving the long-term metabolic health of offspring from obese mothers, our study findings are limited in that we did not examine potential long-term impacts on female offspring or maternal postpartum health.”
Background
Type 1 diabetes mellitus and non-alcoholic fatty liver disease: a two-sample Mendelian randomization study
Tuo, L., Yan, L., Liu, Y., & Yang, X. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1315046 · Cited by 5
“First, the random-effects inverse variance weighted method was used to relax the exclusion restriction assumption by allowing all SNPs to exhibit random pleiotropic effect while maintaining asymptotic unbiasedness even if all SNPs show horizontal pleiotropy (16).”
Knockdown of RASD1 improves MASLD progression by inhibiting the PI3K/AKT/mTOR pathway
Zeng, G., Liu, X., Zheng, Z., Zhao, J., Zhuo, W., Bai, Z., Lin, E., Cai, S., Cai, C., Li, P., et al. (2024) · Lipids in Health and Disease · doi:10.1186/s12944-024-02419-z · Cited by 5
An insight on the additive impact of type 2 diabetes mellitus and nonalcoholic fatty liver disease on cardiovascular consequences
Bhardwaj, M., & Mazumder, P. M. (2025) · Molecular Biology Reports · doi:10.1007/s11033-025-10249-0 · Cited by 5
“Glucose also triggered the de novo lipogenesis through the carbohydrate response element-binding protein and insulin determined the sterol regulatory element binding protein 1c (SREBP 1c) (ChREBP) [56–58].”
Hepatic effects of low-dose rate radiation in natural mouse populations (Apodemus uralensisandApodemus agrarius): comparative interspecific analysis
Orekhova, N. A. (2020) · International Journal of Radiation Biology · doi:10.1080/09553002.2020.1770362 · Cited by 6
“In addition to the dietary, genetic, and endocrine factors, long-term stress including chronic radiation exposure can lead to the fatty dystrophy of hepatocytes (Shishkina et al. 1992; Donnelly et al. 2005; Lambert et al. 2014; Bhagavan and Chung-Eun 2015; BragaTanaka et al. 2018).”
Background
Determining the temporal, dose, and composition effects of nutritional substrates in an in vitro model of intrahepatocellular triglyceride accumulation
Nagarajan, S. R., Cross, E., Johnson, E. M., Sanna, F., Daniels, L. J., Ray, D. W., & Hodson, L. (2022) · Physiological Reports · doi:10.14814/phy2.15463 · Cited by 4
Molecular Basis for Pathogenesis of Steatohepatitis: Contemporary Understanding and New Insights
Parkash, O., & Saeed, S. (2018) · InTech eBooks · doi:10.5772/intechopen.71405 · Cited by 5
Alterations in hepatic fatty acids reveal depletion of total polyunsaturated fatty acids following irinotecan plus 5-fluorouracil treatment in an animal model of colorectal cancer
Monirujjaman, M., Pant, A., Nelson, R. C., Bathe, O. F., Jacobs, R. L., & Mazurak, V. C. (2021) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2021.102359 · Cited by 5
Sugar, Sugar . . . Not So Sweet for the Liver
Vos, M. B., & Goran, M. I. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.07.029 · Cited by 5
Protein lactylation in metabolic dysfunction-associated steatotic liver disease: a mechanistic review
Chen, H., Ye, Y., He, T., Li, B., & Wang, Q. (2026) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-026-02105-3 · Cited by 5
“Consequently, molecular targets associated with DNL regulation hold potential as therapeutic strategies for MASLD [48–50].”
MASLD and the cardiovascular-kidney-liver-metabolic syndrome
Angelidi, A. M., Boutari, C., Kokkorakis, M., Stefanakis, K., Mikhailidis, D. P., Jacob, G., & Mantzoros, C. S. (2026) · Endocrine Reviews · doi:10.1210/endrev/bnag023 · Cited by 6
Molecular Insights of Nonalcoholic Fatty Liver Disease Pathogenesis
Dawood, R. M., Salum, G. M., El-Meguid, M. A., & Fotouh, B. E.-S. (2024) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2023.0162 · Cited by 4
“Also, NEAT1 and miR-140 were considerably overexpressed in liver tissues from NAFLD mice and in HepG2 cells treated with FFAs.”
Influential
Elevation of hepatic de novo lipogenesis in mice with overnutrition is dependent on multiple substrates
Strober, J. W., Siebel, S., Murray, S. F., Rodríguez, M. G., Gonzalez, C. R.-N., & Vatner, D. F. (2025) · Journal of Lipid Research · doi:10.1016/j.jlr.2025.100838 · Cited by 4
“This is consistent with data previously described in both mouse models and in humans, where insulin-resistant subjects have increased levels of DNL when compared to insulin-sensitive subjects (4, 6, 11, 29).”
Influential
Diet-induced obesity disrupts sexually dimorphic gene expression in mice
Ribas, V., Morón‐Ros, S., Marí, H., Gracia-Batllori, A., Brugnara, L., Herrero-Gómez, A., Eyre, E., Claret, M., Marco‐Rius, I., Novials, A., et al. (2025) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00098.2025 · Cited by 4
Sortilin-Driven Cancer Secretome Enhances Tumorigenic Properties of Hepatocellular Carcinoma via de Novo Lipogenesis
Chan, K. K., Au, K. K., Suen, L.-H., Leung, B., Wong, C., Leow, W. Q., Lim, T. K. H., Ng, I. O., Chung, C. Y., & Lo, R. C. (2023) · American Journal Of Pathology · doi:10.1016/j.ajpath.2023.08.005 · Cited by 4
Associations between dietary fatty acid and plasma fatty acid composition in non-alcoholic fatty liver disease: secondary analysis from a randomised trial with a hypoenergetic low-carbohydrate high-fat and intermittent fasting diet
Tillander, V., Holmer, M., Hagström, H., Petersson, S., Brismar, T. B., Stal, P. I., & Lindqvist, C. (2024) · British Journal Of Nutrition · doi:10.1017/s0007114524001673 · Cited by 5
“However, one-third of the accumulating lipids during steatosis originate directly from the diet or hepatic DNL, where the latter is known to increase in patients with obesity and NAFLD (8) .”
BackgroundResult

Authors: Lambert, J. E., Ramos–Roman, M. A., Browning, J. D., & Parks, E. J.
Affiliations: The University of Texas Southwestern Medical Center (US)
Corresponding author: Parks, Elizabeth J.
ORCID: Parks, Elizabeth J.
Venue: Gastroenterology
Publisher: Elsevier BV
Published: 2014-03
Volume: 146
Issue: 3
Pages: 726-735
ISSN: 0016-5085 (ISSN-L)
DOI: 10.1053/j.gastro.2013.11.049
PMC: PMC6276362
OpenAlex: W2139351004
Cited by: 1,069
References: 58
Citations by year: 2026: 67 · 2025: 111 · 2024: 110 · 2023: 108 · 2022: 124 · 2021: 111 · 2020: 106 · 2019: 92 · 2018: 75 · 2017: 47 · 2016: 49 · 2015: 45 · 2014: 23
FWCI: 28.42
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Gastroenterology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (RL1DK081187, UL1DE019584, UL1-RR024982)
National Center for Advancing Translational Sciences (RL1DK081187, UL1DE019584, UL1-RR024982)
Topics: Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Keywords: de novo lipogenesis, non-alcoholic fatty liver disease, fatty acid synthesis, triglyceride synthesis, liver fat, metabolic syndrome, insulin sensitivity, stable isotope tracer studies, hepatic lipid metabolism, insulin
MeSH terms: Fatty Acids, Nonesterified, Fatty Liver, Female, Humans, Hyperlipidemias, Liver, Magnetic Resonance Imaging, Male, Comorbidity, Case-Control Studies, Metabolic Syndrome, Lipogenesis, Non-alcoholic Fatty Liver Disease

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Increased De Novo Lipogenesis Is a Distinct Characteristic of Individuals With Nonalcoholic Fatty Liver Disease

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