Cited by 1,107Diabetes, Cardiovascular Risks, and LipoproteinsLipid metabolism and disordersLipid metabolism and biosynthesis

Disordered lipid metabolism and the pathogenesis of insulin resistance.

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Savage, David B., Petersen, Kitt Falk, Shulman, Gerald I.·2007·Physiological Reviews

Abstract

Although abnormal glucose metabolism defines type 2 diabetes mellitus (T2DM) and accounts for many of its symptoms and complications, efforts to understand the pathogenesis of T2DM are increasingly focused on disordered lipid metabolism. Here we review recent human studies exploring the mechanistic links between disorders of fatty acid/lipid metabolism and insulin resistance. As “mouse models of insulin resistance” were comprehensively reviewed in Physiological Reviews by Nandi et al. in 2004, we will concentrate on human studies involving the use of isotopes and/or magnetic resonance spectroscopy, occasionally drawing on mouse models which provide additional mechanistic insight.

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Crossref · 10.1152/physrev.00024.2006

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143 of 143 references verified0 citation errors · 0 not checkable

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  • Lipid excess has been linked experimentally to induction of insulin resistance and alterations in insulin signal transduction.

    “Moreover, lipid excess has been linked experimentally to induction of insulin resistance (96) and alterations in insulin signal transduction (97-99).”
  • Increased tissue lipid load, as with obesity and/or sustained inactivity, may lead to accumulation of fatty acyl CoA, diacylglycerols, ceramides, products of incomplete oxidation, and ROS, all of which have been linked experimentally to reduced insulin signaling and action.

    “Increased tissue lipid load, as with obesity, and/or sustained inactivity, may lead to the accumulation of fatty acyl coenzyme A (CoA), diacylglycerols, ceramides, products of incomplete oxidation, and ROS, all of which have been linked experimentally to reduced insulin signaling and action (96 -102).”

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Authors
Savage, D. B., Petersen, K. F., & Shulman, G. I.
Affiliations
Howard Hughes Medical Institute (US)
Venue
Physiological Reviews
Published
2007-04
Volume
87
Issue
2
Pages
507-520
ISSN
  • 0031-9333 (ISSN-L)
  • 1522-1210
OpenAlex
W2140434971
Cited by
1,107
References
143
Citations by year
2026: 20 · 2025: 48 · 2024: 53 · 2023: 50 · 2022: 40 · 2021: 39 · 2020: 60 · 2019: 43 · 2018: 48 · 2017: 63 · 2016: 37 · 2015: 58 · 2014: 63 · 2013: 92 · 2012: 83
FWCI
11.24
Type
journal article
Language
en
Open access
Locations
  • Physiological Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Wellcome Trust
  • National Institute on Aging (R01-AG-23686, R01AG023686)
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01DK049230, R01-DK40936, U24DK59635, R01DK040936, U24DK059635, R01 DK-49230, P01-DK-68829)
  • National Center for Research Resources (M01RR000125, M01 RR-00125)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Keywords
insulin resistance, type 2 diabetes, lipid metabolism, fatty acid metabolism, glucose metabolism, pathogenesis, isotope tracers, magnetic resonance spectroscopy, human subjects research
MeSH terms
Adipose Tissue, Animals, Fatty Acids, Glucose, Humans, Insulin Resistance, Liver, Muscles, Magnetic Resonance Spectroscopy, Obesity, Lipid Metabolism Disorders

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