The DOI matches its Crossref record; 259 of the 259 references it cites were found in a registry or an index.
Cell Death and Cell Death Responses in Liver Disease: Mechanisms and Clinical Relevance
Open accessAbstract
Summary Hepatocellular death is present in almost all types of human liver disease and is used as a sensitive parameter for the detection of acute and chronic liver disease of viral, toxic, metabolic, or autoimmune origin. Clinical data and animal models suggest that hepatocyte death is the key trigger of liver disease progression, manifested by the subsequent development of inflammation, fibrosis, cirrhosis, and hepatocellular carcinoma. Modes of hepatocellular death differ substantially between liver diseases. Different modes of cell death such as apoptosis, necrosis, and necroptosis trigger specific cell death responses and promote progression of liver disease through distinct mechanisms. In this review, we first discuss molecular mechanisms by which different modes of cell death, damage-associated molecular patterns, and specific cell death responses contribute to the development of liver disease. We then review the clinical relevance of cell death, focusing on biomarkers; the contribution of cell death to drug-induced, viral, and fatty liver disease and liver cancer; and evidence for cell death pathways as therapeutic targets.
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1 retracted
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Cited by
Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins
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Hepatic stellate cells as key target in liver fibrosis
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Liver Fibrosis: Mechanistic Concepts and Therapeutic Perspectives
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Liver fibrosis: Pathophysiology, pathogenetic targets and clinical issues
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Self-citation
Metadata
- Authors
- Luedde, T., Kaplowitz, N., & Schwabe, R. F.
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2014-10
- Volume
- 147
- Issue
- 4
- Pages
- 765-783.e4
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W2142225943
- Cited by
- 759
- References
- 259
- FWCI
- 18.86
- Type
- journal article
- Language
- en
- Open access
- green
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- Luedde, T., Kaplowitz, N., & Schwabe, R. F. (2014). Cell Death and Cell Death Responses in Liver Disease: Mechanisms and Clinical Relevance. Gastroenterology. https://doi.org/10.1053/j.gastro.2014.07.018
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
