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Cited by 454

The DOI matches its Crossref record; 81 of the 81 references it cites were found in a registry or an index.

Helicobacter pylori Update: Gastric Cancer, Reliable Therapy, and Possible Benefits

Open access
Graham, David Y.·2015·Gastroenterology

Abstract

Helicobacter pylori infection contributes to development of diverse gastric and extra-gastric diseases. The infection is necessary but not sufficient for development of gastric adenocarcinoma. Its eradication would eliminate a major worldwide cause of cancer death, so there is much interest in identifying how, if, and when this can be accomplished. There are several mechanisms by which H pylori contributes to development of gastric cancer. Gastric adenocarcinoma is one of many cancers associated with inflammation, which is induced by H pylori infection, yet the bacteria also cause genetic and epigenetic changes that lead to genetic instability in gastric epithelial cells. H pylori eradication reduces both. However, many factors must be considered in determining whether treating this bacterial infection will prevent cancer or only reduce its risk—these must be considered in designing reliable and effective eradication therapies. Furthermore, H pylori infection has been proposed to provide some benefits, such as reducing the risks of obesity or childhood asthma, although there are no convincing data to support the benefits of H pylori infections.

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Metadata

Authors
Graham, D. Y.
Venue
Gastroenterology
Publisher
Elsevier BV
Published
2015-04
Volume
148
Issue
4
Pages
719-731.e3
ISSN
0016-5085 (ISSN-L)
OpenAlex
W2117044556
Cited by
454
References
81
FWCI
53.02
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Helicobacter pylori Update: Gastric Cancer, Reliable Therapy, and Possible Benefits. https://app.cochat.ai/papers/10.1053/j.gastro.2015.01.040
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Graham, D. Y. (2015). Helicobacter pylori Update: Gastric Cancer, Reliable Therapy, and Possible Benefits. Gastroenterology. https://doi.org/10.1053/j.gastro.2015.01.040

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.