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Cited by 2,353Inflammasome and immune disordersFerroptosis and cancer prognosisCell death mechanisms and regulation

Pyroptosis: Mechanisms and Diseases

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Yu, Pian, Zhang, Xu, Liu, Nian, Tang, Ling, Peng, Cong, Chen, Xiang·2021·Signal Transduction and Targeted Therapy
DOI 10.1038/s41392-021-00507-5PMC PMC8005494
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Abstract

Currently, pyroptosis has received more and more attention because of its association with innate immunity and disease. The research scope of pyroptosis has expanded with the discovery of the gasdermin family. A great deal of evidence shows that pyroptosis can affect the development of tumors. The relationship between pyroptosis and tumors is diverse in different tissues and genetic backgrounds. In this review, we provide basic knowledge of pyroptosis, explain the relationship between pyroptosis and tumors, and focus on the significance of pyroptosis in tumor treatment. In addition, we further summarize the possibility of pyroptosis as a potential tumor treatment strategy and describe the side effects of radiotherapy and chemotherapy caused by pyroptosis. In brief, pyroptosis is a double-edged sword for tumors. The rational use of this dual effect will help us further explore the formation and development of tumors, and provide ideas for patients to develop new drugs based on pyroptosis.

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  • Pyroptosis is an inflammatory form of RCD mediated by activation of the inflammasome and caspase-1, resulting in gasdermin-mediated membrane pore formation and cytokine release.

    “In contrast, pyroptosis is an inflammatory form of RCD mediated by activation of the inflammasome and caspase-1, resulting in membrane pore formation mediated by gasdermin and cytokine release [37,38].”

    From Role of Regulated Cell Death Pathways in Snakebite Envenomation: Mechanisms, Crosstalk, and Therapeutic Opportunities (2026) · cites this paper as [37]

    The Canonical pathway section describes inflammasome activation of caspase-1, followed by gasdermin D pore formation and IL-1β/IL-18 release. But the Introduction and Fig. 2 also describe pyroptosis pathways involving other caspases that do not require caspase-1. The citing sentence presents the canonical mechanism as though it applies to all pyroptosis. (LLM, conf=0.88)

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  1. [1]Friedlander AM Macrophages are sensitive to anthrax lethal toxin through an acid-dependent process J. Biol. Chem. 1986 261 7123 7126 10.1016/S0021-9258(17)38364-3 3711080 · DOI
  2. [2]Black RA Kronheim SR Merriam JE March CJ Hopp TP A pre-aspartate-specific protease from human leukocytes that cleaves pro-interleukin-1 beta J. Biol. Chem. 1989 264 5323 5326 10.1016/S0021-9258(18)83546-3 2784432 · DOI
  3. [3]Thornberry NA A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes Nature 1992 356 768 774 10.1038/356768a0 1574116 · DOI
  4. [4]Cerretti DP Molecular cloning of the interleukin-1 beta converting enzyme Science 1992 256 97 100 10.1126/science.1373520 1373520 · DOI
  5. [5]Zychlinsky A Prevost MC Sansonetti PJ Shigella flexneri induces apoptosis in infected macrophages Nature 1992 358 167 169 10.1038/358167a0 1614548 · DOI
  6. [6]Chen Y Smith MR Thirumalai K Zychlinsky A A bacterial invasin induces macrophage apoptosis by binding directly to ICE EMBO J. 1996 15 3853 3860 10.1002/j.1460-2075.1996.tb00759.x 8670890 PMC452076 · DOI
  7. [7]D’Souza CA Heitman J Dismantling the Cryptococcus coat Trends Microbiol 2001 9 112 113 10.1016/S0966-842X(00)01945-4 11303499 · DOI
  8. [8]Martinon F Burns K Tschopp J The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-β Mol. Cell 2002 10 417 426 10.1016/S1097-2765(02)00599-3 12191486 · DOI · Paper page
  9. [10]Cookson BT Brennan MA Pro-inflammatory programmed cell death Trends Microbiol. 2001 9 113 114 10.1016/S0966-842X(00)01936-3 11303500 · DOI
  10. [11]Bergsbaken T Fink SL Cookson BT Pyroptosis: host cell death and inflammation Nat. Rev. Microbiol. 2009 7 99 109 10.1038/nrmicro2070 19148178 PMC2910423 · DOI
  11. [12]Kovacs SB Miao EA Gasdermins: effectors of pyroptosis Trends Cell Biol. 2017 27 673 684 10.1016/j.tcb.2017.05.005 28619472 PMC5565696 · DOI
  12. [13]Taabazuing CY Okondo MC Bachovchin DA Pyroptosis and apoptosis pathways engage in bidirectional crosstalk in monocytes and macrophages Cell Chem. Biol. 2017 24 507 514.e4 10.1016/j.chembiol.2017.03.009 28392147 PMC5467448 · DOI
  13. [14]Ruhl S ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation Science 2018 362 956 960 10.1126/science.aar7607 30467171 · DOI
  14. [15]Humphries, F. et al. Succination inactivates gasdermin D and blocks pyroptosis. Science, 369, 1633–1637 (2020). PMC8744141 32820063
  15. [16]Wang Y Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin Nature 2017 547 99 103 10.1038/nature22393 28459430 · DOI · Paper page
  16. [18]Newton K Activity of caspase-8 determines plasticity between cell death pathways Nature 2019 575 679 682 10.1038/s41586-019-1752-8 31723262 · DOI
  17. [19]Zhang Z Gasdermin E suppresses tumour growth by activating anti-tumour immunity Nature 2020 579 415 420 10.1038/s41586-020-2071-9 32188940 PMC7123794 · DOI
  18. [20]Zhou Z Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells Science 2020 368 eaaz7548 10.1126/science.aaz7548 32299851 · DOI · Paper page
  19. [21]Hou J PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis Nat. Cell Biol. 2020 22 1264 1275 10.1038/s41556-020-0575-z 32929201 PMC7653546 · DOI
  20. [22]Cerella C Teiten MH Radogna F Dicato M Diederich M From nature to bedside: pro-survival and cell death mechanisms as therapeutic targets in cancer treatment Biotechnol. Adv. 2014 32 1111 1122 10.1016/j.biotechadv.2014.03.006 24681093 · DOI
  21. [23]Shi J Gao W Shao F Pyroptosis: gasdermin-mediated programmed necrotic cell death Trends Biochem Sci. 2017 42 245 254 10.1016/j.tibs.2016.10.004 27932073 · DOI · Paper page
  22. [24]Fernandes-Alnemri T The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation Cell Death Differ. 2007 14 1590 1604 10.1038/sj.cdd.4402194 17599095 PMC3345951 · DOI · Paper page
  23. [26]Shen HH NLRP3: a promising therapeutic target for autoimmune diseases Autoimmun. Rev. 2018 17 694 702 10.1016/j.autrev.2018.01.020 29729449 · DOI
  24. [27]Jia C Role of pyroptosis in cardiovascular diseases Int. Immunopharmacol. 2019 67 311 318 10.1016/j.intimp.2018.12.028 30572256 · DOI
  25. [28]Pezuk JA Pyroptosis in combinatorial treatment to improve cancer patients’ outcome, is that what we want? EBioMedicine 2019 41 17 18 10.1016/j.ebiom.2019.03.007 30879924 PMC6443691 · DOI
  26. [29]Shi J Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death Nature 2015 526 660 665 10.1038/nature15514 26375003 · DOI · Paper page
  27. [30]Ding J Pore-forming activity and structural autoinhibition of the gasdermin family Nature 2016 535 111 116 10.1038/nature18590 27281216 · DOI · Paper page
  28. [31]He WT Gasdermin D is an executor of pyroptosis and required for interleukin-1beta secretion Cell Res. 2015 25 1285 1298 10.1038/cr.2015.139 26611636 PMC4670995 · DOI · Paper page
  29. [32]Yu J Inflammasome activation leads to Caspase-1-dependent mitochondrial damage and block of mitophagy Proc. Natl Acad. Sci. USA 2014 111 15514 15519 10.1073/pnas.1414859111 25313054 PMC4217429 · DOI
  30. [33]Bergsbaken T Fink SL den Hartigh AB Loomis WP Cookson BT Coordinated host responses during pyroptosis: caspase-1-dependent lysosome exocytosis and inflammatory cytokine maturation J. Immunol. 2011 187 2748 2754 10.4049/jimmunol.1100477 21804020 PMC3660150 · DOI
  31. [34]Wu C BioGPS: an extensible and customizable portal for querying and organizing gene annotation resources Genome Biol. 2009 10 R130 10.1186/gb-2009-10-11-r130 19919682 PMC3091323 · DOI
  32. [35]Rogers C Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation Nat. Commun. 2019 10 1689 10.1038/s41467-019-09397-2 30976076 PMC6459836 · DOI
  33. [36]Brennan MA Cookson BT Salmonella induces macrophage death by caspase-1-dependent necrosis Mol. Microbiol. 2000 38 31 40 10.1046/j.1365-2958.2000.02103.x 11029688 · DOI
  34. [37]Kuang S Structure insight of GSDMD reveals the basis of GSDMD autoinhibition in cell pyroptosis Proc. Natl Acad. Sci. USA 2017 114 10642 10647 10.1073/pnas.1708194114 28928145 PMC5635896 · DOI
  35. [38]Liu Z Crystal structures of the full-length murine and human gasdermin D reveal mechanisms of autoinhibition, lipid binding, and oligomerization Immunity 2019 51 43 49.e4 10.1016/j.immuni.2019.04.017 31097341 PMC6640092 · DOI
  36. [39]Kayagaki N Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling Nature 2015 526 666 671 10.1038/nature15541 26375259 · DOI · Paper page
  37. [40]Liu X Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores Nature 2016 535 153 158 10.1038/nature18629 27383986 PMC5539988 · DOI · Paper page
  38. [41]Aglietti RA Dueber EC Recent insights into the molecular mechanisms underlying pyroptosis and gasdermin family functions Trends Immunol. 2017 38 261 271 10.1016/j.it.2017.01.003 28196749 · DOI
  39. [42]Sollberger G Gasdermin D plays a vital role in the generation of neutrophil extracellular traps Sci. Immunol. 2018 3 eaar6689 10.1126/sciimmunol.aar6689 30143555 · DOI
  40. [43]Kambara H Gasdermin D exerts anti-inflammatory effects by promoting neutrophil death Cell Rep. 2018 22 2924 2936 10.1016/j.celrep.2018.02.067 29539421 PMC5878047 · DOI
  41. [44]Burgener SS Cathepsin G inhibition by Serpinb1 and Serpinb6 prevents programmed necrosis in neutrophils and monocytes and reduces GSDMD-driven inflammation Cell Rep. 2019 27 3646 3656.e5 10.1016/j.celrep.2019.05.065 31216481 PMC7350907 · DOI
  42. [45]Xi G GSDMD is required for effector CD8(+) T cell responses to lung cancer cells Int. Immunopharmacol. 2019 74 105713 10.1016/j.intimp.2019.105713 31276977 · DOI
  43. [46]Saeki N GASDERMIN, suppressed frequently in gastric cancer, is a target of LMO1 in TGF-beta-dependent apoptotic signalling Oncogene 2007 26 6488 6498 10.1038/sj.onc.1210475 17471240 · DOI
  44. [47]Runkel F The dominant alopecia phenotypes Bareskin, Rex-denuded, and Reduced Coat 2 are caused by mutations in gasdermin 3 Genomics 2004 84 824 835 10.1016/j.ygeno.2004.07.003 15475261 · DOI
  45. [48]Tanaka S A new Gsdma3 mutation affecting anagen phase of first hair cycle Biochem. Biophys. Res. Commun. 2007 359 902 907 10.1016/j.bbrc.2007.05.209 17572385 · DOI
  46. [49]Zhou Y Gsdma3 mutation causes bulge stem cell depletion and alopecia mediated by skin inflammation Am. J. Pathol. 2012 180 763 774 10.1016/j.ajpath.2011.10.034 22155111 · DOI
  47. [50]Shi P Loss of conserved Gsdma3 self-regulation causes autophagy and cell death Biochem J. 2015 468 325 336 10.1042/BJ20150204 25825937 · DOI
  48. [51]Das S GSDMB induces an asthma phenotype characterized by increased airway responsiveness and remodeling without lung inflammation Proc. Natl Acad. Sci. USA 2016 113 13132 13137 10.1073/pnas.1610433113 27799535 PMC5135378 · DOI
  49. [52]Hergueta-Redondo M Gasdermin B expression predicts poor clinical outcome in HER2-positive breast cancer Oncotarget 2016 7 56295 56308 10.18632/oncotarget.10787 27462779 PMC5302915 · DOI
  50. [53]Hergueta-Redondo M Gasdermin-B promotes invasion and metastasis in breast cancer cells PLoS ONE 2014 9 e90099 10.1371/journal.pone.0090099 24675552 PMC3967990 · DOI
  51. [54]Miguchi M Gasdermin C is upregulated by inactivation of transforming growth factor beta receptor type II in the presence of mutated Apc, promoting colorectal cancer proliferation PLoS ONE 2016 11 e0166422 10.1371/journal.pone.0166422 27835699 PMC5105946 · DOI
  52. [55]Kusumaningrum N Lee DH Yoon HS Park CH Chung JH Ultraviolet light-induced gasdermin C expression is mediated via TRPV1/calcium/calcineurin/NFATc1 signaling Int. J. Mol. Med 2018 42 2859 2866 30226565
  53. [56]Kusumaningrum N Gasdermin C is induced by ultraviolet light and contributes to MMP-1 expression via activation of ERK and JNK pathways J. Dermatol Sci. 2018 90 180 189 10.1016/j.jdermsci.2018.01.015 29428815 · DOI
  54. [57]Van Laer L Nonsyndromic hearing impairment is associated with a mutation in DFNA5 Nat. Genet 1998 20 194 197 10.1038/2503 9771715 · DOI
  55. [58]Booth KT Exonic mutations and exon skipping: lessons learned from DFNA5 Hum. Mutat. 2018 39 433 440 10.1002/humu.23384 29266521 PMC5805621 · DOI
  56. [59]Kim MS Aberrant promoter methylation and tumor suppressive activity of the DFNA5 gene in colorectal carcinoma Oncogene 2008 27 3624 3634 10.1038/sj.onc.1211021 18223688 · DOI
  57. [60]Croes L Large-scale analysis of DFNA5 methylation reveals its potential as biomarker for breast cancer Clin. Epigenetics 2018 10 51 10.1186/s13148-018-0479-y 29682089 PMC5896072 · DOI
  58. [61]Delmaghani S Mutations in the gene encoding pejvakin, a newly identified protein of the afferent auditory pathway, cause DFNB59 auditory neuropathy Nat. Genet. 2006 38 770 778 10.1038/ng1829 16804542 · DOI
  59. [62]Schwander M A forward genetics screen in mice identifies recessive deafness traits and reveals that pejvakin is essential for outer hair cell function J. Neurosci. 2007 27 2163 2175 10.1523/JNEUROSCI.4975-06.2007 17329413 PMC6673480 · DOI
  60. [63]Defourny J Pejvakin-mediated pexophagy protects auditory hair cells against noise-induced damage Proc. Natl Acad. Sci. USA 2019 116 8010 8017 10.1073/pnas.1821844116 30936319 PMC6475433 · DOI
  61. [64]Kurokawa M Kornbluth S Caspases and kinases in a death grip Cell 2009 138 838 854 10.1016/j.cell.2009.08.021 19737514 PMC3390419 · DOI
  62. [65]Kerr JF Wyllie AH Currie AR Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics Br. J. Cancer 1972 26 239 257 10.1038/bjc.1972.33 4561027 PMC2008650 · DOI
  63. [66]Chen X Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis Cell Res. 2016 26 1007 1020 10.1038/cr.2016.100 27573174 PMC5034106 · DOI · Paper page
  64. [67]Rudel T Bokoch GM Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2 Science 1997 276 1571 1574 10.1126/science.276.5318.1571 9171063 · DOI
  65. [69]Coleman ML Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I Nat. Cell Biol. 2001 3 339 345 10.1038/35070009 11283606 · DOI
  66. [70]Sebbagh M Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbing Nat. Cell Biol. 2001 3 346 352 10.1038/35070019 11283607 · DOI · Paper page
  67. [71]Zheng TS Caspase-3 controls both cytoplasmic and nuclear events associated with Fas-mediated apoptosis in vivo Proc. Natl Acad. Sci. USA 1998 95 13618 13623 10.1073/pnas.95.23.13618 9811849 PMC24868 · DOI
  68. [72]Fackler OT Grosse R Cell motility through plasma membrane blebbing J. Cell Biol. 2008 181 879 884 10.1083/jcb.200802081 18541702 PMC2426937 · DOI
  69. [73]Torgerson RR McNiven MA The actin-myosin cytoskeleton mediates reversible agonist-induced membrane blebbing J. Cell Sci. 1998 111 2911 2922 9730983
  70. [74]Janicke RU Ng P Sprengart ML Porter AG Caspase-3 is required for alpha-fodrin cleavage but dispensable for cleavage of other death substrates in apoptosis J. Biol. Chem. 1998 273 15540 15545 10.1074/jbc.273.25.15540 9624143 · DOI
  71. [75]Balasubramanian K Mirnikjoo B Schroit AJ Regulated externalization of phosphatidylserine at the cell surface: implications for apoptosis J. Biol. Chem. 2007 282 18357 18364 10.1074/jbc.M700202200 17470427 · DOI
  72. [76]Tomiyoshi G Horita Y Nishita M Ohashi K Mizuno K Caspase-mediated cleavage and activation of LIM-kinase 1 and its role in apoptotic membrane blebbing Genes Cells 2004 9 591 600 10.1111/j.1356-9597.2004.00745.x 15189451 · DOI
  73. [77]Tang R Ferroptosis, necroptosis, and pyroptosis in anticancer immunity J. Hematol. Oncol. 2020 13 110 10.1186/s13045-020-00946-7 32778143 PMC7418434 · DOI
  74. [78]Fink SL Cookson BT Pillars Article: Caspase-1-dependent pore formation during pyroptosis leads to osmotic lysis of infected host macrophages. Cell Microbiol. 2006. 8: 1812-1825 J. Immunol. 2019 202 1913 1926 30885987
  75. [79]Fink SL Cookson BT Caspase-1-dependent pore formation during pyroptosis leads to osmotic lysis of infected host macrophages Cell Microbiol 2006 8 1812 1825 10.1111/j.1462-5822.2006.00751.x 16824040 · DOI
  76. [80]Zhang Y Chen X Gueydan C Han J Plasma membrane changes during programmed cell deaths Cell Res. 2018 28 9 21 10.1038/cr.2017.133 29076500 PMC5752838 · DOI
  77. [81]Chen S Cheng AC Wang MS Peng X Detection of apoptosis induced by new type gosling viral enteritis virus in vitro through fluorescein annexin V-FITC/PI double labeling World J. Gastroenterol. 2008 14 2174 2178 10.3748/wjg.14.2174 18407590 PMC2703841 · DOI
  78. [82]Zhang, W. & Liang, Z. [Comparison between annexin V-FITC/PI and Hoechst33342/PI double stainings in the detection of apoptosis by flow cytometry]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi30, 1209–1212 (2014). 25374090
  79. [83]Chen Y Noncovalent proteasome inhibitor PI1840 induces apoptosis and autophagy in osteosarcoma cells Oncol. Rep. 2019 41 2803 2817 30864717 PMC6448088
  80. [84]Ray M Hostetter DR Loeb CR Simko J Craik CS Inhibition of Granzyme B by PI-9 protects prostate cancer cells from apoptosis Prostate 2012 72 846 855 10.1002/pros.21486 21919028 PMC3401211 · DOI
  81. [85]Siegel RM Caspases at the crossroads of immune-cell life and death Nat. Rev. Immunol. 2006 6 308 317 10.1038/nri1809 16557262 · DOI
  82. [86]Tajima T β-hydroxybutyrate attenuates renal ischemia-reperfusion injury through its anti-pyroptotic effects Kidney Int. 2019 95 1120 1137 10.1016/j.kint.2018.11.034 30826015 · DOI
  83. [87]Li MY Adrenomedullin alleviates the pyroptosis of Leydig cells by promoting autophagy via the ROS-AMPK-mTOR axis Cell Death Dis. 2019 10 489 10.1038/s41419-019-1728-5 31222000 PMC6586845 · DOI
  84. [88]Jia C Endothelial cell pyroptosis plays an important role in Kawasaki disease via HMGB1/RAGE/cathespin B signaling pathway and NLRP3 inflammasome activation Cell Death Dis. 2019 10 778 10.1038/s41419-019-2021-3 31611559 PMC6791856 · DOI
  85. [89]Ezquerro S Ghrelin reduces TNF-α-induced human hepatocyte apoptosis, autophagy, and pyroptosis: role in obesity-associated NAFLD J. Clin. Endocrinol. Metab. 2019 104 21 37 30137403
  86. [90]Liang J Wang Q Li JQ Guo T Yu D Long non-coding RNA MEG3 promotes cerebral ischemia-reperfusion injury through increasing pyroptosis by targeting miR-485/AIM2 axis Exp. Neurol. 2020 325 113139 10.1016/j.expneurol.2019.113139 31794744 · DOI
  87. [91]Zhao N Sun C Zheng M Liu S Shi R Amentoflavone suppresses amyloid β1-42 neurotoxicity in Alzheimer’s disease through the inhibition of pyroptosis Life Sci. 2019 239 117043 10.1016/j.lfs.2019.117043 31722188 · DOI
  88. [92]Li Z DHA attenuates hepatic ischemia reperfusion injury by inhibiting pyroptosis and activating PI3K/Akt pathway Eur. J. Pharm. 2018 835 1 10 10.1016/j.ejphar.2018.07.054 30075219 · DOI
  89. [93]Zhao MW Yang P Zhao LL Chlorpyrifos activates cell pyroptosis and increases susceptibility on oxidative stress-induced toxicity by miR-181/SIRT1/PGC-1α/Nrf2 signaling pathway in human neuroblastoma SH-SY5Y cells: Implication for association between chlorpyrifos and Parkinson’s disease Environ. Toxicol. 2019 34 699 707 10.1002/tox.22736 30835941 · DOI
  90. [94]Jorgensen I Miao EA Pyroptotic cell death defends against intracellular pathogens Immunol. Rev. 2015 265 130 142 10.1111/imr.12287 25879289 PMC4400865 · DOI · Paper page
  91. [95]Bergsbaken T Cookson BT Macrophage activation redirects yersinia-infected host cell death from apoptosis to caspase-1-dependent pyroptosis PLoS Pathog. 2007 3 e161 10.1371/journal.ppat.0030161 17983266 PMC2048529 · DOI
  92. [96]Mariathasan S Weiss DS Dixit VM Monack DM Innate immunity against Francisella tularensis is dependent on the ASC/caspase-1 axis J. Exp. Med. 2005 202 1043 1049 10.1084/jem.20050977 16230474 PMC2213215 · DOI
  93. [97]Xu YJ Zheng L Hu YW Wang Q Pyroptosis and its relationship to atherosclerosis Clin. Chim. Acta 2018 476 28 37 10.1016/j.cca.2017.11.005 29129476 · DOI
  94. [98]Jaeschke H Duan L Akakpo JY Farhood A Ramachandran A The role of apoptosis in acetaminophen hepatotoxicity Food Chem. Toxicol. 2018 118 709 718 10.1016/j.fct.2018.06.025 29920288 PMC6087673 · DOI
  95. [99]Walker PR Leblanc J Smith B Pandey S Sikorska M Detection of DNA fragmentation and endonucleases in apoptosis Methods 1999 17 329 338 10.1006/meth.1999.0747 10196104 · DOI
  96. [100]Kijima M Mizuta R Histone H1 quantity determines the efficiencies of apoptotic DNA fragmentation and chromatin condensation Biomed. Res. 2019 40 51 56 10.2220/biomedres.40.51 30787263 · DOI
  97. [101]Broz P Dixit VM Inflammasomes: mechanism of assembly, regulation and signalling Nat. Rev. Immunol. 2016 16 407 420 10.1038/nri.2016.58 27291964 · DOI · Paper page
  98. [103]Orning P Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death Science 2018 362 1064 1069 10.1126/science.aau2818 30361383 PMC6522129 · DOI
  99. [104]Sarhan J Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection Proc. Natl Acad. Sci. USA 2018 115 E10888 E10897 10.1073/pnas.1809548115 30381458 PMC6243247 · DOI
  100. [105]Chen KW Extrinsic and intrinsic apoptosis activate pannexin-1 to drive NLRP3 inflammasome assembly EMBO J. 2019 38 e101638 30902848 PMC6517827
  101. [108]Angosto D Evolution of inflammasome functions in vertebrates: Inflammasome and caspase-1 trigger fish macrophage cell death but are dispensable for the processing of IL-1beta Innate Immun. 2012 18 815 824 10.1177/1753425912441956 22456941 · DOI
  102. [109]Fang Y Pyroptosis: a new frontier in cancer Biomed. Pharmacother. 2020 121 109595 10.1016/j.biopha.2019.109595 31710896 · DOI
  103. [110]Komada T Muruve DA The role of inflammasomes in kidney disease Nat. Rev. Nephrol. 2019 15 501 520 10.1038/s41581-019-0158-z 31164720 · DOI
  104. [111]Emran AA Do innate killing mechanisms activated by inflammasomes have a role in treating melanoma? Pigment Cell Melanoma Res. 2020 33 660 670 10.1111/pcmr.12870 32027447 PMC7497247 · DOI
  105. [112]Zhou B Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis Cell Res 2018 28 1171 1185 10.1038/s41422-018-0090-y 30287942 PMC6274649 · DOI
  106. [113]Boise LH Collins CM Salmonella-induced cell death: apoptosis, necrosis or programmed cell death? Trends Microbiol 2001 9 64 67 10.1016/S0966-842X(00)01937-5 11173244 · DOI
  107. [114]Kolb R Liu GH Janowski AM Sutterwala FS Zhang W Inflammasomes in cancer: a double-edged sword Protein Cell 2014 5 12 20 10.1007/s13238-013-0001-4 24474192 PMC3938856 · DOI
  108. [117]Li J Yuan J Caspases in apoptosis and beyond Oncogene 2008 27 6194 6206 10.1038/onc.2008.297 18931687 · DOI · Paper page
  109. [118]Ha HC Snyder SH Poly (ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion Proc. Natl Acad. Sci. USA 1999 96 13978 13982 10.1073/pnas.96.24.13978 10570184 PMC24176 · DOI
  110. [119]Xia X The role of pyroptosis in cancer: pro-cancer or pro-“host”? Cell Death Dis. 2019 10 650 10.1038/s41419-019-1883-8 31501419 PMC6733901 · DOI
  111. [120]Frank D Vince JE Pyroptosis versus necroptosis: similarities, differences, and crosstalk Cell Death Differ. 2019 26 99 114 10.1038/s41418-018-0212-6 30341423 PMC6294779 · DOI · Paper page
  112. [122]Man SM Karki R Kanneganti TD AIM2 inflammasome in infection, cancer, and autoimmunity: Role in DNA sensing, inflammation, and innate immunity Eur. J. Immunol. 2016 46 269 280 10.1002/eji.201545839 26626159 PMC4758349 · DOI · Paper page
  113. [123]He Y Amer AO Microbial modulation of host apoptosis and pyroptosis Front. Cell Infect. Microbiol 2014 4 83 10.3389/fcimb.2014.00083 24995165 PMC4062964 · DOI
  114. [124]Nunes T de Souza HS Inflammasome in intestinal inflammation and cancer Mediators Inflamm. 2013 2013 654963 10.1155/2013/654963 23606794 PMC3625567 · DOI
  115. [125]Cervantes J Nagata T Uchijima M Shibata K Koide Y Intracytosolic Listeria monocytogenes induces cell death through caspase-1 activation in murine macrophages Cell Microbiol. 2008 10 41 52 17662073
  116. [126]Kelk P Johansson A Claesson R Hanstrom L Kalfas S Caspase 1 involvement in human monocyte lysis induced by Actinobacillus actinomycetemcomitans leukotoxin Infect. Immun. 2003 71 4448 4455 10.1128/IAI.71.8.4448-4455.2003 12874324 PMC166001 · DOI
  117. [127]Jesenberger V Procyk KJ Yuan J Reipert S Baccarini M Salmonella-induced caspase-2 activation in macrophages: a novel mechanism in pathogen-mediated apoptosis J. Exp. Med. 2000 192 1035 1046 10.1084/jem.192.7.1035 11015444 PMC2193309 · DOI
  118. [128]Li P Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock Cell 1995 80 401 411 10.1016/0092-8674(95)90490-5 7859282 · DOI
  119. [129]He Y Hara H Nunez G Mechanism and regulation of NLRP3 inflammasome activation Trends Biochem. Sci. 2016 41 1012 1021 10.1016/j.tibs.2016.09.002 27669650 PMC5123939 · DOI · Paper page
  120. [130]Thi H Hong S Inflammasome as a therapeutic target for cancer prevention and treatment J. Cancer Prev. 2017 22 62 73 10.15430/JCP.2017.22.2.62 28698859 PMC5503217 · DOI
  121. [132]McAllister SS Weinberg RA Tumor-host interactions: a far-reaching relationship J. Clin. Oncol. 2010 28 4022 4028 10.1200/JCO.2010.28.4257 20644094 · DOI
  122. [133]Munn DH Bronte V Immune suppressive mechanisms in the tumor microenvironment Curr. Opin. Immunol. 2016 39 1 6 10.1016/j.coi.2015.10.009 26609943 PMC5627973 · DOI
  123. [134]Massague J Obenauf AC Metastatic colonization by circulating tumour cells Nature 2016 529 298 306 10.1038/nature17038 26791720 PMC5029466 · DOI · Paper page
  124. [135]Klement GL Eco-evolution of cancer resistance Sci. Transl. Med. 2016 8 327fs5 10.1126/scitranslmed.aaf3802 26912901 · DOI
  125. [136]Finn OJ Beatty PL Cancer immunoprevention Curr. Opin. Immunol. 2016 39 52 58 10.1016/j.coi.2016.01.002 26799207 PMC4805487 · DOI
  126. [137]Solinas G Marchesi F Garlanda C Mantovani A Allavena P Inflammation-mediated promotion of invasion and metastasis Cancer Metastasis Rev. 2010 29 243 248 10.1007/s10555-010-9227-2 20414701 · DOI
  127. [141]Martinon F Burns K Tschopp J The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta Mol. Cell 2002 10 417 426 10.1016/S1097-2765(02)00599-3 12191486 · DOI · Paper page
  128. [142]Rathinam VA Fitzgerald KA Inflammasome complexes: emerging mechanisms and effector functions Cell 2016 165 792 800 10.1016/j.cell.2016.03.046 27153493 PMC5503689 · DOI
  129. [143]Lamkanfi M Dixit VM Mechanisms and functions of inflammasomes Cell 2014 157 1013 1022 10.1016/j.cell.2014.04.007 24855941 · DOI
  130. [144]Place DE Kanneganti TD Recent advances in inflammasome biology Curr. Opin. Immunol. 2018 50 32 38 10.1016/j.coi.2017.10.011 29128729 PMC5857399 · DOI
  131. [146]Miao EA Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria Nat. Immunol. 2010 11 1136 1142 10.1038/ni.1960 21057511 PMC3058225 · DOI · Paper page
  132. [147]Minkiewicz J de Rivero VJ Keane RW Human astrocytes express a novel NLRP2 inflammasome Glia 2013 61 1113 1121 10.1002/glia.22499 23625868 · DOI
  133. [150]Hara H The NLRP6 inflammasome recognizes lipoteichoic acid and regulates Gram-positive pathogen infection Cell 2018 175 1651 1664.e14 10.1016/j.cell.2018.09.047 30392956 PMC6294477 · DOI
  134. [153]Zitvogel L Kepp O Galluzzi L Kroemer G Inflammasomes in carcinogenesis and anticancer immune responses Nat. Immunol. 2012 13 343 351 10.1038/ni.2224 22430787 · DOI · Paper page
  135. [154]Kawai T Akira S Toll-like receptors and their crosstalk with other innate receptors in infection and immunity Immunity 2011 34 637 650 10.1016/j.immuni.2011.05.006 21616434 · DOI · Paper page
  136. [155]Barton GM Medzhitov R Toll-like receptor signaling pathways Science 2003 300 1524 1525 10.1126/science.1085536 12791976 · DOI
  137. [156]Lamkanfi M Emerging inflammasome effector mechanisms Nat. Rev. Immunol. 2011 11 213 220 10.1038/nri2936 21350580 · DOI
  138. [158]Chavarria-Smith J Mitchell PS Ho AM Daugherty MD Vance RE Functional and evolutionary analyses identify proteolysis as a general Mechanism for NLRP1 inflammasome activation PLoS Pathog. 2016 12 e1006052 10.1371/journal.ppat.1006052 27926929 PMC5142783 · DOI
  139. [159]Boyden ED Dietrich WF Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin Nat. Genet. 2006 38 240 244 10.1038/ng1724 16429160 · DOI
  140. [160]Chavarria-Smith J Vance RE Direct proteolytic cleavage of NLRP1B is necessary and sufficient for inflammasome activation by anthrax lethal factor PLoS Pathog. 2013 9 e1003452 10.1371/journal.ppat.1003452 23818853 PMC3688554 · DOI
  141. [161]Levinsohn JL Anthrax lethal factor cleavage of Nlrp1 is required for activation of the inflammasome PLoS Pathog. 2012 8 e1002638 10.1371/journal.ppat.1002638 22479187 PMC3315489 · DOI
  142. [162]Okondo MC DPP8 and DPP9 inhibition induces pro-caspase-1-dependent monocyte and macrophage pyroptosis Nat. Chem. Biol. 2017 13 46 53 10.1038/nchembio.2229 27820798 PMC5477230 · DOI
  143. [163]Ewald SE Chavarria-Smith J Boothroyd JC NLRP1 is an inflammasome sensor for Toxoplasma gondii Infect. Immun. 2014 82 460 468 10.1128/IAI.01170-13 24218483 PMC3911858 · DOI
  144. [164]Swanson KV Deng M Ting JP The NLRP3 inflammasome: molecular activation and regulation to therapeutics Nat. Rev. Immunol. 2019 19 477 489 10.1038/s41577-019-0165-0 31036962 PMC7807242 · DOI · Paper page
  145. [165]Kofoed EM Vance RE Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity Nature 2011 477 592 595 10.1038/nature10394 21874021 PMC3184209 · DOI
  146. [166]Zhao Y The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus Nature 2011 477 596 600 10.1038/nature10510 21918512 · DOI
  147. [167]Franchi L Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages Nat. Immunol. 2006 7 576 582 10.1038/ni1346 16648852 · DOI · Paper page
  148. [168]Ren T Zamboni DS Roy CR Dietrich WF Vance RE Flagellin-deficient Legionella mutants evade caspase-1- and Naip5-mediated macrophage immunity PLoS Pathog. 2006 2 e18 10.1371/journal.ppat.0020018 16552444 PMC1401497 · DOI
  149. [169]Lightfield KL Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin Nat. Immunol. 2008 9 1171 1178 10.1038/ni.1646 18724372 PMC2614210 · DOI
  150. [170]Duncan JA Canna SW The NLRC4 Inflammasome Immunol. Rev. 2018 281 115 123 10.1111/imr.12607 29247997 PMC5897049 · DOI
  151. [171]Roberts TL HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA Science 2009 323 1057 1060 10.1126/science.1169841 19131592 · DOI
  152. [172]Jin T Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor Immunity 2012 36 561 571 10.1016/j.immuni.2012.02.014 22483801 PMC3334467 · DOI
  153. [175]Pierini R AIM2/ASC triggers caspase-8-dependent apoptosis in Francisella-infected caspase-1-deficient macrophages Cell Death Differ. 2012 19 1709 1721 10.1038/cdd.2012.51 22555457 PMC3438500 · DOI
  154. [176]Jones JW Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis Proc. Natl Acad. Sci. USA 2010 107 9771 9776 10.1073/pnas.1003738107 20457908 PMC2906881 · DOI
  155. [177]Matyszewski M Morrone SR Sohn J Digital signaling network drives the assembly of the AIM2-ASC inflammasome Proc. Natl Acad. Sci. USA 2018 115 E1963 E1972 10.1073/pnas.1712860115 29440442 PMC5834677 · DOI
  156. [178]Xu H Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome Nature 2014 513 237 241 10.1038/nature13449 24919149 · DOI
  157. [179]Chung LK The Yersinia virulence factor YopM hijacks host kinases to inhibit type III effector-triggered activation of the pyrin inflammasome Cell Host Microbe 2016 20 296 306 10.1016/j.chom.2016.07.018 27569559 PMC5025386 · DOI
  158. [180]Ratner D The yersinia pestis effector YopM inhibits pyrin inflammasome activation PLoS Pathog. 2016 12 e1006035 10.1371/journal.ppat.1006035 27911947 PMC5135138 · DOI
  159. [181]Park YH Wood G Kastner DL Chae JJ Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS Nat. Immunol. 2016 17 914 921 10.1038/ni.3457 27270401 PMC4955684 · DOI
  160. [182]Masters SL Familial autoinflammation with neutrophilic dermatosis reveals a regulatory mechanism of pyrin activation Sci. Transl. Med. 2016 8 332ra45 10.1126/scitranslmed.aaf1471 27030597 · DOI
  161. [183]Gao W Yang J Liu W Wang Y Shao F Site-specific phosphorylation and microtubule dynamics control Pyrin inflammasome activation Proc. Natl Acad. Sci. USA 2016 113 E4857 E4866 10.1073/pnas.1601700113 27482109 PMC4995971 · DOI
  162. [184]Sollberger G Strittmatter GE Garstkiewicz M Sand J Beer HD Caspase-1: the inflammasome and beyond Innate Immun. 2014 20 115 125 10.1177/1753425913484374 23676582 · DOI
  163. [185]Sborgi L GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death EMBO J. 2016 35 1766 1778 10.15252/embj.201694696 27418190 PMC5010048 · DOI · Paper page
  164. [186]Carty M Cell survival and cytokine release after inflammasome activation is regulated by the Toll-IL-1R protein SARM Immunity 2019 50 1412 1424.e6 10.1016/j.immuni.2019.04.005 31076360 · DOI
  165. [188]Chu LH The oxidized phospholipid oxPAPC protects from septic shock by targeting the non-canonical inflammasome in macrophages Nat. Commun. 2018 9 996 10.1038/s41467-018-03409-3 29520027 PMC5843631 · DOI
  166. [189]Aglietti RA GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes Proc. Natl Acad. Sci. USA 2016 113 7858 7863 10.1073/pnas.1607769113 27339137 PMC4948338 · DOI · Paper page
  167. [190]Baker PJ NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5 Eur. J. Immunol. 2015 45 2918 2926 10.1002/eji.201545655 26173988 · DOI
  168. [191]Ruhl S Broz P Caspase-11 activates a canonical NLRP3 inflammasome by promoting K (+) efflux Eur. J. Immunol. 2015 45 2927 2936 10.1002/eji.201545772 26173909 · DOI
  169. [192]Schmid-Burgk JL Caspase-4 mediates non-canonical activation of the NLRP3 inflammasome in human myeloid cells Eur. J. Immunol. 2015 45 2911 2917 10.1002/eji.201545523 26174085 · DOI
  170. [193]Yang D He Y Muñoz-Planillo R Liu Q Núñez G Caspase-11 requires the pannexin-1 channel and the purinergic P2X7 pore to mediate pyroptosis and endotoxic shock Immunity 2015 43 923 932 10.1016/j.immuni.2015.10.009 26572062 PMC4795157 · DOI
  171. [195]Schadendorf D Melanoma Nat. Rev. Dis. Prim. 2015 1 15003 10.1038/nrdp.2015.3 27188223 · DOI
  172. [196]Ellerhorst JA Clinical correlates of NRAS and BRAF mutations in primary human melanoma Clin. Cancer Res. 2011 17 229 235 10.1158/1078-0432.CCR-10-2276 20975100 PMC3022950 · DOI · Paper page
  173. [197]Schadendorf D Melanoma Lancet 2018 392 971 984 10.1016/S0140-6736(18)31559-9 30238891 · DOI
  174. [198]O’Neill CH Scoggins CR Melanoma J. Surg. Oncol. 2019 120 873 881 10.1002/jso.25604 31246291 · DOI
  175. [199]Lugovic-Mihic L Melanoma development: current knowledge on melanoma pathogenesis Acta Dermatovenerol. Croat. 2019 27 163 168 31542060
  176. [200]Smalley KSM Two Worlds Collide: unraveling the role of the immune system in BRAF–MEK inhibitor responses Cancer Discov. 2020 10 176 178 10.1158/2159-8290.CD-19-1441 32024680 · DOI
  177. [201]Erkes DA Mutant BRAF and MEK inhibitors regulate the tumor immune microenvironment via pyroptosis Cancer Discov. 2020 10 254 269 10.1158/2159-8290.CD-19-0672 31796433 PMC7007378 · DOI · Paper page
  178. [202]Zhao Q Novel HSP90-PI3K dual inhibitor suppresses melanoma cell proliferation by interfering with HSP90-EGFR interaction and downstream signaling pathways Int. J. Mol. Sci. 2020 21 1845 10.3390/ijms21051845 PMC7084941 32156008 · DOI
  179. [203]Bollino D Colunga A Li B Aurelian L ΔPK oncolytic activity includes modulation of the tumour cell milieu J. Gen. Virol. 2016 97 496 508 10.1099/jgv.0.000353 26602205 PMC5972308 · DOI
  180. [204]Lage H Helmbach H Grottke C Dietel M Schadendorf D DFNA5 (ICERE-1) contributes to acquired etoposide resistance in melanoma cells FEBS Lett. 2001 494 54 59 10.1016/S0014-5793(01)02304-3 11297734 · DOI
  181. [205]Dixon SJ Ferroptosis: an iron-dependent form of nonapoptotic cell death Cell 2012 149 1060 1072 10.1016/j.cell.2012.03.042 22632970 PMC3367386 · DOI · Paper page
  182. [206]Dixon SJ Stockwell BR The role of iron and reactive oxygen species in cell death Nat. Chem. Biol. 2014 10 9 17 10.1038/nchembio.1416 24346035 · DOI · Paper page
  183. [207]Aykin-Burns N Ahmad IM Zhu Y Oberley LW Spitz DR Increased levels of superoxide and H2O2 mediate the differential susceptibility of cancer cells versus normal cells to glucose deprivation Biochem. J. 2009 418 29 37 10.1042/BJ20081258 18937644 PMC2678564 · DOI
  184. [208]Doskey CM Tumor cells have decreased ability to metabolize H2O2: Implications for pharmacological ascorbate in cancer therapy Redox Biol. 2016 10 274 284 10.1016/j.redox.2016.10.010 27833040 PMC5106370 · DOI
  185. [209]Yu P Eukaryotic elongation factor-2 kinase regulates the cross-talk between autophagy and pyroptosis in doxorubicin-treated human melanoma cells in vitro Acta Pharm. Sin. 2019 40 1237 1244 10.1038/s41401-019-0222-z PMC6786479 30914761 · DOI
  186. [210]Verma D Inflammasome polymorphisms confer susceptibility to sporadic malignant melanoma Pigment Cell Melanoma Res. 2012 25 506 513 10.1111/j.1755-148X.2012.01008.x 22524199 · DOI
  187. [211]Davis BK Wen H Ting JP The inflammasome NLRs in immunity, inflammation, and associated diseases Annu Rev. Immunol. 2011 29 707 735 10.1146/annurev-immunol-031210-101405 21219188 PMC4067317 · DOI · Paper page
  188. [212]Liu W Dual role of apoptosis-associated speck-like protein containing a CARD (ASC) in tumorigenesis of human melanoma J. Invest. Dermatol. 2013 133 518 527 10.1038/jid.2012.317 22931929 PMC3511638 · DOI
  189. [213]Zhai Z NLRP1 promotes tumor growth by enhancing inflammasome activation and suppressing apoptosis in metastatic melanoma Oncogene 2017 36 3820 3830 10.1038/onc.2017.26 28263976 PMC5501746 · DOI
  190. [214]Street SE Cretney E Smyth MJ Perforin and interferon-gamma activities independently control tumor initiation, growth, and metastasis Blood 2001 97 192 197 10.1182/blood.V97.1.192 11133760 · DOI
  191. [215]Gilfillan S DNAM-1 promotes activation of cytotoxic lymphocytes by nonprofessional antigen-presenting cells and tumors J. Exp. Med. 2008 205 2965 2973 10.1084/jem.20081752 19029380 PMC2605240 · DOI
  192. [216]Werneck MB Lugo-Villarino G Hwang ES Cantor H Glimcher LH T-bet plays a key role in NK-mediated control of melanoma metastatic disease J. Immunol. 2008 180 8004 8010 10.4049/jimmunol.180.12.8004 18523263 PMC3709580 · DOI
  193. [217]Takeda K IFN-gamma production by lung NK cells is critical for the natural resistance to pulmonary metastasis of B16 melanoma in mice J. Leukoc. Biol. 2011 90 777 785 10.1189/jlb.0411208 21712396 · DOI
  194. [218]Chow MT NLRP3 suppresses NK cell-mediated responses to carcinogen-induced tumors and metastases Cancer Res. 2012 72 5721 5732 10.1158/0008-5472.CAN-12-0509 22986739 · DOI
  195. [220]van Deventer HW The inflammasome component NLRP3 impairs antitumor vaccine by enhancing the accumulation of tumor-associated myeloid-derived suppressor cells Cancer Res. 2010 70 10161 10169 10.1158/0008-5472.CAN-10-1921 21159638 PMC3059219 · DOI · Paper page
  196. [221]Janowski AM NLRC4 suppresses melanoma tumor progression independently of inflammasome activation J. Clin. Invest. 2016 126 3917 3928 10.1172/JCI86953 27617861 PMC5096827 · DOI
  197. [222]Poyet JL Identification of Ipaf, a human caspase-1-activating protein related to Apaf-1 J. Biol. Chem. 2001 276 28309 28313 10.1074/jbc.C100250200 11390368 · DOI
  198. [223]Zhao Y Shao F The NAIP-NLRC4 inflammasome in innate immune detection of bacterial flagellin and type III secretion apparatus Immunol. Rev. 2015 265 85 102 10.1111/imr.12293 25879286 · DOI
  199. [224]Leach DR Krummel MF Allison JP Enhancement of antitumor immunity by CTLA-4 blockade Science 1996 271 1734 1736 10.1126/science.271.5256.1734 8596936 · DOI · Paper page
  200. [225]Freeman GJ Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation J. Exp. Med 2000 192 1027 1034 10.1084/jem.192.7.1027 11015443 PMC2193311 · DOI · Paper page

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Cited by

Sorted by citations

Authors
Yu, P., Zhang, X., Liu, N., Tang, L., Peng, C., & Chen, X.
Affiliations
Central South University (CN)
Corresponding author
  • Peng, Cong
  • Chen, Xiang
ORCID
Venue
Signal Transduction and Targeted Therapy
Publisher
Springer Science and Business Media LLC
Published
2021-03-29
Volume
6
Issue
1
Pages
128-128
ISSN
2059-3635 (ISSN-L)
DOI
10.1038/s41392-021-00507-5
PMC
PMC8005494
OpenAlex
W3142080073
Cited by
2,353
References
35
Citations by year
2026: 361 · 2025: 581 · 2024: 612 · 2023: 486 · 2022: 279 · 2021: 33
FWCI
37.79
Type
journal article
Language
en
Open access
Licence
Locations
  • Signal Transduction and Targeted Therapy (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Natural Science Foundation of China (82073458, 111 Project, B20017, 81830096, 81773341, 81620108024)
  • Higher Education Discipline Innovation Project (B20017)
  • Project 211 (111 Project No. B20017, 111 Project, #B20017, No. B20017)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Ferroptosis and cancer prognosis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Keywords
pyroptosis, innate immunity, carcinogenesis, cancer therapy, radiotherapy complications, chemotherapy side effects
MeSH terms
Pyroptosis, Gasdermins, Humans, Immunity, Innate, Neoplasm Proteins, Neoplasms, Radiotherapy, Pore Forming Cytotoxic Proteins, Drug-Related Side Effects and Adverse Reactions

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