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Obesity Early in Adulthood Increases Risk but Does Not Affect Outcomes of Hepatocellular Carcinoma
Open accessAbstract
Background & aims Despite the significant association between obesity and several cancers, it has been difficult to establish an association between obesity and hepatocellular carcinoma (HCC). Patients with HCC often have ascites, making it a challenge to determine body mass index (BMI) accurately, and many factors contribute to the development of HCC. We performed a case-control study to investigate whether obesity early in adulthood affects risk, age of onset, or outcomes of patients with HCC.Methods We interviewed 622 patients newly diagnosed with HCC from January 2004 through December 2013, along with 660 healthy controls (frequency-matched by age and sex) to determine weights, heights, and body sizes (self-reported) at various ages before HCC development or enrollment as controls. Multivariable logistic and Cox regression analyses were performed to determine the independent effects of early obesity on risk for HCC and patient outcomes, respectively. BMI was calculated, and patients with a BMI of 30 kg/m(2) or greater were considered obese.Results Obesity in early adulthood (age, mid-20s to mid-40s) is a significant risk factor for HCC. The estimated odds ratios were 2.6 (95% confidence interval [CI], 1.4-4.4), 2.3 (95% CI, 1.2-4.4), and 3.6 (95% CI, 1.5-8.9) for the entire population, for men, and for women, respectively. Each unit increase in BMI at early adulthood was associated with a 3.89-month decrease in age at HCC diagnosis (P < .001). Moreover, there was a synergistic interaction between obesity and hepatitis virus infection. However, we found no effect of obesity on the overall survival of patients with HCC.Conclusions Early adulthood obesity is associated with an increased risk of developing HCC at a young age in the absence of major HCC risk factors, with no effect on outcomes of patients with HCC.
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“The early onset of obesity has a meaningful impact on the development of HCC, as shown in a case-control study comparing 622 individuals with newly diagnosed HCC and 660 healthy controls, where obesity in early adulthood was associated with HCC development.”
From EASL-EASD-EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD). (2024) · cites this paper as [48]
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Cites
Wild, S., Roglic, G., Green, A., Sicree, R., & King, H. (2004) · Diabetes Care · doi:10.2337/diacare.27.5.1047 · Cited by 15,297
Sorafenib in advanced hepatocellular carcinoma
Llovet, J. M., Ricci, S., Mazzaferro, V., Hilgard, P., Gane, E., Blanc, J.-F., de Oliveira, A. C., Santoro, A., Raoul, J.-L., Forner, A., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0708857 · Cited by 13,097
Ng, M., Fleming, T., Robinson, M., Thomson, B., Graetz, N., Margono, C., Mullany, E. C., Biryukov, S., Abbafati, C., Abera, S. F., et al. (2014) · The Lancet · doi:10.1016/s0140-6736(14)60460-8 · Cited by 11,952
A New Era of Systemic Therapy for Hepatocellular Carcinoma with Regorafenib and Lenvatinib
Kudo, M. (2017) · Liver Cancer · doi:10.1159/000462153 · Cited by 5,974
Sorafenib in Advanced Hepatocellular Carcinoma
정, 재. (2008) · Cited by 5,586
Renehan, A. G., Tyson, M., Egger, M., Heller, R. F., & Zwahlen, M. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60269-x · Cited by 5,219
Llovet, J. M., Burroughs, A. K., & Bruix, J. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14964-1 · Cited by 3,637
Altekruse, S. F., McGlynn, K. A., & Reichman, M. E. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2008.20.7753 · Cited by 1,695
Prognostic prediction and treatment strategy in hepatocellular carcinoma
Bruix, J., & Llovet, J. M. (2002) · Hepatology · doi:10.1053/jhep.2002.32089 · Cited by 1,102
The Incidence and Epidemiology of Hepatocellular Carcinoma: A Global and Regional Perspective
Venook, A. P., Papandreou, C. N., Furuse, J., & de Guevara, L. L. (2010) · The Oncologist · doi:10.1634/theoncologist.2010-s4-05 · Cited by 966
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McGlynn, K. A., Petrick, J. L., & El‐Serag, H. B. (2020) · Hepatology · doi:10.1002/hep.31288 · Cited by 2,200
Tacke, F., Horn, P., Wai-Sun Wong, V., Ratziu, V., Bugianesi, E., Francque, S., Zelber-Sagi, S., Valenti, L., Roden, M., Schick, F., et al. (2024) · Journal of Hepatology · doi:10.1016/j.jhep.2024.04.031 · Cited by 2,210
Global epidemiology of NAFLD-related HCC: trends, predictions, risk factors and prevention
Huang, D. Q., El-Serag, H. B., & Loomba, R. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-00381-6 · Cited by 1,855
Hepatocellular Carcinoma From Epidemiology to Prevention: Translating Knowledge into Practice
Singal, A. G., & El-Serag, H. B. (2015) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2015.08.014 · Cited by 530
Global epidemiology of alcohol-associated cirrhosis and HCC: trends, projections and risk factors
Huang, D. Q., Mathurin, P., Cortez-Pinto, H., & Loomba, R. (2023) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-022-00688-6 · Cited by 553
(2024) · Obesity Facts · doi:10.1159/000539371 · Cited by 545
Alexander, M., Loomis, A. K., van der Lei, J., Duarte-Salles, T., Prieto-Alhambra, D., Ansell, D., Pasqua, A., Lapi, F., Rijnbeek, P., Mosseveld, M., et al. (2019) · BMC Medicine · doi:10.1186/s12916-019-1321-x · Cited by 317
Long-term Effects of Hepatitis B Immunization of Infants in Preventing Liver Cancer
Chang, M., You, S., Chen, C., Liu, C., Lai, M., Wu, T., Wu, S., Lee, C., Yang, S., Chu, H.-C., et al. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.05.048 · Cited by 258
NAFLD‐related hepatocellular carcinoma: The growing challenge
Shah, P. A., Patil, R., & Harrison, S. A. (2022) · Hepatology · doi:10.1002/hep.32542 · Cited by 270
Nonalcoholic fatty liver disease and hepatocellular carcinoma
Zoller, H., & Tilg, H. (2016) · Metabolism · doi:10.1016/j.metabol.2016.01.010 · Cited by 179
Should we undertake surveillance for HCC in patients with NAFLD?
Younes, R., & Bugianesi, E. (2018) · Journal of Hepatology · doi:10.1016/j.jhep.2017.10.006 · Cited by 165
Hassan, M. M., Botrus, G., Abdel‐Wahab, R., Wolff, R. A., Li, D., Tweardy, D. J., Phan, A. T., Hawk, E. T., Javle, M. M., Lee, J., et al. (2017) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2017.05.036 · Cited by 140
Gut roundtable meeting paper: selected recent advances in hepatocellular carcinoma
Gerbes, A. L., Zoulim, F., Tilg, H., Dufour, J., Bruix, J., Paradis, V., Salem, R., Peck‐Radosavljevic, M., Galle, P. R., Greten, T. F., et al. (2017) · Gut · doi:10.1136/gutjnl-2017-315068 · Cited by 127
Parikh, N. D., Marrero, W. J., Wang, J., Steuer, J., Tapper, E. B., Konerman, M. A., Singal, A. G., Hutton, D. W., Byon, E., & Lavieri, M. S. (2017) · Hepatology · doi:10.1002/hep.29473 · Cited by 122
Aller, R., Fernández‐Rodríguez, C., Iacono, O. L., Bañares, R., Abad, J., Carrión, J. A., García‐Monzón, C., Caballería, J., Berenguer, M., Rodríguez‐Perálvarez, M., et al. (2018) · Gastroenterología y Hepatología · doi:10.1016/j.gastrohep.2017.12.003 · Cited by 120
Yi, S., Choi, J., Yi, J., Lee, Y., & Han, K. J. (2018) · Cancer · doi:10.1002/cncr.31406 · Cited by 103
Aguilar-Olivos, N. E., Almeda-Valdes, P., Aguilar-Salinas, C. A., Uribe, M., & Méndez-Sánchez, N. (2016) · Metabolism · doi:10.1016/j.metabol.2015.09.004 · Cited by 100
Hagström, H., Tynelius, P., & Rasmussen, F. E. (2017) · Gut · doi:10.1136/gutjnl-2016-313622 · Cited by 98
Sun, H., Yang, W., Tian, Y., Zeng, X., Zhou, J., Mok, M. T. S., Tang, W., Feng, Y., Xu, L., Chan, A. W. H., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-07402-8 · Cited by 93
Doycheva, I., Watt, K. D. S., Rifai, G., Mrad, R. A., López, R., Zein, N. N., Carey, W. D., & Alkhouri, N. (2017) · Digestive Diseases and Sciences · doi:10.1007/s10620-017-4492-3 · Cited by 83
Genomic Profiling and Metabolic Homeostasis in Primary Liver Cancers
Gingold, J. A., Zhu, D., Lee, D., Kaseb, A. O., & Chen, J. (2018) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2018.02.006 · Cited by 72
Gutiérrez‐Cuevas, J., Lucano‐Landeros, S., López-Cifuentes, D., Santos, A., & Armendáriz‐Borunda, J. (2022) · Cancers · doi:10.3390/cancers15010023 · Cited by 64
Hidayat, K., Du, X., & Shi, B. (2018) · Obesity Reviews · doi:10.1111/obr.12705 · Cited by 61
The Changing Global Epidemiology of Hepatocellular Carcinoma
Caines, A. N., Selim, R., & Salgia, R. J. (2020) · Clinics in Liver Disease · doi:10.1016/j.cld.2020.06.001 · Cited by 59
Epidemiology of Hepatocellular Carcinoma
El‐Serag, H. B. (2020) · Wiley eBooks · doi:10.1002/9781119436812.ch59 · Cited by 53
Aleksandrova, K., Stelmach-Mardas, M., & Schlesinger, S. (2016) · Recent results in cancer research/Recent Results in Cancer Research · doi:10.1007/978-3-319-42542-9_10 · Cited by 52
Small but Heavy Role: MicroRNAs in Hepatocellular Carcinoma Progression
Chen, E., Xu, X., Liu, R., & Liu, T. (2018) · BioMed Research International · doi:10.1155/2018/6784607 · Cited by 47
Rao, S., Yang, X., Ohshiro, K., Zaidi, S., Wang, Z., Shetty, K., Xiang, X., Hassan, M. I., Mohammad, T., Latham, P. S., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abk2267 · Cited by 47
Sex and Ethnic Differences in the Association of Obesity With Risk of Hepatocellular Carcinoma
Setiawan, V. W., Lim, U., Lipworth, L. P., Lu, S. C.-L., Shepherd, J., Ernst, T. M., Wilkens, L. R., Henderson, B. E., & Marchand, L. L. (2015) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2015.09.015 · Cited by 46
Adiposity across the adult life course and incidence of primary liver cancer: The NIH‐AARP cohort
Yang, B., Petrick, J. L., Kelly, S. P., Graubard, B. I., Freedman, N. D., & McGlynn, K. A. (2017) · International Journal of Cancer · doi:10.1002/ijc.30737 · Cited by 44
Hagström, H., Hegmar, H., & Moreno, C. (2024) · United European Gastroenterology Journal · doi:10.1002/ueg2.12524 · Cited by 40
Hepatic myeloid-derived suppressor cells in cancer
Medina‐Echeverz, J., Eggert, T., Han, M., & Greten, T. F. (2015) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-015-1736-y · Cited by 39
Surveillance for Hepatocellular Carcinoma in Patients with NASH
Kolly, P., & Dufour, J. (2016) · Diagnostics · doi:10.3390/diagnostics6020022 · Cited by 38
Yoo, J.-J., Park, M. Y., Cho, E. J., Yu, S. J., Kim, S. G., Kim, Y. J., Kim, Y. S., & Yoon, J.-H. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12093336 · Cited by 36
Yao, L., Abe, M., Kawasaki, K., Akbar, S. M. F., Matsuura, B., Onji, M., & Hiasa, Y. (2016) · PLoS ONE · doi:10.1371/journal.pone.0149948 · Cited by 33
Hepatitis C and insulin action: An intimate relationship
Knobler, H. (2016) · World Journal of Hepatology · doi:10.4254/wjh.v8.i2.131 · Cited by 32
Lee, I., Lei, H.-J., Chau, G., Yeh, Y., Wu, C.-J., Su, C., Huo, T., Chao, Y., Lin, H., Hou, M., et al. (2021) · PubMed Central · Cited by 31
Bariatric Surgery and Hepatocellular Carcinoma: a Propensity Score-Matched Analysis
Njei, B. M., McCarty, T. R., Sharma, P., Lange, A., Najafian, N., Ngu, J. N., Ngomba, V., & Echouffo-Tcheugui, J. B. (2018) · Obesity Surgery · doi:10.1007/s11695-018-3431-5 · Cited by 31
Indian Hedgehog links obesity to development of hepatocellular carcinoma
Chong, Y. C., Lim, T. E., Fu, Y., Shin, E. M., Tergaonkar, V., & Han, W. (2019) · Oncogene · doi:10.1038/s41388-018-0585-5 · Cited by 29
Strathearn, L. S., Stepanov, A. I., & Font-Burgada, J. (2020) · Nutrients · doi:10.3390/nu12040933 · Cited by 26
Jun, B. G., Kim, M., Shin, H. S., Yi, J., & Yi, S. (2022) · British Journal of Cancer · doi:10.1038/s41416-022-01771-0 · Cited by 25
Bettinger, D., Spode, R., Glaser, N., Buettner, N., Boettler, T., Neumann‐Haefelin, C., Brunner, T. B., Gkika, E., Maruschke, L., Thimme, R., et al. (2017) · BMC Gastroenterology · doi:10.1186/s12876-017-0656-z · Cited by 24
Changing Epidemiology of HCC: How to Screen and Identify Patients at Risk?
Lange, N. F., & Dufour, J. (2019) · Digestive Diseases and Sciences · doi:10.1007/s10620-019-05515-8 · Cited by 20
Dietary N‐Nitroso Compounds and Risk of Hepatocellular Carcinoma: A USA‐Based Study
Zheng, J., Daniel, C. R., Hatia, R. I., Stuff, J. E., Abdelhakeem, A. A. F., Rashid, A., Chun, Y. S., Jalal, P. K., Kaseb, A. O., Li, D., et al. (2021) · Hepatology · doi:10.1002/hep.32046 · Cited by 23
Alqahtani, S. A., Sanai, F. M., Alolayan, A. A. M., Abaalkhail, F. A., Alsuhaibani, H., Hassanain, M. M., Alhazzani, W. A., Alsuhaibani, A. A., Algarni, A. A., Forner, A., et al. (2020) · Saudi Journal of Gastroenterology · doi:10.4103/sjg.sjg_477_20 · Cited by 24
Zhang, G., Cao, F., Shi, L., Ma, T., & Zhang, L. (2019) · Digestive and Liver Disease · doi:10.1016/j.dld.2019.10.012 · Cited by 19
Dietary Patterns and Hepatocellular Carcinoma Risk among US Adults
Moussa, I., Day, R. S., Li, R., Du, X. L., Kaseb, A. O., Jalal, P. K., Daniel, C. R., Hatia, R. I., Abdelhakeem, A. A. F., Rashid, A., et al. (2021) · Nutrients · doi:10.3390/nu13062011 · Cited by 19
Association of dietary fat intake and hepatocellular carcinoma among US adults
Moussa, I., Day, R. S., Li, R., Kaseb, A. O., Jalal, P. K., Daniel, C. R., Hatia, R. I., Abdelhakeem, A. A. F., Rashid, A., Chun, Y. S., et al. (2021) · Cancer Medicine · doi:10.1002/cam4.4256 · Cited by 19
Cernea, S., & Onișor, D. M. (2023) · World Journal of Gastroenterology · doi:10.3748/wjg.v29.i2.286 · Cited by 18
Aller, R., Fernández‐Rodríguez, C., Iacono, O. L., Bañares, R., Abad, J., Carrión, J. A., García‐Monzón, C., Caballería, J., Berenguer, M., Rodríguez‐Perálvarez, M., et al. (2018) · Gastroenterología y Hepatología (English Edition) · doi:10.1016/j.gastre.2018.05.013 · Cited by 16
Morris, J. S., Hassan, M. M., Zohner, Y. E., Wang, Z., Xiao, L., Rashid, A., Haque, A., Abdel‐Wahab, R., Mohamed, Y. I., Ballard, K., et al. (2020) · Hepatology · doi:10.1002/hep.31555 · Cited by 16
Obesity Predicts Liver Function Testing and Abnormal Liver Results
Li, W., Homer, K., Hull, S., Boomla, K., Robson, J. P., & Alazawi, W. (2019) · Obesity · doi:10.1002/oby.22669 · Cited by 15
Risk Assessment of Hepatocellular Carcinoma in Patients with Hepatitis C in China and the USA
Parikh, N. D., Fu, S., Rao, H., Yang, M., Li, Y., Powell, C. C., Wu, E., Lin, A., Xing, B., Wei, L., et al. (2017) · Digestive Diseases and Sciences · doi:10.1007/s10620-017-4776-7 · Cited by 15
Lifestyle and Environmental Approaches for the Primary Prevention of Hepatocellular Carcinoma
Simon, T. G., & Chan, A. T. (2020) · Clinics in Liver Disease · doi:10.1016/j.cld.2020.06.002 · Cited by 15
When the journey from obesity to cirrhosis takes an early start.
Ratziu, V., & Marchesini, G. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.05.021 · Cited by 13
Nonalcoholic fatty liver disease and hepatocellular carcinoma.
Klein, S., & Dufour, J. (2017) · Hepatic Oncology · doi:10.2217/hep-2017-0013 · Cited by 8
Adiposity, Adulthood Weight Change, and Risk of Incident Hepatocellular Carcinoma
Simon, T. G., Kim, M. N., Luo, X., Liu, X., Yang, W., Ma, Y., Chong, D. Q., Fuchs, C. S., Stampfer, M. J., Giovannucci, E. L., et al. (2021) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-20-0549 · Cited by 14
Abraham, J., & Golubnitschaja, O. (2016) · Personalized Medicine · doi:10.2217/pme-2016-0013 · Cited by 12
Shinkawa, H., Tanaka, S., Takemura, S., Ito, T., Aota, T., Koda, M., Miyazaki, T., Yamamoto, T., & Kubo, S. (2018) · Annals of Gastroenterological Surgery · doi:10.1002/ags3.12183 · Cited by 13
Dou, J., Han, Z., Liu, F., Cheng, Z., Yu, X., Yu, J., & Liang, P. (2020) · International Journal of Hyperthermia · doi:10.1080/02656736.2020.1712482 · Cited by 13
Saeed, U., Nordsletten, M., Myklebust, T. Å., Robsahm, T. E., Møller, B., Skålhegg, B. S., Mala, T., & Yaqub, S. (2023) · HPB · doi:10.1016/j.hpb.2023.07.882 · Cited by 13
Body Mass Index Trajectories, Weight Gain, and Risks of Liver and Biliary Tract Cancers
Yang, W., Zeng, X., Petrick, J. L., Danford, C. J., Florio, A. A., Lü, B., Nan, H., Ma, J., Wang, L., Zeng, H., et al. (2022) · JNCI Cancer Spectrum · doi:10.1093/jncics/pkac056 · Cited by 12
Pomo, J. M., Taylor, R. M., & Gullapalli, R. R. (2016) · Cancer Cell International · doi:10.1186/s12935-016-0318-1 · Cited by 10
Liang, Y., Chiou, Y., Chiu, A. P., Shiao, M., Teng, W., Lin, C., Cheng, M., Huang, Y., Liang, K., Su, C., et al. (2023) · Journal of Medical Virology · doi:10.1002/jmv.29325 · Cited by 9
Obesity and Hepatocellular Carcinoma: A Complex Relationship
Henry, Z. H., & Caldwell, S. H. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.05.024 · Cited by 8
Cirrhosis regression: extrahepatic angiogenesis and liver hyperarterialization persist
Payancé, A., & Rautou, P. (2018) · Clinical Science · doi:10.1042/cs20180129 · Cited by 8
Childhood obesity: time bomb for future burden of chronic liver disease
Marietti, M., & Bugianesi, E. (2016) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.120 · Cited by 7
Bhat, S., Majeed, Y., Yatoo, G. N., Hassan, S., Khan, T., Sofi, P. A., Ganai, B. A., Fazili, K. M., & Zargar, S. M. (2024) · Molecular Biology Reports · doi:10.1007/s11033-024-09695-z · Cited by 6
Hepatocellular Carcinoma: the Impact of NAFLD
Allaire, M., Dupont, B., Nahon, P., Ganne-Carrié, N., & Nault, J. (2016) · Current Hepatology Reports · doi:10.1007/s11901-016-0303-0 · Cited by 3
The Impact of Metabolic Health and Obesity on Liver Transplant Candidates and Recipients
Vogel, A. S., Roediger, R., von Ahrens, D., Fortune, B. E., Schwartz, J. M., Frager, S., Chacko, K. R., & Tow, C. (2024) · Life · doi:10.3390/life14060685 · Cited by 6
You, Y., Yang, T., Wei, S., Liu, Z., Liu, C., Shen, Z., Yang, Y., Feng, Y., Yao, P., & Zhu, Q. (2023) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s416280 · Cited by 5
Bevers, T. B., El‐Serag, H. B., Hanash, S., Thrift, A. P., Tsai, K. Y., Maresso, K. C., & Hawk, E. T. (2020) · Elsevier eBooks · doi:10.1016/b978-0-323-47674-4.00023-2 · Cited by 9
Epidemiology and Comorbidities
Mathus-Vliegen, E. M. H., & Dargent, J. (2018) · Springer eBooks · doi:10.1007/978-3-319-90074-2_1 · Cited by 5
Hatia, R. I., Eluri, M., Hawk, E. T., Shalaby, A. S., Karatas, E., Shalaby, A., Abdelhakeem, A. A. F., Abdel‐Wahab, R., Chang, P., Rashid, A., et al. (2023) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-23-0388 · Cited by 4
Chao, D. T., Shah, N., Zeh, H. J., Singhi, A. D., Bahary, N., McGrath, K. M., Fasanella, K. E., Zureikat, A. H., Whitcomb, D. C., & Brand, R. E. (2018) · Gastroenterology Research and Practice · doi:10.1155/2018/2380596 · Cited by 4
Younes, R., & Bugianesi, E. (2018) · Current Hepatology Reports · doi:10.1007/s11901-018-0422-x · Cited by 4
Kim, K., Choi, S., Lee, G., Son, J. S., Kim, K. H., & Park, S. M. (2020) · European Journal of Cancer Prevention · doi:10.1097/cej.0000000000000610 · Cited by 4
Central Obesity Early in Adulthood May Affect Outcomes of Hepatocellular Carcinoma
Pang, Q., Qu, K., & Liu, C. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.05.064 · Cited by 4
Johnston, M. P., Patel, J., & Byrne, C. D. (2020) · HepatoBiliary Surgery and Nutrition · doi:10.21037/hbsn.2019.10.09 · Cited by 4
Abdel‐Hamid, M. S., Mansour, A. M., Hassan, M. H., Abdelhady, R., Elsadek, B., El-Sayed, E.-S. M., & Salama, S. A. (2023) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b23-00342 · Cited by 3
Risk Factors for Hepatocellular Carcinoma: A Historical Perspective
Natarajan, Y., & El‐Serag, H. B. (2021) · Clinical Liver Disease · doi:10.1002/cld.1042 · Cited by 3
Hepatocellular carcinoma associated with hepatitis B virus and environmental factors
Bazir, H., Bessi, H., Benchekroun, M. N., & Ennaji, M. M. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-824152-3.00020-2 · Cited by 3
Epidemiology of hepatocellular carcinoma in nonalcoholic fatty liver disease
Moriguchi, M., Seko, Y., Takahashi, A., & Itoh, Y. (2019) · Hepatoma Research · doi:10.20517/2394-5079.2019.20 · Cited by 4
Weinfurtner, K. M., Dodge, J. L., Yao, F. Y., & Mehta, N. J. (2020) · Transplantation Direct · doi:10.1097/txd.0000000000001060 · Cited by 3
Obesity and Risk of Liver and Biliary Tract Cancer: Does Timing and Trajectory Matter?
Befort, C. A., & Weinman, S. A. (2022) · JNCI Cancer Spectrum · doi:10.1093/jncics/pkac057 · Cited by 3
Fang, W., Yuan, X., Li, W., Seery, S., Chen, G., Cai, Z., Huang, Z., Wang, X., Wu, W., Chen, Z., et al. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1281203 · Cited by 2
Wu, R., Liu, R., Chen, R., Li, Y., Xue, X., Zhang, Y., Li, F., Qu, J., Qin, L., Wang, C., et al. (2025) · Chinese Medicine · doi:10.1186/s13020-025-01097-y · Cited by 2
Kim, M., Jun, B. G., Shin, H. S., Yi, J., Kim, S. G., & Yi, S. (2025) · PLoS ONE · doi:10.1371/journal.pone.0316175 · Cited by 2
Kawata, K., Takahashi, H., Arai, T., Seko, Y., Chida, T., Noritake, H., Toyoda, H., Hayashi, H., Yamaguchi, K., Iwaki, M., et al. (2026) · Journal of Gastroenterology · doi:10.1007/s00535-026-02393-6 · Cited by 1
Wang, D., & Ma, Z. (2024) · Medicine · doi:10.1097/md.0000000000039167 · Cited by 1
Risk and Prognosis of Hepatocellular Carcinoma in Mexican Americans with Type 2 Diabetes Mellitus
Hatia, R. I., Hwang, L., Li, R., Troisi, C. L., Jalal, P. K., Amos, C. I., Gomez, H. F., Chun, Y. S., Rashid, A., Kaseb, A. O., et al. (2025) · Journal of Hepatocellular Carcinoma · doi:10.2147/jhc.s477141 · Cited by 1
Carcinome hépatocellulaire : nouveautés épidémiologiques et démarche diagnostique
Blanc, J. (2017) · ONCOLOGIE · doi:10.1007/s10269-017-2709-x · Cited by 1
Kim, M. N., Han, K., Yoo, J., Ha, Y., Chon, Y. E., Lee, J. H., & Hwang, S. G. (2021) · International Journal of Cancer · doi:10.1002/ijc.33920 · Cited by 1
Etiological Treatments: Lifestyle Management
Bañares, R., & Ibáñez, L. (2015) · Springer eBooks · doi:10.1007/978-3-319-23018-4_13
Hassan, M. M., Abdel‐Wahab, R., Li, D., & Kaseb, A. O. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.09.035
Neoplasia in Patients with Excess Fat Mass
Hurley, D. L. (2018) · Springer eBooks · doi:10.1007/978-3-319-95655-8_17
The Spectrum of NAFLD: From the Organ to the System
Sanchez-Torrijos, Y., & Ampuero, J. (2020) · Springer eBooks · doi:10.1007/978-3-030-37173-9_1
NAFLD, Hepatocellular Carcinoma, and Extrahepatic Cancers
Younes, R., & Bugianesi, E. (2020) · Springer eBooks · doi:10.1007/978-3-319-95828-6_10
Obesity and Hepatocellular Carcinoma: Epidemiology and Mechanisms
Akkız, H. (2021) · Liver Cancer in the Middle East · doi:10.1007/978-3-030-78737-0_4
Data from Adiposity, Adulthood Weight Change, and Risk of Incident Hepatocellular Carcinoma
Simon, T. G., Kim, M. N., Luo, X., Liu, X., Yang, W., Ma, Y., Chong, D. Q., Fuchs, C. S., Stampfer, M. J., Giovannucci, E. L., et al. (2023) · doi:10.1158/1940-6207.c.6547276.v1
Metadata
- Authors
- Hassan, M. M., Abdel-Wahab, R., Kaseb, A., Shalaby, A., Phan, A. T., El-Serag, H. B., Hawk, E., Morris, J., Singh Raghav, K. P., Lee, J.-S., Vauthey, J.-N., Bortus, G., Torres, H. A., Amos, C. I., Wolff, R. A., & Li, D.
- Affiliations
- The University of Texas MD Anderson Cancer Center (US)
- Houston Methodist (US)
- Dartmouth College (US)
- Corresponding author
- Hassan, Manal M.
- ORCID
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2015-07
- Volume
- 149
- Issue
- 1
- Pages
- 119-129
- ISSN
- 0016-5085 (ISSN-L)
- PMC
- PMC4778392
- OpenAlex
- W2052145855
- Cited by
- 110
- References
- 66
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 9 · 2023: 10 · 2022: 6 · 2021: 9 · 2020: 15 · 2019: 7 · 2018: 15 · 2017: 11 · 2016: 11 · 2015: 8
- FWCI
- 6.55
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Cancer Institute (CA106458-01, K07CA106458, P30CA023108, P30CA016672)
- National Institute of Environmental Health Sciences (R03ES11481, R03ES011481)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Risks and Factors
- Health Sciences › Medicine › Hepatology › Hepatocellular Carcinoma Treatment and Prognosis
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Keywords
- hepatocellular carcinoma, obesity, early adulthood, body mass index, cancer risk, age at diagnosis, hepatitis virus infection, overall survival, sex differences
- MeSH terms
- Adult, Aged, Aging, Female, Carcinoma, Hepatocellular, Humans, Liver Neoplasms, Male, Middle Aged, Obesity, Risk Factors, Body Mass Index, Case-Control Studies, Age of Onset, Young Adult
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