The DOI matches its Crossref record; 53 of the 54 references it cites were found in a registry or an index.
Efficacy of Sterile Fecal Filtrate Transfer for Treating Patients With Clostridium difficile Infection
Open accessAbstract
BACKGROUND & AIMS: Fecal microbiota transplantation (FMT) is a highly effective therapy for recurrent Clostridium difficile infection (CDI). However, transferring undefined living bacteria entails uncontrollable risks for infectious and metabolic or malignant diseases, particularly in immunocompromised patients. We investigated whether sterile fecal filtrates (containing bacterial debris, proteins, antimicrobial compounds, metabolic products, and oligonucleotides/DNA), rather than intact microorganisms, are effective in patients with CDI. METHODS: We performed a clinical case series to investigate the effects of fecal filtrate transfer (FFT) in 5 patients with symptomatic chronic-relapsing CDI at the Department of Internal Medicine I at the University Hospital Schleswig-Holstein (Kiel, Germany). Patients were followed up for at least 6 months and for up to 33 months. Stool was collected from 5 donors selected by the patients, and fully characterized according to FMT standards. Stool was sterile-filtered to remove small particles and bacteria; the filtrate was transferred to patients in a single administration via nasojejunal tube. Fecal samples were collected from patients before and at 1 week and 6 weeks after FFT. Microbiome, virome, and proteome profiles of donors and patients were compared. RESULTS: In all 5 patients, FFT restored normal stool habits and eliminated symptoms of CDI for a minimum period of 6 months. Proteome analyses of selected FFT filtrates showed no obvious protein candidates associated with therapeutic efficacy. 16S ribosomal RNA gene sequencing detected diverse bacterial DNA signatures in the filtrates. Analysis of virus-like particles from a filtrate found to reduce symptoms of CDI showed a complex signature of bacteriophages. Bacterial phylogeny and virome profile analyses of fecal samples from recipients indicated longitudinal changes in microbial and viral community structures after FFT. CONCLUSIONS: A preliminary investigation of 5 patients with CDI shows that transfer of sterile filtrates from donor stool (FFT), rather than fecal microbiota, can be sufficient to restore normal stool habits and eliminate symptoms. This finding indicates that bacterial components, metabolites, or bacteriophages mediate many of the effects of FMT, and that FFT might be an alternative approach, particularly for immunocompromised patients.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Following successful treatment of C. difficile infection by FFT transplantation, the gut microbiota of a patient with loss of renal function resembled that of the faecal donor with remarkable elimination of Proteobacteria, which had dominated before FFT226.”
From The gut microbiota and the brain–gut–kidney axis in hypertension and chronic kidney disease (2018) · cites this paper as [226]
In the citing paper
“The risk of secondary infection may be lower with FFT than with FMT, as FFT does not involve the transfer of live bacteria226.”
From The gut microbiota and the brain–gut–kidney axis in hypertension and chronic kidney disease (2018) · cites this paper as [226]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Trimmomatic: a flexible trimmer for Illumina sequence data
Bolger, A. M., Lohse, M., & Usadel, B. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btu170 · Cited by 65,548
Schloss, P. D., Westcott, S. L., Ryabin, T., Hall, J. R., Hartmann, M., Hollister, E. B., Lesniewski, R. A., Oakley, B. B., Parks, D. H., Robinson, C. J., et al. (2009) · Applied and Environmental Microbiology · doi:10.1128/aem.01541-09 · Cited by 21,481
PAST: PALEONTOLOGICAL STATISTICAL SOFTWARE PACKAGE FOR EDUCATION AND DATA ANALYSIS
Hammer, Ø., Harper, D. A. T., & Ryan, P. D. (2001) · Palaeontologia Electronica · Cited by 17,871
UCHIME improves sensitivity and speed of chimera detection
Edgar, R. C., Haas, B. J., Clemente, J. C., Quince, C., & Knight, R. (2011) · Bioinformatics · doi:10.1093/bioinformatics/btr381 · Cited by 15,114
Ultra-high-throughput microbial community analysis on the Illumina HiSeq and MiSeq platforms
Caporaso, J. G., Lauber, C. L., Walters, W. A., Berg-Lyons, D., Huntley, J., Fierer, N., Owens, S. M., Betley, J., Fraser, L., Bauer, M., et al. (2012) · The ISME Journal · doi:10.1038/ismej.2012.8 · Cited by 8,839
Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice
Ridaura, V. K., Faith, J. J., Rey, F. E., Cheng, J., Duncan, A. E., Kau, A. L., Griffin, N. W., Lombard, V., Henrissat, B., Bain, J. R., et al. (2013) · Science · doi:10.1126/science.1241214 · Cited by 3,788
Duodenal Infusion of Donor Feces for Recurrent Clostridium difficile
van Nood, E., Vrieze, A., Nieuwdorp, M., Fuentes, S., Zoetendal, E. G., de Vos, W. M., Visser, C. E., Kuijper, E. J., Bartelsman, J. F. W. M., Tijssen, J. G. P., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1205037 · Cited by 3,708
Fadrosh, D. W., Ma, B., Gajer, P., Sengamalay, N., Ott, S., Brotman, R. M., & Ravel, J. (2014) · Microbiome · doi:10.1186/2049-2618-2-6 · Cited by 1,698
Self-citationAssembling Single-Cell Genomes and Mini-Metagenomes From Chimeric MDA Products
Nurk, S., Bankevich, A., Antipov, D., Gurevich, A. A., Korobeynikov, A., Lapidus, A. L., Prjibelski, A. D., Pyshkin, A., Sirotkin, A., Sirotkin, Y., et al. (2013) · Journal of Computational Biology · doi:10.1089/cmb.2013.0084 · Cited by 1,352
Disease-Specific Alterations in the Enteric Virome in Inflammatory Bowel Disease
Norman, J. M., Handley, S. A., Baldridge, M. T., Droit, L., Liu, C. Y., Keller, B. C., Kambal, A., Monaco, C. L., Zhao, G., Fleshner, P., et al. (2015) · Cell · doi:10.1016/j.cell.2015.01.002 · Cited by 1,285
Flagged first, then by citations
1 of the 54 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Reyes, 2010, Viruses in the faecal microbiota of monozygotic twins and their mothers, Nature, 466, 334, 10.1038/nature09199 · DOI
Cited by
Sorted by citations
Items 401–500 of 697
The influence of early life exposures on the infant gut virome
Zhang, Y., Castro-Mejía, J. L., Deng, L., Shah, S. A., Thorsen, J., Rodríguez, C. L., Jessen, L. E., Dion, M. B., Chawes, B., Bønnelykke, K., et al. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2501194 · Cited by 9
Indole dysbiosis and mucosal inflammation
Kim, J. Y., Cartwright, I. M., & Colgan, S. P. (2025) · Microbiota and Host · doi:10.1530/mah-25-0004 · Cited by 9
Kong, F., Wang, F., Zhang, Y., Wang, S., Wang, W., & Li, S. (2024) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-023-00963-9 · Cited by 10
The Role of the Human Gut Microbiome in Inflammatory Bowel Disease and Radiation Enteropathy
Fernandes, D., & Andreyev, J. N. (2022) · Microorganisms · doi:10.3390/microorganisms10081613 · Cited by 9
Viral Dark Matter in the Gut Virome of Elderly HumansPreprint
Stockdale, S. R., Ryan, F. J., McCann, A., Dalmasso, M., Ross, R. P., & Hill, C. (2018) · Preprints.org · doi:10.20944/preprints201807.0101.v1 · Cited by 9
The Role of Viruses in the Pathogenesis of Immune-Mediated Gastro-Intestinal Diseases
Bernardi, F., Ungaro, F., D’Amico, F., Zilli, A., Parigi, T. L., Massimino, L., Allocca, M., Danese, S., & Furfaro, F. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25158301 · Cited by 8
A single-stranded based library preparation method for virome characterization
Zhai, X., Gobbi, A., Kot, W., Krych, Ł., Nielsen, D. S., & Deng, L. (2024) · Microbiome · doi:10.1186/s40168-024-01935-5 · Cited by 8
The role of fecal microbiota transplantation in type 2 diabetes mellitus treatment
Wang, H., Li, S., Zhang, L., & Zhang, N. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1469165 · Cited by 8
Franklin, H. C., Makhlouf, R., Ha, A. D., Bataglioli, R. A., Baker, Z. R., Murphy, S. A., Jirsa, H., Heuler, J., Southard, T. L., Aylward, F. O., et al. (2025) · Cell Host & Microbe · doi:10.1016/j.chom.2025.04.002 · Cited by 9
Zhao, X., Cai, Y., Hou, Y., Wu, Y., Wei, T., Li, L., Duan, Z., Lu, X., Meng, J., Zhou, H., et al. (2025) · Advanced Science · doi:10.1002/advs.202505204 · Cited by 9
Lahoud, C., Habib, T., Kalta, D., Dimachkie, R., Sayegh, S. E. E., & Deeb, L. S. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14155260 · Cited by 9
Wu, P., Li, X., Long, W., Ma, Y., Xue, B., Xie, W., & Ma, X. (2025) · Annals of Medicine · doi:10.1080/07853890.2025.2557514 · Cited by 13
Bryson, S., Sisson, Z., Nelson, B., Grove, J., Reister, E., Liachko, I., Auch, B., Graiziger, C. T., & Khoruts, A. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2559019 · Cited by 8
What Lies Beneath? Taking the Plunge into the Murky Waters of Phage Biology
Zünd, M., Dunham, S. J. B., Rothman, J. A., & Whiteson, K. (2023) · mSystems · doi:10.1128/msystems.00807-22 · Cited by 8
Li, H., Li, Y., & Qian, J. (2023) · Chinese Medical Journal · doi:10.1097/cm9.0000000000002704 · Cited by 9
The Human Gut Phageome: Identification and Roles in the Diseases
Nabi‐Afjadi, M., Teymouri, S., Monfared, F. N., Varnosfaderani, S. M. N., & Halimi, H. (2023) · Journal of Cellular Signaling · doi:10.33696/signaling.4.100 · Cited by 7
Diwan, B., Yadav, R., Singh, A., Kumar, D., & Sharma, R. (2023) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-023-04193-4 · Cited by 8
Barko, P. C., Nguyen-Edquilang, J., Williams, D. A., & Gal, A. (2024) · PLoS ONE · doi:10.1371/journal.pone.0294730 · Cited by 8
Cryopreservation of stool samples altered the microbial viability quantitively and compositionally
Chen, A., Hu, Y., Zhang, Y., Li, Z., Zeng, Y., & Pang, X. (2022) · Archives of Microbiology · doi:10.1007/s00203-022-03169-1 · Cited by 8
Gut microbiome and neurosurgery: Implications for treatment
Willman, J., Willman, M., Reddy, R., Fusco, A. F., Sriram, S., Mehkri, Y., Charles, J. H., Goeckeritz, J., & Lucke-Wold, B. P. (2022) · Clinical and Translational Discovery · doi:10.1002/ctd2.139 · Cited by 9
Anonye, B. O. (2018) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2018.00104 · Cited by 8
Lu, H., Xie, L., Guo, L., Gu, X., Zhu, R., Yang, Y., Tang, F., Li, M., Liu, C., Wang, D., et al. (2024) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2024.110608 · Cited by 7
Wang, H., Tian, J., & Mi, J. (2025) · Current Research in Microbial Sciences · doi:10.1016/j.crmicr.2025.100415 · Cited by 7
Gut microbiome dysregulation in noninfectious uveitis
Liu, M., Geng, J., Liu, T., & Liu, X. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1614304 · Cited by 7
Microbiome Therapeutics for Clostridioides difficile Infection
Lucky, C. W., Medernach, R. L., Kelly, B. J., Kwon, J. H., & Woodworth, M. H. (2025) · Infectious Disease Clinics of North America · doi:10.1016/j.idc.2025.07.007 · Cited by 8
Cervantes-Echeverría, M., Jiménez-Rico, M. A., Manzo, R., Hernández-Reyna, A., Cornejo‐Granados, F., Bikel, S., González, V., Hurtado-Ramírez, J. M., Sánchez-López, F., Salazar‐León, J., et al. (2025) · PLoS ONE · doi:10.1371/journal.pone.0337760 · Cited by 7
Gedgaudas, R., Bajaj, J. S., Skiecevičienė, J., Valantienė, I., Kiudeliene, E., Bang, C., Franke, A., Schreiber, S., & Kupčinskas, J. (2023) · Journal of Gastrointestinal and Liver Diseases · doi:10.15403/jgld-4906 · Cited by 7
Self-citationMultimodal Approach to Assessment of Fecal Microbiota Donors based on Three Complementary Methods
Biliński, J., Dziurzyński, M., Grzesiowski, P., Podsiadły, E., Stelmaszczyk‐Emmel, A., Dzieciątkowski, T., Dziewit, Ł., & Basak, G. W. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9072036 · Cited by 7
Meng, Y., Feng, Y., Hang, L., Zhou, Y., Wang, E., & Yuan, J. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.995567 · Cited by 7
The Mechanism of Important Components in Canine Fecal Microbiota Transplantation
Li, K., Yang, J., Zhou, X., Wang, H., Ren, Y., Huang, Y., Liu, H., Zhong, Z., Peng, G., Zheng, C., et al. (2022) · Veterinary Sciences · doi:10.3390/vetsci9120695 · Cited by 11
Encapsulation protocol for fecal microbiota transplantation
Sipos, D., Varga, A., Kappéter, Á., Halda-Kiss, B., Kása, P., Pál, S., Kocsis, B., & Péterfi, Z. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1424376 · Cited by 8
The need to move away from fecal transplant towards targeted, refined microbiome therapy
Russell, L. A., Monaghan, T. M., & Kao, D. H. (2018) · Journal of Thoracic Disease · doi:10.21037/jtd.2018.09.80 · Cited by 7
He, J., Lange, J., Μαρίνος, Γ., Bathia, J., Harris, D. M. M., Soluch, R., Vaibhvi, V., Deines, P., Hassani, M. A., Wagner, K., et al. (2019) · BioEssays · doi:10.1002/bies.201900211 · Cited by 10
Microbiota modification in hematology: still at the bench or ready for the bedside?
Severyn, C. J., Brewster, R., & Andermann, T. M. (2019) · Hematology · doi:10.1182/hematology.2019000365 · Cited by 8
Diagnosing and engineering gut microbiomes
Barazzone, E. C., Diard, M., Hug, I., Larsson, L., & Slack, E. M. C. (2024) · EMBO Molecular Medicine · doi:10.1038/s44321-024-00149-4 · Cited by 7
Islam, J., Ohtani, N., Shimizu, Y., Tanimizu, M., Gotō, Y., Sato, M., Makino, E., Shimada, T., Ueda, C., Matsuo, A., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-79267-5 · Cited by 6
Yan, A., Butcher, J., Mack, D. R., & Stintzi, A. P. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2539450 · Cited by 6
Phage-Microbiota Interactions in the Gut: Implications for Health and Therapeutic Strategies
Naderian, R., Alibabaei, F., Paraandavaji, E., Dehghan, P., & Eslami, M. (2025) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-025-10784-z · Cited by 6
The gut-liver axis in animal diseases: roles, mechanisms, and veterinary clinical applications
Peng, F., Tang, S., Cui, Y., & Zeng, Y. (2026) · Frontiers in Veterinary Science · doi:10.3389/fvets.2026.1812064 · Cited by 6
Insights into the human gut virome by sampling a population from the Indian subcontinent
Bhardwaj, K., Garg, A., Pandey, A. D., Sharma, H., Kumar, M., & Vrati, S. (2022) · Journal of General Virology · doi:10.1099/jgv.0.001774 · Cited by 5
Fecal microbiota transfer to treat ulcerative colitis: Medical and legal challenges
Steube, A., Stallhofer, J., & Stallmach, A. (2023) · Frontiers in Gastroenterology · doi:10.3389/fgstr.2023.1161610 · Cited by 6
Dry alginate beads for fecal microbiota transplantation: From model strains to fecal samples
Rakotonirina, A., Galperine, T. K., Audry, M., Kroemer, M., Ballif, A., Carrez, L., Sadeghipour, F., Schrenzel, J., Guery, B. P., & Allémann, É. (2023) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2023.122961 · Cited by 6
Sintes, R., McLellan, P., Navelli, G., Landman, C., Delage, S., Truong, S., Benech, N., Kapel, N., Sabater, A. M., Schnuriger, A., et al. (2024) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00734-24 · Cited by 6
Human Gut Microbiome: A Potential Prospective to Counter Antibiotic-Resistant Pathogens
Yadav, M. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819265-8.00005-x · Cited by 6
Gibbons, J., Yoo, J. Y., Mutka, T., Groer, M. E., & Ho, T. T. B. (2021) · mSphere · doi:10.1128/msphere.00806-21 · Cited by 6
The intestinal virome: lessons from animal models
Chaffringeon, L., Lamy-Besnier, Q., Debarbieux, L., & Sordi, L. D. (2021) · Current Opinion in Virology · doi:10.1016/j.coviro.2021.09.016 · Cited by 7
Singh, A., Mahajan, R., Kahlon, B. K., Dhaliwal, A. S., Midha, V., Mehta, V., Bansal, N., Singh, D., & Sood, A. (2022) · Indian Journal of Gastroenterology · doi:10.1007/s12664-022-01257-0 · Cited by 6
van Lier, Y. F., Rolling, T., Armijo, G. K., Zhai, B., Haverkate, N. J. E., Meijer, E., Nur, E., Blom, B., Peled, J. U., van den Brink, M. R. M., et al. (2022) · Transplantation and Cellular Therapy · doi:10.1016/j.jtct.2022.10.011 · Cited by 6
Brüssow, H. (2023) · Microbiome Research Reports · doi:10.20517/mrr.2022.20 · Cited by 7
Stallmach, A., Grunert, P., Pieper, D. H., & Steube, A. (2019) · Zeitschrift für Gastroenterologie · doi:10.1055/a-0874-6603 · Cited by 6
Effect of Holder pasteurization and UV-C irradiation on bacteriophage titres in human milk
Stinson, L. F., Geddes, D. T., & Furfaro, L. L. (2023) · FEMS Microbiology Letters · doi:10.1093/femsle/fnad057 · Cited by 7
Jitsumura, M., Cunningham, A., Hitchings, M. D., Islam, S., Davies, A. P., Row, P. E., Riddell, A. D., Kinross, J. K., Wilkinson, T. S., Jenkins, G. J. S., et al. (2018) · BMJ Open · doi:10.1136/bmjopen-2018-021987 · Cited by 6
Lopes, B. C., Turck, J. L., Tolbert, M. K., Giaretta, P. R., Suchodolski, J. S., & Pilla, R. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1502452 · Cited by 5
Le, J., Hakimjavadi, H., Parsana, R., Chamala, S., & Michail, S. K. (2025) · Gastro Hep Advances · doi:10.1016/j.gastha.2025.100741 · Cited by 6
Kenneth, M. J., Chen, J., Fang, C., Tsai, H., Wu, C., Hsu, T.-K., Chen, C., & Hsu, B. (2025) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2025.107585 · Cited by 6
Fecal microbiota transplantation: from empirical remedy to precision medicine
Zhao, J., 樊翌明, Yang, K., & Gao, H. (2026) · Frontiers in Microbiomes · doi:10.3389/frmbi.2026.1863308 · Cited by 6
Li, Y., Wang, K., Shen, D., Liu, J., Li, S., Liu, L., Nagaoka, K., & Li, C. (2024) · Journal of Animal Science · doi:10.1093/jas/skae388 · Cited by 6
Current Approaches to Treat and Prevent Recurrence of Clostridioides difficile
Ressler, A. M., Rao, K., & Young, V. B. (2025) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2025.02.005 · Cited by 5
Rook, G. A. W. (2021) · Advances in environmental microbiology · doi:10.1007/978-3-030-63512-1_18 · Cited by 5
Dwaib, H. S., AlZaim, I., Ajouz, G., Eid, A. H., & EL‐Yazbi, A. F. (2021) · Molecular Pharmacology · doi:10.1124/molpharm.121.000338 · Cited by 5
Environmentally Acquired Bacillus and Their Role in C. difficile Colonization Resistance
Ferreira, W. T., Hong, H. A., Adams, J. R. G., Hess, M., Kotowicz, N. K., Tan, S., Ferrari, E., Brisson, A. R., Zentek, J., Soloviev, M., et al. (2022) · Biomedicines · doi:10.3390/biomedicines10050930 · Cited by 5
Effects of early postnatal gastric and colonic microbiota transplantation on piglet gut health
Larsen, C., Offersen, S. M., Brunse, A., Pirolo, M., Kar, S. K., Guadabassi, L., & Thymann, T. (2023) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-023-00954-w · Cited by 5
Reproducible chemostat cultures to minimize eukaryotic viruses from fecal transplant material
Adamberg, S., Rasmussen, T. S., Larsen, S. B., Mao, X., Nielsen, D. S., & Adamberg, K. (2024) · iScience · doi:10.1016/j.isci.2024.110460 · Cited by 8
Hidden players: the bacteria-killing viruses of the gut microbiome
King, A. (2024) · Nature · doi:10.1038/d41586-024-03532-w · Cited by 5
Gut microbiome in hematopoietic stem cell transplantation: patient- and treatment-related factors
Goloshchapov, O. V., Kucher, М. A., & Чухловин, А. Б. (2018) · Cellular Therapy and Transplantation · doi:10.18620/ctt-1866-8836-2018-7-4-16-28 · Cited by 5
Towards a rational design of faecal transplant analogues
Larsen, O. F. A., Koning, A. H. J., van der Spek, P. J., & Claassen, E. (2019) · Scientific Reports · doi:10.1038/s41598-019-42043-x · Cited by 5
Phage Therapy for Alcohol‐Associated Hepatitis
Suh, G. A. (2020) · Hepatology · doi:10.1002/hep.31623 · Cited by 5
Manipulating the Microbiome: An Alternative Treatment for Bile Acid Diarrhoea
Hillman, E. B. M., Rijpkema, S. G. T., Carson, D., Arasaradnam, R. P., Wellington, E. M. H., & Amos, G. C. A. (2021) · Microbiology Research · doi:10.3390/microbiolres12020023 · Cited by 5
Li, Y., Cai, H., Sussman, D. A., Donet, J. A., Dholaria, K., Yang, J., Panara, A. J., Croteau, R., & Barkin, J. S. (2021) · Digestive Diseases and Sciences · doi:10.1007/s10620-021-07229-2 · Cited by 5
Bacteriophages in Therapeutics
Bhardwaj, S. B. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.90988 · Cited by 5
Fecal Microbiota Transplantation
Borody, T. J. (2019) · Elsevier eBooks · doi:10.1016/b978-0-323-54843-4.00018-0 · Cited by 7
Stadlbauer, V. (2023) · Journal of Personalized Medicine · doi:10.3390/jpm13020220 · Cited by 6
Prevention and treatment of C. difficile in cancer patients
Puerta‐Alcalde, P., García‐Vidal, C., & Soriano, À. (2023) · Current Opinion in Infectious Diseases · doi:10.1097/qco.0000000000000954 · Cited by 5
Lin, D. M., & Lin, H. C. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.95469 · Cited by 5
Faecal microbiota transplantation: past, present and future
Brandt, L. J. (2017) · The Medical Journal of Australia · doi:10.5694/mja17.00372 · Cited by 5
Viral Dark Matter in the Gut Virome of Elderly HumansPreprint
Stockdale, S. R., Ryan, F. J., McCann, A., Dalmasso, M., Ross, R. P., & Hill, C. (2018) · Preprints.org · doi:10.20944/preprints201807.0128.v1 · Cited by 5
Mao, X., Larsen, S. B., Zachariassen, L. F., Brunse, A., Adamberg, S., Castro-Mejía, J. L., Larsen, F., Adamberg, K., Nielsen, D. S., Hansen, A. K., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.03.20.532903 · Cited by 5
Validation methods for encapsulated faecal microbiota transplantation: a scoping review
Rågård, N., Baunwall, S. M. D., Paaske, S. E., Hansen, M. M., Høyer, K. L., Mikkelsen, S., Erikstrup, C., Dahlerup, J. F., & Hvas, C. L. (2025) · Therapeutic Advances in Gastroenterology · doi:10.1177/17562848251314820 · Cited by 4
Spiegelhauer, M. R., Offersen, S. M., Krych, Ł., Nielsen, D. S., Gambino, M., Brunse, A., & Nguyen, D. N. (2025) · Future Virology · doi:10.1080/17460794.2025.2497647 · Cited by 4
Colica, C., & Vecchio, I. (2025) · Microbial Pathogenesis · doi:10.1016/j.micpath.2025.108213 · Cited by 8
Commensal enteric virome regulates intestinal carbohydrate digestion and absorption
Lin, F., Li, L., He, Y., Xu, S., Mo, Q., Cao, W., Fu, A., & Li, W. (2026) · Cell Host & Microbe · doi:10.1016/j.chom.2026.01.019 · Cited by 8
Not just passengers: Phages as agents of genetic exchange in fecal microbiota transplantation
Pastor, B. G., Shkoporov, A. N., & Hill, C. (2026) · Cell Host & Microbe · doi:10.1016/j.chom.2026.03.017 · Cited by 4
Signal Versus Noise: How to Analyze the Microbiome and Make Progress on Antimicrobial Resistance
Golob, J. L., & Rao, K. K. (2021) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiab184 · Cited by 4
Fäkaler Mikrobiomtransfer – Indikationen, Risiken und Chancen
Stallmach, A., Steube, A., Stallhofer, J., Grunert, P., Merkel, U., & Hartmann, M. (2022) · Die Innere Medizin · doi:10.1007/s00108-022-01399-5 · Cited by 4
Comparing In Vitro Faecal Fermentation Methods as Surrogates for Phage Therapy Application
Ács, N., Holohan, R., Dunne, L. J., Fernandes, A. R., Clooney, A. G., Draper, L. A., Ross, R. P., & Hill, C. (2022) · Viruses · doi:10.3390/v14122632 · Cited by 4
Zhang, H., Dong, M., Zheng, J., Yang, Y., He, J., Liu, T., & Wei, H. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1343752 · Cited by 4
Gut microbiota dysbiosis: the hidden roles in human aging and age-related diseases
Zhan, Y., Su, W., & Liu, X. (2025) · Oral Science and Homeostatic Medicine · doi:10.26599/oshm.2025.9610012 · Cited by 4
General characteristics, results and prospects for the clinical application of bacteriophage therapy
Nacharov, P. V., Krivopalov, A. A., & Shustova, T. I. (2023) · Meditsinskiy sovet = Medical Council · doi:10.21518/ms2023-106 · Cited by 4
Fecal Transplant: The Benefits and Harms of Fecal Microbiota Transplantation
Goldenberg, D., & Melmed, G. (2023) · Springer eBooks · doi:10.1007/978-3-031-46712-7_9 · Cited by 4
Shah, S. C., Faith, J. J., & Colombel, J. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.06.081 · Cited by 4
Gut microbes as a therapeutic armory
Bhardwaj, N., & Geva‐Zatorsky, N. (2018) · Drug Discovery Today Disease Models · doi:10.1016/j.ddmod.2019.08.007 · Cited by 4
Rook, G. A. W. (2022) · Progress in inflammation research · doi:10.1007/978-3-030-91051-8_2 · Cited by 4
Molekulare Darmmikrobiomdiagnostik
Rosenstiel, P. C. (2017) · Die Gastroenterologie · doi:10.1007/s11377-016-0129-x · Cited by 4
Self-citationEmergencia de nuevos modelos industriales: Problemática del programa i internacional del GERPISA
Boyer, R., & Freyssenet, M. (1996) · Sociologia del trabajo/Sociología del trabajo · Cited by 4
Towards the Characterization and Engineering of Bacteriophages in the Gut Microbiome
Hsu, B. B. (2021) · mSystems · doi:10.1128/msystems.00735-21 · Cited by 4
Drivers and Determinants of Strain Dynamics Following Faecal Microbiota TransplantationPreprint
Schmidt, T., Li, S. S., Maistrenko, O. M., Akanni, W. A., Coelho, L. P., Dolai, S., Fullam, A., Glazek, A. M., Hercog, R., Herrema, H., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.09.30.462010 · Cited by 4
Reproducible chemostat cultures to eliminate eukaryotic viruses from fecal transplant materialPreprint
Adamberg, S., Rasmussen, T. S., Larsen, S. B., Mao, X., Nielsen, D. S., & Adamberg, K. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.03.15.529189 · Cited by 4
Junca, H., Steube, A., Mrowietz, S., Stallhofer, J., Vital, M., Borges, L. G. D. A., Pieper, D. H., & Stallmach, A. (2024) · ISME Communications · doi:10.1093/ismeco/ycae167 · Cited by 3
Xiao, L., Wu, X., Zang, W., Zhou, Z., Cui, W., Ying, C., & Yang, H. (2025) · Virulence · doi:10.1080/21505594.2025.2529454 · Cited by 5
Tools and approaches to study the human gut virome: from the bench to bioinformatics
Hallowell, H. A., Malogan, J., & Suez, J. (2026) · mSystems · doi:10.1128/msystems.01002-25 · Cited by 3
Metadata
- Authors
- Ott, S. J., Waetzig, G. H., Rehman, A., Moltzau-Anderson, J., Bharti, R., Grasis, J. A., Cassidy, L., Tholey, A., Fickenscher, H., Seegert, D., Rosenstiel, P., & Schreiber, S.
- Affiliations
- University Hospital Schleswig-Holstein (DE)
- Conaris (DE)
- Christian-Albrechts-Universität zu Kiel (DE)
- San Diego State University (US)
- Corresponding author
- Schreiber, Stefan
- ORCID
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2017-03
- Volume
- 152
- Issue
- 4
- Pages
- 799-811.e7
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W2550586225
- Cited by
- 695
- References
- 54
- Citations by year
- 2026: 37 · 2025: 64 · 2024: 83 · 2023: 73 · 2022: 85 · 2021: 96 · 2020: 65 · 2019: 82 · 2018: 69 · 2017: 38
- FWCI
- 58.44
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Gastroenterology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion, cc-by-nc-nd)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (CRC 1182)
- Exzellenzclusters Entzündungsforschung
- Topics
- Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- fecal microbiota transplantation, Clostridium difficile infection, recurrent Clostridium difficile infection, sterile filtration, bacteriophages, virome, microbiome, immunocompromised patients, bacterial community structure
- MeSH terms
- Gastrointestinal Microbiome, Fecal Microbiota Transplantation, Aged, Enterocolitis, Pseudomembranous, Female, Filtration, Humans, Male, Middle Aged, Recurrence, Sterilization, Clostridioides difficile, Proteome, Gastrointestinal Tract
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
