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Association of Liver Injury From Specific Drugs, or Groups of Drugs, With Polymorphisms in HLA and Other Genes in a Genome-Wide Association Study
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Several genetic studies have identified distinct HLA alleles as risk factors for specific drugs.
“Several genetic studies have also identified distinct human leukocyte antigen (HLA) alleles as risk factors for specific drugs.”
From Drug-induced liver injury. Part I: Classification, diagnosis and treatment (2025) · cites this paper as [31]
Pretreatment HLA testing will likely not prove useful in most circumstances to prevent DILI, but HLA testing may be helpful in DILI diagnosis and causality assessment.
“Therefore, pretreatment HLA testing will likely not prove useful in most circumstances to prevent DILI, but HLA testing may be helpful in DILI diagnosis and causality assessment [29-32].”
From Drug-induced liver injury. Part I: Classification, diagnosis and treatment (2025) · cites this paper as [31]
HLA-B*35:02 is associated with minocycline-induced DILI.
“HLA-B*57:01 is associated with flucloxacillin, HLA-B*35:02 with minocycline, and HLA-A*33:01 with terbinafine.”
From Drug-induced liver injury. Part I: Classification, diagnosis and treatment (2025) · cites this paper as [31]
HLA-B*57:01 is associated with flucloxacillin-induced DILI.
“HLA-B*57:01 is associated with flucloxacillin, HLA-B*35:02 with minocycline, and HLA-A*33:01 with terbinafine.”
From Drug-induced liver injury. Part I: Classification, diagnosis and treatment (2025) · cites this paper as [31]
HLA-A*33:01 is associated with terbinafine-induced DILI.
“HLA-B*57:01 is associated with flucloxacillin, HLA-B*35:02 with minocycline, and HLA-A*33:01 with terbinafine.”
From Drug-induced liver injury. Part I: Classification, diagnosis and treatment (2025) · cites this paper as [31]
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Cites
Principal components analysis corrects for stratification in genome-wide association studies
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Drug-Induced Acute Liver Failure: Results of a U.S. Multicenter, Prospective Study
Reuben, A., Koch, D. G., & Lee, W. M. (2010) · Hepatology · doi:10.1002/hep.23937 · Cited by 772
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Self-citationThe future of drug safety testing: expanding the view and narrowing the focus
Stevens, J. L., & Baker, T. K. (2009) · Drug Discovery Today · doi:10.1016/j.drudis.2008.11.009 · Cited by 286
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Metadata
- Authors
- Nicoletti, P., Aithal, G. P., Bjornsson, E. S., Andrade, R. J., Sawle, A., Arrese, M., Barnhart, H. X., Bondon-Guitton, E., Hayashi, P. H., Bessone, F., Carvajal, A., Cascorbi, I., Cirulli, E. T., Chalasani, N., Conforti, A., Coulthard, S. A., Daly, M. J., Day, C. P., Dillon, J. F., Fontana, R. J., Grove, J. I., Hallberg, P., Hernández, N., Ibáñez, L., Kullak-Ublick, G. A., Laitinen, T., Larrey, D., Lucena, M. I., Maitland-van der Zee, A. H., Martin, J. H., Molokhia, M., Pirmohamed, M., Powell, E. E., Qin, S., Serrano, J., Stephens, C., Stolz, A., Wadelius, M., Watkins, P. B., Floratos, A., Shen, Y., Nelson, M. R., Urban, T. J., & Daly, A. K.
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2017-04
- Volume
- 152
- Issue
- 5
- Pages
- 1078-1089
- ISSN
- 0016-5085
- PMC
- PMC5367948
- Cited by
- 221
- References
- 8
- Language
- en
- Licence
- Funders
- Merck
- Novartis
- Hjärt-Lungfonden (20120557)
- Amgen
- Pfizer
- GlaxoSmithKline
- Vetenskapsrådet (521-2011-2440)
- Instituto de Salud Carlos III
- Guy's and St Thomas' NHS Foundation Trust
- Svenska Läkaresällskapet (2008-21619)
- Indiana University (U01DK065193)
- National Institute for Health and Care Research
- Roche
- King's College London (EC08/00250)
- Sanofi
- University of Southern California (U01-DK100928)
- Duke University (U01-DK065201)
- University of Nottingham
- School of Medicine, CHA University (UL1 RR024986, UL1 RR025761, UL1 TR001111)
- Comisión Nacional de Investigación Científica y Tecnológica (PIA/Basal PFB12)
- Daiichi-Sankyo
- University of Texas Southwestern Medical Center (U01-DK083027)
- University of North Carolina (U01-DK065184)
- University of Michigan (U01-DK065211)
- University of Connecticut (U01-DK065238)
- University of North Carolina Wilmington
- Takeda Pharmaceutical Company
- Wellcome Trust
- Manchester Biomedical Research Centre
- Mayo Clinic (U01-DK083020)
- Abbott Laboratories
- European Regional Development Fund (FIS PI12/00378, P10-CTS-6470)
- National Institutes of Health (U01-DK065176)
- National Institute of Diabetes and Digestive and Kidney Diseases
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