CoChat
Sign Up
Cited by 223Hepatitis C virus researchAlcohol Consumption and Health EffectsLiver Disease Diagnosis and Treatment

The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.

Changing trends in etiology‐based annual mortality from chronic liver disease, from 2007 through 2016

Open access
Kim, Donghee, Li, Andrew A., Gadiparthi, Chiranjeevi, Khan, Muhammad Ali, Cholankeril, George, Glenn, Jeffrey S., Ahmed, Aijaz·2018·Gastroenterology
DOI 10.1053/j.gastro.2018.07.008PMC PMC6467699
Open this paper in CoChat — free account

Abstract

Background & aims Although treatment of hepatitis C virus (HCV) infection has improved, the prevalence of alcoholic liver disease (ALD) has been increasing, so we need an updated estimate of the burden and etiology-specific mortality of chronic liver diseases. We studied trends in age-standardized mortality of chronic liver diseases in adults at least 20 years old in the United States from 2007 through 2016.Methods We collected data from the US Census and National Center for Health Statistics mortality records and identified individuals with HCV infection, ALD, nonalcoholic fatty liver disease, or hepatitis B virus infection using ICD-10 codes. We obtained temporal mortality rate patterns using joinpoint trend analysis with estimates of annual percentage change (APC).Results Age-standardized HCV-related mortality increased from 7.17 per 100,000 persons in 2007 to 8.14 per 100,000 persons in 2013, followed by a marked decrease in the time period at which patients began receiving treatment with direct-acting antiviral agents (from 8.09 per 100,000 persons in 2014 to 7.15 per 100,000 persons in 2016). The APC in HCV mortality increased 2.0%/year from 2007 through 2014 but decreased 6.4%/year from 2014 through 2016. In contrast, age-standardized mortality increased for ALD (APC 2.3% from 2007 through 2013 and APC 5.5% from 2013 through 2016) and nonalcoholic fatty liver disease (APC 6.1% from 2007 through 2013 and APC 11.3% from 2013 through 2016). Mortality related to hepatitis B virus decreased steadily from 2007 through 2016, with an average APC of -2.1% (95% CI -3.0 to -1.2). Etiology-based mortality in minority populations was higher. HCV-related mortality (per 100,000 persons) was highest in non-Hispanic blacks (10.28) and whites (6.92), followed by Hispanics (5.94), and lowest in non-Hispanic Asians (2.33). Non-Hispanic Asians had higher mortality for hepatitis B virus infection (2.82 per 100,000 vs 1.02 for non-Hispanic blacks and 0.47 for non-Hispanic whites).Conclusion In our population-based analysis of chronic liver disease mortality in the United States, the decrease in HCV-related mortality coincided with the introduction of direct-acting antiviral therapies, whereas mortality from ALD and nonalcoholic fatty liver disease increased during the same period. Minorities in the United States have disproportionately higher mortality related to chronic liver disease.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1053/j.gastro.2018.07.008

Cites

38 of 38 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Flagged first, then by citations

Show all 38 references

Cited by

Sorted by citations

Items 101–200 of 223

Related

See all

Metadata

Authors
Kim, D., Li, A. A., Gadiparthi, C., Khan, M. A., Cholankeril, G., Glenn, J. S., & Ahmed, A.
Affiliations
  • Stanford Medicine (US)
  • University of Tennessee Health Science Center (US)
Corresponding author
Kim, Donghee
ORCID
Venue
Gastroenterology
Publisher
Elsevier BV
Published
2018-10
Volume
155
Issue
4
Pages
1154-1163.e3
ISSN
0016-5085 (ISSN-L)
DOI
10.1053/j.gastro.2018.07.008
PMC
PMC6467699
OpenAlex
W2884426912
Cited by
223
References
38
Citations by year
2026: 9 · 2025: 23 · 2024: 21 · 2023: 23 · 2022: 30 · 2021: 34 · 2020: 40 · 2019: 36 · 2018: 5
FWCI
18.01
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Gastroenterology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Diabetes and Digestive and Kidney Diseases (T32DK007056)
Topics
  • Health Sciences › Medicine › Hepatology › Hepatitis C virus research
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
  • Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
Keywords
chronic liver disease, hepatitis C virus, alcoholic liver disease, non-alcoholic fatty liver disease, hepatitis B virus, mortality trends, direct-acting antivirals, age-standardized mortality rates, racial and ethnic disparities, minority groups, mortality burden, annual percent change, ICD-10
MeSH terms
Adult, Antiviral Agents, Asian, Black or African American, Cause of Death, Female, Hispanic or Latino, Humans, Liver Diseases, Alcoholic, Male, Middle Aged, Risk Factors, Time Factors, United States, Prevalence, Age Distribution, Censuses, Hepatitis B, Chronic, Hepatitis C, Chronic, White People, Health Status Disparities, Young Adult, Non-alcoholic Fatty Liver Disease

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review