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Cited by 554

The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.

Effects of Organized Colorectal Cancer Screening on Cancer Incidence and Mortality in a Large Community-Based Population

Open access
Levin, Theodore R., Corley, Douglas A., Jensen, Christopher D., Schottinger, Joanne E., Quinn, Virginia P., Zauber, Ann G., Lee, Jeffrey K., Zhao, Wei K., Udaltsova, Natalia, Ghai, Nirupa R., Lee, Alexander T., Quesenberry, Charles P., Fireman, Bruce H., Doubeni, Chyke A.·2018·Gastroenterology
DOI 10.1053/j.gastro.2018.07.017
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Abstract

Background & Aims: Little information is available on the effectiveness of organized colorectal cancer (CRC) screening on screening uptake, incidence, and mortality in community-based populations. Methods: We contrasted screening rates, age-adjusted annual CRC incidence, and incidence-based mortality rates before (baseline year 2000) and after (through 2015) implementation of organized screening outreach, from 2007 through 2008 (primarily annual fecal immunochemical testing and colonoscopy), in a large, community-based population. Among screening-eligible individuals 51–75 years old, we calculated annual up to date status for cancer screening (by fecal test, sigmoidoscopy, or colonoscopy), CRC incidence, cancer stage distributions, and incidence-based mortality. Results: Initiation of organized CRC screening significantly increased the up to date status of screening, from 38.9% in 2000 to 82.7% in 2015 (P<.01). Higher rates of screening were associated with a 25.5% reduction in annual CRC incidence between 2000 and 2015, from 95.8 to 71.4 cases/100,000 (P<.01), and a 52.4% reduction in cancer mortality, from 30.9 to 14.7 deaths/100,000 (P<.01). Increased screening was initially associated with increased CRC incidence, largely due to greater detection of early-stage cancers, followed by decreases in cancer incidence. Advanced-stage CRC incidence rates decreased 36.2%, from 45.9 to 29.3 cases/100,000 (P<.01), and early-stage CRC incidence rates decreased 14.5%, from 48.2 to 41.2 cases/100,000 (P<.04). Conclusions: Implementing an organized CRC screening program in a large, community-based population rapidly increased screening participation to the ≥80% target set by national organizations. Screening rates were sustainable and associated with substantial decreases in CRC incidence and mortality within short time intervals, consistent with early detection and cancer prevention.

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Metadata

Authors
Levin, T. R., Corley, D. A., Jensen, C. D., Schottinger, J. E., Quinn, V. P., Zauber, A. G., Lee, J. K., Zhao, W. K., Udaltsova, N., Ghai, N. R., Lee, A. T., Quesenberry, C. P., Fireman, B. H., & Doubeni, C. A.
Venue
Gastroenterology
Publisher
Elsevier BV
Published
2018-11
Volume
155
Issue
5
Pages
1383-1391.e5
ISSN
0016-5085 (ISSN-L)
DOI
10.1053/j.gastro.2018.07.017
OpenAlex
W2883374138
Cited by
554
References
60
FWCI
17.36
Type
journal article
Language
en
Open access
bronze

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The paper
Levin, T. R., Corley, D. A., Jensen, C. D., Schottinger, J. E., Quinn, V. P., Zauber, A. G., Lee, J. K., Zhao, W. K., Udaltsova, N., Ghai, N. R., Lee, A. T., Quesenberry, C. P., Fireman, B. H., & Doubeni, C. A. (2018). Effects of Organized Colorectal Cancer Screening on Cancer Incidence and Mortality in a Large Community-Based Population. Gastroenterology. https://doi.org/10.1053/j.gastro.2018.07.017

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.