Serologic response to Helicobacter pylori proteins associated with risk of colorectal cancer among diverse populations in the United States
Open accessAbstract
Background & aims Previous studies reported an association of the bacteria Helicobacter pylori, the primary cause of gastric cancer, and risk of colorectal cancer (CRC). However, these findings have been inconsistent, appear to vary with population characteristics, and may be specific for virulence factor VacA. To more thoroughly evaluate the potential association of H pylori antibodies with CRC risk, we assembled a large consortium of cohorts representing diverse populations in the United States.Methods We used H pylori multiplex serologic assays to analyze serum samples from 4063 incident cases of CRC, collected before diagnosis, and 4063 matched individuals without CRC (controls) from 10 prospective cohorts for antibody responses to 13 H pylori proteins, including virulence factors VacA and CagA. The association of seropositivity to H pylori proteins, as well as protein-specific antibody level, with odds of CRC was determined by conditional logistic regression.Results Overall, 40% of controls and 41% of cases were H pylori-seropositive (odds ratio [OR], 1.09; 95% CI, 0.99-1.20). H pylori VacA-specific seropositivity was associated with an 11% increased odds of CRC (OR, 1.11; 95% CI, 1.01-1.22), and this association was particularly strong among African Americans (OR, 1.45; 95% CI, 1.08-1.95). Additionally, odds of CRC increased with level of VacA antibody in the overall cohort (P = .008) and specifically among African Americans (P = .007).Conclusions In an analysis of a large consortium of cohorts representing diverse populations, we found serologic responses to H pylori VacA to associate with increased risk of CRC risk, particularly for African Americans. Future studies should seek to understand whether this marker is related to virulent H pylori strains carried in these populations.
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Epidemiology studies associated a serologic response to Helicobacter pylori with increased colorectal cancer risk among African Americans.
“Moreover, epidemiology studies associated a serologic response to Helicobacter pylori with increased risk of CRC among African Americans.71”
From Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer (2020) · cites this paper as [71]
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Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer
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Self-citation
- Authors
- Butt, J., Varga, M. G., Blot, W. J., Teras, L., Visvanathan, K., Le Marchand, L., Haiman, C., Chen, Y., Bao, Y., Sesso, H. D., Wassertheil-Smoller, S., Ho, G. Y. F., Tinker, L. E., Peek, R. M., Potter, J. D., Cover, T. L., Hendrix, L. H., Huang, L.-C., Hyslop, T., Um, C., Grodstein, F., Song, M., Zeleniuch-Jacquotte, A., Berndt, S., Hildesheim, A., Waterboer, T., Pawlita, M., & Epplein, M.
- Affiliations
- Duke University (US)
- University of North Carolina at Chapel Hill (US)
- Vanderbilt University Medical Center (US)
- American Cancer Society (US)
- Johns Hopkins University (US)
- University of Southern California (US)
- New York University (US)
- Brigham and Women's Hospital (US)
- Albert Einstein College of Medicine (US)
- Northwell Health (US)
- Fred Hutch Cancer Center (US)
- VA Tennessee Valley Healthcare System (US)
- Harvard University (US)
- National Institutes of Health (US)
- German Cancer Research Center (DE)
- Corresponding author
- Epplein, Meira
- ORCID
- Butt, Julia
- Varga, Matthew G.
- Blot, William J.
- Teras, Lauren
- Visvanathan, Kala
- Haiman, Christopher
- Chen, Yu
- Bao, Ying
- Sesso, Howard D.
- Wassertheil-Smoller, Sylvia
- Ho, Gloria Y.F.
- Peek, Richard M.
- Potter, John D.
- Cover, Timothy L.
- Huang, Li-Ching
- Hyslop, Terry
- Um, Caroline
- Grodstein, Francine
- Song, Mingyang
- Berndt, Sonja
- Hildesheim, Allan
- Waterboer, Tim
- Pawlita, Michael
- Epplein, Meira
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2019-01
- Volume
- 156
- Issue
- 1
- Pages
- 175-186.e2
- ISSN
- 0016-5085 (ISSN-L)
- PMC
- PMC6309494
- OpenAlex
- W2894700038
- Cited by
- 114
- References
- 41
- Citations by year
- 2026: 8 · 2025: 11 · 2024: 14 · 2023: 14 · 2022: 12 · 2021: 18 · 2020: 21 · 2019: 16
- FWCI
- 14.30
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- The National Cancer Institute (R01 CA190428)
- Southern Community Cohort Study (U01 CA202979)
- New York University Women’s Health Study (UM1 CA182934)
- Nurses’ Health Study/Health Professionals Follow-Up Study (U01 CA167552, P01 CA087969, UM1 CA186107, UM1 CA167552)
- Physicians’ Health Study (R01 CA097193, R01 CA040360, R01 HL034595)
- Multiethnic Cohort Study (U01 CA164973)
- National Institutes of Health (R01 AI039657, R01 AI118932, P01 CA116087)
- Department of Veterans Affairs (BX000627)
- American Cancer Society (MRSG-17-220-01–NEC)
- American Association for Cancer Research-AstraZeneca Fellowship in Immuno-oncology Research (17-40-12-SONG)
- National Heart, Lung, and Blood Institute
- NOH
- US Department of Health and Human Services (HHSN268201600018C, HHSN268201600001C, HHSN268201600002C, HHSN268201600003C, HHSN268201600004C)
- Joint Initiative for Innovation and Research of the German Helmholtz Association
- Topics
- Health Sciences › Medicine › Surgery › Helicobacter pylori-related gastroenterology studies
- Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
- Health Sciences › Medicine › Oncology › Colorectal Cancer Screening and Detection
- Keywords
- Helicobacter pylori, colorectal cancer, VacA, CagA, seropositivity, antibody levels, African Americans, cancer risk, virulence factors
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Antibodies, Bacterial, Bacterial Proteins, Female, Humans, Male, Middle Aged, Prospective Studies, Risk Factors, United States, Virulence, Colorectal Neoplasms, Biomarkers, Incidence, Case-Control Studies, Seroepidemiologic Studies, Helicobacter pylori, Helicobacter Infections, Host-Pathogen Interactions, Young Adult
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