Mechanisms, Evaluation, and Management of Chronic Constipation

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Items 601–654 of 654

1. Herb Pair of Aurantii Fructus Immaturus–Atractylodis Macrocephalae Rhizoma Alleviates Slow‐Transit Constipation in Rats by Regulating Mitophagy and Modulating Gut Microbiota
   Yahui Wang, Shuguang Zhen, Mingming Sun, Lianlin Su, Shuai Yan · 2026 · Neurogastroenterology & Motility
2. Therapeutic Effects of Shengdu Pingmu Formula on Loperamide-Induced Constipation in Rats via PI3K/AKT Signaling and Gut Microbiota Regulation
   Beibei Wang, Fanglan Li, Haoyang Chen, Ruijie Dai, Lingzhi Chen, Xiangdong Zhao, Weilin Li · 2026 · Journal of Visualized Experiments
3. Changes in bowel-movement frequency, gut microbiota, and emotional issues in postoperative constipation patients
   Chen Ye, Yilong Wang, Yunkun Liu, Wanyong Zhu, Mingming Dai, Le Wang, Yan Xu, Li Li, Zhongchen Liu, Ling Ni et al. · 2026 · Gastroenterology report
4. Kaempferol in Jichuan decoction alleviates slow-transit constipation by attenuating oxidative stress-induced interstitial cells of Cajal apoptosis: A network pharmacological study
   Jun Fu, Qiuyuan Yao, Yan Joann Zhou, Fuming Feng, Xuyan Zhou, Yan Huang, Shen Huang · 2026 · Journal of Chromatography B
5. Efficacy of biofeedback therapy for chronic constipation in adults: a systematic review and meta-analysis of randomized controlled trials
   Yuyuan Tu, Zihao Zhou, Yuanlin Li, Ziyan He, Defu Liao, Boyu Li, Boyu Li, 周祖刚, Shuangchun Ai · 2026 · Frontiers in Medicine
6. Patients Perceive Straining as Burdensome Despite Limited Perceived Benefit in Constipation
   Prashant Raj Bhatt, Shoon Lei Oo, Bharathan Radhakrishnan, Theo Hutt, Yuying Luo, Laurie Keefer, Sonia Grego, Miranda A.L. van Tilburg · 2026 · Research Square
7. Clinical, social, and motility factors influencing transanal irrigation response in pediatric patients
   Stephanie Sutton, Amanda L. Willis, Juliana Ramirez, Xiang Zhu, Roberto A. Gomez‐Suarez · 2026 · Journal of Pediatric Gastroenterology and Nutrition
8. Management of constipation: A narrative review of evolving strategies and methodological challenges
   Manjeet Kumar Goyal, Gayatri Brahmandam, Rishi Chowdhary, sowmya durga subhasri guna, Dhruvi Shah, Prerna Goyal, Ashita Rukmini Vuthaluru, Omesh Goyal · 2026 · World Journal of Methodology
9. A Multicenter, Sham-Controlled, Pilot, Randomized Controlled Trial of Interferential Therapy for the Treatment of Chronic Constipation
   Jenna Clukey, Joseph J. Locascio, Jack R. Semler, Yogi Patel, James C. Makous, Ashok Attaluri, Braden Kuo, Kyle D. Staller · 2026 · Journal of Clinical Gastroenterology
10. Polygonatum sibiricum combined with Poria cocos prevents spleen deficiency constipation via the gut microbiota–mediated brain–gut axis
    Menghui She, Xianqing Sun, 谭周进 · 2026 · Frontiers in Pharmacology
11. Postpartum Pelvic Floor Dysfunction and Subsequent Anorectal Symptoms: A Cohor t Study Based on Routine Postpartum Screening
    Yang Shi, Hui Tao, Qian Gu, Jing Xiang · 2026 · Research Square
12. Management of Common GI Presentations in the Hospitalized Older Adult
    Calley Levine, Evan B. Grossman, Alec Chang, David W. Wan · 2026 · Current Treatment Options in Gastroenterology
13. USO DA CORRENTE INTERFERENCIAL EM MULHERES CONSTIPADAS
    Cibbele da Silva Mendonça, Silvana Maria de Macêdo Uchôa · 2026 · Aracê.
14. BIN1 and ALDH1B1 Deficiency in Colonic Smooth Muscle Drives Mitochondrial Dysfunction and Fibrosis in Slow‐Transit Constipation
    Jianbo Liu, Haitao Zhang, Wenhao Qiao, Ran Liu, Jie Sun, Xiaopei Li, Qi Li, Dongbo Zhao, DJ Chen, Jingxin Li et al. · 2026 · Advanced Science
15. Efficacy of different dietary fibers for chronic idiopathic constipation: a systematic review and network meta-analysis.
    Jian-Jiao Mou, Lian-Lin Zeng, Yang-an Li, Meng Sun, Qian-Long Li, Ke-Hui Hu, Qiong Wang · 2026 · Food & Function
16. Tea and digestive system health: integrating gut microbiota-involved ADME and personalized nutrition for gastrointestinal disorders intervention
    Rongbosen Yue, Yuqi Wen, Sibo Zhao, Xijia Liu, Liyong Luo, Yan Liu, Liang Zeng · 2026 · Critical Reviews in Food Science and Nutrition
17. Twenty-Five Years of Pathophysiology-Based Surgery of Slow-Transit Constipation: Outcomes After Segmental, Subtotal and Total Colectomy
    Gennaro Melone, Paolo Luffarelli, Ludovico Carbone, Chiara Cascone, Natale Calomino, Marzio Angelo Zullo, Valter Ripetti · 2026 · Journal of Clinical Medicine
18. Constipation with bloating: a clinical approach to evaluation and management
    David J. Cangemi, Adam P. Laitman, Orit Faiman, Bianca W Chang · 2026 · Annals medicus
19. Dispelling myths and misconceptions of constipation with a focus on stimulant laxatives
    Brian E. Lacy, Darren M. Brenner, Jordi Serra, Daniel Pohl, Viola Andresen, Alexia Aran · 2026 · Frontline Gastroenterology
20. Shouhui Tongbian Capsules alleviate constipation by modulating the gut microbiota–tryptophan metabolism–AhR signaling axis: a mechanistic study
    Y Y Liang, Yang Zhang, Yu Shi, Qimeng Zhang, Hongxi Zhang · 2026 · Frontiers in Microbiology
21. The acute effects of abdominal massage on arterial stiffness, muscle oxygenation, and exercise capacity in patients with chronic constipation
    Betül Yoleri, Musa Güneş, Ramazan Kozan, Elif Sıla KARAVELİ, Merve BAYRAK, Zeyneb Süeda KALEDİBİ, Meral Boşnak Güçlü · 2026 · Journal of Bodywork and Movement Therapies
22. EEFC-Net for disease classification based on resting-state functional connectivity: Application in the detection of functional constipation
    Xiaoyu Wu, Yu Xiang, Feng Liu, Yiming Li, C C, Yi Ji, Chao Wang, Zi Wang, Xiaomeng Fan, 郑霏霏 · 2026 · Biomedical Signal Processing and Control
23. Fecal microbiota transplantation for chronic constipation following bowel surgery in an elderly patient: A case report
    De-Xiang Liao, Xicheng Zhang, Ding Cao, Xun Cai, Huiling Sun, Wei-Dong Jin, Tao Fu · 2026 · Medicine
24. An inulin from Asparagus cochinchinensis relieves slow transit constipation associated with Akkermansia muciniphila enrichment, kynurenic acid restoration, and NLRP3 attenuation
    Fangxu Yin, ZiYing Jiang, Chong Hou, Jie Gao, Wenqiang Li, Wei Sun, Yikui Tian, Dina Xie, Mingyue Wang, Bo Wang et al. · 2026 · Carbohydrate Polymers
25. Symptom Overlap Stratifies Prokinetic Response in Functional Dyspepsia: A Real‐World Multicenter Study of 1297 Chinese Patients
    Dan Zhou, Tao Bai, Jie Chen, Doneke Wang, Jinsong Liu, Xiaohua Hou · 2026 · JGH Open
26. Colon Capsule Endoscopy-Measured Colonic Transit Time Is Associated with Frailty in Older Adults
    K. Nakaji, Mitsutaka Kumamoto, Y. Nakae · 2026 · Medicina
27. Selected Problems of Aging
    Archana M. Kudrimoti · 2026 · Springer eBooks
28. Pancreatic mu opioid receptors regulate metabolism and ingestive behaviors
    Diego De Gregorio, Daniel C. Castro · 2026 · Physiology & Behavior
29. Gut microbiota and constipation: from causal evidence to therapeutic strategies—a state-of-the-art narrative review
    Yi Chen, Wenqian Duan, Mengdie Du, Miaomiao Guo, Yongshun Sun · 2026 · Frontiers in Microbiology
30. Prevalence and biopsychosocial associations of functional constipation: a cross-sectional study among adults in Türkiye
    Cansu Memiç İnan, Emre Duman, Eren Canbolat, Ayşe Nur SONGÜR BOZDAĞ, Mustafa Çapraz · 2026 · BMC Gastroenterology
31. MaZiRenWan alleviates slow-transit constipation in rats: an integrated network pharmacology and experimental study
    Wei Xie, Zhigang He, Fangdong Kong, Hai He · 2026 · Next research.
32. Mechanistic insights into Cistanche deserticola aqueous extract in alleviating functional constipation: Integration of gut microbiota remodeling and focal adhesion-associated mucosal repair
    Jiangshan Hu, Xuran Ma, Yifei Wang, Lu Liu, Meng Tang, Xiao Tian, Haibin Liu, Yan Gao, Jing Lv · 2026 · Journal of Ethnopharmacology
33. Shugan Tongbian Decoction ameliorates constipation and mental disorder by inhibiting UPRmt via Wnt/Retromer axis
    Jiali Liu, Dehao Wang, Hongxia Mi, Sihang Chen, Yanting Cao, Guanlu Li, Yunzhi Qian, Haihua Qian, Dan Zhang · 2026 · Journal of Ethnopharmacology
34. Distinct enteric nervous system pattern in obstructed defecation syndrome and slow-transit constipation: a controlled digital pathology study
    Tillmann Bedau, Aryan Mirzaie-Kuzehgarani, Joshy Madukkakuzhy, Luisa Halbe, Alexander Quaas, Claudia Rudroff · 2026 · International Journal of Colorectal Disease
35. Bioactive components of medicinal-food homology substances alleviating constipation via gut microbiota modulation: a review
    Xinyuan Zhao, Yishan Song, Jiahui Zhu, Binghua Ma, Dong Liang, Zheng Xu, Yuhao Ma · 2026 · Frontiers in Pharmacology
36. Aspergillus oryzae fermentation modifies the composition of Massa Medicata Fermentata and its effects on the gut microbiota in mice with spleen-deficiency constipation
    Xianqing Sun, Qin He, Liwen Li, 谭周进, Xuejuan Liang · 2026 · Frontiers in Microbiology
37. Subtotal colectomy with antiperistaltic caecorectal anastomosis versus total colectomy with ileorectal anastomosis for refractory slow-transit constipation: a comparative analysis
    Ugo Grossi, Alice Pecorino, Sayali Valiyeva, Nicola Passuello, Carla Felice, Matteo Fassan, Emanuela Tessari, Luca Faccio, Antonio Rella, Renato Pietroletti et al. · 2026 · Updates in Surgery
38. Acteoside alleviates slow transit constipation with attenuation of NLRP3 inflammasome activation and preservation of enteric neurons
    Baohong Zhao, Yaqian Ping, Xiaohui Dou, Ziying Jiang, Fangxu Yin, Daqing Sun · 2026 · Frontiers in Pharmacology
39. Accuracy and Readability of Large Language Models in Addressing Constipation-Related Questions: A Comparative Study (Preprint)
    Yi Chen, Muyaseer Aishan, Jie Zhang, Shurong Chen, Yu Li, Nan Wang, Qin Huang, Chunxiao Li · 2026
40. Meclizine
    W. Roth · 2026 · Elsevier eBooks
41. The Intersection of Diabetes and Gastrointestinal Health: A Narrative Review
    Sina Hemmati Bi’aragh, Reza Afsahi, Ali Ebrahimi Nasab, Mahan Khani, Kimia Rasouli, Mehdi Hassani Ahangar, Abbas Sarvari Soltani, Ramtin Pourahmad · 2026 · SN Comprehensive Clinical Medicine
42. Association Between Health-Related Quality of Life and Ultrasound-Based Transverse Rectal Diameter in Pediatric Functional Constipation
    Pola Waissman, Shimon Reif, Yaniv Nudelman, Michael Wilschanski, Shmuel Springer, Mordechai Slae · 2026 · Children
43. Dysbiosis Testing and Chronic Intestinal Inflammation
    Moien Khan, Godfrey Grech, Nadiya Boyko · 2026 · Advances in predictive, preventive and personalised medicine
44. Pediococcus acidilactici PA53 Supplementation Improves Stool Form and Modulates Gut Microbiota and Inflammatory Responses in Adults With Functional Constipation: A Randomized, Double‐Blind, Placebo‐Controlled Trial
    Yuhan Xia, Yongmei Cai, Yongwei Zhang, Rui Cai, Hanshu Liu, Zhiwen Qiang · 2026 · Food Science & Nutrition
45. Shared genetic architecture between constipation and aging-related phenotypes
    Yixuan Liao, Wei Liu, Xiaojin Liu, Yingying Xiao · 2026 · Medicine
46. Clinical Outcomes of Peripheral Magnetic Stimulation in Patients with Functional Defecation Disorders
    Wenxuan Ma, Chengjing Feng, Manman Fan, Wenqing Gu, Caiyun Peng, Min Ni · 2026 · Healthcare
47. Mendelian randomization of gut microbiota and exploratory testing of preventive effect of commercial Rothia mucilaginosa in constipated mice
    Peishi Jiang, 杨小清, 张城浩, Yuwei Li, Chen Xu · 2026 · Frontiers in Microbiology
48. Effectiveness of self-administered acupressure intervention in managing constipation of adult psychiatric out-patient – a pilot study
    Wai Kit Wong, Oi Yin Jessica Wong, Ching Chuen Law, King Leong Wong, Yuen Ling Man, Tak Shing Chun, Sek Lim Leong, Wai Ming Lee, Alex Chan, Ng Ka Yan et al. · 2026 · International Journal of Nursing Studies Advances
49. Polygonatum cyrtonema Polysaccharide Ameliorates Functional Constipation in Mice via the Gut Microbiota–Pentadecanoic Acid–GPR40 Axis
    Xiaoying Liu, Zhongyu Zhang, Yuanyuan Fang, Beixin Yuan, Huilong Lian, Wenxin Yin, Jinming Zhang, Qin Yuan, Shengpeng Wang · 2026 · Journal of Agricultural and Food Chemistry
50. Gut relief revisited: plecanatide in chronic idiopathic constipation and irritable bowel syndrome with constipation — a systematic review and meta-analysis with GRADE assessment
    Menna M. Aboelkhier, Ibrahim Suleiman Elnaggar, Nourhan Yasser Elsamahy, Fatima Breim, Alaa A. Youssef, Ahmed Reda Alsayed · 2026 · BMC Gastroenterology
51. BindingDB Entry 50023560: Novel gut-restricted bivalent agonists targeting mucosal 5-HT4R: Design, synthesis, and biological evaluation.
    BindingDB · 2026 · UC San Diego
52. Overlooked and Undertreated: National Shortfalls in Anorectal Evaluation for Gastroparesis-Associated Constipation and Defecatory Disorders
    Mohamed H. Eldesouki, Eslam Mohammed Rabea, EzzElDien A. Ibrahim, Tareq Alsaleh, Mohamed Elzayat, Muhammad M. Elsharkawy, Swapna Gayam, Amol Sharma · 2026 · Digestive Diseases and Sciences
53. Irritable bowel syndrome and related disorders of gut–brain interaction
    Christopher J. Black, Kee Huat Chuah, Yasmin Nasser, José María Remes-Troche, Andrea Shin, Alexander Charles Ford · 2026 · The Lancet
54. Pelvic floor magnetic stimulation combined with biofeedback-based electrical stimulation for obstructed defecation syndrome: a retrospective cohort study
    Kun Tang, Run Zhang, Kuiling Wang, Rui Ding, Wenhui Liu, Er-Juan Wang, Li Ming · 2026 · Frontiers in Medicine