The DOI matches its Crossref record; 78 of the 79 references it cites were found in a registry or an index.
An Update on the Epidemiology, Molecular Characterization, Diagnosis, and Screening Strategies for Early-Onset Colorectal Cancer
Open accessAbstract
Rising trends in the incidence and mortality of early-onset CRC in those who are ages less than 50 years have been well-established. These trends have spurred intense investigation focused on elucidating the epidemiology and characteristics of early-onset CRC, as well on identifying strategies for early detection and prevention. In this review, we provide a contemporary update on early-onset CRC with a particular focus on epidemiology, molecular characterization, red flag signs and symptoms, and screening for early-onset CRC.
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“Currently, two strategies are used for CRC screening: (1) Screening based on preliminary determination of risk factors, which allows selecting patients for further examination; and (2) Population screening based on a large-scale examination of individuals in a certain population using epidemiological methods[21].”
From Risk factors, prevention and screening of colorectal cancer: A rising problem (2025) · cites this paper as [21]
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Colorectal cancer statistics, 2020
Siegel, R. L., Miller, K. D., Sauer, A. G., Fedewa, S. A., Butterly, L. F., Anderson, J. C., Cercek, A., Smith, R. A., & Jemal, A. (2020) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21601 · Cited by 5,080
Role of nrf2 in oxidative stress and toxicity
Ma, Q. (2013) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-011112-140320 · Cited by 4,903
The repertoire of mutational signatures in human cancer
Alexandrov, L. B., Kim, J., Haradhvala, N. J., Huang, M. N., Tian Ng, A. W., Wu, Y., Boot, A., Covington, K. R., Gordenin, D. A., Bergstrom, E. N., et al. (2020) · Nature · doi:10.1038/s41586-020-1943-3 · Cited by 3,496
Weisenberger, D. J., Siegmund, K. D., Campan, M., Young, J. P., Long, T. I., Faasse, M. A., Kang, G. H., Widschwendter, M., Weener, D., Buchanan, D. D., et al. (2006) · Nature Genetics · doi:10.1038/ng1834 · Cited by 1,990
Wolf, A. M. D., Fontham, E. T. H., Church, T. R., Flowers, C. R., Guerra, C. E., LaMonte, S. J., Etzioni, R., McKenna, M. T., Oeffinger, K. C., Shih, Y. T., et al. (2018) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21457 · Cited by 1,944
Bailey, C. E., Hu, C., You, Y. N., Bednarski, B. K., Rodrı́guez-Bigas, M. A., Skibber, J. M., Cantor, S. B., & Chang, G. J. (2014) · JAMA Surgery · doi:10.1001/jamasurg.2014.1756 · Cited by 1,081
Global patterns and trends in colorectal cancer incidence in young adults
Siegel, R. L., Torre, L. A., Soerjomataram, I., Hayes, R. B., Bray, F., Weber, T. K., & Jemal, A. (2019) · Gut · doi:10.1136/gutjnl-2019-319511 · Cited by 979
Pearlman, R., Frankel, W. L., Swanson, B. J., Zhao, W., Yılmaz, A. U., Miller, K., Bacher, J., Bigley, C. J., Nelsen, L., Goodfellow, P. J., et al. (2016) · JAMA Oncology · doi:10.1001/jamaoncol.2016.5194 · Cited by 722
Epidemiology and Mechanisms of the Increasing Incidence of Colon and Rectal Cancers in Young Adults
Stoffel, E. M., & Murphy, C. C. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.07.055 · Cited by 679
Early‐onset colorectal cancer in young individuals
Mauri, G., Bianchi, A. S., Russo, A. G., Marsoni, S., Bardelli, A., & Siena, S. (2018) · Molecular Oncology · doi:10.1002/1878-0261.12417 · Cited by 653
Cited by
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Patel, S. G., Karlitz, J. J., Yen, T., Lieu, C. H., & Boland, C. R. (2022) · The Lancet Gastroenterology & Hepatology · doi:10.1016/s2468-1253(21)00426-x · Cited by 812
Li, N., Lu, B., Luo, C., Cai, J., Lu, M., Zhang, Y., Chen, H., & Dai, M. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.09.034 · Cited by 447
Tong, H., Jiang, Z., Song, L., Tan, K., Yin, X., He, C., Huang, J., Li, X., Jing, X., Hong, Y., et al. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.10.019 · Cited by 180
Early-Onset Cancer in the Gastrointestinal Tract Is on the Rise—Evidence and Implications
Ben‐Aharon, I., van Laarhoven, H. W. M., Fontana, E., Obermannova, R. L., Nilsson, M., & Lordick, F. (2023) · Cancer Discovery · doi:10.1158/2159-8290.cd-22-1038 · Cited by 171
Delphi Initiative for Early-Onset Colorectal Cancer (DIRECt) International Management Guidelines
Cavestro, G. M., Mannucci, A., Balaguer, F., Hampel, H., Kupfer, S. S., Repici, A., Bianchi, A. S., Seppälä, T. T., Valentini, V., Boland, C. R., et al. (2022) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2022.12.006 · Cited by 151
Metadata
- Authors
- Burnett-Hartman, A. N., Lee, J. K., Demb, J., & Gupta, S.
- Affiliations
- Kaiser Permanente (US)
- University of California San Diego (US)
- Corresponding author
- Lee, Jeffrey K.
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2021-03
- Volume
- 160
- Issue
- 4
- Pages
- 1041-1049
- ISSN
- 0016-5085 (ISSN-L)
- PMC
- PMC8273929
- OpenAlex
- W3119321686
- Semantic Scholar
- 8244c2b40e175dc72040bb05f875308e37bfb4c4
- Cited by
- 298
- References
- 79
- Citations by year
- 2026: 27 · 2025: 60 · 2024: 88 · 2023: 71 · 2022: 43 · 2021: 9
- FWCI
- 6.39
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Cancer Institute (U24 CA 221936, R01 CA196337)
- Topics
- Health Sciences › Medicine › Oncology › Colorectal Cancer Screening and Detection
- Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
- Health Sciences › Medicine › Oncology › Colorectal Cancer Surgical Treatments
- Keywords
- early-onset colorectal cancer, colorectal cancer incidence, molecular characterization, colorectal cancer screening, early detection, cancer prevention, young adults
- MeSH terms
- Humans, Mass Screening, Risk Factors, Triage, Biomarkers, Tumor, Colorectal Neoplasms, Practice Guidelines as Topic, Age of Onset, Microsatellite Instability, Early Detection of Cancer, Precision Medicine
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