Cited by 298Colorectal Cancer Screening and DetectionGenetic factors in colorectal cancerColorectal Cancer Surgical Treatments

The DOI matches its Crossref record; 78 of the 79 references it cites were found in a registry or an index.

An Update on the Epidemiology, Molecular Characterization, Diagnosis, and Screening Strategies for Early-Onset Colorectal Cancer

Open access

Burnett-Hartman, Andrea N., Lee, Jeffrey K., Demb, Joshua, Gupta, Samir·2021·Gastroenterology

DOI 10.1053/j.gastro.2020.12.068PMC PMC8273929

Open this paper in CoChat — free account

Abstract

Rising trends in the incidence and mortality of early-onset CRC in those who are ages less than 50 years have been well-established. These trends have spurred intense investigation focused on elucidating the epidemiology and characteristics of early-onset CRC, as well on identifying strategies for early detection and prevention. In this review, we provide a contemporary update on early-onset CRC with a particular focus on epidemiology, molecular characterization, red flag signs and symptoms, and screening for early-onset CRC.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1053/j.gastro.2020.12.068

Cites

78 of 78 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Colorectal cancer statistics, 2020
Siegel, R. L., Miller, K. D., Sauer, A. G., Fedewa, S. A., Butterly, L. F., Anderson, J. C., Cercek, A., Smith, R. A., & Jemal, A. (2020) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21601 · Cited by 5,080
Role of nrf2 in oxidative stress and toxicity
Ma, Q. (2013) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-011112-140320 · Cited by 4,903
The repertoire of mutational signatures in human cancer
Alexandrov, L. B., Kim, J., Haradhvala, N. J., Huang, M. N., Tian Ng, A. W., Wu, Y., Boot, A., Covington, K. R., Gordenin, D. A., Bergstrom, E. N., et al. (2020) · Nature · doi:10.1038/s41586-020-1943-3 · Cited by 3,496
CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer
Weisenberger, D. J., Siegmund, K. D., Campan, M., Young, J. P., Long, T. I., Faasse, M. A., Kang, G. H., Widschwendter, M., Weener, D., Buchanan, D. D., et al. (2006) · Nature Genetics · doi:10.1038/ng1834 · Cited by 1,990
Colorectal cancer screening for average‐risk adults: 2018 guideline update from the American Cancer Society
Wolf, A. M. D., Fontham, E. T. H., Church, T. R., Flowers, C. R., Guerra, C. E., LaMonte, S. J., Etzioni, R., McKenna, M. T., Oeffinger, K. C., Shih, Y. T., et al. (2018) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21457 · Cited by 1,944
Increasing Disparities in the Age-Related Incidences of Colon and Rectal Cancers in the United States, 1975-2010
Bailey, C. E., Hu, C., You, Y. N., Bednarski, B. K., Rodrı́guez-Bigas, M. A., Skibber, J. M., Cantor, S. B., & Chang, G. J. (2014) · JAMA Surgery · doi:10.1001/jamasurg.2014.1756 · Cited by 1,081
Global patterns and trends in colorectal cancer incidence in young adults
Siegel, R. L., Torre, L. A., Soerjomataram, I., Hayes, R. B., Bray, F., Weber, T. K., & Jemal, A. (2019) · Gut · doi:10.1136/gutjnl-2019-319511 · Cited by 979
Prevalence and Spectrum of Germline Cancer Susceptibility Gene Mutations Among Patients With Early-Onset Colorectal Cancer
Pearlman, R., Frankel, W. L., Swanson, B. J., Zhao, W., Yılmaz, A. U., Miller, K., Bacher, J., Bigley, C. J., Nelsen, L., Goodfellow, P. J., et al. (2016) · JAMA Oncology · doi:10.1001/jamaoncol.2016.5194 · Cited by 722
Epidemiology and Mechanisms of the Increasing Incidence of Colon and Rectal Cancers in Young Adults
Stoffel, E. M., & Murphy, C. C. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.07.055 · Cited by 679
Early‐onset colorectal cancer in young individuals
Mauri, G., Bianchi, A. S., Russo, A. G., Marsoni, S., Bardelli, A., & Siena, S. (2018) · Molecular Oncology · doi:10.1002/1878-0261.12417 · Cited by 653

Show all 79 references

Sorted by citations

The rising tide of early-onset colorectal cancer: a comprehensive review of epidemiology, clinical features, biology, risk factors, prevention, and early detection
Patel, S. G., Karlitz, J. J., Yen, T., Lieu, C. H., & Boland, C. R. (2022) · The Lancet Gastroenterology & Hepatology · doi:10.1016/s2468-1253(21)00426-x · Cited by 812
Incidence, mortality, survival, risk factor and screening of colorectal cancer: A comparison among China, Europe, and northern America
Li, N., Lu, B., Luo, C., Cai, J., Lu, M., Zhang, Y., Chen, H., & Dai, M. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.09.034 · Cited by 447
Dual impacts of serine/glycine-free diet in enhancing antitumor immunity and promoting evasion via PD-L1 lactylation
Tong, H., Jiang, Z., Song, L., Tan, K., Yin, X., He, C., Huang, J., Li, X., Jing, X., Hong, Y., et al. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.10.019 · Cited by 180
Early-Onset Cancer in the Gastrointestinal Tract Is on the Rise—Evidence and Implications
Ben‐Aharon, I., van Laarhoven, H. W. M., Fontana, E., Obermannova, R. L., Nilsson, M., & Lordick, F. (2023) · Cancer Discovery · doi:10.1158/2159-8290.cd-22-1038 · Cited by 171
Delphi Initiative for Early-Onset Colorectal Cancer (DIRECt) International Management Guidelines
Cavestro, G. M., Mannucci, A., Balaguer, F., Hampel, H., Kupfer, S. S., Repici, A., Bianchi, A. S., Seppälä, T. T., Valentini, V., Boland, C. R., et al. (2022) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2022.12.006 · Cited by 151
Cause, Epidemiology, and Histology of Polyps and Pathways to Colorectal Cancer
Sullivan, B. A., Noujaim, M. G., & Roper, J. (2022) · Gastrointestinal Endoscopy Clinics of North America · doi:10.1016/j.giec.2021.12.001 · Cited by 152
Colorectal Cancer: Current Updates and Future Perspectives
Marcellinaro, R., Spoletini, D., Grieco, M., Avella, P., Cappuccio, M., Troiano, R., Lisi, G., Garbarino, G. M., & Carlini, M. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm13010040 · Cited by 154
The association between the body roundness index and the risk of colorectal cancer: a cross-sectional study
Gao, W., Jin, L., Li, D., Zhang, Y., Zhao, W., Zhao, Y., Gao, J., Zhou, L., Chen, P., & Dong, G. (2023) · Lipids in Health and Disease · doi:10.1186/s12944-023-01814-2 · Cited by 107
Short-chain fatty acid concentrations in the incidence and risk-stratification of colorectal cancer: a systematic review and meta-analysis
Alvandi, E., Wong, W. K. M., Joglekar, M. V., Spring, K. J., & Hardikar, A. A. (2022) · BMC Medicine · doi:10.1186/s12916-022-02529-4 · Cited by 101
Nanomaterials-based photosensitizers and delivery systems for photodynamic cancer therapy
Yu, X., Sui, S., Yuxuan, H., Yu, C., & Peng, Q. (2022) · Biomaterials Advances · doi:10.1016/j.bioadv.2022.212725 · Cited by 105
Alterations in the Gut Microbiota and Their Metabolites in Colorectal Cancer: Recent Progress and Future Prospects
Li, J., Zhang, A., Wu, F., & Wang, X. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.841552 · Cited by 99
Red Flag Signs and Symptoms for Patients With Early-Onset Colorectal Cancer
Demb, J., Kolb, J. M., Dounel, J., Fritz, C. D. L., Advani, S., Cao, Y., Coppernoll-Blach, P., Dwyer, A. J., Perea, J., Heskett, K. M., et al. (2024) · JAMA Network Open · doi:10.1001/jamanetworkopen.2024.13157 · Cited by 92
Self-citation
Red-flag signs and symptoms for earlier diagnosis of early-onset colorectal cancer
Fritz, C. D. L., Otegbeye, E. E., Zong, X., Demb, J., Nickel, K. B., Olsen, M. A. A., Mutch, M. G., Davidson, N., Gupta, S., & Cao, Y. (2023) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djad068 · Cited by 87
Self-citation
Early-Onset Colorectal Cancer: Current Insights
Ullah, F., Pillai, A. B., Omar, N., Dima, D., & Harichand, S. (2023) · Cancers · doi:10.3390/cancers15123202 · Cited by 91
Evolving landscape of colorectal cancer: Global and regional burden, risk factor dynamics, and future scenarios (the Global Burden of Disease 1990–2050)
Zhou, J., Yang, Q., Zhao, S., Sun, L., Li, R., Wang, J., Wang, L., & Wang, L. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102666 · Cited by 91
Integrated multi-omics approach to distinct molecular characterization and classification of early-onset colorectal cancer
Du, M., Gu, D., Xin, J., Peters, U., Song, M., Cai, G., Li, S., Ben, S., Meng, Y., Chu, H., et al. (2023) · Cell Reports Medicine · doi:10.1016/j.xcrm.2023.100974 · Cited by 81
A Liquid Biopsy Signature for the Detection of Patients With Early-Onset Colorectal Cancer
Nakamura, K., Hernández, G., Sharma, G. G., Wada, Y., Banwait, J. K., González, N., Perea, J., Balaguer, F., Takamaru, H., Saito, Y., et al. (2022) · Gastroenterology · doi:10.1053/j.gastro.2022.06.089 · Cited by 75
Birth Cohort Colorectal Cancer (CRC): Implications for Research and Practice
Gupta, S. N., May, F. P., Kupfer, S. S., & Murphy, C. C. (2023) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2023.11.040 · Cited by 84
Self-citation
Disease Burden of Total and Early-Onset Colorectal Cancer in China from 1990 to 2019 and Predictions of Cancer Incidence and Mortality
Shao, B., Zhu, M., Shen, K., Luo, L., Du, P., Li, J., Xu, J., Deng, Y., Lin, N., Wu, J., et al. (2023) · Clinical Epidemiology · doi:10.2147/clep.s391058 · Cited by 50
Burden of early-onset colorectal cancer along with attributable risk factors from 1990 to 2019: a comparative study between China and other G20 countries
Li, Q., Yu, M., Lv, H., Zhang, L., Deng, Y., & Yu, H. (2023) · BMC Public Health · doi:10.1186/s12889-023-16407-y · Cited by 48
The multispecies microbial cluster of Fusobacterium , Parvimonas , Bacteroides and Faecalibacterium as a precision biomarker for colorectal cancer diagnosis
Conde‐Pérez, K., Aja‐Macaya, P., Buetas, E., Trigo‐Tasende, N., Nasser‐Ali, M., Rumbo‐Feal, S., Nión, P., Arribas, E. M., Estévez, L. S., Otero‐Alén, B., et al. (2024) · Molecular Oncology · doi:10.1002/1878-0261.13604 · Cited by 44
Risk factors, prevention and screening of colorectal cancer: A rising problem
Tsukanov, V. V., Vasyutin, A. V., & Tonkikh, J. L. (2025) · World Journal of Gastroenterology · doi:10.3748/wjg.v31.i5.98629 · Cited by 42
Cancer in Patients With Familial Adenomatous Polyposis: A Nationwide Danish Cohort Study With Matched Controls
Karstensen, J. G., Bülow, S., Højen, H., Jelsig, A. M., Jespersen, N., Andersen, K. K., Wewer, M. D., Burisch, J. M., & Pommergaard, H. (2023) · Gastroenterology · doi:10.1053/j.gastro.2023.05.010 · Cited by 39
Molecular Mechanisms of the Antitumor Effects of Mesalazine and Its Preventive Potential in Colorectal Cancer
Słoka, J., Madej, M., & Strzałka‐Mrozik, B. (2023) · Molecules · doi:10.3390/molecules28135081 · Cited by 38
Early Onset Metastatic Colorectal Cancer: Current Insights and Clinical Management of a Rising Condition
Medici, B., Riccò, B., Caffari, E., Zaniboni, S., Salati, M., Spallanzani, A., Garajová, I., Benatti, S., Chiavelli, C., Dominici, M., et al. (2023) · Cancers · doi:10.3390/cancers15133509 · Cited by 43
Dual miRNA-Triggered DNA Walker Assisted by APE1 for Specific Recognition of Tumor Cells
Zhou, Q., Li, T., Li, X., Wei, L.-T., Luo, J., Bai, L., Duan, W., Xie, B., Sun, B., Chen, J.-X., et al. (2024) · Analytical Chemistry · doi:10.1021/acs.analchem.4c00554 · Cited by 38
A panel of platelet-associated circulating long non-coding RNAs as potential biomarkers for colorectal cancer
Ye, B., Li, F., Chen, M., Weng, Y., Qi, C., Xie, Y., Zhang, Q., Ding, H., Zhang, J., & Gao, X. (2021) · Genomics · doi:10.1016/j.ygeno.2021.11.026 · Cited by 35
KCTD9 inhibits the Wnt/β-catenin pathway by decreasing the level of β-catenin in colorectal cancer
Yao, H., Ren, D., Wang, Y., Wu, L., Wu, Y., Wang, W., Li, Q., & Liu, L. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-05200-1 · Cited by 33
Mobile App–Based Lifestyle Coaching Intervention for Patients With Nonalcoholic Fatty Liver Disease: Randomized Controlled Trial
Kwon, O. Y., Lee, M. K., Lee, H. W., Kim, H., Lee, J. S., & Jang, Y. (2024) · Journal of Medical Internet Research · doi:10.2196/49839 · Cited by 32
Self-citation
Comorbidity Patterns in Patients Newly Diagnosed With Colorectal Cancer: Network-Based Study
Qiu, H., Wang, L., Zhou, L., & Wang, X. (2023) · JMIR Public Health and Surveillance · doi:10.2196/41999 · Cited by 30
Clinicopathologic characteristics of early-onset colorectal cancer
Park, K. S., Hong, Y. K., Choi, Y. J., & Kang, J. G. (2022) · Annals of Coloproctology · doi:10.3393/ac.2021.00976.0139 · Cited by 29
Increasing Colorectal Cancer Incidence Before and After Age 50: Implications for Screening Initiation and Promotion of “On-Time” Screening
Cho, M. Y., Siegel, D. A., Demb, J., Richardson, L. C., & Gupta, S. N. (2021) · Digestive Diseases and Sciences · doi:10.1007/s10620-021-07213-w · Cited by 28
Self-citation
Global incidence trends of early-onset colorectal cancer and related exposures in early-life: an ecological analysis based on the GBD 2019
Wang, Z., Yao, W., Wu, W., Huang, J., Ma, Y., Yang, C., Shi, J., Fu, J., Wang, Y., Wong, M. C. S., et al. (2024) · Frontiers in Public Health · doi:10.3389/fpubh.2024.1367818 · Cited by 27
Lactylation as a metabolic epigenetic modification: Mechanistic insights and regulatory pathways from cells to organs and diseases
Chen, C., Wang, J., Zhu, X., Zhang, S., Yuan, X., Hu, J., Liu, C., Liu, L., Zhang, Z., & Li, J. (2025) · Metabolism · doi:10.1016/j.metabol.2025.156289 · Cited by 31
Serum 25-Hydroxyvitamin D Levels and Risk of Colorectal Cancer: An Age-Stratified Analysis
Kim, Y., Chang, Y., Cho, Y., Chang, J., Kim, K., Park, D. I., Park, S., Joh, H., Kim, M. K., Kim, C., et al. (2023) · Gastroenterology · doi:10.1053/j.gastro.2023.06.029 · Cited by 26
Alternative splicing of HSPA12A pre‐RNA by SRSF11 contributes to metastasis potential of colorectal cancer
Pan, Y., Huo, F., Kang, M., Liu, B., Wu, M., & Pei, D. (2022) · Clinical and Translational Medicine · doi:10.1002/ctm2.1113 · Cited by 25
Oxymatrine Synergistically Enhances Doxorubicin Anticancer Effects in Colorectal Cancer
Pan, D., Zhang, W., Zhang, N., Xu, Y., Chen, Y., Peng, J., Chen, Y., Zhang, Y., & Shen, X. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.673432 · Cited by 24
LoC-SERS platform for rapid and sensitive detection of colorectal cancer protein biomarkers
Cao, X., Liu, Z., Qin, X., Gu, Y., Huang, Y. C., Qian, Y., Wang, Z., Li, H., Zhu, Q., & Wei, W. (2023) · Talanta · doi:10.1016/j.talanta.2023.125563 · Cited by 24
Global, region and national trends and age-period-cohort effects in colorectal cancer burden from 1990 to 2019, with predictions to 2039
Hu, S., Li, Y., Zhu, W., Liu, J., & Wei, S. (2023) · Environmental Science and Pollution Research · doi:10.1007/s11356-023-28223-3 · Cited by 21
Risk of Colorectal Cancer in Patients With Irritable Bowel Syndrome: A Meta-Analysis of Population-Based Observational Studies
Wu, X., Wang, J., Ye, Z., Wang, J., Liao, X., Liv, M., & Svn, Z. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.819122 · Cited by 22
c-MYC and HIF1α promoter G-quadruplexes dependent metabolic regulation mechanism of berberine in colon cancer
Wen, L., Han, Z., Li, J., & Du, Y. (2022) · Journal of Gastrointestinal Oncology · doi:10.21037/jgo-22-389 · Cited by 22
Identification of specific susceptibility loci for the early-onset colorectal cancer
Wang, H., Cai, Y., Jin, M., Huang, C. Q., Ning, C., Niu, S., Fan, L., Li, B., Zhang, M., Lu, Z., et al. (2023) · Genome Medicine · doi:10.1186/s13073-023-01163-w · Cited by 26
Genome-wide polygenic risk scores for colorectal cancer have implications for risk-based screening
Tamlander, M., Jermy, B. S., Seppälä, T. T., Färkkilä, M. A., FinnGen, Widén, E., Ripatti, S., & Mars, N. (2024) · British Journal of Cancer · doi:10.1038/s41416-023-02536-z · Cited by 25
Irritable bowel syndrome – controversies in diagnosis and management
Duncanson, K., Tikhe, D., Williams, G. M., & Talley, N. J. (2023) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2023.2223975 · Cited by 21
Global, regional, and national burden of early-onset colorectal cancer and projection to 2050: An analysis based on the Global Burden of Disease Study 2021
Li, X., Xiao, X., Wu, Z., Li, A., Wang, W., & Lin, R. (2024) · Public Health · doi:10.1016/j.puhe.2024.12.011 · Cited by 21
Food-derived bioactive peptides as emerging therapeutic agents: Unlocking novel strategies for colorectal cancer treatment
Chen, C., Xia, P., Gan, Y., Zheng, X., Yang, P., Shi, A., Liu, X., Zhang, J., Yu, P., & Zhang, D. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107819 · Cited by 21
MIL-100(Fe)-based Co-delivery platform as cascade synergistic chemotherapy and immunotherapy agents for colorectal cancer via the cGAS-STING pathway
Wang, P., Liu, H., Guo, L., Tang, Y., Lan, T., Zhou, R., Xu, H., Wang, L., Wang, X., Chen, J., et al. (2025) · Acta Biomaterialia · doi:10.1016/j.actbio.2025.08.021 · Cited by 22
Developing a RiskScore Model based on Angiogenesis-related lncRNAs for Colon Adenocarcinoma Prognostic Prediction
Li, X., Lei, J., Shi, Y., Peng, Z., Gong, M., & Shu, X. (2023) · Current Medicinal Chemistry · doi:10.2174/0109298673277243231108071620 · Cited by 21
Association of changes in obesity and abdominal obesity status with early-onset colorectal cancer risk: a nationwide population-based cohort study
Song, J. H., Seo, J. Y., Jin, E. H., Chung, G. E., Kim, Y. S., Bae, J. H., Kim, S., Han, K., & Yang, S. Y. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2023.1208489 · Cited by 23
Machine-Learning-Based Bibliometric Analysis of Pancreatic Cancer Research Over the Past 25 Years
Wang, K., & Herr, I. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.832385 · Cited by 20
Low neighborhood socioeconomic status is associated with poor outcomes in young adults with colorectal cancer
Ko, T. M., Laraia, K. N., Alexander, H. R., Ecker, B. L., Grandhi, M. S., Kennedy, T. J., In, H., Langan, R. C., Pitt, H. A., Stroup, A. M., et al. (2024) · Surgery · doi:10.1016/j.surg.2024.05.031 · Cited by 18
Colorectal Cancer Screening and Management in Low- and Middle-Income Countries and High-Income Countries: A Narrative Review
Lopez, B. A. A., Pinto-Colmenarez, R., Caliwag, F. M. C., Ponce-Lujan, L., Madera, M. D. F., Cortés, A. V. G., Martínez, A. G. M., Martinez, I. G. Z., & León, F. G. (2024) · Cureus · doi:10.7759/cureus.70933 · Cited by 20
Trends, global comparisons, and projections of early onset colorectal cancer burden in China based on GBD study 2021
Ong, S., Xu, L., Deng, X., Lu, H., & Xu, T. (2025) · Scientific Reports · doi:10.1038/s41598-025-87730-0 · Cited by 18
Age-related variations in colon and rectal cancer: An analysis of the national cancer database
Gefen, R., Emile, S. H., Horesh, N., Garoufalia, Z., & Wexner, S. D. (2023) · Surgery · doi:10.1016/j.surg.2023.08.007 · Cited by 18
Causal relationship of sugar-sweetened and sweet beverages with colorectal cancer: a Mendelian randomization study
Liu, C., Zheng, S., Gao, H., Yuan, X., Zhang, Z., Xie, J., Yu, C., & Xu, L. (2022) · European Journal of Nutrition · doi:10.1007/s00394-022-02993-x · Cited by 18
Multilevel analysis of social determinants of advanced stage colorectal cancer diagnosis
Dantas, A. A. G., de Oliveira, N. P. D., Costa, G. A. B., Martins, L. F. L., dos Santos, J. E. M., Migowski, A., Cancela, M. D. C., & de Souza, D. L. B. (2024) · Scientific Reports · doi:10.1038/s41598-024-60449-0 · Cited by 17
CCDC113 promotes colorectal cancer tumorigenesis and metastasis via TGF-β signaling pathway
Hou, C., Yang, Y., Wang, P., Xie, H., Jin, S., Zhao, L., Wu, G., Xing, H., Chen, H., Liu, B., et al. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-07036-3 · Cited by 17
Global burden of early-onset colorectal cancer among people aged 40–49 years from 1990 to 2019 and predictions to 2030
Tang, X., Peng, J., Huang, S., Xu, H., Wang, P., Jiang, J., Zhang, W., Shi, X., Shi, L., Zhong, X., et al. (2023) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-023-05395-6 · Cited by 15
Stigma, colorectal cancer knowledge and self-efficacy among colorectal cancer survivors: A cross-sectional study based on random forest analysis
Mi, B., Jin, Y., Zheng, M., Cheng, H., & Zhang, J. (2025) · European Journal of Oncology Nursing · doi:10.1016/j.ejon.2025.102858 · Cited by 14
Biological and clinical implications of early-onset cancers: A unique subtype
He, T., Li, J., Xu, Z., Chen, Q., Yin, H., Pu, N., Wang, W., & Liu, L. (2023) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2023.104120 · Cited by 15
Mortality‐to‐incidence ratio of early‐onset colorectal cancer in high‐income Asian and Middle Eastern countries: A systemic analysis of the Global Burden of Diseases Study 2019
Ramadan, M. M., Alsiary, R., & Aboalola, D. A. (2023) · Cancer Medicine · doi:10.1002/cam4.6631 · Cited by 14
Association between metabolic syndrome and early-stage colorectal cancer
Zhang, C., Zhang, L., Tian, Y., Guan, B., & Li, S. (2023) · BMC Cancer · doi:10.1186/s12885-023-11537-3 · Cited by 14
CXCL10Expression in Human Colorectal Cancer Tissue and its Correlation With Serum Levels of CXCL10
Li, L., Kanemitsu, K., Ohnishi, K., Yamada, R., Yano, H., Fujiwara, Y., Miyamoto, Y., Mikami, Y., Hibi, T., Baba, H., et al. (2023) · Cancer Genomics & Proteomics · doi:10.21873/cgp.20429 · Cited by 14
Serum IGFBP-1 as a promising diagnostic and prognostic biomarker for colorectal cancer
Huang, B.-L., Wei, L., Lin, Y.-W., Huang, L., Qu, Q.-Q., Li, X.-H., Chu, L., Xu, Y., Wang, W., Peng, Y., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-52220-2 · Cited by 14
Effective Delivery of siRNA-Loaded Nanoparticles for Overcoming Oxaliplatin Resistance in Colorectal Cancer
Zhou, Y., Zhang, Q., Wang, M., Huang, C., & Yao, X. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.827891 · Cited by 14
Consumption of Yoghurt and Other Dairy Products and Risk of Colorectal Cancer in Iran: The IROPICAN Study
Collatuzzo, G., Seyyedsalehi, M. S., Rezaeianzadeh, A., Marzban, M., Rashidian, H., Hadji, M., Kamangar, F., Etemadi, A., Pukkala, ., Zendehdel, K., et al. (2022) · Nutrients · doi:10.3390/nu14122506 · Cited by 14
Epidemiological trends of early-onset gastrointestinal cancers from 1990 to 2021 and predictions for 2036: analysis from the global burden of disease study 2021
Gong, Y.-Q., Lu, C.-J., Xiao, Y.-R., Zhang, J., Xu, Z., Li, J., & Huang, W.-F. (2025) · Annals of Medicine · doi:10.1080/07853890.2025.2555518 · Cited by 14
Long Non-Coding RNAs ASB16-AS1 and AFAP1-AS1: Diagnostic, Prognostic Impact and Survival Analysis in Colorectal Cancer
Elabd, N. S., Soliman, S. E.-S., Elhamouly, M. S., Gohar, S. F., Elgamal, A., Alabassy, M. M., Soliman, H. A., Gadallah, A.-N. A.-A., Elbahr, O. D., Soliman, G. M., et al. (2022) · The Application of Clinical Genetics · doi:10.2147/tacg.s370242 · Cited by 13
The clinical impacts of postoperative complications after colon cancer surgery for the clinical course of adjuvant treatment and survival
Aoyama, T., Oba, K., Honda, M., Muto, M., Mayanagi, S., Maeda, H., Kanda, M., Kashiwabara, K., Sakamoto, J., & Yoshikawa, T. (2023) · International Journal of Clinical Oncology · doi:10.1007/s10147-023-02332-y · Cited by 13
Neoadjuvant chemotherapy is noninferior to chemoradiotherapy for early-onset locally advanced rectal cancer in the FOWARC trial
Cai, J., Lin, K., Luo, T., Weng, J., Liu, H., Yuan, Z., Wan, Z., Han, J., Lin, J., Liu, X., et al. (2024) · British Journal of Cancer · doi:10.1038/s41416-024-02652-4 · Cited by 13
Comparison of the short‐ and long‐term prognosis of early‐onset colorectal cancer compared with later‐onset colorectal cancer: A systematic review and meta‐analysis
Jin, T., Li, X., Ji, J., Li, J., Yin, X., Xu, K. L., Wang, W., Zhang, W., Xu, X., Hu, Z., et al. (2023) · Health Science Reports · doi:10.1002/hsr2.1307 · Cited by 13
Early‐onset colorectal cancer: why it should be high on our list of differentials
Garrett, C., Steffens, D., Solomon, M. J., & Koh, C. (2022) · ANZ Journal of Surgery · doi:10.1111/ans.17698 · Cited by 12
Oxidative imbalance increases the risk for colonic polyp and colorectal cancer development
Tsounis, D., Villiotou, V., Melpidou, A., Pantsiou, C., Argyrou, A., Giannopoulou, C., Grigoratou, A., Rontogianni, D. P., Mantzaris, G. J., & Papatheodoridis, G. (2022) · World Journal of Gastrointestinal Oncology · doi:10.4251/wjgo.v14.i11.2208 · Cited by 12
Types of DNA damage and research progress
Liu, N., Li, X., Rongcheng, L., & Song-Bai, L. (2023) · Nucleosides Nucleotides & Nucleic Acids · doi:10.1080/15257770.2023.2277194 · Cited by 13
CD24-Targeted NIR-II Fluorescence Imaging Enables Early Detection of Colorectal Neoplasia
Guo, X., Luo, S., Wang, X., Cui, Y., Li, M., Zhang, Z., Fu, L., Cao, C., Shi, X., Liu, H., et al. (2024) · Cancer Research · doi:10.1158/0008-5472.can-24-0012 · Cited by 12
The construction of a novel ferroptosis-related lncRNA model to predict prognosis in colorectal cancer patients
Chen, W., Deng, J., & Zhou, Y. (2023) · Medicine · doi:10.1097/md.0000000000033114 · Cited by 11
Colorectal cancer pre-diagnostic symptoms are associated with anatomic cancer site
Briggs, N. L., Ton, M., Malen, R. C., Reedy, A. M., Cohen, S. A., Phipps, A. I., Burnett‐Hartman, A. N., & Newcomb, P. A. (2024) · BMC Gastroenterology · doi:10.1186/s12876-024-03152-8 · Cited by 14
Self-citation
Identification of enterotype and its predictive value for patients with colorectal cancer
Li, Q., Jing, Z., Zhanbo, Q., Chu, J., Yifei, S., Wu, Y., & Han, S. (2024) · Gut Pathogens · doi:10.1186/s13099-024-00606-y · Cited by 12
Multiclassification of Colorectal Polyps from Colonoscopy Images Using AI for Early Diagnosis
Selvaraj, J., Sadaf, K., Aslam, S. M., & Umapathy, S. (2025) · Diagnostics · doi:10.3390/diagnostics15101285 · Cited by 12
Early onset metastatic colorectal cancer in patients receiving panitumumab‐based upfront strategy: Overall and sex‐specific outcomes in the Valentino trial
Raimondi, A., Randon, G., Prisciandaro, M., Pagani, F., Lonardi, S., Antoniotti, C., Bozzarelli, S., Bianchi, A. S., Tampellini, M., Fanchini, L., et al. (2022) · International Journal of Cancer · doi:10.1002/ijc.34156 · Cited by 11
Autophagy in gastrointestinal cancers
Shao, B., Chai, N., Yao, Y., Li, J., Law, H., & Linghu, E. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.975758 · Cited by 11
Risk of colorectal cancer by family history of both colorectal carcinomas and colorectal polyps: a nationwide cohort study
Hu, Y., Kharazmi, E., Liang, Q., Brenner, H., Sundquist, J., Sundquist, K., & Fallah, M. (2025) · 癌症：英文版 · doi:10.1002/cac2.70059 · Cited by 10
Log odds of positive lymph nodes show better predictive performance on the prognosis of early-onset colorectal cancer
Liang, Z., Xiang, D., Feng, J., Lyu, H., Li, Z., Mai, G., Yang, Q., Wang, W., & Zhang, X. (2023) · International Journal of Colorectal Disease · doi:10.1007/s00384-023-04490-x · Cited by 10
In vivo staging of colitis, adenoma and carcinoma in CRC progression by combination of H4R/DRD4-targeted fluorescent probes
Wang, X., Yin, X., Huang, K., Li, C., Liu, C., Chen, X., Li, S., Li, S., Han, Z., & Gu, Y. (2024) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2024.116560 · Cited by 10
Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates the ZNF334 gene to inhibit the growth of colorectal cancer
Wang, Q., Ma, C., Mao, H., & Wang, J. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.134580 · Cited by 10
Reduced expression of alanyl aminopeptidase is a robust biomarker of non‐familial adenomatous polyposis and non‐hereditary nonpolyposis colorectal cancer syndrome early‐onset colorectal cancer
Ha, Y. J., Shin, Y. J., Tak, K. H., Park, J., Kim, J., Lee, J. L., Yoon, Y. S., Kim, C. W., Kim, S., & Kim, J. C. (2023) · Cancer Medicine · doi:10.1002/cam4.5675 · Cited by 9
Self-citation
Development of deep learning-based narrow-band imaging endocytoscopic classification for predicting colorectal lesions from a retrospective study
Wang, J., Liu, M., Liao, H., Fan, J., Zhu, H., Ma, T., Yang, D., Ni, F., Zhang, F., Jin, G., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-63812-5 · Cited by 10
Unlocking the predictive potential of long non-coding RNAs: a machine learning approach for precise cancer patient prognosis
Mo, Y., Adu‐Amankwaah, J., Qin, W., Gao, T., Hou, X., Fan, M., Liao, X., Jia, L., Zhao, J., Yuan, J., et al. (2023) · Annals of Medicine · doi:10.1080/07853890.2023.2279748 · Cited by 7
LINC00294/miR-620/MKRN2 axis provides biomarkers and negatively regulates malignant progression in colorectal carcinoma
Qi, P., Yexie, Z.-H., Xue, C., Huang, G., Zhao, Z., & Zhang, X. (2023) · Human & Experimental Toxicology · doi:10.1177/09603271231167577 · Cited by 8
Microenvironmental Metabolites in the Intestine: Messengers between Health and Disease
Zaurito, A. E., & Tschurtschenthaler, M. (2022) · Metabolites · doi:10.3390/metabo12010046 · Cited by 8
Molecular and clinical insights into early-onset endometrial cancer
Wu, Z., Hu, Z., Li, Q., Liu, G., Oaknin, A., Grau-Béjar, J. F., Mills, G. B., Ma, D., Sun, C., & Chen, G. (2025) · Trends in cancer · doi:10.1016/j.trecan.2025.03.002 · Cited by 9
The Balance and Imbalance of Microbial Communities
Zhao, Z., Yuan, Z., Li, Y. F., & Huang, X. (2025) · American Journal of Clinical Oncology · doi:10.1097/coc.0000000000001213 · Cited by 7
Early onset colorectal cancer
Chambers, A., Merriel, S. W., Beard, G., Greer, H., Messenger, D. E., & McCarthy, K. L. (2025) · BMJ · doi:10.1136/bmj-2024-082452 · Cited by 7
Cancer care for adolescents and young adults under the age of 50 in Saudi Arabia: policy review, research gaps, and future directions
Alessy, S. A., Alghamdi, M. A., Al‐Bawardy, B., Alghamdi, S. A., Al-hamoudi, W., AlOmaim, W. S., Abaalkhail, F. A., Alqarni, A., Alsharm, A. A., Alqurashi, Y. D., et al. (2025) · EClinicalMedicine · doi:10.1016/j.eclinm.2025.103188 · Cited by 7
Targeting drug resistant colorectal cancer with apigenin nanoarchitectures
Goleij, P., Ferdousmakan, S., Tabari, M. A. K., Amini, A., Larsen, D. S., Daglia, M., Javan, A., Li, T., Khan, H., & Xu, Y. (2025) · Translational Oncology · doi:10.1016/j.tranon.2025.102455 · Cited by 7
Differences in the peripheral blood immune landscape between early-onset and late-onset colorectal cancer
Sánchez-Menéndez, C., Rodríguez-Pérez, J., Fuertes, D., Leguizamon, V., González-Sanmartin, M., Mateos, E., Cervero, M., José, E. S., Sanz, G., Álvaro, E., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1692382 · Cited by 9
Trends and disparities in the US colorectal cancer mortality, 1999–2023: an analysis of the CDC WONDER database
Feng, Y., Fa, X., Liu, J., & Qi, H. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1693240 · Cited by 7
Survival Contradiction in Stage II, IIIA, And IIIB Colon Cancer: A Surveillance, Epidemiology, and End Result-Based Analysis
Li, Y., Hua, R., He, J., & Zhang, H. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/4088117 · Cited by 7
Things I need you to know: a qualitative analysis of advice-giving statements in early-onset colorectal cancer patients’ personal accounts published online
Lamprell, K., Pulido, D. F., Arnolda, G., Owais, S. S., Easpaig, B. N. G., Tran, Y., Liauw, W., & Braithwaite, J. (2023) · BMJ Open · doi:10.1136/bmjopen-2022-068073 · Cited by 7
Knowledge mapping of early-onset colorectal cancer from 2000 to 2022: A bibliometric analysis
Zhang, M., Zhu, S., Chen, L., Wu, Y., Ye, Y., Wang, G., Gui, Z., Zhang, C., & Zhang, M. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e18499 · Cited by 8

Authors: Burnett-Hartman, A. N., Lee, J. K., Demb, J., & Gupta, S.
Affiliations: Kaiser Permanente (US)
University of California San Diego (US)
Corresponding author: Lee, Jeffrey K.
ORCID: Lee, Jeffrey K.
Demb, Joshua
Gupta, Samir
Venue: Gastroenterology
Publisher: Elsevier BV
Published: 2021-03
Volume: 160
Issue: 4
Pages: 1041-1049
ISSN: 0016-5085 (ISSN-L)
DOI: 10.1053/j.gastro.2020.12.068
PMC: PMC8273929
OpenAlex: W3119321686
Semantic Scholar: 8244c2b40e175dc72040bb05f875308e37bfb4c4
Cited by: 298
References: 79
Citations by year: 2026: 27 · 2025: 60 · 2024: 88 · 2023: 71 · 2022: 43 · 2021: 9
FWCI: 6.39
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Gastroenterology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: National Cancer Institute (U24 CA 221936, R01 CA196337)
Topics: Health Sciences › Medicine › Oncology › Colorectal Cancer Screening and Detection
Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
Health Sciences › Medicine › Oncology › Colorectal Cancer Surgical Treatments
Keywords: early-onset colorectal cancer, colorectal cancer incidence, molecular characterization, colorectal cancer screening, early detection, cancer prevention, young adults
MeSH terms: Humans, Mass Screening, Risk Factors, Triage, Biomarkers, Tumor, Colorectal Neoplasms, Practice Guidelines as Topic, Age of Onset, Microsatellite Instability, Early Detection of Cancer, Precision Medicine

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

An Update on the Epidemiology, Molecular Characterization, Diagnosis, and Screening Strategies for Early-Onset Colorectal Cancer

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks