Methemoglobinemia: a review and recommendations for management
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Methemoglobinemia becomes clinically significant when baseline levels of metHgb (1-3%) rise to 5-12%, with cyanosis and fatal toxicity occurring at levels between 30-50%.
“Methemogobinemia becomes clinically significant when baseline levels of metHgb (1–3%) rise to 5–12%, with cyanosis and fatal toxicity occurring at levels between 30–50%[153].”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [153]
Cites
Miller, R. D. (2005) · Cited by 1,240 · see citing works
Cabot, R. C., Scully, R. E., Mark, E. J., McNeely, W. F., McNeely, B. U., Harris, W. H., & Rosenberg, A. E. (1990) · New England Journal of Medicine · doi:10.1056/nejm199008233230808 · Cited by 896 · see citing works
Tremper, K. K., & Barker, S. J. (1989) · Anesthesiology · doi:10.1097/00000542-198901000-00019 · Cited by 438 · see citing works
Effects of Methemoglobinemia on Pulse Oximetry and Mixed Venous Oximetry
Barker, S. J., Tremper, K. K., & Hyatt, J. (1989) · Anesthesiology · doi:10.1097/00000542-198901000-00021 · Cited by 384 · see citing works
Curry, S. C. (1982) · Annals of Emergency Medicine · doi:10.1016/s0196-0644(82)80502-7 · Cited by 233 · see citing works
Improved Accuracy of Methemoglobin Detection by Pulse CO-Oximetry During Hypoxia
Feiner, J., & Bickler, P. E. (2010) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e3181f46da8 · Cited by 57 · see citing works
Accuracy of Methemoglobin Detection by Pulse CO-Oximetry During Hypoxia
Feiner, J., Bickler, P. E., & Mannheimer, P. D. (2010) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e3181c91bb6 · Cited by 57 · see citing works
Benzocaine-Induced Methemoglobinemia in an Adult: Accuracy of Pulse Oximetry with Methemoglobinemia
Anderson, S. T., Hajduczek, J., & Barker, S. J. (1988) · Anesthesia & Analgesia · doi:10.1213/00000539-198811000-00015 · Cited by 53 · see citing works
Benzocaine-Induced Methemoglobinemia in an Adult: Accuracy of Pulse Oximetry with Methemoglobinemia
Anderson, S. T., Hajduczek, J., & Barker, S. J. (1988) · Anesthesia & Analgesia · doi:10.1213/00000539-198867110-00015 · Cited by 51 · see citing works
El-Husseini, A. A., & Azarov, N. (2010) · The American Journal of Emergency Medicine · doi:10.1016/j.ajem.2009.10.014 · Cited by 50 · see citing works
Methemoglobinemia Induced by Topical Anesthesia: A Case Report and Review
Khan, N. A., & Kruse, J. A. (1999) · The American Journal of the Medical Sciences · doi:10.1016/s0002-9629(15)40667-6 · Cited by 49 · see citing works
Anesthetic Management of a Patient with Methemoglobinemia
Groeper, K., Katcher, K., & Tobias, J. D. (2003) · Southern Medical Journal · doi:10.1097/01.smj.0000051342.99317.99 · Cited by 35 · see citing works
Hurford, W. E., & Kratz, A. F. (2004) · New England Journal of Medicine · doi:10.1056/nejmcpc049013 · Cited by 34 · see citing works
Abu‐Laban, R. B., Zed, P. J., Purssell, R. A., et al. (2001) · Canadian Journal of Emergency Medicine · doi:10.1017/s1481803500005182 · Cited by 31 · see citing works
Fundamental Principles of Monitoring Instrumentation
Szocik, J., Barker, S. J., & Tremper, K. K. (2010) · Elsevier eBooks · doi:10.1016/b978-0-443-06959-8.00038-8 · Cited by 29 · see citing works
Methemoglobinemia Induced by Topical Anesthesia: A Case Report and Review
Khan, N. A., & Kruse, J. A. (1999) · The American Journal of the Medical Sciences · doi:10.1097/00000441-199912000-00009 · Cited by 28 · see citing works
Benzocaine-induced methemoglobinemia during general anesthesia
Spielman, F. J., Anderson, J. A., & Terry, W. C. (1984) · Journal of Oral and Maxillofacial Surgery · doi:10.1016/0278-2391(84)90424-5 · Cited by 23 · see citing works
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Koch, C. D., Gladwin, M. T., Freeman, B. A., Lundberg, J. O., Weitzberg, E., & Morris, A. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.12.015 · Cited by 186 · see citing works
- Authors
- Cortazzo, J. A., & Lichtman, A. D.
- Affiliations
- Cornell University (US)
- Corresponding author
- Lichtman, Adam D.
- ORCID
- Lichtman, Adam D.
- Venue
- Journal of Cardiothoracic and Vascular Anesthesia
- Publisher
- Elsevier BV
- Published
- 2014-08
- Volume
- 28
- Issue
- 4
- Pages
- 1043-1047
- ISSN
- 1053-0770 (ISSN-L)
- OpenAlex
- W2022746069
- Cited by
- 180
- References
- 17
- Citations by year
- 2026: 16 · 2025: 11 · 2024: 17 · 2023: 16 · 2022: 20 · 2021: 20 · 2020: 17 · 2019: 22 · 2018: 10 · 2017: 9 · 2016: 7 · 2015: 12 · 2014: 2
- FWCI
- 5.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Cardiothoracic and Vascular Anesthesia (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Methemoglobinemia and Tumor Lysis Syndrome
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Sedative Agents
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hemoglobin structure and function
- Keywords
- methemoglobinemia, benzocaine, topical anesthetics, local anesthetic toxicity, transesophageal echocardiography, intraoperative complications, acquired methemoglobinemia, diagnosis, treatment, drug safety
- MeSH terms
- Anesthesia, Local, Anesthetics, Local, Female, Humans, Methemoglobin, Methemoglobinemia, Middle Aged, Pain, Postoperative, Postoperative Pain, Practice Guidelines as Topic, Disease Management
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