The DOI matches its Crossref record; 25 of the 26 references it cites were found in a registry or an index.
PET/MR in Dementia and Other Neurodegenerative Diseases
Abstract
The spectrum of neurodegenerative diseases covers the dementias, parkinsonian syndromes, Huntington disease, amyotrophic lateral sclerosis, and prion diseases. In these entities, brain MRI is often used in clinical routine to exclude other pathologies and to demonstrate specific atrophy patterns. [18F]FDG PET delivers early and sensitive readouts of neural tissue loss, and more specific PET tracers currently in use clinically target β-amyloid plaques or dopaminergic deficiency. The recent integration of PET into MR technology offers a new chance to improve early and differential diagnosis of many neurodegenerative diseases. Initial evidence in the literature is available to support this notion. New emerging PET tracers, such as tracers that bind to tau or α-synuclein aggregates, as well as MR techniques, like diffusion-tensor imaging, resting-state functional MRI, and arterial spin labeling, have the potential to broaden the diagnostic capabilities of combined PET/MRI to image dementias, Parkinson disease, and other neurodegenerative diseases. The ultimate goal is to establish combined PET/MRI as a first-line imaging technique to provide, in a one-stop-shop fashion with improved patient comfort, all biomarker information required to increase diagnostic confidence toward specific diagnoses. The technical challenge of accurate PET data attenuation correction within PET/MRI systems needs yet to be solved. Apart from the projected clinical routine applications, future research would need to answer the questions of whether combined brain PET/MRI is able to improve basic research of neurodegenerative diseases and antineurodegeneration drug testing.
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“Diagnosis of neurodegenerative diseases is usually based on subjective cognitive tests in combination with neuroimaging [131–133], but the current techniques are not able to successfully diagnose these diseases in their earlier stages, when the pathology is already present but does not cause symptoms yet.”
From Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation (2019) · cites this paper as [131]
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Cites
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“This led to the stratification of 33%, 48%, and 19% of the MCI subjects as unlikely owing to AD, intermediate, and high likelihood of MCI due to AD, respectively, according to established diagnostic criteria.(19) For the remaining 41 patients with AD dementia, 59% had pathologic PET and 44%had pathologic PETþMR images.”
Albert, M., DeKosky, S. T., Dickson, D. W., Dubois, B., Feldman, H., Fox, N. C., Gamst, A. C., Holtzman, D. M., Jagust, W. J., Petersen, R. C., et al. (2013) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.11.1.96 · Cited by 2,643
Simultaneous PET-MRI: a new approach for functional and morphological imaging
Judenhofer, M. S., Wehrl, H. F., Newport, D. F., Catana, C., Siegel, S. B., Becker, M., Thielscher, A., Kneilling, M., Lichy, M. P., Eichner, M., et al. (2008) · Nature Medicine · doi:10.1038/nm1700 · Cited by 983
Simultaneous MR/PET Imaging of the Human Brain: Feasibility Study
Schlemmer, H.-P., Pichler, B. J., Schmand, M. J., Burbar, Z., Michel, C. J., Ladebeck, R., Jattke, K., Townsend, D. W., Nahmias, C., Jacob, P. K., et al. (2008) · Radiology · doi:10.1148/radiol.2483071927 · Cited by 473
Molecular Basis of the Neurodegenerative Disorders
Martin, J. B. (1999) · New England Journal of Medicine · doi:10.1056/nejm199906243402507 · Cited by 422
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In Vivo Quantitative Susceptibility Mapping (QSM) in Alzheimer's Disease
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PET/MRI for Neurologic Applications
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Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation
Lima Giacobbo, B., Doorduin, J., Klein, H. C., Dierckx, R. A. J. O., Bromberg, E., & de Vries, E. F. J. (2019) · Molecular Neurobiology · doi:10.1007/s12035-018-1283-6 · Cited by 750
Test–retest measurements of dopamine D1-type receptors using simultaneous PET/MRI imaging
Kaller, S., Rullmann, M., Patt, M., Becker, G.-A., Luthardt, J., Girbardt, J., Meyer, P. M., Werner, P., Barthel, H., Bresch, A., et al. (2017) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-017-3645-0 · Cited by 152
Self-citationTalwar, P., Kushwaha, S. S., Chaturvedi, M., & Mahajan, V. (2021) · Clinical Neuroradiology · doi:10.1007/s00062-021-01057-7 · Cited by 142
Deep learning-based PET image denoising and reconstruction: a review
Hashimoto, F., Onishi, Y., Ote, K., Tashima, H., Reader, A. J., & Yamaya, T. (2024) · Radiological Physics and Technology · doi:10.1007/s12194-024-00780-3 · Cited by 113
MR/PET Imaging of the Cardiovascular System
Robson, P. M., Dey, D., Newby, D. E., Berman, D. S., Li, D., Fayad, Z. A., & Dweck, M. R. (2017) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2017.07.008 · Cited by 96
Metadata
- Authors
- Barthel, H., Schroeter, M. L., Hoffmann, K.-T., & Sabri, O.
- Affiliations
- University Hospital Leipzig (DE)
- Max Planck Institute for Human Cognitive and Brain Sciences (DE)
- Leipzig University (DE)
- Corresponding author
- Barthel, Henryk
- Venue
- Seminars in Nuclear Medicine
- Publisher
- Elsevier BV
- Published
- 2015-05
- Volume
- 45
- Issue
- 3
- Pages
- 224-233
- ISSN
- 0001-2998 (ISSN-L)
- OpenAlex
- W1987273610
- Cited by
- 123
- References
- 26
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 10 · 2023: 6 · 2022: 10 · 2021: 12 · 2020: 7 · 2019: 12 · 2018: 16 · 2017: 13 · 2016: 20 · 2015: 5
- FWCI
- 14.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Seminars in Nuclear Medicine (publishedVersion)
- PubMed (publishedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Keywords
- PET/MRI, neurodegenerative diseases, dementia, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, prion disease, FDG-PET, amyloid PET tracers, tau PET tracers, diffusion tensor imaging, resting-state fMRI, arterial spin labeling, PET attenuation correction, neurodegeneration biomarkers, differential diagnosis
- MeSH terms
- Dementia, Humans, Magnetic Resonance Imaging, Parkinsonian Disorders, Positron-Emission Tomography, Multimodal Imaging
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