Cited by 123Dementia and Cognitive Impairment ResearchMedical Imaging Techniques and ApplicationsAdvanced MRI Techniques and Applications

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PET/MR in Dementia and Other Neurodegenerative Diseases

Barthel, Henryk, Schroeter, Matthias L., Hoffmann, Karl-Titus, Sabri, Osama·2015·Seminars in Nuclear Medicine

DOI 10.1053/j.semnuclmed.2014.12.003

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Abstract

The spectrum of neurodegenerative diseases covers the dementias, parkinsonian syndromes, Huntington disease, amyotrophic lateral sclerosis, and prion diseases. In these entities, brain MRI is often used in clinical routine to exclude other pathologies and to demonstrate specific atrophy patterns. [18F]FDG PET delivers early and sensitive readouts of neural tissue loss, and more specific PET tracers currently in use clinically target β-amyloid plaques or dopaminergic deficiency. The recent integration of PET into MR technology offers a new chance to improve early and differential diagnosis of many neurodegenerative diseases. Initial evidence in the literature is available to support this notion. New emerging PET tracers, such as tracers that bind to tau or α-synuclein aggregates, as well as MR techniques, like diffusion-tensor imaging, resting-state functional MRI, and arterial spin labeling, have the potential to broaden the diagnostic capabilities of combined PET/MRI to image dementias, Parkinson disease, and other neurodegenerative diseases. The ultimate goal is to establish combined PET/MRI as a first-line imaging technique to provide, in a one-stop-shop fashion with improved patient comfort, all biomarker information required to increase diagnostic confidence toward specific diagnoses. The technical challenge of accurate PET data attenuation correction within PET/MRI systems needs yet to be solved. Apart from the projected clinical routine applications, future research would need to answer the questions of whether combined brain PET/MRI is able to improve basic research of neurodegenerative diseases and antineurodegeneration drug testing.

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Authors: Barthel, H., Schroeter, M. L., Hoffmann, K.-T., & Sabri, O.
Affiliations: University Hospital Leipzig (DE)
Max Planck Institute for Human Cognitive and Brain Sciences (DE)
Leipzig University (DE)
Corresponding author: Barthel, Henryk
ORCID: Barthel, Henryk
Schroeter, Matthias L.
Hoffmann, Karl-Titus
Sabri, Osama
Venue: Seminars in Nuclear Medicine
Publisher: Elsevier BV
Published: 2015-05
Volume: 45
Issue: 3
Pages: 224-233
ISSN: 0001-2998 (ISSN-L)
DOI: 10.1053/j.semnuclmed.2014.12.003
OpenAlex: W1987273610
Cited by: 123
References: 26
Citations by year: 2026: 3 · 2025: 9 · 2024: 10 · 2023: 6 · 2022: 10 · 2021: 12 · 2020: 7 · 2019: 12 · 2018: 16 · 2017: 13 · 2016: 20 · 2015: 5
FWCI: 14.60
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Seminars in Nuclear Medicine (publishedVersion)
PubMed (publishedVersion)
MPG.PuRe (Max Planck Society) (submittedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Keywords: PET/MRI, neurodegenerative diseases, dementia, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, prion disease, FDG-PET, amyloid PET tracers, tau PET tracers, diffusion tensor imaging, resting-state fMRI, arterial spin labeling, PET attenuation correction, neurodegeneration biomarkers, differential diagnosis
MeSH terms: Dementia, Humans, Magnetic Resonance Imaging, Parkinsonian Disorders, Positron-Emission Tomography, Multimodal Imaging

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PET/MR in Dementia and Other Neurodegenerative Diseases

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