Hnf4: A Central Regulator of Hepatocyte Differentiation and Function
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HNF4A is a key TF in liver as its loss is associated with transcriptional repression of genes.
“HNF4A is a key TF in liver as its loss is associated with transcriptional repression of genes (5, 10).”
From Hepatocyte Nuclear Factor 4‐Alpha Is Essential for the Active Epigenetic State at Enhancers in Mouse Liver (2019) · cites this paper as [10]
Cites
SRC-1 and GRIP1 Coactivate Transcription with Hepatocyte Nuclear Factor 4
Wang, J.-C., Stafford, J. M., & Granner, D. K. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.47.30847 · Cited by 147 · see citing works
Functional Association between CBP and HNF4 inTrans-activation
Yoshida, E., Aratani, S., Itou, H., Miyagishi, M., Takiguchi, M., Osumu, T., Murakami, K., & Fukamizu, A. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.7871 · Cited by 104 · see citing works
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Inoue, F., Kircher, M., Martin, B., Cooper, G. M., Witten, D. M., McManus, M. T., Ahituv, N., & Shendure, J. (2017) · Genome Research · doi:10.1101/gr.212092.116 · Cited by 331 · see citing works
HNF4α is a therapeutic target that links AMPK to WNT signalling in early-stage gastric cancer
Chang, H. R., Nam, S., Kook, M.-C., Kim, K.-T., Liu, X., Yao, H., Jung, H. R., Lemos, R., Seo, H. H., Park, H. S., et al. (2016) · Gut · doi:10.1136/gutjnl-2014-307918 · Cited by 119 · see citing works
Lotto, J., Drissler, S., Cullum, R., Wei, W., Setty, M., Bell, E. M., Boutet, S. C., Nowotschin, S., Kuo, Y.-Y., Garg, V., et al. (2020) · Cell · doi:10.1016/j.cell.2020.09.012 · Cited by 86 · see citing works
Thakur, A., Wong, J. C. H., Wang, E. Y., Lotto, J., Kim, D., Cheng, J., Mingay, M., Cullum, R., Moudgil, V., Ahmed, N., et al. (2019) · Hepatology · doi:10.1002/hep.30631 · Cited by 75 · see citing works
“HNF4A is a key TF in liver given that its loss is associated with transcriptional repression of genes.(5,10) Although various TFs were shown to regulate gene expression by influencing histone(24,37) and DNA modifications at gene-regulatory regions,(24,37,38) the role of HNF4A in epigenetic-mediated gene regulation in…”
BackgroundBeaudry, J.-B., Pierreux, C. E., Hayhurst, G. P., Plumb-Rudewiez, N., Weiss, M. C., Rousseau, G. G., & Lemaigre, F. P. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.02445-05 · Cited by 56 · see citing works
Acetylation: a new target for protein degradation in cancer
Crawford, C. E. W., & Burslem, G. M. (2025) · Trends in Cancer · doi:10.1016/j.trecan.2025.01.013 · Cited by 20 · see citing works
HNF4A guides the MLL4 complex to establish and maintain H3K4me1 at gene regulatory elements
Thakur, A., Park, K., Cullum, R., Fuglerud, B. M., Khoshnoodi, M., Drissler, S., Stephan, T. L., Lotto, J., Kim, D., Gonzalez, F. J., et al. (2024) · Communications Biology · doi:10.1038/s42003-024-05835-0 · Cited by 10 · see citing works
- Authors
- Watt, A. J., Garrison, W. D., & Duncan, S. A.
- Affiliations
- Medical College of Wisconsin (US)
- ORCID
- Duncan, Stephen A.
- Venue
- Hepatology
- Published
- 2003-06
- Volume
- 37
- Issue
- 6
- Pages
- 1249-1253
- ISSN
- 0270-9139 (ISSN-L)
- OpenAlex
- W1971225285
- Cited by
- 307
- References
- 2
- Citations by year
- 2026: 6 · 2025: 11 · 2024: 10 · 2023: 15 · 2022: 25 · 2021: 13 · 2020: 19 · 2019: 14 · 2018: 5 · 2017: 10 · 2016: 17 · 2015: 14 · 2014: 19 · 2013: 10 · 2012: 13
- FWCI
- 1.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hepatology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (DK55703, DK60064, R01DK060064)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Hepatology › Hepatocellular Carcinoma Treatment and Prognosis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- HNF4, hepatocyte differentiation, hepatocyte function, transcription factors, liver development, hepatocyte-specific gene expression
- MeSH terms
- Aging, Animals, Cell Differentiation, DNA-Binding Proteins, Embryo, Mammalian, Gene Expression Regulation, Humans, Liver, Mutation, Phosphoproteins, Transcription Factors, Hepatocytes, Hepatocyte Nuclear Factor 4, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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