Recurrence of primary biliary cirrhosis after liver transplantation: Histologic estimate of incidence and natural history
Open accessAbstract
The goals of this study were to determine the rate of recurrent primary biliary cirrhosis (PBC) after orthotopic liver transplantation (OLT) based on strict morphologic criteria and to evaluate histologic progression of recurrent PBC over time. Strict criteria for PBC recurrence were established as the presence of a florid duct lesion or destructive lymphocytic cholangitis within a dense portal infiltrate. Of the 784 OLTs performed at the Mayo Clinic during the first 12 years of the program, 100 met criteria for the PBC study group, and 35 met criteria for the control group. Strict histologic criteria for recurrent PBC were observed in 17 of 100 (17%) study patients (14 with florid duct lesion, 3 with destructive lymphocytic cholangitis within dense portal infiltrate). Mean follow-up for the PBC group was 4.7 years (range, 1.0 to 13.8). Mean time to recurrence was 3.7 years (median, 3.1; range, 0.3 to 7.9). In those who met strict criteria for recurrent PBC, 2 of 17 progressed to septal fibrosis (stage 3). No florid duct lesions, destructive lymphocytic cholangitis, or septal fibrosis were observed in the control group. Other less specific morphologic features of PBC (portal infiltrates, plasma cells, dense lymphoplasmacytic infiltrates, and lymphocytic cholangitis) were also evaluated in the course of this study. Based on strict criteria, a conservative histologic estimate of the rate of recurrent PBC is 17% with a mean of 4.7 years of follow-up. When criteria for histologic recurrence are expanded to include moderate lymphocytic cholangitis with lymphoplasmacytic portal infiltrate, the recurrence rate of PBC is estimated as 26%.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Recurrent PBC develops in 20%-30% of transplant recipients by 10 years and up to 50% by 20 years.
“Some 20% to 30% of patients with PBC who undergo transplantation develop recurrent disease over 10 years, and up to 50% do so by 20 years of follow-up.”
From Primary Biliary Cholangitis: 2018 Practice Guidance from the American Association for the Study of Liver Diseases (2019) · cites this paper as [257]
The Recurrence Rate section reports recurrent PBC in 17% of patients using strict histologic criteria; Table 4 gives an estimate of 26% using expanded criteria. Neither is a 10-year estimate: the Patient Groups section reports mean follow-up of 4.7 years and a maximum of 13.8 years. The paper does not support the claim of up to 50% recurrence by 20 years. (LLM, conf=0.88)
Experimental — accuracy not yet measuredRecurrent PBC rarely impacts long-term patient or graft survival.
“Fortunately, recurrent PBC infrequently affects long-term patient or graft survival.(258)”
From Primary Biliary Cholangitis: 2018 Practice Guidance from the American Association for the Study of Liver Diseases (2019) · cites this paper as [258]
The Introduction says clinically recognized recurrent PBC has rarely been reported, and the Conclusion reports progression to septal fibrosis in only 2 of 17 patients with histologic recurrence. Those findings support limited observed clinical impact, but the paper does not establish an effect on long-term patient or graft survival; the Conclusion says longer follow-up is needed to assess clinical significance. (LLM, conf=0.78)
Experimental — accuracy not yet measuredMedian time to PBC recurrence after transplantation is 3 to 6 years.
“The median time to recurrence is 3 to 6 years.(256,257)”
From Primary Biliary Cholangitis: 2018 Practice Guidance from the American Association for the Study of Liver Diseases (2019) · cites this paper as [257]
Post-transplant UDCA use is associated with lower recurrence rates (21% vs 62%; P = 0.004).
“patients on UDCA post liver transplantation appear to have lower recurrence rates compared with patients who did not receive UDCA post transplant (21% versus 62%; P = 0.004).(257)”
From Primary Biliary Cholangitis: 2018 Practice Guidance from the American Association for the Study of Liver Diseases (2019) · cites this paper as [257]
The Recurrence Rate and Conclusion sections report an overall histologic recurrence rate of 17%, but do not compare patients who did and did not receive UDCA. Searches for UDCA, ursodeoxycholic acid, and the claimed percentages and P value found no passage addressing the treatment comparison. (LLM, conf=0.75)
Experimental — accuracy not yet measuredHigher MELD score at wait list registration is linked to more PBC recurrence after transplantation.
“In a recent study, a higher Model for End-Stage Liver Disease score at the time of wait list registration was also associated with increased recurrence rates.(257)”
From Primary Biliary Cholangitis: 2018 Practice Guidance from the American Association for the Study of Liver Diseases (2019) · cites this paper as [257]
The Patient Groups and Conclusion sections describe the transplant cohort and estimate histologic PBC recurrence, but do not link recurrence to a MELD score at wait-list registration. Searches for “MELD,” “wait list registration,” and pretransplant disease severity found no passage addressing that association. (LLM, conf=0.72)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Garcia, R. F. L., Garcia, C. E., McMaster, P., & Neuberger, J. (2001) · Hepatology · doi:10.1053/jhep.2001.20894 · Cited by 254 · see citing works
Recurrence of Primary Biliary Cirrhosis after Liver Transplantation
Neuberger, J., Portmann, B., Macdougall, B. R. D., Calne, R., & Williams, R. L. (1982) · New England Journal of Medicine · doi:10.1056/nejm198201073060101 · Cited by 251 · see citing works
Portmann, B. C., Pópper, H., Neuberger, J., & Williams, R. L. (1985) · Gastroenterology · doi:10.1016/0016-5085(85)90001-0 · Cited by 135 · see citing works
Evidence for disease recurrence after liver transplantation for primary biliary cirrhosis
Polson, R. J., Portmann, B., Neuberger, J., Calne, R., & Williams, R. L. (1989) · Gastroenterology · doi:10.1016/0016-5085(89)90643-4 · Cited by 111 · see citing works
de Water, J. V. (1996) · Hepatology · doi:10.1053/jhep.1996.v24.pm0008903379 · Cited by 104 · see citing works
Histological evidence for recurrence of primary biliary cirrhosis after liver transplantation
Balan, V., Batts, K. P., Porayko, M. K., Krom, R. A. F., Ludwig, J., & Wiesner, R. H. (1993) · Hepatology · doi:10.1002/hep.1840180617 · Cited by 102 · see citing works
Self-citationde Water, J. V., Gerson, L. B., Ferrell, L. D., et al. (1996) · Hepatology · doi:10.1002/hep.510240517 · Cited by 96 · see citing works
Liver transplantation for primary biliary cirrhosis: A long-term pathologic study
Khettry, U., Anand, N., Faul, P. N., Lewis, D. W., Pomfret, E. A., Pomposelli, J. J., Jenkins, R. L., & Gordon, F. D. (2003) · Liver Transplantation · doi:10.1053/jlts.2003.36392 · Cited by 94 · see citing works
Recurrence of primary biliary cirrhosis in the liver allograft: the effect of immunosuppression
Dmitrewski, J., Hübscher, S. G., Mayer, A. D., & Neuberger, J. M. (1996) · Journal of Hepatology · doi:10.1016/s0168-8278(96)80001-8 · Cited by 92 · see citing works
Ultrastructural lesions of bile ducts in primary biliary cirrhosis
Bernuau, D., Feldmann, G., Degott, C., & Gisselbrecht, C. (1981) · Human Pathology · doi:10.1016/s0046-8177(81)80081-0 · Cited by 78 · see citing works
Wong, P. Y. N., Portmann, B., O'Grady, J. G., Devlin, J., Hegarty, J. E., Tan, K. C., & Williams, R. L. (1993) · Journal of Hepatology · doi:10.1016/s0168-8278(05)80206-5 · Cited by 74 · see citing works
Sebagh, M., Farges, O., Dubel, L., Samuel, D., Bismuth, H., & REYNES, M. (1998) · Transplantation · doi:10.1097/00007890-199805270-00008 · Cited by 67 · see citing works
Pathogenesis of primary biliary cirrhosis
Jones, D. E. (2003) · Journal of Hepatology · doi:10.1016/s0168-8278(03)00270-8 · Cited by 62 · see citing works
Clinical and statistical analyses of new and evolving therapies for primary biliary cirrhosis
Wiesner, R. H., Grambsch, P. M., Lindor, K. D., Ludwig, J., & Dickson, E. R. (1988) · Hepatology · doi:10.1002/hep.1840080339 · Cited by 61 · see citing works
Self-citationRussell, S. M. (1992) · Gastroenterology Nursing · doi:10.1097/00001610-199202000-00016 · Cited by 44 · see citing works
Clinical significance of recurrent primary biliary cirrhosis after liver transplantation
Knoop, M., Bechstein, W., Schrem, H., Lobeck, H., Hopf, U., & Neuhaus, P. (1996) · Transplant International · doi:10.1111/j.1432-2277.1996.tb01586.x · Cited by 19 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- Neuberger J, Portmann B, MacDougall BRD, Calne RY, Wil- liams R. Recurrence of primary biliary cirrhosis after liver trans- plantation. N Engl J Med 1982;306:1-4.
- Hubscher SG, Buckels JAC, Elias E, Mayer AD, McMaster P, Neuberger JM. Does primary biliary cirrhosis recur after liver transplantation [abstract]? Hepatology 1992;16:545.
Cited by
Sorted by citations
Lindor, K. D., Gershwin, E. M., Poupon, R., Kaplan, M., Bergasa, N. V., & Heathcote, J. E. (2009) · Hepatology · doi:10.1002/hep.22906 · Cited by 1,099 · see citing works
Lindor, K. D., Bowlus, C. L., Boyer, J., Levy, C., & Mayo, M. (2019) · Hepatology · doi:10.1002/hep.30145 · Cited by 913 · see citing works
Tsukada, S., Parsons, C. J., & Rippe, R. A. (2005) · Clinica Chimica Acta · doi:10.1016/j.cca.2005.06.014 · Cited by 353 · see citing works
Selmi, C., Bowlus, C. L., Gershwin, M. E., & Coppel, R. L. (2011) · The Lancet · doi:10.1016/s0140-6736(10)61965-4 · Cited by 334 · see citing works
Recurrence of autoimmune liver disease after liver transplantation: A systematic review
Gautam, M., Cheruvattath, R., & Balan, V. (2006) · Liver Transplantation · doi:10.1002/lt.20910 · Cited by 272 · see citing works
Lleo, A., Wang, G.-Q., Gershwin, M. E., & Hirschfield, G. M. (2020) · The Lancet · doi:10.1016/s0140-6736(20)31607-x · Cited by 253 · see citing works
Recent advances in clinical practice: Epidemiology of autoimmune liver diseases
Trivedi, P. J., & Hirschfield, G. M. (2021) · Gut · doi:10.1136/gutjnl-2020-322362 · Cited by 244 · see citing works
Diagnosis and Management of Primary Biliary Cholangitis
Younossi, Z. M., Bernstein, D., Shiffman, M. L., Kwo, P. Y., Kim, W. R., Kowdley, K. V., & Jacobson, I. M. (2018) · The American Journal of Gastroenterology · doi:10.1038/s41395-018-0390-3 · Cited by 213 · see citing works
Charatcharoenwitthaya, P., Pimentel, S., Talwalkar, J. A., Enders, F. T., Lindor, K. D., Krom, R. A. F., & Wiesner, R. H. (2007) · Liver Transplantation · doi:10.1002/lt.21124 · Cited by 179 · see citing works
Self-citationKumagi, T., & Heathcote, E. J. (2008) · Orphanet Journal of Rare Diseases · doi:10.1186/1750-1172-3-1 · Cited by 179 · see citing works
Current understanding of primary biliary cholangitis
Tanaka, A. (2020) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2020.0028 · Cited by 159 · see citing works
Montaño‐Loza, A. J., Hansen, B. E., Corpechot, C., Roccarina, D., Thorburn, D., Trivedi, P. J., Hirschfield, G. M., McDowell, P., Poupon, R. Y., Dumortier, J., et al. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.10.001 · Cited by 129 · see citing works
Systematic review: recurrent autoimmune liver diseases after liver transplantation
Montaño‐Loza, A. J., Bhanji, R. A., Wasilenko, S. T., & Mason, A. L. (2016) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13894 · Cited by 124 · see citing works
Jacob, D., Neumann, U. P., Bahra, M., Klupp, J., Puhl, G., Neuhaus, R., & Langrehr, J. M. (2006) · Clinical Transplantation · doi:10.1111/j.1399-0012.2005.00471.x · Cited by 119 · see citing works
Bosch, A., Dumortier, J., Maucort-Boulch, D., Scoazec, J.-Y., Wendum, D., Conti, F., Morard, I., Rubbia-Brandt, L., Terris, B., Radenne, S., et al. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.07.038 · Cited by 114 · see citing works
Liver transplantation and autoimmune liver diseases
Liberal, R., Zen, Y., Mieli‐Vergani, G., & Vergani, D. (2013) · Liver Transplantation · doi:10.1002/lt.23704 · Cited by 103 · see citing works
Liver transplantation in PBC and PSC: Indications and disease recurrence
Carbone, M., & Neuberger, J. (2011) · Clinics and Research in Hepatology and Gastroenterology · doi:10.1016/j.clinre.2011.02.007 · Cited by 89 · see citing works
Recurrent Primary Biliary Cirrhosis
Guy, J. E., Qian, P., Lowell, J. A., & Peters, M. G. (2005) · Liver Transplantation · doi:10.1002/lt.20511 · Cited by 87 · see citing works
Recurrent primary biliary cirrhosis after liver transplantation
Silveira, M. G., Talwalkar, J. A., Lindor, K. D., & Wiesner, R. H. (2010) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2010.03038.x · Cited by 86 · see citing works
Self-citationLiver transplantation in autoimmune liver diseases
Ilyas, J. A., O'Mahony, C. A., & Vierling, J. M. (2011) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2011.09.008 · Cited by 80 · see citing works
Schreuder, T. C. M. A., Hübscher, S. G., & Neuberger, J. (2008) · Transplant International · doi:10.1111/j.1432-2277.2008.00729.x · Cited by 71 · see citing works
Manousou, P., Arvaniti, V., Tsochatzis, E. A., Isgrò, G., Jones, K., Shirling, G., Dhillon, A. P., O’Beirne, J. P., Patch, D., & Burroughs, A. K. (2009) · Liver Transplantation · doi:10.1002/lt.21960 · Cited by 70 · see citing works
Recurrence of Diseases Following Orthotopic Liver Transplantation
Kotlyar, D. S., Campbell, M. S., & Reddy, K. R. (2006) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2006.00586.x · Cited by 68 · see citing works
Morioka, D., Egawa, H., Kasahara, M., Jo, T., Sakamoto, S., Ogura, Y., Haga, H., Takada, Y., Shimada, H., & Tanaka, K. (2006) · Liver Transplantation · doi:10.1002/lt.20856 · Cited by 61 · see citing works
Transplantation in autoimmune liver diseases.
Mottershead, M., & Neuberger, J. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.3388 · Cited by 58 · see citing works
Galoosian, A., Hanlon, C. L., Zhang, J., Holt, E. W., & Yimam, K. K. (2020) · Journal of Clinical and Translational Hepatology · doi:10.14218/jcth.2019.00049 · Cited by 57 · see citing works
Visseren, T., & Murad, S. D. (2017) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2017.04.004 · Cited by 53 · see citing works
Liver Transplantation for Cholestatic Liver Diseases in Adults
Khungar, V., & Goldberg, D. S. (2015) · Clinics in Liver Disease · doi:10.1016/j.cld.2015.08.011 · Cited by 52 · see citing works
Histological recurrence of autoimmune liver diseases after living‐donor liver transplantation
Haga, H., Miyagawa‐Hayashino, A., Taira, K., Morioka, D., Egawa, H., Takada, Y., Manabe, T., & Üemoto, S. (2007) · Hepatology Research · doi:10.1111/j.1872-034x.2007.00245.x · Cited by 50 · see citing works
Guo, Z., Zhong, J., Jiang, J., Zhang, J., Xiang, B., & Li, L. (2014) · Annals of Surgical Oncology · doi:10.1245/s10434-014-3704-8 · Cited by 49 · see citing works
Recurrent and De Novo Autoimmune Liver Diseases
Mendes, F. D., Couto, C. A., & Levy, C. (2011) · Clinics in Liver Disease · doi:10.1016/j.cld.2011.08.008 · Cited by 49 · see citing works
Natural History of Primary Biliary Cirrhosis
Mayo, M. J. (2008) · Clinics in Liver Disease · doi:10.1016/j.cld.2008.02.012 · Cited by 45 · see citing works
Autoimmune Liver Disease Post-Liver Transplantation
Edmunds, C., & Ekong, U. D. (2015) · Transplantation · doi:10.1097/tp.0000000000000922 · Cited by 43 · see citing works
Mechanisms governing bystander activation of T cells
Yosri, M., Dokhan, M., Aboagye, E., Moussawy, M. A., & Abdelsamed, H. A. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1465889 · Cited by 38 · see citing works
Recurrence of autoimmune liver diseases after liver transplantation
Faisal, N. (2015) · World Journal of Hepatology · doi:10.4254/wjh.v7.i29.2896 · Cited by 37 · see citing works
Kogiso, T., Egawa, H., Teramukai, S., Taniai, M., Hashimoto, E., Tokushige, K., Sakisaka, S., Sakabayashi, S., Yamamoto, M., Umeshita, K., et al. (2017) · Hepatology Communications · doi:10.1002/hep4.1037 · Cited by 31 · see citing works
Liver transplantation in primary biliary cirrhosis.
Milkiewicz, P. (2008) · Clinical Liver Disease · doi:10.1016/j.cld.2008.02.015 · Cited by 14 · see citing works
Diagnosis and Management of Allograft Failure
Burton, J. R., & Rosen, H. R. (2006) · Clinics in Liver Disease · doi:10.1016/j.cld.2006.05.003 · Cited by 31 · see citing works
PBC-transplantation and disease recurrence
Nevens, F. (2018) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2018.09.001 · Cited by 27 · see citing works
Hytiroglou, P., Gutierrez, J. A., Freni, M., Odin, J. A., Stanca, C. M., Merati, S., Schiano, T. D., Branch, A. D., & Thung, S. N. (2009) · Hepatology Research · doi:10.1111/j.1872-034x.2008.00483.x · Cited by 26 · see citing works
Current Status of Liver Transplantation for Primary Biliary Cholangitis.
Aguilar, M. T., & Carey, E. J. (2018) · Clinical Liver Disease · doi:10.1016/j.cld.2018.03.011 · Cited by 23 · see citing works
The diagnosis and treatment of primary biliary cirrhosis
Kim, K., & Jeong, S. (2011) · The Korean Journal of Hepatology · doi:10.3350/kjhep.2011.17.3.173 · Cited by 25 · see citing works
Liver Transplant for Cholestatic Liver Diseases
Carrion, A. F., & Bhamidimarri, K. R. (2013) · Clinics in Liver Disease · doi:10.1016/j.cld.2012.12.005 · Cited by 25 · see citing works
Satapathy, S. K., Jones, O. D., Vanatta, J. M., Kamal, F., Kedia, S., Jiang, Y., Nair, S. P., & Eason, J. D. (2017) · Transplantation Direct · doi:10.1097/txd.0000000000000693 · Cited by 24 · see citing works
Tanaka, A., Kono, H., Leung, P. S. C., & Gershwin, M. E. (2019) · Cellular Immunology · doi:10.1016/j.cellimm.2019.104021 · Cited by 22 · see citing works
Liver Transplantation for Primary Biliary Cholangitis
Martin, E. F. (2022) · Clinics in Liver Disease · doi:10.1016/j.cld.2022.06.014 · Cited by 22 · see citing works
Phenotypic Expression of Recurrent Disease After Liver Transplantation
O’Grady, J. G. (2010) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2010.03080.x · Cited by 21 · see citing works
The Gastroenterologist's Guide to Management of the Post-Liver Transplant Patient
Chascsa, D. M. H., & Vargas, H. E. (2018) · The American Journal of Gastroenterology · doi:10.1038/s41395-018-0049-0 · Cited by 20 · see citing works
Lasker, J. N., Sogolow, E. D., Olenik, J. M., Sass, D. A., & Weinrieb, R. M. (2010) · Women & Health · doi:10.1080/03630242.2010.498750 · Cited by 20 · see citing works
Lasker, J. N., Sogolow, E. D., Short, L. M., & Sass, D. A. (2010) · British Journal of Health Psychology · doi:10.1348/135910710x527964 · Cited by 19 · see citing works
Recurrence of autoimmune liver diseases after liver transplantation: clinical aspects
Cholongitas, Ε., & Burroughs, A. K. (2012) · Autoimmunity Highlights · doi:10.1007/s13317-012-0040-5 · Cited by 18 · see citing works
Long‐term clinical outcome of living‐donor liver transplantation for primary biliary cirrhosis
Hashimoto, E., Taniai, M., Yatsuji, S., Tokushige, K., Shiratori, K., Yamamoto, M., & Fuchinoue, S. (2007) · Hepatology Research · doi:10.1111/j.1872-034x.2007.00246.x · Cited by 18 · see citing works
Sogolow, E. D., Lasker, J. N., Sharim, R. R., Weinrieb, R. M., & Sass, D. A. (2010) · Illness Crisis & Loss · doi:10.2190/il.18.3.e · Cited by 17 · see citing works
Angulo, P., & Lindor, K. D. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-6189-2.00089-5 · Cited by 17 · see citing works
Management of the liver transplant patient
Gelb, B. E., & Feng, S. (2009) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/egh.09.58 · Cited by 16 · see citing works
Clouston, A. D., & Hübscher, S. G. (2017) · Elsevier eBooks · doi:10.1016/b978-0-7020-6697-9.00014-5 · Cited by 15 · see citing works
Primary biliary cirrhosis and liver transplantation
Akamatsu (2012) · Intractable & Rare Diseases Research · doi:10.5582/irdr.2012.v1.2.66 · Cited by 15 · see citing works
Carbone, M., Gerussi, A., Cardinale, V., Cazzagon, N., Cossiga, V., Lleò, A., Marrone, G., Marzioni, M., Moschetta, A., Muratori, L., et al. (2024) · Digestive and Liver Disease · doi:10.1016/j.dld.2024.05.002 · Cited by 16 · see citing works
Liver transplantation in chronic cholestatic conditions.
Milkiewicz, P., Wunsch, E., & Elias, E. (2012) · Frontiers in Bioscience · doi:10.2741/3966 · Cited by 13 · see citing works
Hasegawa, K., Sugawara, Y., Imamura, H., Ikeda, M., Kokudo, N., & Makuuchi, M. (2005) · Transplant International · doi:10.1111/j.1432-2277.2005.00129.x · Cited by 13 · see citing works
Zhang, J., Jiang, H., Xia, W., Jiang, Y., Tan, X., Liu, P., Jia, H., Yang, X., & Shen, G. (2015) · Tumor Biology · doi:10.1007/s13277-015-3771-x · Cited by 12 · see citing works
Activated-memory T cells influence naïve T cell fate: a noncytotoxic function of human CD8 T cells
Sasaki, K., Moussawy, M. A., Abou‐Daya, K. I., Macedo, C., Hosni-Ahmed, A., Liu, S., Juya, M., Zahorchak, A. F., Metes, D., Thomson, A. W., et al. (2022) · Communications Biology · doi:10.1038/s42003-022-03596-2 · Cited by 11 · see citing works
Recurrent primary biliary cirrhosis after liver transplantation--the disease and its management.
Schreibman, I. R., & Regev, A. (2006) · PubMed Central · Cited by 10 · see citing works
Management of Autoimmune Liver Diseases after Liver Transplantation
Barba, R., Medina‐Morales, E., Goyes, D., Patwardhan, V. R., & Bonder, A. (2021) · Transplantology · doi:10.3390/transplantology2020016 · Cited by 9 · see citing works
Gao, Z. (2009) · Advances in Anatomic Pathology · doi:10.1097/pap.0b013e31819946aa · Cited by 9 · see citing works
Induction and Maintenance of Immunosuppression
Chinnakotla, S., & Klintmalm, G. B. G. (2005) · Elsevier eBooks · doi:10.1016/b978-0-7216-0118-2.50080-x · Cited by 9 · see citing works
Pretransplant Evaluation and Liver Transplantation Outcome in PBC Patients
Mijić, M., Saric, I., Delija, B., Lalovac, M., Sobočan, N., Radetić, E., Martinčević, D., & Kanižaj, T. F. (2022) · Canadian Journal of Gastroenterology and Hepatology · doi:10.1155/2022/7831165 · Cited by 8 · see citing works
Hübscher, S. G., & Clouston, A. D. (2011) · Elsevier eBooks · doi:10.1016/b978-0-7020-3398-8.00015-5 · Cited by 8 · see citing works
Lindor, K. D., & Levy, C. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4377-0881-3.00041-3 · Cited by 8 · see citing works
Mitchell, O. J. L., COŞAR, A. M., Malik, M. U., & Gurakar, A. O. (2015) · Hepatology International · doi:10.1007/s12072-015-9685-2 · Cited by 8 · see citing works
[Liver transplantation for primary biliary cirrhosis].
Genda, T., & Ichida, T. (2013) · Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology · doi:10.1007/978-4-431-54789-1_21 · Cited by 1 · see citing works
Posttransplant immune-mediated cholangiopathies
Dumortier, J., Conti, F., & Scoazec, J. (2021) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000815 · Cited by 7 · see citing works
Cirrhose biliaire primitive et grossesse
Ducarme, G., Bernuau, J., & Luton, D. (2013) · Journal de gynécologie, obstétrique et biologie de la reproduction. Supplément/Journal de gynécologie obstétrique et biologie de la reproduction · doi:10.1016/j.jgyn.2013.03.016 · Cited by 7 · see citing works
Role of Transplant in Biliary Disease
Romine, M. M., & White, J. A. (2019) · Surgical Clinics of North America · doi:10.1016/j.suc.2018.12.009 · Cited by 7 · see citing works
Naini, B. V., & Lassman, C. (2013) · Surgical pathology clinics · doi:10.1016/j.path.2013.03.004 · Cited by 6 · see citing works
Recurrence of Nonviral Diseases
Oo, Y. H., & Neuberger, J. (2007) · Clinics in Liver Disease · doi:10.1016/j.cld.2007.04.012 · Cited by 6 · see citing works
Lee, D. U., Ponder, R. D., Lee, K., Menegas, S., Fan, G. H., Chou, H., Jung, D., Lee, K., Hastie, D. J., & Urrunaga, N. H. (2022) · Hepatology International · doi:10.1007/s12072-022-10468-8 · Cited by 5 · see citing works
van Hooff, M. C., de Veer, R. C., Karam, V. H., Adam, R. A., Taimr, P., Polak, W. G., Pashtoun, H., Murad, S. D., Corpechot, C., Mirza, D. F., et al. (2024) · JHEP Reports · doi:10.1016/j.jhepr.2024.101100 · Cited by 5 · see citing works
Wang, S., Dong, V., Montaño‐Loza, A. J., & Mason, A. L. (2021) · Hepatoma Research · doi:10.20517/2394-5079.2020.163 · Cited by 4 · see citing works
Mehtani, R., & Rathi, S. (2024) · Journal of Clinical and Experimental Hepatology · doi:10.1016/j.jceh.2024.101432 · Cited by 4 · see citing works
Key roles of hepatologists in successful liver transplantation
Kogiso, T., & Tokushige, K. (2018) · Hepatology Research · doi:10.1111/hepr.13183 · Cited by 4 · see citing works
Rezidiv der Grunderkrankung nach Lebertransplantation
Beckebaum, S., Cicinnati, V. R., Broelsch, C. E., & Gerken, G. (2006) · Medizinische Klinik - Intensivmedizin und Notfallmedizin · doi:10.1007/s00063-006-1118-5 · Cited by 4 · see citing works
Care of the Liver Transplant Patient
Kallwitz, E. R., & Cotler, S. J. (2008) · Disease-a-Month · doi:10.1016/j.disamonth.2008.03.003 · Cited by 4 · see citing works
Song, J., Wang, Y., Guo, R., Wang, K. Y., Hu, Y., Cui, M., Wang, G., Hao, H., Wang, H., & Xu, X. (2026) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2026.178910 · Cited by 3 · see citing works
Treatment of Primary Biliary Cholangitis including Transplantation
Muzahim, Y., Wakil, A., Bassi, M., & Pyrsopoulos, N. (2023) · Clinics in Liver Disease · doi:10.1016/j.cld.2023.07.003 · Cited by 3 · see citing works
Late Complications of Liver Transplantation and Recurrence of Disease
Charlton, M., & Menon, K. V. (2005) · Elsevier eBooks · doi:10.1016/b978-0-7216-0118-2.50070-7 · Cited by 3 · see citing works
Pathology of Liver Transplantation
Jiang, W., & Farber, J. L. (2016) · Springer eBooks · doi:10.1007/978-3-319-05543-5_21-1 · Cited by 4 · see citing works
Pathology of Liver Transplantation
Jiang, W., & Farber, J. L. (2017) · Springer eBooks · doi:10.1007/978-3-319-07209-8_21 · Cited by 3 · see citing works
Pathology of Liver Transplantation
Saxena, R., & Thung, S. N. (2011) · Elsevier eBooks · doi:10.1016/b978-0-443-06803-4.00042-3 · Cited by 3 · see citing works
(2006) · Springer eBooks · doi:10.1007/3-540-28977-1_40 · Cited by 3 · see citing works
Passos, P. R. C., Filho, V. O. C., Noronha, M. M., Rossi, Y. I., Vitor, I. C., Tomé, M. R., Amador, W. F. O., Silveira, I. B., Leite, M. D. A. B. C., Motta, R. V., et al. (2025) · American Journal of Transplantation · doi:10.1016/j.ajt.2025.10.009 · Cited by 2 · see citing works
Histopathological Evaluation of Recurrent Primary Biliary Cholangitis after Liver Transplantation
Weldemichael, W., Zhang, D., & Lin, J. (2022) · Journal of Clinical and Translational Pathology · doi:10.14218/jctp.2022.00021 · Cited by 2 · see citing works
Tanaka, A., Leung, P. S. C., Bowlus, C. L., & Gershwin, M. E. (2020) · Springer eBooks · doi:10.1007/978-3-030-51709-0_22 · Cited by 2 · see citing works
Harnois, D. M., Yataco, M. L., & Nakhleh, R. E. (2014) · Clinical Liver Disease · doi:10.1002/cld.341 · Cited by 2 · see citing works
Cholestasis Post-Liver Transplantation
Harnois, D. M., & Watt, K. D. S. (2014) · Clinical gastroenterology · doi:10.1007/978-1-4939-1013-7_10 · Cited by 2 · see citing works
The Liver in Organ Transplantation
Lefkowitch, J. H. (2010) · Elsevier eBooks · doi:10.1016/b978-0-7020-3410-7.00022-8 · Cited by 2 · see citing works
Kanel, G. C., & Korula, J. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4377-0765-6.10011-4 · Cited by 2 · see citing works
Cholestasis Post Liver Transplantation
Watt, K. D. S., & McCashland, T. M. (2008) · Humana Press eBooks · doi:10.1007/978-1-59745-118-5_10 · Cited by 2 · see citing works
Sclair, S. N., & Levy, C. (2018) · Elsevier eBooks · doi:10.1016/b978-0-323-37591-7.00042-2 · Cited by 2 · see citing works
Mayo, M. J., & Thiele, D. L. (2015) · Yamada's Textbook of Gastroenterology · doi:10.1002/9781118512074.ch100 · Cited by 2 · see citing works
- Authors
- Sylvestre, P. B., Batts, K. P., Burgart, L. J., Poterucha, J. J., & Wiesner, R. H.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Sylvestre, Pamela B.
- ORCID
- Sylvestre, Pamela B.
- Venue
- Liver Transplantation
- Published
- 2003-10
- Volume
- 9
- Issue
- 10
- Pages
- 1086-1093
- ISSN
- 1527-6465 (ISSN-L)
- OpenAlex
- W2086612029
- Cited by
- 148
- References
- 15
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 5 · 2023: 4 · 2022: 8 · 2021: 5 · 2020: 9 · 2019: 2 · 2018: 11 · 2017: 7 · 2016: 5 · 2015: 12 · 2014: 6 · 2013: 4 · 2012: 5
- FWCI
- 3.49
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Liver Transplantation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
- Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
- Health Sciences › Medicine › Surgery › Pediatric Hepatobiliary Diseases and Treatments
- Keywords
- primary biliary cirrhosis, recurrence, septal fibrosis, histological criteria, natural history (disease), lymphoplasmacytic infiltration
- MeSH terms
- Bile Ducts, Cholangitis, Fibrosis, Follow-Up Studies, Humans, Liver Cirrhosis, Biliary, Plasma Cells, Postoperative Complications, Recurrence, Incidence, Liver Transplantation, Disease Progression
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
