Stress and the adrenocortical control of epinephrine synthesis
Abstract
Psychologic states produced by environmental or physiologic stresses are usually associated with hypersecretion of adrenal hormones, particularly epinephrine and the glucocorticoids (hydrocortisone in humans or corticosterone in rats). A common mechanism links the secretion of these hormones, even though the adrenal medulla and cortex have different embryologic origins and biochemical properties and very different mechanisms controlling their secretory activities, ie, a cholinergic nervous input stimulates medullary secretion while a hormone, corticotropin (ACTH), activates secretion from the cortex. This mechanism is made possible by an intra-adrenal portal vascular system, which provides the medulla with uniquely high concentrations of glucocorticoids. These high concentrations are needed to induce the medullary enzyme, phenylethanolamine-N-methyltransferase (PNMT), which controls the synthesis of epinephrine from norepinephrine. By suppressing glucocorticoid secretion, pituitary failure compromises epinephrine synthesis and decreases the rate at which epinephrine is secreted; in contrast, prolonged chronic stress can enhance epinephrine synthesis and secretion within the adrenal, the brain, or both organs. This control mechanism could be involved in the long-term consequences of stress.
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Purification and Properties of Phenylethanolamine-N-methyl Transferase
Axelrod, J. (1962) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)83758-4 · Cited by 623 · see citing works
Adrenaline Synthesis: Control by the Pituitary Gland and Adrenal Glucocorticoids
Wurtman, R. J., & Axelrod, J. (1965) · Science · doi:10.1126/science.150.3702.1464 · Cited by 320 · see citing works
Self-citationThe formation of adrenaline from noradrenaline
Kirshner, N., & Goodall, M. (1957) · Biochimica et Biophysica Acta · doi:10.1016/0006-3002(57)90271-8 · Cited by 194 · see citing works
ADRENOCORTICAL CONTROL OF EPINEPHRINE SYNTHESIS
Pohorecky, L. A., & Wurtman, R. J. (1971) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06886-3 · Cited by 186 · see citing works
Self-citationWurtman, R. J. (1966) · Endocrinology · doi:10.1210/endo-79-3-608 · Cited by 134 · see citing works
Self-citationON THE MORPHOLOGY AND ADRENALINE-NORADRENALINE CONTENT OF CHROMAFFIN TISSUE
COUPLAND, R. E. (1953) · Journal of Endocrinology · doi:10.1677/joe.0.0090194 · Cited by 106 · see citing works
ENZYMATIC CONVERSION OF NOREPINEPHRINE TO EPINEPHRINE BY THE BRAIN
Pohorecky, L. A., Zigmond, M. J., Karten, H. J., & Wurtman, R. J. (1969) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)28179-4 · Cited by 99 · see citing works
Self-citationStachowiak, M. K., Rigual, R. J., Lee, P. H. K., Viveros, O. H., & Hong, J. (1988) · Molecular Brain Research · doi:10.1016/0169-328x(88)90050-2 · Cited by 62 · see citing works
Sauter, A., Baba, Y., Stone, E. A., & Goldstein, M. (1978) · Brain Research · doi:10.1016/0006-8993(78)90170-1 · Cited by 62 · see citing works
Hung, W., & Migeon, C. J. (1968) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-28-2-146 · Cited by 51 · see citing works
Luft, R., & von Euler, U. S. (1956) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-16-8-1017 · Cited by 35 · see citing works
Cahill, A. L., Eertmoed, A. L., Mangoura, D. A., & Perlman, R. L. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.67031217.x · Cited by 25 · see citing works
Impaired secretion of epinephrine in response to insulin among hypophysectomized dogs.
Wurtman, R. J., Casper, A., Pohorecky, L. A., & Bartter, F. C. (1968) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.61.2.522 · Cited by 24 · see citing works
Self-citationDecreased Corticotropin Reserve as Isolated Pituitary Defect
GREEN, W. L. (1961) · Archives of Internal Medicine · doi:10.1001/archinte.1961.03620120129018 · Cited by 21 · see citing works
Turner, B. B., Katz, R. J., & Carroll, B. J. (1979) · Brain Research · doi:10.1016/0006-8993(79)90233-6 · Cited by 19 · see citing works
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Particulate Matter Exposure and Stress Hormone Levels
Li, H., Cai, J., Chen, R., Zhao, Z., Ying, Z., Wang, L., Chen, J., Hao, K., Kinney, P. L., Chen, H., et al. (2017) · Circulation · doi:10.1161/circulationaha.116.026796 · Cited by 521 · see citing works
Neuroendocrine aspects of the response to stress
Miller, D. B., & O'Callaghan, J. P. (2002) · Metabolism · doi:10.1053/meta.2002.33184 · Cited by 496 · see citing works
Interpreting Stress Responses during Routine Toxicity Studies
Everds, N. E., Snyder, P. W., Bailey, K. L., Bolon, B. N., Creasy, D. M., Foley, G. L., Rosol, T. J., & Sellers, T. S. (2013) · Toxicologic Pathology · doi:10.1177/0192623312466452 · Cited by 338 · see citing works
Glucocorticoids and Skeletal Muscle
Bodine, S. C., & Furlow, J. D. (2015) · Advances in experimental medicine and biology · doi:10.1007/978-1-4939-2895-8_7 · Cited by 176 · see citing works
Homeostasis as the Mechanism of Evolution
Torday, J. S. (2015) · Biology · doi:10.3390/biology4030573 · Cited by 122 · see citing works
Particulate matter air pollutants and cardiovascular disease: Strategies for intervention
Aryal, A., Harmon, A. C., & Dugas, T. R. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107890 · Cited by 116 · see citing works
Fagundes, A. T. S., de Moura, E. G., Passos, M. C. F., Oliveira, E., Toste, F. P., Bonomo, I. T., Trevenzoli, I. H., Garcia, R. M. G., & Lisboa, P. C. (2007) · British Journal Of Nutrition · doi:10.1017/s0007114507750924 · Cited by 104 · see citing works
Hsieh, M. ‐., Lyu, R. ‐., Chang, W. ‐., Chang, K. ‐., Chen, C. ‐., Chang, H. ‐., Wu, Y. ‐., Chen, S. ‐., & Ro, L. ‐. (2008) · European Journal of Neurology · doi:10.1111/j.1468-1331.2008.02132.x · Cited by 78 · see citing works
Human adrenal glands secrete vitamin C in response to adrenocorticotrophic hormone
Padayatty, S. J., Doppman, J. L., Chang, R. C.-A., Wang, Y., Gill, J. R., Papanicolaou, D. A., & Levine, M. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.1.145 · Cited by 76 · see citing works
Clement, G. R., & Ngo‐Anh, T. J. (2012) · European Journal of Applied Physiology · doi:10.1007/s00421-012-2509-3 · Cited by 74 · see citing works
Kino, T., & Chrousos, G. P. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.12.001 · Cited by 74 · see citing works
Psychological stress‐induced changes in salivary alpha‐amylase and adrenergic activity
Kang, Y. (2010) · Nursing & Health Sciences · doi:10.1111/j.1442-2018.2010.00562.x · Cited by 67 · see citing works
Torday, J. S. (2015) · Medical Hypotheses · doi:10.1016/j.mehy.2015.03.019 · Cited by 66 · see citing works
Oliveira, E., Pinheiro, C. R., Santos-Silva, A. P., Trevenzoli, I. H., Abreu‐Villaça, Y., Neto, J. F. N., dos Reis, A. M., Passos, M. C. F., de Moura, E. G., & Lisboa, P. C. (2010) · Journal of Endocrinology · doi:10.1677/joe-09-0430 · Cited by 63 · see citing works
Stone, E. A., Lin, Y., Rosengarten, H., Kramer, H. K., & Quartermain, D. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300222 · Cited by 60 · see citing works
Kino, T., & Chrousos, G. P. (2010) · Endocrine development · doi:10.1159/000321232 · Cited by 55 · see citing works
Kanczkowski, W., Sue, M., & Bornstein, S. R. (2016) · Frontiers in Endocrinology · doi:10.3389/fendo.2016.00156 · Cited by 55 · see citing works
Kvetnansky, R., Kubovcakova, L., Tillinger, A., Micutkova, L., Krizanova, O., & Sabban, E. L. (2006) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-006-9063-7 · Cited by 53 · see citing works
Inflammatory Signaling in Hypertension: Regulation of Adrenal Catecholamine Biosynthesis
Byrne, C. J., Khurana, S., Kumar, A., & Tai, T. C. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00343 · Cited by 49 · see citing works
Ji, Y., Salavaggione, O. E., Wang, L., Adjei, A. A., Eckloff, B. W., Wieben, E. D., & Weinshilboum, R. M. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03453.x · Cited by 47 · see citing works
Lorenzo, M. D., Barra, T., Rosati, L., Valiante, S., Capaldo, A., Falco, M. D., & Laforgia, V. (2020) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2020.113550 · Cited by 46 · see citing works
The cell as the mechanistic basis for evolution
Torday, J. S. (2015) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.1305 · Cited by 45 · see citing works
Björnsdóttir, S., Øksnes, M., Isaksson, M., Methlie, P., Nilsen, R. M., Hustad, S., Kämpe, O., Hulting, A., Husebye, E. S., Løvås, K., et al. (2014) · Clinical Endocrinology · doi:10.1111/cen.12670 · Cited by 44 · see citing works
Principles of Catecholamine Biosynthesis, Metabolism and Release
Schulz, C., Eisenhofer, G., & Lehnert, H. (2003) · KARGER eBooks · doi:10.1159/000074656 · Cited by 40 · see citing works
Lin, X., Liu, H., Hsu, S.-J., Zhang, R., Chen, J., Chen, J., Gao, D., Cui, J., Ren, Z., & Chen, R. (2020) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-020-01568-0 · Cited by 39 · see citing works
Schneider, J., Lother, A., Hein, L., & Gilsbach, R. (2011) · Basic Research in Cardiology · doi:10.1007/s00395-011-0166-z · Cited by 36 · see citing works
The adrenal gland microenvironment in health, disease and during regeneration
Kanczkowski, W., Sue, M., & Bornstein, S. R. (2017) · HORMONES · doi:10.14310/horm.2002.1744 · Cited by 34 · see citing works
Potential effects of stress in critical illness through the role of stress neuropeptides
Papathanassoglou, E. D. E., Giannakopoulou, M. D., Mpouzika, M. D. A., Bozas, E., & Karabinis, A. (2010) · Nursing in Critical Care · doi:10.1111/j.1478-5153.2010.00363.x · Cited by 33 · see citing works
Sakihara, S., Kageyama, K., Nigawara, T., Kidani, Y., & Suda, T. (2007) · Endocrine Journal · doi:10.1507/endocrj.k07-012 · Cited by 32 · see citing works
Review: Feed efficiency and metabolic flexibility in livestock
Rauw, W. M., Baumgard, L. H., & Dekkers, J. C. M. (2024) · animal · doi:10.1016/j.animal.2024.101376 · Cited by 31 · see citing works
Gangloff, E. J., & Greenberg, N. L. (2023) · Springer eBooks · doi:10.1007/978-3-030-86012-7_4 · Cited by 30 · see citing works
Yamaguchi, N., Okada, S., Shimizu, T., Usui, D., Nakamura, K., Lu, L., & Yokotani, K. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.02.021 · Cited by 30 · see citing works
Adrenal Medulla and Paraganglia
McNicol, A. M. (2009) · Springer eBooks · doi:10.1007/978-1-4419-1069-1_12 · Cited by 29 · see citing works
GABA Signaling and Neuroactive Steroids in Adrenal Medullary Chromaffin Cells
Harada, K., Matsuoka, H., Fujihara, H., Ueta, Y., Yanagawa, Y., & Inoue, M. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00100 · Cited by 27 · see citing works
Eltahan, H. M., Bahry, M. A., Yang, H., Han, G., Nguyen, L. T. N., Ikeda, H., Ali, M. N., Amber, K. A., Furuse, M., & Chowdhury, V. S. (2017) · Physiological Reports · doi:10.14814/phy2.13511 · Cited by 27 · see citing works
Karbownik, M. S., Kręczyńska, J., Kwarta, P., Cybula, M., Wiktorowska-Owczarek, A., Kowalczyk, E., Pietras, T., & Szemraj, J. (2020) · Nutrients · doi:10.3390/nu12051469 · Cited by 26 · see citing works
Mitochondrial and metabolic features of salugenesis and the healing cycle
Naviaux, R. K. (2023) · Mitochondrion · doi:10.1016/j.mito.2023.04.003 · Cited by 25 · see citing works
On the Evolution of the Mammalian Brain
Torday, J. S., & Miller, W. B. (2016) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2016.00031 · Cited by 25 · see citing works
Jirout, M., Friese, R. S., Mahapatra, N. R., Mahata, M., Taupenot, L., Mahata, S. K., Křen, V., Zı́dek, V., Fischer, J., Maatz, H., et al. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq135 · Cited by 24 · see citing works
Strong, R. A., Hester, P. Y., Eicher, S. D., Hu, J., & Cheng, H. W. (2015) · PLoS ONE · doi:10.1371/journal.pone.0141215 · Cited by 23 · see citing works
Non-Canonical Effects of ACTH: Insights Into Adrenal Insufficiency
Hasenmajer, V., Bonaventura, I., Minnetti, M., Sada, V., Sbardella, E., & Isidori, A. M. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.701263 · Cited by 23 · see citing works
Modulation of learning and memory by adrenal and ovarian hormones
Korol, D. L., & Gold, P. E. (2007) · Elsevier eBooks · doi:10.1016/b978-012372540-0/50008-x · Cited by 22 · see citing works
Life Is Simple—Biologic Complexity Is an Epiphenomenon
Torday, J. S. (2016) · Biology · doi:10.3390/biology5020017 · Cited by 21 · see citing works
Kubovčáková, L., Mičutková, L., Bartošová, Z., Sabban, E. L., Križanová, O., & Květňanský, R. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03832.x · Cited by 21 · see citing works
Geiger, A. M., Pitts, K. P., Feldkamp, J., Kirschbaum, C., & Wolf, J. M. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.07.010 · Cited by 20 · see citing works
Proctor, C. M., Freeman, E. W., & Brown, J. L. (2009) · Zoo Biology · doi:10.1002/zoo.20292 · Cited by 20 · see citing works
Scientific and Regulatory Policy Committee Review
Fikes, J. D., Patrick, D. J., Francke, S., Frazier, K. S., Reindel, J. F., Romeike, A., Spaet, R. H., Tomlinson, L., & Schafer, K. A. (2015) · Toxicologic Pathology · doi:10.1177/0192623315596382 · Cited by 19 · see citing works
Malcher‐Lopes, R., & Buzzi, M. (2009) · Vitamins and hormones · doi:10.1016/s0083-6729(09)81011-x · Cited by 18 · see citing works
Validity of mental and physical stress models
Hendry, E., McCallister, B., Elman, D. J., Freeman, R. L., Borsook, D., & Elman, I. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105566 · Cited by 17 · see citing works
Stress and skin leukocyte trafficking as a dual-stage process
Neeman, E., Shaashua, L., Benish, M., Page, G. G., Zmora, O., & Ben‐Eliyahu, S. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.09.007 · Cited by 17 · see citing works
Yaglova, N. V., Tsomartova, D. A., & Yaglov, V. V. (2017) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-017-3819-6 · Cited by 16 · see citing works
Milde, A. S., Böttiger, B. W., & Morcos, M. (2005) · Der Anaesthesist · doi:10.1007/s00101-005-0867-5 · Cited by 14 · see citing works
Child Sexual Abuse is a Global Public Health Problem: Where is Australia?
Purvis, M., & Joyce, A. (2005) · Psychiatry Psychology and Law · doi:10.1375/pplt.12.2.334 · Cited by 14 · see citing works
Sexual dimorphism in the effect of nonhabituating stress on neurogenic plasma extravasation
Green, P. G., & Levine, J. D. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.03872.x · Cited by 14 · see citing works
Karbownik, M. S., Kręczyńska, J., Wiktorowska‐Owczarek, A., Kwarta, P., Cybula, M., Stilinović, N., Pietras, T., & Kowalczyk, E. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.800023 · Cited by 13 · see citing works
The genetic basis of adrenal gland weight and structure in BXD recombinant inbred mice
Curzio, D. L. D., & Goldowitz, D. (2011) · Mammalian Genome · doi:10.1007/s00335-011-9315-9 · Cited by 13 · see citing works
Evolution and Cell Physiology. 1. Cell signaling is all of biology
Torday, J. S. (2013) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00197.2013 · Cited by 13 · see citing works
Bioapplications of Electrochemical Sensors and Biosensors
Dumitrescu, E., & Andreescu, S. (2017) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2017.01.017 · Cited by 13 · see citing works
Mokhtar, D. M., Hussein, M. T., & Hassan, A. H. S. (2017) · Microscopy and Microanalysis · doi:10.1017/s1431927617012727 · Cited by 12 · see citing works
Tanaka, Y., Kanazawa, M., Kano, M., Tashiro, M., & Fukudo, S. (2018) · PLoS ONE · doi:10.1371/journal.pone.0199698 · Cited by 12 · see citing works
Jurkovich, V., Bakony, M., Laky, E., Ruff, F., Kézér, F. L., Bende, A., & Kovács, L. (2019) · Domestic Animal Endocrinology · doi:10.1016/j.domaniend.2019.106388 · Cited by 12 · see citing works
Capaldo, A., Gay, F., Valiante, S., Laforgia, V., & Varano, L. (2004) · Journal of Morphology · doi:10.1002/jmor.10188 · Cited by 11 · see citing works
Cell Signaling Within Endocrine Glands: Thyroid, Parathyroids and Adrenal Glands
Pereira, S. S., Lobato, C. B., & Monteiro, M. P. (2020) · Springer eBooks · doi:10.1007/978-3-030-44436-5_3 · Cited by 10 · see citing works
Hoshino, C., Satoh, N., Narita, M., Kikuchi, A., & Inoue, M. (2011) · BMJ Case Reports · doi:10.1136/bcr.01.2011.3735 · Cited by 10 · see citing works
Stuver, S. O., Lyons, J. G., Coviello, A. D., & Fredman, L. (2016) · Journal of Applied Gerontology · doi:10.1177/0733464815624153 · Cited by 10 · see citing works
STRESS MEASURES: A NARRATIVE REVIEW
Faro, A., & Pereira, M. E. (2013) · Psicologia Saúde & Doenças · doi:10.15309/13psd140107 · Cited by 10 · see citing works
The Brain Epinephrine-α1-Adrenoceptor System in Behavioral Activation and Depression
Stone, E., & Quartermain, D. (2005) · Current Psychiatry Reviews · doi:10.2174/1573400052953565 · Cited by 10 · see citing works
Ramsay, S. D., Nenke, M., Meyer, E. J., Torpy, D., & Young, R. L. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1508848 · Cited by 9 · see citing works
Riveros-Rivera, A., Penzel, T., Gunga, H., Opatz, O. S., Paul, F., Klug, L., Boschmann, M., & Mähler, A. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.899636 · Cited by 9 · see citing works
Zubidat, A. E., Nelson, R. J., & Haim, A. (2007) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.08.024 · Cited by 9 · see citing works
The synchronic, diachronic cell as the holism of consciousness
Torday, J. S. (2024) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2024.02.006 · Cited by 8 · see citing works
Luza, S. M., Arancibia, S., Venegas, M., & Lara, H. E. (2003) · Neuroendocrinology · doi:10.1159/000070282 · Cited by 8 · see citing works
Capaldo, A., Gay, F., Valiante, S., Laforgia, V., & Varano, L. (2003) · Journal of Morphology · doi:10.1002/jmor.10157 · Cited by 8 · see citing works
An unusual presentation of pheochromocytoma
Taliercio, J. J., & Bravo, E. (2011) · Clinical Kidney Journal · doi:10.1093/ndtplus/sfr055 · Cited by 7 · see citing works
Subjective versus objective stress in noncritically ill hospitalized and outpatient adult men
Karkow, F. J., Spiandorello, W. P., de Godoy, R. F., Pezzi, P., Karkow, A. G. M., & Faintuch, J. (2004) · Revista do Hospital das Clínicas · doi:10.1590/s0041-87812004000400002 · Cited by 6 · see citing works
Effect of acute heat stress on rat adrenal medulla — a morphological and ultrastructural study
Petrović-Kosanović, D., Čakić-Milošević, M., Budeč, M., & Koko, V. (2012) · Open Life Sciences · doi:10.2478/s11535-012-0044-1 · Cited by 6 · see citing works
Wrońska, D., Kania, B. F., & Blachuta, M. (2017) · Polish Journal of Veterinary Sciences · doi:10.1515/pjvs-2017-0041 · Cited by 6 · see citing works
Adaptive remodeling of the stimulus-secretion coupling: Lessons from the ‘stressed’ adrenal medulla
Guérineau, N. C. (2023) · Vitamins and hormones · doi:10.1016/bs.vh.2023.05.004 · Cited by 5 · see citing works
Hester, P. Y. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-800879-9.00032-9 · Cited by 5 · see citing works
Hanson, E. D., Bates‐Fraser, L. C., Moertl, K. M., & Evans, E. S. (2021) · Endocrines · doi:10.3390/endocrines2020012 · Cited by 5 · see citing works
Gardner, S. T., Kepas, M. E., Simons, C. R., Horne, L. M., Savitzky, A. H., & Mendonça, M. T. (2020) · Ecology and Evolution · doi:10.1002/ece3.7118 · Cited by 5 · see citing works
Hypoglycemia-Associated Autonomic Failure in Type 1 Diabetes: Beyond Hypoglycemia Unawareness
Giannakopoulos, A., Efthymiadou, A., Chrysanthakopoulou, A., & Chrysis, D. (2021) · Clinical Diabetes · doi:10.2337/cd21-0100 · Cited by 4 · see citing works
Dingley, R., Hourtovenko, C., Lee, J. D., Tharmalingam, S., & Tai, T. C. (2025) · Current Issues in Molecular Biology · doi:10.3390/cimb47090725 · Cited by 3 · see citing works
Laposata, E. A. (2007) · Humana Press eBooks · doi:10.1007/978-1-59745-015-7_5 · Cited by 3 · see citing works
Harris, H. A., Chan, D. M., Fix, L. E., Nicholson, B. D., & Acevedo, E. O. (2026) · PLOS One · doi:10.1371/journal.pone.0344981 · Cited by 2 · see citing works
“[8 –10] It has been observed that norepinephrine is converted into epinephrine via the Phenylethanolamine N-methyltransferase (PNMT) enzyme [11].”
Introduction to neurobiology and pharmacology of stress
Abbasi-Maleki, S., Nakhaei, B., Mehr, S. R., & Moradikor, N. (2025) · Progress in brain research · doi:10.1016/bs.pbr.2025.01.006 · Cited by 2 · see citing works
The holism of evolution as consciousness
Torday, J. S. (2024) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2024.01.004 · Cited by 2 · see citing works
Xu, L. N., Gao, J., Yao, J. W., Jiao, H., Wang, X. J., Lin, H., & Zhao, J. P. (2024) · Poultry Science · doi:10.1016/j.psj.2024.104014 · Cited by 2 · see citing works
Boesch, J. M., Gleed, R. D., Buss, P. E., Tordiffe, A. S. W., Zeiler, G. E., Miller, M. A., Viljoen, F. P., Harvey, B. H., Parry, S. A., & Meyer, L. C. R. (2025) · Conservation Physiology · doi:10.1093/conphys/coaf009 · Cited by 3 · see citing works
The Implications of an Evolutionary Perspective on Mental Health Promotion
Joyce, A., Howat, P. A., & Maycock, B. R. (2005) · International Journal of Mental Health Promotion · doi:10.1080/14623730.2005.9721956 · Cited by 2 · see citing works
Systemic stress response and hyperglycemia after abdominal surgery in rat and man
Hager, P. (2008) · Figshare · Cited by 2 · see citing works
Westhuizen, L. V. D. (2018) · Cited by 2 · see citing works
Kondaurova, E. M., Antonov, E. V., Bazhenova, E. Y., Базовкина, Д. В., & Naumenko, V. S. (2021) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-021-01099-x · Cited by 1 · see citing works
Experimental Study of Taurine Antitoxic Activity in the Model of Chronic Epinephrine Intoxication
Oleynikova, O. N., Макарова, Л. М., Погорелый, В. Е., & Novikova, N. A. (2015) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-15126-7_44 · Cited by 1 · see citing works
Stout, K. W., Pearson, J. R., Hambleton, C., Deckert, J. A., & Gallagher, P. M. (2023) · Human performance in extreme environments · doi:10.7771/2327-2937.1152 · Cited by 1 · see citing works
Soejima, Y., Iwata, N., Yamamoto, K., Suyama, A., Nakano, Y., & Otsuka, F. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25031585 · Cited by 1 · see citing works
Liebscher, M., White, S., Hass, S., Chocat, A., Mézenge, F., Landeau, B., Delarue, M., Hébert, O., Turpin, A., Marchant, N. L., et al. (2024) · Biological Psychiatry Global Open Science · doi:10.1016/j.bpsgos.2024.100431 · Cited by 1 · see citing works
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Tsuji, Y., Uchihashi, K., & Nishikawa, Y. (2011) · Journal of Osaka Dental University · doi:10.18905/jodu.45.2_185 · Cited by 1 · see citing works
González‐Torres, S. (2012) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
- Authors
- Wurtman, R. J.
- Affiliations
- Massachusetts Institute of Technology (US)
- Corresponding author
- Wurtman, Richard J.
- Venue
- Metabolism
- Publisher
- Elsevier BV
- Published
- 2002-06
- Volume
- 51
- Issue
- 6
- Pages
- 11-14
- ISSN
- 0026-0495 (ISSN-L)
- OpenAlex
- W2030689507
- Cited by
- 126
- References
- 15
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 8 · 2023: 5 · 2022: 3 · 2021: 6 · 2020: 16 · 2019: 1 · 2018: 3 · 2017: 11 · 2016: 5 · 2015: 9 · 2014: 1 · 2013: 4 · 2012: 4
- FWCI
- 2.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Medicinal Plants and Bioactive Compounds
- Keywords
- epinephrine synthesis, stress, adrenal medulla, adrenal cortex, phenylethanolamine N-methyltransferase, norepinephrine, glucocorticoids, ACTH, cholinergic innervation, pituitary failure, chronic stress, cortisol, corticosterone
- MeSH terms
- Adrenal Cortex, Adrenocorticotropic Hormone, Animals, Brain, Epinephrine, Glucocorticoids, Humans, Phenylethanolamine N-Methyltransferase, Pituitary Gland, Stress, Physiological
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