Brain development and the onset of mood disorders
Abstract
Research in mood disorder pathophysiology has stimulated considerable interest in clinical and biologic aspects of mood disorders among children and adolescents. From the clinical perspective, developmental aspects of psychiatric disorders have crystallized in the relatively new theoretical school known as developmental psychopathology. This school attempts to understand the nature of developmental changes in behavior, with the goal of differentiating normal from abnormal stage-related behavior. This perspective has exerted major impact on conceptualizations of psychiatric disorders. From the basic science perspective, biologic findings in emotion have stimulated an integration of basic and clinical approaches to mood disorders. The term emotion is often used to refer to brain states elicited by stimuli for which an organism will extend effort to obtain (rewards) or avoid (punishments). Imaging studies suggest that brain regions engaged by rewarding and punishing stimuli in lower mammals are also implicated in mood disorders. Other studies suggest that environmental factors exert profound effects on the development of these brain regions. The impact of 4 areas of research on our understanding of depression pathophysiology is reviewed: (1) mood disorder onset, (2) structural magnetic resonance imaging (MRI), (3) behavioral or cognitive correlates of major depression, and (4) functional MRI of brain regions engaged across development. This is a US government work. There are no restrictions on its use.
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Adolescence is often a time when various mental illnesses emerge, including mood disorders, drug abuse disorders, eating disorders, and psychoses.
“adolescence is often a time when various mental illnesses emerge such as mood disorders, drug abuse disorders, eating disorders, and psychoses (Pine 2002; Chambers, Taylor et al. 2003; Sisk and Zehr 2005; Paus, Keshavan et al. 2008)”
From Developmental imaging genetics: Linking dopamine function to adolescent behavior (2014) · cites this paper as Pine 2002
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Sturman, D. A., & Moghaddam, B. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.04.003 · Cited by 341 · see citing works
“…to the added risks of normal adolescent development, it is also the time when symptoms of a variety of mental illnesses often manifest, including mood disorders, eating disorders, and psychotic disorders such as schizophrenia (Paus et al., 2008; Pine, 2002; Sisk and Zehr, 2005; Volkmar, 1996).”
A biopsychosocial model as a guide for psychoeducation and treatment of depression
Schotte, C., Bossche, B. V. D., Doncker, D. D., Claes, S. J., & Cosyns, P. R. (2006) · Depression and Anxiety · doi:10.1002/da.20177 · Cited by 214 · see citing works
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“Limited structural and functional imaging data in pediatric populations also support these models (Pine, 2002; Rosenberg et al, 2006).”
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“Our study focused on adolescent behaviors, because this is a period of psychiatric vulnerability and the typical time of symptomatic onset of several psychopathologies, including schizophrenia (25,56).”
Striatum processes reward differently in adolescents versus adults
Sturman, D. A., & Moghaddam, B. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1114137109 · Cited by 98 · see citing works
Nelson, E. E., Tone, E. B., Monk, C. S., Zarahn, E., Leibenluft, E., Pine, D. S., & Monique Ernst, D. (2003) · Journal of Child Psychology and Psychiatry · doi:10.1111/1469-7610.00186 · Cited by 96 · see citing works
Self-citationDevelopmental imaging genetics: Linking dopamine function to adolescent behavior
Padmanabhan, A., & Luna, B. (2014) · Brain and Cognition · doi:10.1016/j.bandc.2013.09.011 · Cited by 87 · see citing works
“…adolescence is often a time when various mental illnesses emerge such as mood disorders, drug abuse disorders, eating disorders, and psychoses (Chambers, Taylor, et al., 2003; Paus, Keshavan, et al., 2008; Pine, 2002; Sisk & Zehr, 2005), the risk factors for which are not fully characterized.”
Ehrlich, D. E., Ryan, S. J., & Rainnie, D. G. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2012.237453 · Cited by 86 · see citing works
“Characterizing how neurons of the amygdala develop is fundamental to understanding normative emotional development and, in turn, how risk factors and genetic predispositions are translated into developmental emotional disorders like anxiety, depression, autism spectrum disorders, and schizophrenia (Pine, 2002; Kim-Coh…”
BackgroundPostnatal maturation of GABAergic transmission in the rat basolateral amygdala.
Ehrlich, D. E., Ryan, S., Hazra, R., Guo, J.-D., & Rainnie, D. (2013) · Journal of Neurophysiology · doi:10.1152/jn.01105.2012 · Cited by 84 · see citing works
Adolescents exhibit behavioral differences from adults during instrumental learning and extinction
Sturman, D. A., Mandell, D. R., & Moghaddam, B. (2010) · Behavioral Neuroscience · doi:10.1037/a0018463 · Cited by 69 · see citing works
“It is during adolescence that the symptoms of several psychiatric disorders typically arise, including depression, eating disorders, and schizophrenia (Pine, 2002; Sisk & Zehr, 2005; Volkmar, 1996).”
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Developmental Risk I: Depression and the Developing Brain
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“However, there are several challenges in designing neurocognitive activation paradigms for pediatric patients (Ernst and Rumsey, 2000; Pine, 2002; Leibenluft et al., 2003).”
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“The development of new, safe technologies for exploring brain structure and function in young individuals [3,18] is creating great excitement about possible advances in the understanding of the biological underpinnings of depression.”
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“Practical obstacles to imaging manic children, as well as the ongoing development of the prefrontal cortex during adolescence (Pine, 2000) add to the challenges of future research.”
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Padmanabhan, A. (2013) · D-Scholarship@Pitt (University of Pittsburgh)
- Authors
- Pine, D. S.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Pine, Daniel S.
- ORCID
- Pine, Daniel S.
- Venue
- Seminars in Clinical Neuropsychiatry
- Publisher
- Elsevier BV
- Published
- 2002-10
- Volume
- 7
- Issue
- 4
- Pages
- 223-233
- ISSN
- 1084-3612 (ISSN-L)
- OpenAlex
- W2011479449
- Cited by
- 26
- References
- 0
- Citations by year
- 2021: 1 · 2018: 1 · 2017: 1 · 2015: 1 · 2013: 5 · 2012: 3
- FWCI
- 0.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Seminars in Clinical Neuropsychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Keywords
- mood disorders, depression pathophysiology, brain development, developmental psychopathology, children and adolescents, emotions, reward and punishment, structural MRI, functional MRI
- MeSH terms
- Adolescent, Adolescent Behavior, Brain, Child, Child Behavior, Emotions, Humans, Magnetic Resonance Imaging, Nerve Net, Age of Onset, Mood Disorders
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