Advances in the biology and treatment of myeloma bone disease.
Abstract
The major clinical manifestations of multiple myeloma are related to the loss of bone. This bone loss often leads to pathologic fractures, spinal cord compression, hypercalcemia, and bone pain. This article reviews the cytokine network involved in myeloma bone disease; describes the signaling cascade involved in osteoclastogenesis and mechanisms of action of novel therapeutic options for myeloma bone disease such as osteoprotegerin, RANK human immunoglobulin fusion protein, the proteasome inhibitor PS-341, and bisphosphonates; and summarizes the latest clinical trial results using oral and intravenous bisphosphonates for bone disease in multiple myeloma.
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Multiple myeloma has deleterious effects on bone by increasing bone resorption while suppressing bone formation.
“Multiple myeloma also has deletrious effects on bone by virtue of increasing bone resorption while suppressing bone formation (305).”
From Receptor Activator of Nuclear Factor κB Ligand and Osteoprotegerin Regulation of Bone Remodeling in Health and Disease (2008) · cites this paper as [305]
Cited by
Sorted by citations
Kearns, A. E., Khosla, S., & Kostenuik, P. J. (2008) · Endocrine Reviews · doi:10.1210/er.2007-0014 · Cited by 824 · see citing works
- Authors
- Berenson, J. R.
- Affiliations
- Cedars-Sinai Medical Center (US)
- Corresponding author
- Berenson, James R.
- ORCID
- Berenson, James R.
- Venue
- Seminars in Oncology
- Publisher
- Elsevier BV
- Published
- 2002-12
- Volume
- 29
- Issue
- 6 Suppl 17
- Pages
- 11-16
- ISSN
- 0093-7754 (ISSN-L)
- OpenAlex
- W3146339815
- Cited by
- 30
- References
- 0
- Citations by year
- 2021: 1 · 2020: 2 · 2016: 1 · 2015: 2 · 2014: 1
- FWCI
- 1.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Seminars in Oncology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Multiple Myeloma Research and Treatments
- Health Sciences › Medicine › Oncology › Bone health and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Keywords
- myeloma bone disease, multiple myeloma, bone loss, pathological fracture, hypercalcemia, bone pain, cytokine network, osteoclastogenesis, osteoprotegerin, RANK ligand, proteasome inhibitors, bortezomib, bisphosphonates, oral bisphosphonates, intravenous bisphosphonates
- MeSH terms
- Bortezomib, Zoledronic Acid, Pamidronate, Bone Resorption, Boronic Acids, Carrier Proteins, Clinical Trials as Topic, Diphosphonates, Glycoproteins, Humans, Imidazoles, Immunoglobulin Fc Fragments, Lymphokines, Membrane Glycoproteins, Multiple Myeloma, Pyrazines, Recombinant Fusion Proteins, Signal Transduction, Cytokines, Endothelial Growth Factors, Receptors, Tumor Necrosis Factor, Receptors, Cytoplasmic and Nuclear, Intercellular Signaling Peptides and Proteins, Vascular Endothelial Growth Factors, Vascular Endothelial Growth Factor A, Osteoprotegerin, RANK Ligand, Receptor Activator of Nuclear Factor-kappa B
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