The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
EGCG, a major component of green tea, inhibits tumour growth by inhibiting VEGF induction in human colon carcinoma cells
Open accessAbstract
Catechins are key components of teas that have antiproliferative properties. We investigated the effects of green tea catechins on intracellular signalling and VEGF induction in vitro in serum-deprived HT29 human colon cancer cells and in vivo on the growth of HT29 cells in nude mice. In the in vitro studies, (-)-epigallocatechin gallate (EGCG), the most abundant catechin in green tea extract, inhibited Erk-1 and Erk-2 activation in a dose-dependent manner. However, other tea catechins such as (-)-epigallocatechin (EGC), (-)-epicatechin gallate (ECG), and (-)-epicatechin (EC) did not affect Erk-1 or 2 activation at a concentration of 30 microM. EGCG also inhibited the increase of VEGF expression and promoter activity induced by serum starvation. In the in vivo studies, athymic BALB/c nude mice were inoculated subcutaneously with HT29 cells and treated with daily intraperitoneal injections of EC (negative control) or EGCG at 1.5 mg day(-1)mouse(-1)starting 2 days after tumour cell inoculation. Treatment with EGCG inhibited tumour growth (58%), microvessel density (30%), and tumour cell proliferation (27%) and increased tumour cell apoptosis (1.9-fold) and endothelial cell apoptosis (3-fold) relative to the control condition (P< 0.05 for all comparisons). EGCG may exert at least part of its anticancer effect by inhibiting angiogenesis through blocking the induction of VEGF.
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Pinnell, S. R. (2003) · Journal of the American Academy of Dermatology · doi:10.1067/mjd.2003.16 · Cited by 544
Mechanisms of Cancer Prevention by Tea Constituents
Lambert, J. D., & Yang, C. S. (2003) · The Journal of Nutrition · doi:10.1093/jn/133.10.3262s · Cited by 490
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‘Angioprevention’: angiogenesis is a common and key target for cancer chemopreventive agents
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Metadata
- Authors
- Jung, Y. D., Kim, M. S., Shin, B. A., Chay, K. O., Ahn, B. W., Liu, W., Bucana, C. D., Gallick, G. E., & Ellis, L. M.
- Venue
- British Journal of Cancer
- Published
- 2001
- Volume
- 84
- Issue
- 6
- Pages
- 844-850
- ISSN
- 0007-0920 (ISSN-L)
- 1532-1827
- OpenAlex
- W2154621970
- Cited by
- 329
- References
- 26
- FWCI
- 9.76
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Jung, Y. D., Kim, M. S., Shin, B. A., Chay, K. O., Ahn, B. W., Liu, W., Bucana, C. D., Gallick, G. E., & Ellis, L. M. (2001). EGCG, a major component of green tea, inhibits tumour growth by inhibiting VEGF induction in human colon carcinoma cells. British Journal of Cancer. https://doi.org/10.1054/bjoc.2000.1691
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