Mechanism of hypertriglyceridaemia associated with contraceptive steroids.

Kissebah, A.; Harrigan, P.; Wynn, V.

doi:10.1055/s-0028-1093969

Cited by 107Lipid metabolism and disordersLipoproteins and Cardiovascular HealthLipid metabolism and biosynthesis

Mechanism of hypertriglyceridaemia associated with contraceptive steroids.

Kissebah, A., Harrigan, P., Wynn, V.·1973·Hormone and Metabolic Research

DOI 10.1055/s-0028-1093969

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Abstract

Plasma free fatty acid and triglyceride turnover rates were determined in thirty-five premenopausal adult healthy females. Eleven subjects were studied while taking a combined oestrogen-progestagen contraceptive preparation, seven women were taking either progesterone or megestrol alone, five women were taking an oestrogen preparation alone, and fifteen women served as controls. The plasma free fatty acid concentration and turnover rate were not affected by any of these steroids. The triglyceride concentration and turnover rate were increased in women taking either the combined preparation, or oestrogen alone. The intake of combined preparation was associated with increased clearance of both endogenous and exogenous triglycerides, though the post heparin plasma lipolytic activity was not altered. Women using either progesterone or megestrol showed a decrease in serum triglyceride concentration associated with both increased triglyceride clearance and increased activity of post-heparin plasma lipolytic activity. In this group, the triglyceride turnover rate was not affected. Women taking oestrogen alone had normal rates of clearance of plasma triglycerides. These results suggest that the increase in triglyceride turnover is the result of the oestrogenic component while the increase in triglyceride clearance is the net effect of the progestagen moiety. The changes in triglyceride turnover rate were significantly conelated with the duration of administration and the peak plasma insulin response to an oral glucose load.

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Oral estrogens increase the hepatic secretion of VLDL, leading to an increase in serum triglyceride levels.
“Oral estrogens increase the hepatic secretion of VLDL, leading in turn to an increase in serum triglyceride levels (108).”
From Evaluation and Treatment of Hypertriglyceridemia: An Endocrine Society Clinical Practice Guideline (2012) · cites this paper as [108]

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Eaker, E. D., Chesebro, J. H., Sacks, F. M., Wenger, N. K., Whisnant, J. P., & Winston, M. C. (1993) · Circulation · doi:10.1161/01.cir.88.4.1999 · Cited by 348 · see citing works
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Godsland, I. F., Wynn, V., Crook, D., & Miller, N. E. (1987) · American Heart Journal · doi:10.1016/0002-8703(87)90552-7 · Cited by 322 · see citing works
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Self-citation
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Applebaum, D., Goldberg, A. P., Pykälistö, O., Brunzell, J. D., & Hazzard, W. R. (1977) · Journal of Clinical Investigation · doi:10.1172/jci108677 · Cited by 206 · see citing works
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Kim, H. J., & Kalkhoff, R. K. (1975) · Journal of Clinical Investigation · doi:10.1172/jci108168 · Cited by 158 · see citing works
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Kushwaha, R. S., HAZZARD, W. R., Gagné, C., CHAIT, A., & ALBERS, J. J. (1977) · Annals of Internal Medicine · doi:10.7326/0003-4819-87-5-517 · Cited by 137 · see citing works
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Effects of estrogenic compounds on triglyceride kinetics
Glueck, C. J., Fallat, R. W., & Scheel, D. (1975) · Metabolism · doi:10.1016/0026-0495(75)90078-5 · Cited by 128 · see citing works
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Ockner, R. K., Lysenko, N., Manning, J. A., Monroe, S. E., & Burnett, D. A. (1980) · Journal of Clinical Investigation · doi:10.1172/jci109753 · Cited by 125 · see citing works
Women Produce Fewer but Triglyceride-Richer Very Low-Density Lipoproteins than Men
Magkos, F., Patterson, B. W., Mohammed, B. S., Klein, S., & Mittendorfer, B. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-2215 · Cited by 124 · see citing works
Effect of Estrogen on Very Low Density Lipoprotein and Low Density Lipoprotein Subclass Metabolism in Postmenopausal Women1
Campos, H., Walsh, B. W., Judge, H., & Sacks, F. M. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.12.4437 · Cited by 125 · see citing works
“This is consistent with the known effects of estrogen to increase hepatic triglyceride synthesis, which would increase the size of the apoB-containing particles that are secreted (39, 40 ).”
Background
Sex Differences in Long Chain Fatty Acid Utilization and Fatty Acid Binding Protein Concentration in Rat Liver
Ockner, R. K., Burnett, D. A., Lysenko, N., et al. (1979) · Journal of Clinical Investigation · doi:10.1172/jci109437 · Cited by 118 · see citing works
High-Density Lipoprotein Metabolism
Nicoll, A. D., Miller, N. E., & Lewis, B. (1980) · Advances in lipid research · doi:10.1016/b978-0-12-024917-6.50008-2 · Cited by 104 · see citing works
Oral Contraceptive and Postmenopausal Estrogen Effects on Lipoprotein Triglyceride and Cholesterol in an Adult Female Population: Relationships to Estrogen and Progestin Potency*
Knopp, R. H., Walden, C. E., Wahl, P. W., et al. (1981) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-53-6-1123 · Cited by 102 · see citing works
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Larsson‐Cohn, U., Fåhraeus, L., Wallentin, L. C., et al. (1981) · Fertility and Sterility · doi:10.1016/s0015-0282(16)45318-5 · Cited by 98 · see citing works
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Reiser, S., Bickard, M. C., Hallfrisch, J. G., Michaelis, O. E., & Prather, E. S. (1981) · Journal of Nutrition · doi:10.1093/jn/111.6.1045 · Cited by 93 · see citing works
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Post-menopausal hormone replacement therapy: effects of progestogens on serum lipids and lipoproteins. A review
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Walsh, B. W., & Sacks, F. M. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116437 · Cited by 76 · see citing works
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SHULMAN, L. P., Yankov, V., & Uhl, K. (2002) · Menopause The Journal of The North American Menopause Society · doi:10.1097/00042192-200205000-00008 · Cited by 73 · see citing works
Lipid metabolism in pregnancy. II. Postheparin lipolytic activity and hypertriglyceridemia in the pregnant rat
Knopp, R. H., Boroush, M. A., & O’Sullivan, J. B. (1975) · Metabolism · doi:10.1016/0026-0495(75)90073-6 · Cited by 66 · see citing works
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Sacks, F. M., & Walsh, B. W. (1990) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1990.tb30339.x · Cited by 63 · see citing works
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Magkos, F., Patterson, B. W., & Mittendorfer, B. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00246.2006 · Cited by 57 · see citing works
“Estrogens have been found to increase VLDL-TG secretion (18, 52); however, only one study investigated the effect of progestins on TG kinetics and found no differences in TG secretion into plasma in women who received compared with those who did not receive progestins (28).”
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Brun, L., Gagn, C., Rousseau, C., Moorjani, S., & Paul-Lupien, J. (1986) · Cancer · doi:10.1002/1097-0142(19860601)57:11 · Cited by 56 · see citing works
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Weinstein, I., Soler‐Argilaga, C., Werner, H. V., & Heimberg, M. (1979) · Biochemical Journal · doi:10.1042/bj1800265 · Cited by 52 · see citing works
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Self-citation
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Self-citation
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Vermeulen, A., & Thiéry, M. (1982) · Contraception · doi:10.1016/0010-7824(82)90149-4 · Cited by 43 · see citing works
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Self-citation
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Samsioe, G. (1982) · Contraception · doi:10.1016/0010-7824(82)90038-5 · Cited by 40 · see citing works
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Jin, J., Sun, D., Cao, Y., Zhang, H., Guo, Y., Wu, N., Zhu, C., Gao, Y., Dong, Q., Liu, G., et al. (2018) · EBioMedicine · doi:10.1016/j.ebiom.2018.11.001 · Cited by 34 · see citing works
“Additionally, the measurement of plasma TG has unavoidable intraindividual biological variation and is easily affected by drugs and diet, which increase the difficulty in the diagnosis of SHTG [6,7].”
Background
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Glueck, C. J., Gartside, P. S., Fallat, R. W., et al. (1976) · Metabolism · doi:10.1016/0026-0495(76)90059-7 · Cited by 35 · see citing works
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Tada, H., Kawashiri, M., Nakahashi, T., Yagi, K., Chujo, D., Ohbatake, A., Mori, Y., Mori, S., Kometani, M., Fujii, H., et al. (2015) · Journal of clinical lipidology · doi:10.1016/j.jacl.2015.05.004 · Cited by 33 · see citing works
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Self-citation
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Self-citation
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Falko, J. M., Schonfeld, G., Witztum, J. L., Kolar, J. B., & Weidman, S. W. (1979) · Metabolism · doi:10.1016/0026-0495(79)90158-6 · Cited by 33 · see citing works
Estrogenic effect of gestodene- or desogestrel-containing oral contraceptives on lipoprotein metabolism
Leuven, J. A. G., Dersjant-Roorda, M. C., Helmerhorst, F. M., de Boer, R., Neymeyer-Leloux, A., & Havekes, L. M. (1990) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(90)90582-r · Cited by 32 · see citing works
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Potashnik, G. (2009) · Andrologia · doi:10.1111/j.1439-0272.1983.tb00132.x · Cited by 33 · see citing works
Metabolic effects of three new low-dose pills: A six-month experience
Miccoli, R., Mc, O., Fruzzetti, F., Giampietro, O., Melis, G. B., Ricci, C., Bertolotto, A., FIORETTI, P., & Navalesi, R. (1989) · Contraception · doi:10.1016/0010-7824(89)90039-5 · Cited by 30 · see citing works
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Chiuve, S. E., Martin, L. A., Campos, H., & Sacks, F. M. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031564 · Cited by 29 · see citing works
8 Effects of sex steroids on serum lipids and lipoproteins
Jensen, J. (1991) · Baillière s Clinical Obstetrics and Gynaecology · doi:10.1016/s0950-3552(05)80294-9 · Cited by 28 · see citing works
EFFECT OF PROGESTINS ON GLUCOSE AND LIPID METABOLISM*
Beck, P. A. (1977) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1977.tb29435.x · Cited by 29 · see citing works
Altered apolipoproteins in sex steroid-treated rats
Kim, H., & Kalkhoff, R. K. (1978) · Metabolism · doi:10.1016/0026-0495(78)90024-0 · Cited by 29 · see citing works
Biochemical Basis for the Selection of Oral Contraceptives
Briggs, M. H. (1979) · International Journal of Gynecology & Obstetrics · doi:10.1002/j.1879-3479.1979.tb00960.x · Cited by 26 · see citing works
Differential effects of raloxifene and continuous combined hormone replacement therapy on biochemical markers of cardiovascular risk: results from the Euralox 1 study
Nickélsen, T., Creatsas, G. K., Rechberger, T., Depypere, H. T., Erenus, M., Quail, D., Arndt, T., & Bonnar, J. (2001) · Climacteric · doi:10.1080/cmt.4.4.320.331 · Cited by 27 · see citing works
Regulation of the metabolism of polyunsaturated fatty acids
Hagve, T., Christensen, E., Grønn, M., & Christophersen, B. O. (1988) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365518809168292 · Cited by 23 · see citing works
PARADOXICAL EFFECTS OF THE ANTI‐ANDROGEN CYPROTERONE ACETATE ON LIPID AND LIPOPROTEIN METABOLISM
Wynn, V., Godsland, I., Seed, M., & Jacobs, H. S. (1986) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1986.tb00761.x · Cited by 22 · see citing works
Self-citation
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Magkos, F., Fabbrini, E., Mohammed, B. S., Patterson, B. W., Klein, S., & Mittendorfer, B. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-0341 · Cited by 19 · see citing works
Relationship of exercise, oral contraceptive use, and body fat to concentrations of plasma lipids and lipoprotein cholesterol in young women
Merians, D. R., Haskell, W. L., VRANIZAN, K. M., Phelps, J., Woods, P. D., & Superko, H. R. (1985) · The American Journal of Medicine · doi:10.1016/0002-9343(85)90212-8 · Cited by 20 · see citing works
Prospective evaluation of insulin resistance and lipid metabolism in women receiving oral contraceptives
Sheu, W. H., Hsu, C., Chen, Y., Jeng, C.-Y., & Fuh, M. M.-T. (1994) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1994.tb02476.x · Cited by 19 · see citing works
Sex-related differences in desaturation and chain elongation of essential fatty acids studied in isolated rat hepatocytes
Hagve, T., & Christophersen, B. O. (1987) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(87)90254-2 · Cited by 18 · see citing works
Changes in plasma lipids, lipoproteins, triglyceride secretion and removal in chicks with estrogen implants
Park, J. R., & Cho, B. H. S. (1988) · Lipids · doi:10.1007/bf02537343 · Cited by 18 · see citing works
EFFECTS OF THREE DIFFERENT COMBINATIONS OF ETHINYL ESTRADIOL AND LEVONORGESTREL ON PLASMA LIPIDS AND HIGH DENSITY LIPOPROTEINS
Larsson‐Cohn, U., Wallentin, L. C., & Zador, G. (1979) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.3109/00016347909157230 · Cited by 18 · see citing works
Effect of estrogen and progesterone on metabolism of apoprotein B in baboons
Kushwaha, R. S., Foster, D. M., Barrett, P. H. R., & Carey, K. D. (1990) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1990.258.1.e172 · Cited by 17 · see citing works
Effects of ethynyl estradiol on incorporation of [1-14C] oleate into triglyceride and ketone bodies by the liver
Weinstein, I., Soler‐Argilaga, C., & Heimberg, M. (1977) · Biochemical Pharmacology · doi:10.1016/0006-2952(77)90136-8 · Cited by 17 · see citing works
Exposure of Ldlr−/− Mice to a PFAS Mixture and Outcomes Related to Circulating Lipids, Bile Acid Excretion, and the Intestinal Transporter ASBT
Roth, K., Yang, Z., Agarwal, M., Birbeck, J. A., Westrick, J. A., Lydic, T. A., Gurdziel, K., & Petriello, M. C. (2024) · Environmental Health Perspectives · doi:10.1289/ehp14339 · Cited by 18 · see citing works
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Samsioe, G. (1982) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.3109/00016348209155360 · Cited by 14 · see citing works
Alterations of lipid metabolism by contraceptive steroids
Beck, P. A. (1975) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(75)90334-9 · Cited by 14 · see citing works
Vitellogenesis in reptiles as a model for mammalian sex-differentiated hepatic protein synthesis
Callard, I. P., Riley, D., & Perez, L. E. (1990) · Journal of Experimental Zoology · doi:10.1002/jez.1402560418 · Cited by 13 · see citing works
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Beck, P. A., Arnett, D. M., Alsever, R. N., & Eaton, R. P. (1976) · Metabolism · doi:10.1016/0026-0495(76)90156-6 · Cited by 12 · see citing works
A comparative study of the effects of a monophasic and a triphasic oral contraceptive containing ethinyl estradiol and levonorgestrel on lipid and lipoprotein metabolism
Loke, D. F. M., Ng, C. S. A., Samsioe, G., Hoick, S., & Ratnam, S. S. (1990) · Contraception · doi:10.1016/0010-7824(90)90081-6 · Cited by 11 · see citing works
Effect of contraceptive steroids on arginine-stimulated glucagon and insulin secretion in women. III. Medroxyprogesterone acetate
Beck, P. A., Zimmerman, D. E., & Eaton, R. P. (1977) · Metabolism · doi:10.1016/0026-0495(77)90111-1 · Cited by 11 · see citing works
Chylomicron and very low-density lipoprotein apolipoprotein B metabolism: Mechanism of the response to stanozolol in a patient with severe hypertriglyceridemia
Hazzard, W. R., Kushwaha, R. S., Applebaum-Bowden, D. M., Haffner, S. M., Steinmetz, A., & Foster, D. M. (1984) · Metabolism · doi:10.1016/0026-0495(84)90239-7 · Cited by 10 · see citing works
Sex differences in response to dietary carbohydrates
Macdonald, I. (1976) · Proceedings of The Nutrition Society · doi:10.1079/pns19760027 · Cited by 10 · see citing works
Putative apolipoprotein B-100 in the freshwater turtle Chrysemys picta: effects of estrogen and progesterone
Perez, L. E., Williams, D. L., & Callard, I. P. (1992) · Comparative Biochemistry and Physiology Part B Comparative Biochemistry · doi:10.1016/0305-0491(92)90394-7 · Cited by 9 · see citing works
Effects of estrogen on very-low-density lipoprotein triacylglycerol metabolism in chicks
Park, J. R., & Cho, B. H. S. (1990) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(90)90148-q · Cited by 9 · see citing works
Serum Lipids During Oestradiol‐Valerate/Norgestrel Treatment of Menopausal Women
CHRISTENSEN, N. C., Davidsen, P. C., Secher, N. J., et al. (1975) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.3109/00016347509157763 · Cited by 9 · see citing works
Oral contraceptives and depression
Warnes, H., & Fitzpatrick, C. (1979) · Psychosomatics · doi:10.1016/s0033-3182(79)70860-7 · Cited by 9 · see citing works
Effects of estrogen on very low density lipoproteins (VLDL) synthesis in avian liver slices in vitro: Lack of correlation with nuclear estrogen receptors
Chan, L., Eriksson, H., Jackson, R. L., et al. (1977) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(77)90072-3 · Cited by 9 · see citing works
Physiological interindividual variability in endogenous estradiol concentration does not influence adipose tissue and hepatic lipid kinetics in women
Magkos, F., Fabbrini, E., Patterson, B. W., Mittendorfer, B., & Klein, S. (2022) · European Journal of Endocrinology · doi:10.1530/eje-22-0410 · Cited by 6 · see citing works
Monitoring of Follicular Development in Gonadotropin-Stimulated Cycles
Insler, V., & Potashnik, G. (1983) · Springer eBooks · doi:10.1007/978-3-642-68800-3_9 · Cited by 6 · see citing works
Carbohydrate tolerance and serum lipid responses to type of dietary carbohydrate and oral contraceptive use in young women.
Moser, P. B., Behall, K. M., Kelsay, J., et al. (1986) · Journal of the American College of Nutrition · doi:10.1080/07315724.1986.10720111 · Cited by 6 · see citing works
Effect of oral alanine loads on the serum triglycerides of oral contraceptive users and normal subjects
Rose, D., Leklem, J., Fardal, L., et al. (1977) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/30.5.691 · Cited by 6 · see citing works
Effect of tamoxifen on lipids and lipid metabolising marker enzymes in experimental atherosclerosis in Wistar rats
Vinitha, R., Thangaraju, M., & Sachdanandam, P. (1997) · Molecular and Cellular Biochemistry · doi:10.1023/a:1006859220232 · Cited by 6 · see citing works
“Oestrogens produce a well known hypertriglycerimic effect [ 32 , 33].”
Background
Metabolic Effects of Oral Contraceptives
Bemben, D. A. (1993) · Sports Medicine · doi:10.2165/00007256-199316050-00001 · Cited by 6 · see citing works
OESTROGEN INDUCED HYPERTRIGLYCERIDAMIA: ROLE OF THE ADRENAL CORTEX
AFOLABI, S. K., TULLOCH, B. R., Kissebah, A. H., et al. (1976) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1976.tb01946.x · Cited by 6 · see citing works
Self-citation
The ovary learns to ovulate
Lunenfeld, B., Kraiem, Z., Eshkol, A., & Werner-Zodrow, I. (1978) · Journal of Biosocial Science · doi:10.1017/s0021932000024056 · Cited by 4 · see citing works
Secondary Hyperlipoproteinemia: Oral Contraceptives and Pregnancy
Glueck, C. J., & Fallat, R. W. (1976) · Springer eBooks · doi:10.1007/978-3-642-66302-4_21 · Cited by 4 · see citing works
Stoffwechseluntersuchungen unter Einnahme oraler Kontrazeptiva
Hauschildt, S. (1978) · Zeitschrift für Ernährungswissenschaft · doi:10.1007/bf02020687 · Cited by 3 · see citing works
Plasma lipoproteins and fatty acid composition after “minipill”
Sassolas, A., Lagarde, M., Guichardant, M., et al. (1983) · Contraception · doi:10.1016/0010-7824(83)90038-0 · Cited by 2 · see citing works
PLASMA-TRYPTOPHAN AND ORAL CONTRACEPTIVES
Briggs, M. (1974) · The Lancet · doi:10.1016/s0140-6736(74)92424-6 · Cited by 2 · see citing works
Advances in Oral Contraception
Hickey, M. J., & Levin, J. H. (1993) · Springer eBooks · doi:10.1007/978-1-4612-4340-3_12 · Cited by 2 · see citing works
Verschiedene Plasmalipide unter Ovulationshemmern unterschiedlichen Typs und Zusammensetzung
Hausmann, L., Kaffarnik, H., Lorenz, D., et al. (1976) · Verhandlungen der Deutschen Gesellschaft für Innere Medizin · doi:10.1007/978-3-642-85451-4_202 · Cited by 1 · see citing works

Authors: Kissebah, A., Harrigan, P., & Wynn, V.
Affiliations: St Mary's Hospital (GB)
Venue: Hormone and Metabolic Research
Publisher: Georg Thieme Verlag KG
Published: 1973
Volume: 5
Issue: 03
Pages: 184-190
ISSN: 0018-5043 (ISSN-L)
1439-4286
DOI: 10.1055/s-0028-1093969
OpenAlex: W2067803293
Cited by: 106
References: 0
Citations by year: 2024: 1 · 2022: 1 · 2020: 1 · 2018: 2 · 2017: 1 · 2015: 1 · 2014: 1 · 2012: 1
FWCI: 8.75
Type: journal article
Language: en
Open access: closed
Locations: Hormone and Metabolic Research (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Keywords: hypertriglyceridemia, contraceptive steroids, progesterone, megestrol, estrogen, triglyceride turnover, triglyceride clearance, free fatty acids, insulin response, premenopausal women
MeSH terms: Adolescent, Adult, Body Weight, Carbon Isotopes, Contraceptives, Oral, Ethinyl Estradiol, Ethynodiol Diacetate, Fatty Acids, Nonesterified, Female, Heparin, Humans, Insulin Antibodies, Kinetics, Lipoproteins, VLDL, Megestrol, Mestranol, Norethindrone, Palmitic Acids, Progesterone, Time Factors, Triglycerides

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Mechanism of hypertriglyceridaemia associated with contraceptive steroids.

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