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Cited by 18Cardiovascular Syncope and Autonomic DisordersAdrenal Hormones and DisordersHeart Rate Variability and Autonomic Control

The DOI matches its Crossref record.

Fludrocortison (Astonin®-H) bei orthostatischen Kreislaufregulationsstörungen

Finke, J., Sagemüller, I.·1975·DMW - Deutsche Medizinische Wochenschrift
DOI 10.1055/s-0028-1106461
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Abstract

The effect of fludrocortisone (Astonin -H) in the management of orthostatic hypotension was tested in a double-blind trial of 30 patients who were receiving 0.3 mg fludrocortisone for seven days, a control group of 30 subjects receiving placebos. Systolic and diastolic brachial and ophthalmic arterial pressures, pulse amplitude and pulse rate were measured at rest, immediately after standing up and 10 minutes later. Comparing the treatment and placebo groups, the former had a higher systolic ophthalmic blood pressure on standing, a smaller fall of pulse volume and less of a rise in heart rate on standing up, and a raised systolic brachial artery pressure even in recumbency. At the same time there was an improvement in symptoms.

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  • Evidence in favour of fludrocortisone comes from two small observational studies and one double-blind trial in 60 patients; the observational studies showed haemodynamic benefit and, in the trial, treated patients were less symptomatic with higher BP.

    “The evidence in favour of fludrocortisone is from two small observational studies (in combination with head-up sleeping) and one double-blind trial in 60 patients; the observational studies showed haemodynamic benefit and, in the trial, treated patients were less symptomatic with higher BP. 322,327,328”

    From 2018 ESC Guidelines for the diagnosis and management of syncope (2018) · cites this paper as [328]

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Metadata

Authors
Finke, J., & Sagemüller, I.
Affiliations
Klinikum Stuttgart (DE)
ORCID
Finke, J.
Venue
DMW - Deutsche Medizinische Wochenschrift
Publisher
Georg Thieme Verlag KG
Published
1975-09
Volume
100
Issue
36
Pages
1790-1792
ISSN
  • 0012-0472 (ISSN-L)
  • 1439-4413
DOI
10.1055/s-0028-1106461
OpenAlex
W1965396212
Cited by
18
References
0
Citations by year
2026: 1 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 2 · 2016: 1 · 2015: 1 · 2014: 1 · 2013: 2
FWCI
0.00
Type
journal article
Language
de
Open access
closed
Locations
  • DMW - Deutsche Medizinische Wochenschrift (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Syncope and Autonomic Disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Keywords
fludrocortisone, orthostatic hypotension, blood pressure response to standing, pulse volume, heart rate, brachial blood pressure, ophthalmic artery pressure
MeSH terms
Adult, Blood Pressure, Brachial Artery, Clinical Trials as Topic, Female, Fludrocortisone, Humans, Hypotension, Orthostatic, Male, Middle Aged, Ophthalmic Artery, Ophthalmodynamometry, Placebos, Posture, Pulse

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