The DOI matches its Crossref record.
Oxidative Stress and Alcoholic Liver Disease
Abstract
Reactive oxygen species (ROS) are highly reactive molecules that are naturally generated in small amounts during the body's metabolic reactions and can react with and damage complex cellular molecules such as lipids, proteins, or DNA. This review describes pathways involved in ROS formation, why ROS are toxic to cells, and how the liver protects itself against ROS. Acute and chronic ethanol treatment increases the production of ROS, lowers cellular antioxidant levels, and enhances oxidative stress in many tissues, especially the liver. Ethanol-induced oxidative stress plays a major role in the mechanisms by which ethanol produces liver injury. Many pathways play a key role in how ethanol induces oxidative stress. This review summarizes some of the leading pathways and discusses the evidence for their contribution to alcohol-induced liver injury.
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In the citing paper
“Liver diseases related to alcohol consumption are partly due to the ROS formation from ethanol (Wu and Cederbaum 2009).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Wu and Cederbaum 2009
In the citing paper
“Hepatic mitochondrial abnormalities are observed in both alcoholic fatty liver disease (AFLD) [4], [5], [6], nonalcoholic fatty liver disease (NAFLD) [7], [8], [9] and acute liver injury.”
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Role of nrf2 in oxidative stress and toxicity
Ma, Q. (2013) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-011112-140320 · Cited by 4,903
“Chronic alcohol consumption increases the production of reactive oxidants, a major factor in the development of alcohol-induced liver disease (AILD) (129).”
BackgroundInfluentialReactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging
Jomova, K., Raptova, R., Alomar, S. Y., Alwasel, S. H., Nepovimova, E., Kuca, K., & Valko, M. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03562-9 · Cited by 2,638
Oxidative Stress: An Essential Factor in the Pathogenesis of Gastrointestinal Mucosal Diseases
Bhattacharyya, A., Chattopadhyay, R., Mitra, S., & Crowe, S. E. (2014) · Physiological Reviews · doi:10.1152/physrev.00040.2012 · Cited by 2,484
“Alcoholic liver disease (324) and alcoholic pancreatitis (217) occur in part due to ROS generated from ethanol.”
BackgroundThe Role of Oxidative Stress and Antioxidants in Liver Diseases
Li, S., Tan, H., Wang, N., Zhang, Z.-J., Lao, L., Wong, C.-W., & Feng, Y. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161125942 · Cited by 1,898
“With regard to hepatic stellate cells, the proliferation and collagen synthesis of hepatic stellate cells is triggered by lipid peroxidation caused by oxidative stress [6–8].”
BackgroundOxidative stress as a crucial factor in liver diseases
Cichoż‐Lach, H. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i25.8082 · Cited by 1,226
Metadata
- Authors
- Wu, D., & Cederbaum, A.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- ORCID
- Wu, Defeng
- Venue
- Seminars in Liver Disease
- Publisher
- Georg Thieme Verlag KG
- Published
- 2009-04-22
- Volume
- 29
- Issue
- 02
- Pages
- 141-154
- ISSN
- 0272-8087 (ISSN-L)
- 1098-8971
- OpenAlex
- W1981280200
- Cited by
- 342
- References
- 0
- Citations by year
- 2026: 11 · 2025: 14 · 2024: 19 · 2023: 19 · 2022: 27 · 2021: 19 · 2020: 19 · 2019: 18 · 2018: 16 · 2017: 23 · 2016: 14 · 2015: 19 · 2014: 29 · 2013: 28 · 2012: 26
- FWCI
- 15.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Seminars in Liver Disease (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
- Keywords
- oxidative stress, alcoholic liver disease, reactive oxygen species, ethanol-induced liver injury, antioxidant defense, alcohol metabolism, lipid peroxidation, DNA damage, protein oxidation
- MeSH terms
- Alcohol Drinking, Ethanol, Animals, Antioxidants, Glutathione, Humans, Iron, Kupffer Cells, Liver, Liver Diseases, Alcoholic, Mitochondria, Liver, Reactive Oxygen Species, Oxidative Stress, Cytochrome P-450 CYP2E1, Reactive Nitrogen Species
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