In Vitro BACE-1 Inhibitory Activity of Resveratrol Oligomers from the Seed Extract of Paeonia lactiflora
Abstract
A new resveratrol oligomer (1) together with eight related components (2- 9) were isolated from the seed extract of Paeonia lactiflora (Paeoniaceae) as active principles responsible for the inhibition of beta-site APP-cleaving enzyme 1 (BACE-1) in vitro. The chemical structure of 1 was established as (-)-7a,8a- CIS- ε-viniferin with the aid of spectroscopic analyses including NOESY experiments. All isolated resveratrol oligomers (1- 9) demonstrated significant inhibition on baculovirus-expressed BACE-1 in a dose-dependent manner, which was assessed by the FRET assay using Rh-EVNLDAEFK as a substrate in vitro.
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Resveratrol affects Aβ production by inhibiting β-secretase activity.
“resveratrol has been demonstrated to affect the Aβ production by inhibiting the activity of β-secretase (Choi et al., 2011; Koukoulitsa et al., 2016)”
From Exploring the Therapeutic Potential of Phytochemicals in Alzheimer’s Disease: Focus on Polyphenols and Monoterpenes (2022) · cites this paper as Choi et al., 2011
Cites
Vassar, R., Bennett, B. D., Babu-Khan, S., Kahn, S., Mendiaz, E. A., Denis, P., Teplow, D. B., Ross, S., Amarante, P., Loeloff, R., et al. (1999) · Science · doi:10.1126/science.286.5440.735 · Cited by 3,876 · see citing works
Purification and cloning of amyloid precursor protein β-secretase from human brain
Sinha, S., Anderson, J. P., Barbour, R., Basi, G. S., Caccavello, R., Davis, D., Doan, M., Dovey, H. F., Frigon, N., Hong, J., et al. (1999) · Nature · doi:10.1038/990114 · Cited by 1,612 · see citing works
Cytotoxic and antimutagenic stilbenes from seeds ofPaeonia lactiflora
Kim, H. J., Chang, E. J., Bae, S.-J., Shim, S. M., Park, H. D., Rhee, C. H., Park, J. H., & Choi, S. W. (2002) · Archives of Pharmacal Research · doi:10.1007/bf02976629 · Cited by 120 · see citing works
Antiallergic effect of the root of Paeonia lactiflora and its constituents paeoniflorin and paeonol
Lee, B., Shin, Y.-W., Bae, E., Han, S.-J., Kim, J.-S., Kang, S.-S., & Kim, D. (2008) · Archives of Pharmacal Research · doi:10.1007/s12272-001-1177-6 · Cited by 117 · see citing works
Triterpenoids from callus tissue cultures of Paeonia species
Ikuta, A. (1995) · Phytochemistry · doi:10.1016/0031-9422(94)00445-y · Cited by 113 · see citing works
Antioxidative Activity of Resveratrol and Its Derivatives Isolated from Seeds ofPaeonia lactiflora
Kim, H. J., Chang, E. J., Cho, S. H., Chung, S., Park, H. D., & Choi, S. W. (2002) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.66.1990 · Cited by 100 · see citing works
Resveratrol Derivatives from the Roots of Vitis thunbergii
Huang, Y., Tsai, W., Shen, C., & Chen, C.-C. (2005) · Journal of Natural Products · doi:10.1021/np049686p · Cited by 92 · see citing works
Four Novel Oligostilbenes from the Roots of Vitis amurensis
Huang, K.-S., Lin, M. T., Yu, L.-N., & Kong, M. (2000) · Tetrahedron · doi:10.1016/s0040-4020(99)01034-0 · Cited by 82 · see citing works
β-secretase (BACE1)-inhibiting stilbenoids from Smilax Rhizoma
Jeon, S. Y., Kwon, S.-H., Seong, Y. H., Bae, K., Hur, J.-M., Lee, Y.-Y., Suh, D., & Song, K. S. (2006) · Phytomedicine · doi:10.1016/j.phymed.2006.09.003 · Cited by 81 · see citing works
Jang, M. H., Piao, X. L., Kim, H. Y., Cho, E., Baek, S. H., Kwon, S. W., & Park, J. H. (2007) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.30.1130 · Cited by 75 · see citing works
Tanaka, T., Kataoka, M., Tsuboi, N., & Kouno, I. (2000) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.48.201 · Cited by 70 · see citing works
A New Specific BACE-1 Inhibitor from the Stembark Extract ofVitis vinifera
Choi, Y. H., Yoo, M. Y., Choi, C. W., Cha, M., Yon, G. H., Kwon, D. Y., Kim, Y. S., Park, W.-K., & Ryu, S. Y. (2009) · Planta Medica · doi:10.1055/s-0029-1185311 · Cited by 43 · see citing works
α-Glucosidase Inhibitiors from Seed Extract of Paeonia lactiflora
Choi, C. W. (2009) · Journal of the Korean Society for Applied Biological Chemistry · doi:10.3839/jksabc.2009.106 · Cited by 12 · see citing works
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Natural stilbenoids: distribution in the plant kingdom and chemotaxonomic interest in Vitaceae
Rivière, C., Pawlus, A. D., & Mérillon, J. (2012) · Natural Product Reports · doi:10.1039/c2np20049j · Cited by 407 · see citing works
Natural polyphenols against neurodegenerative disorders: Potentials and pitfalls
Ebrahimi, A., & Schluesener, H. J. (2012) · Ageing Research Reviews · doi:10.1016/j.arr.2012.01.006 · Cited by 276 · see citing works
Agis-Torres, A., Sollhuber, M., Fernandez, M., & Sanchez-Montero, J. M. (2014) · Current Neuropharmacology · doi:10.2174/1570159x113116660047 · Cited by 202 · see citing works
The Possible Mechanism of Advanced Glycation End Products (AGEs) for Alzheimer’s Disease
Ko, S., Ko, H.-A., Chu, K.-H., Shieh, T., Chi, T.-C., Chen, H., Chang, W., & Chang, S.-S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0143345 · Cited by 139 · see citing works
Applications of Friedel–Crafts reactions in total synthesis of natural products
Heravi, M. M., Zadsirjan, V., Saedi, P., & Momeni, T. (2018) · RSC Advances · doi:10.1039/c8ra07325b · Cited by 117 · see citing works
Cho, H. S., Lee, J., Ryu, S. Y., Joo, S. W., Cho, M. H., & Lee, J. (2013) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf4009313 · Cited by 105 · see citing works
Stilbenes, a Versatile Class of Natural Metabolites for Inflammation—An Overview
Al-Khayri, J. M., Mascarenhas, R., Harish, H. M., Gowda, Y., Lakshmaiah, V. V., Nagella, P., Al-Mssallem, M. Q., Alessa, F. M., Almaghasla, M. I., & Adel Abdel-Sabour, R. E. Z. K. (2023) · Molecules · doi:10.3390/molecules28093786 · Cited by 94 · see citing works
Wang, X., Kim, J., Lee, S.-B., Kim, Y., Jung, M. Y., Kwon, H. W., & Ahn, Y. (2014) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-14-88 · Cited by 94 · see citing works
Resveratrol and Amyloid-Beta: Mechanistic Insights
Jia, Y., Wang, N., & Liu, X. (2017) · Nutrients · doi:10.3390/nu9101122 · Cited by 91 · see citing works
Mani, V., Ramasamy, K., Ahmad, A., Parle, M., Shah, S. A. A., & Majeed, A. B. A. (2011) · Food and Chemical Toxicology · doi:10.1016/j.fct.2011.11.037 · Cited by 75 · see citing works
Wang, X., Perumalsamy, H., Kwon, H. W., Na, Y., & Ahn, Y. (2015) · Scientific Reports · doi:10.1038/srep16127 · Cited by 75 · see citing works
Piccialli, I., Tedeschi, V., Caputo, L., D’Errico, S., Ciccone, R., De Feo, V., Secondo, A., & Pannaccione, A. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.876614 · Cited by 73 · see citing works
Lee, J., Kim, Y., Ryu, S. Y., Cho, M. H., & Lee, J. (2013) · Journal of Natural Products · doi:10.1021/np400756g · Cited by 66 · see citing works
Update on Phytochemistry and Pharmacology of Naturally Occurring Resveratrol Oligomers
Shen, J., Zhou, Q., Li, P., Wang, Z., Liu, S., He, C., Zhang, C., & Xiao, P. (2017) · Molecules · doi:10.3390/molecules22122050 · Cited by 64 · see citing works
Stilbenes Reduce Staphylococcus aureus Hemolysis, Biofilm Formation, and Virulence
Lee, K.-Y., Lee, J., Yong, R. S., Cho, M. H., & Lee, J. (2014) · Foodborne Pathogens and Disease · doi:10.1089/fpd.2014.1758 · Cited by 63 · see citing works
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Zhang, C.-C., Geng, C., Huang, X., Zhang, X., & Chen, J. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b01193 · Cited by 57 · see citing works
Wiciński, M., Domanowska, A., Wódkiewicz, E., & Malinowski, B. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21082749 · Cited by 55 · see citing works
Resveratrol-mediated cleavage of amyloid β1–42 peptide: potential relevance to Alzheimer's disease
Al-Edresi, S., Alsalahat, I., Freeman, S., Aojula, H. S., & Penny, J. I. (2020) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2020.04.012 · Cited by 53 · see citing works
Lee, J., Kim, Y., Raorane, C. J., Ryu, S. Y., Shim, J., & Lee, J. (2019) · Biofouling · doi:10.1080/08927014.2019.1657418 · Cited by 47 · see citing works
Liu, S., Li, Y., Yi, F., Liu, Q., Chen, N., He, X., He, C., & Xiao, P. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.112983 · Cited by 40 · see citing works
Biological and Computational Evaluation of Resveratrol Inhibitors against Alzheimer's Disease
Koukoulitsa, C., Villalonga-Barber, C., Csonka, R., Alexi, X., Leonis, G., Dellis, D., Hamelink, E., Belda, O., Steele, B. R., Micha-Screttas, M., et al. (2016) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.3109/14756366.2014.1003928 · Cited by 37 · see citing works
Antitumoural activity of viniferin-enriched extracts fromVitis viniferaL. cell cultures
Giovannelli, L., Innocenti, M., Santamaria, A. R., Bigagli, E., Pasqua, G., & Mulinacci, N. (2014) · Natural Product Research · doi:10.1080/14786419.2014.924935 · Cited by 35 · see citing works
Relative and Absolute Configuration of Vatiparol (1 mg): A Novel Anti‐inflammatory Polyphenol
Ge, H. M., Sun, H., Jiang, N., Qin, Y. H., Dou, H., Yan, T., Hou, Y. Y., Griesinger, C., & Tan, R. X. (2012) · Chemistry - A European Journal · doi:10.1002/chem.201104078 · Cited by 35 · see citing works
Ryu, H. W., Song, H., Shin, I., Cho, B. O., Jeong, S. H., Kim, D.-Y., Ahn, K., & Oh, S. (2015) · Journal of Functional Foods · doi:10.1016/j.jff.2015.06.036 · Cited by 31 · see citing works
Wang, Y., Wang, K., Yan, J., Zhou, Q., & Wang, X. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232213886 · Cited by 29 · see citing works
Total Synthesis of Laetevirenol A
Choi, Y. L., Kim, B., & Heo, J. (2012) · The Journal of Organic Chemistry · doi:10.1021/jo301345a · Cited by 28 · see citing works
Choi, J., Choi, S.-Y., Hong, Y., Han, Y., Oh, S., Lee, B., Choi, C. W., & Kim, M. S. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114812 · Cited by 27 · see citing works
Okuda, M., Fujita, Y., & Sugimoto, H. (2019) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b19-00332 · Cited by 25 · see citing works
Chemistry and biology of natural stilbenes: an update
Zhou, L., Cai, X., Wang, Y., Yang, J., Wang, Y.-D., Deng, J., Ye, D., Zhang, L., Liu, Y., & Ma, S.-C. (2024) · Natural Product Reports · doi:10.1039/d4np00033a · Cited by 23 · see citing works
High-Resolution Mass Spectrometry and Biological Properties of Grapevine and Wine Stilbenoids
Flamini, R., & Rosso, M. D. (2018) · Studies in natural products chemistry · doi:10.1016/b978-0-444-64183-0.00005-1 · Cited by 23 · see citing works
Profiling of neuraminidase inhibitory polyphenols from the seeds of Paeonia lactiflora
Yuk, H. J., Ryu, H. W., Jeong, S. H., Long, M. J. C., Kim, H. J., Wang, Y., Song, Y. H., & Park, K. H. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2012.12.053 · Cited by 21 · see citing works
Lai, G., Wu, H., Yang, K., Hu, K., Zhao, W., Chen, X., Li, J., Haifeng, W., Lv, Z., Xie, G., et al. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s525960 · Cited by 17 · see citing works
Silva, P., & Vauzour, D. (2018) · Beverages · doi:10.3390/beverages4040096 · Cited by 15 · see citing works
Jang, B.-G., Lee, J., Choi, B., Koh, Y. H., & Kim, M.-J. (2021) · Food and Chemical Toxicology · doi:10.1016/j.fct.2021.112185 · Cited by 15 · see citing works
Mani, V., Azahan, N. S. M., Ramasamy, K., Lim, S. M., James, R. J., Alsharidah, M. S., Alhowail, A. H., & Majeed, A. B. A. (2020) · Pharmacognosy Magazine · doi:10.4103/pm.pm_202_19 · Cited by 12 · see citing works
Kim, J. H., Han, Y., Oh, S., Lee, B., Kwon, O., Choi, C. W., & Kim, M. S. (2023) · Scientific Reports · doi:10.1038/s41598-023-38773-8 · Cited by 11 · see citing works
Sheean, P., Rout, M. K., Head, R. J., & Bennett, L. E. (2012) · FEBS Journal · doi:10.1111/j.1742-4658.2012.08524.x · Cited by 10 · see citing works
Akkol, E. K., Karatoprak, G. Ş., Dumlupınar, B., Açıkara, Ö. B., Arıcı, R., Yücel, Ç., Aynal, L. C., & Sobarzo‐Sánchez, E. (2025) · Molecules · doi:10.3390/molecules30091982 · Cited by 7 · see citing works
Wu, S., Zhang, C.-C., Chen, J., Zhang, X., Guan, M., & Geng, C. (2022) · Fitoterapia · doi:10.1016/j.fitote.2022.105336 · Cited by 7 · see citing works
O'Day, D. (2023) · Biomolecules · doi:10.3390/biom13040678 · Cited by 7 · see citing works
Ravi, S. K., Ramesh, B. N., Kj, S., Poyya, J., Karanth, J., Raju, N. G., & Joshi, C. G. (2022) · Egyptian Journal of Basic and Applied Sciences · doi:10.1080/2314808x.2021.2021749 · Cited by 6 · see citing works
Ablinger, I., Dressel, K., Rott, T., Lauer, A. A., Tiemann, M., Batista, J. P., Taddey, T., Grimm, H. S., & Grimm, M. O. W. (2022) · Biomedicines · doi:10.3390/biomedicines10112922 · Cited by 5 · see citing works
Chang, H., Kim, Y. S., Ryu, S. Y., & Chun, H. S. (2013) · Journal of the Korean Society for Applied Biological Chemistry · doi:10.1007/s13765-013-3108-7 · Cited by 5 · see citing works
Heo, J., Han, Y., Kim, M. S., Cheong, E., Choi, C. W., & Oh, S. (2024) · Phytotherapy Research · doi:10.1002/ptr.8395 · Cited by 4 · see citing works
β‐Secretase (BACE1) Inhibitors from Natural Products
Fang, W., Sun, D., Yang, S., & Guo, N. (2017) · doi:10.1002/9783527805921.ch5 · Cited by 4 · see citing works
Sağlıklı Yaşamda Üzüm ve Üzüm Ürünleri
Aşcı, Ö. A. (2020) · Bilge International Journal of Science and Technology Research · doi:10.30516/bilgesci.815799 · Cited by 3 · see citing works
Lim, T. K. (2014) · Springer eBooks · doi:10.1007/978-94-017-8748-2_44 · Cited by 3 · see citing works
Wang, Y., Wu, X., Yang, K., Liu, Q., Jiang, B., Yang, R., Xiao, P., & He, C. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.952876 · Cited by 3 · see citing works
Bhattacharjee, A., Chakraborty, R., & Sen, S. (2021) · Springer eBooks · doi:10.1007/978-981-15-8127-4_8 · Cited by 2 · see citing works
Polyphenols and Neuroprotection: The Role of Adenosine Receptors
Sánchez-Melgar, A., Albasanz, J. L., & Martı́n, M. (2019) · Journal of Caffeine and Adenosine Research · doi:10.1089/caff.2019.0007 · Cited by 1 · see citing works
Malik, J. (2017) · doi:10.1002/9781119155195.ch8 · Cited by 1 · see citing works
Effects and Possible Mechanisms of Some Phytochemicals on Drosophila Models of Alzheimer’s Disease
왕설 (2016) · Seoul National University Open Repository (Seoul National University)
- Authors
- Choi, C., Choi, Y., Cha, M.-R., Kim, Y., Yon, G., Hong, K., Park, W.-K., Kim, Y., & Ryu, S.
- Affiliations
- Korea Research Institute of Chemical Technology (KR)
- Chungnam National University (KR)
- ORCID
- Venue
- Planta Medica
- Publisher
- Georg Thieme Verlag KG
- Published
- 2010-10-01
- Volume
- 77
- Issue
- 04
- Pages
- 374-376
- ISSN
- 0032-0943 (ISSN-L)
- 1439-0221
- OpenAlex
- W2108384058
- Cited by
- 52
- References
- 13
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 4 · 2022: 6 · 2021: 2 · 2020: 5 · 2019: 4 · 2018: 3 · 2017: 4 · 2016: 1 · 2015: 4 · 2014: 5 · 2013: 4 · 2012: 5
- FWCI
- 3.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Planta Medica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioactive natural compounds
- Keywords
- resveratrol oligomers, Paeonia lactiflora, BACE1 inhibition, ε-viniferin, seed extract, Alzheimer's disease, structure elucidation, NOESY, FRET assay
- MeSH terms
- Resveratrol, Dose-Response Relationship, Drug, Enzyme Inhibitors, Plant Extracts, Seeds, Stilbenes, Molecular Structure, Aspartic Acid Endopeptidases, Baculoviridae, Paeonia, Amyloid Precursor Protein Secretases
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