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The Intrauterine Growth Restriction Phenotype: Fetal Adaptations and Potential Implications for Later Life Insulin Resistance and Diabetes
Open accessAbstract
The intrauterine growth restricted (IUGR) fetus develops unique metabolic adaptations in response to exposure to reduced nutrient supply. These adaptations provide survival value for the fetus by enhancing the capacity of the fetus to take up and use nutrients, thereby reducing the need for nutrient supply. Each organ and tissue in the fetus adapts differently, with the brain showing the greatest capacity for maintaining nutrient supply and growth. Such adaptations, if persistent, also have the potential in later life to promote nutrient uptake and storage, which directly lead to complications of obesity, insulin resistance, reduced insulin production, and type 2 diabetes.
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“Maternal undernutrition may lead to foetal growth restriction (FGR), characterised by reduced pancreatic growth, impaired insulin secretion, and hepatic insulin resistance [28,29,30].”
From Medical Nutrition Therapy for Women with Gestational Diabetes: Current Practice and Future Perspectives (2025) · cites this paper as [29]
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Metadata
- Authors
- Thorn, S., Rozance, P., Brown, L., & Hay, W.
- Affiliations
- University of Colorado Anschutz (US)
- Venue
- Seminars in Reproductive Medicine
- Publisher
- Georg Thieme Verlag KG
- Published
- 2011-05
- Volume
- 29
- Issue
- 03
- Pages
- 225-236
- ISSN
- 1526-4564 (ISSN-L)
- 1526-8004
- PMC
- PMC3216466
- OpenAlex
- W2059299661
- Cited by
- 153
- References
- 122
- Citations by year
- 2026: 9 · 2025: 11 · 2024: 10 · 2023: 4 · 2022: 12 · 2021: 10 · 2020: 16 · 2019: 17 · 2018: 8 · 2017: 7 · 2016: 13 · 2015: 14 · 2014: 7 · 2013: 9 · 2012: 5
- FWCI
- 6.52
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Seminars in Reproductive Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (K01DK090199)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (K12HD057022, K08HD060688)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Keywords
- fetal growth restriction, fetal brain, insulin resistance, type 2 diabetes, obesity, developmental origins of health and disease, fetal programming, insulin production
- MeSH terms
- Adaptation, Physiological, Adult, Animals, Diabetes Mellitus, Type 2, Female, Fetal Growth Retardation, Humans, Insulin Resistance, Male, Obesity, Pregnancy, Prenatal Exposure Delayed Effects, Fetal Development
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