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The Intrauterine Growth Restriction Phenotype: Fetal Adaptations and Potential Implications for Later Life Insulin Resistance and Diabetes
Open accessAbstract
The intrauterine growth restricted (IUGR) fetus develops unique metabolic adaptations in response to exposure to reduced nutrient supply. These adaptations provide survival value for the fetus by enhancing the capacity of the fetus to take up and use nutrients, thereby reducing the need for nutrient supply. Each organ and tissue in the fetus adapts differently, with the brain showing the greatest capacity for maintaining nutrient supply and growth. Such adaptations, if persistent, also have the potential in later life to promote nutrient uptake and storage, which directly lead to complications of obesity, insulin resistance, reduced insulin production, and type 2 diabetes.
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“Maternal undernutrition may lead to foetal growth restriction (FGR), characterised by reduced pancreatic growth, impaired insulin secretion, and hepatic insulin resistance [28,29,30].”
From Medical Nutrition Therapy for Women with Gestational Diabetes: Current Practice and Future Perspectives (2025) · cites this paper as [29]
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Cites
TOR signaling in growth and metabolism
Wullschleger, S., Loewith, R., & Hall, M. N. (2006) · Cell · doi:10.1016/j.cell.2006.01.016 · Cited by 5,787
β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes
Butler, A. E., Janson, J., Bonner-Weir, S., Ritzel, R., Rizza, R. A., & Butler, P. C. (2003) · Diabetes · doi:10.2337/diabetes.52.1.102 · Cited by 4,011
Liu, J.-P., Baker, J. C., Perkins, A. S., Robertson, E. J., & Efstratiadis, A. (1993) · Cell · doi:10.1016/s0092-8674(05)80084-4 · Cited by 2,854
The fetal and infant origins of adult disease.
Barker, D. J. (1990) · BMJ · doi:10.1136/bmj.301.6761.1111 · Cited by 2,768
The thrifty phenotype hypothesis
Hales, C. N., & Barker, D. J. (2001) · British Medical Bulletin · doi:10.1093/bmb/60.1.5 · Cited by 2,722
Ras, PI(3)K and mTOR signalling controls tumour cell growth
Shaw, R. J., & Cantley, L. C. (2006) · Nature · doi:10.1038/nature04869 · Cited by 2,019
Developmental Origins of the Metabolic Syndrome: Prediction, Plasticity, and Programming
Mcmillen, I. C., & Robinson, J. S. (2005) · Physiological Reviews · doi:10.1152/physrev.00053.2003 · Cited by 1,910
Phenotypic plasticity and the epigenetics of human disease
Feinberg, A. P. (2007) · Nature · doi:10.1038/nature05919 · Cited by 1,613
Lillycrop, K. A., Phillips, E. S., Jackson, A. A., Hanson, M. A., & Burdge, G. C. (2005) · Journal of Nutrition · doi:10.1093/jn/135.6.1382 · Cited by 1,139
Randomised trial of early diet in preterm babies and later intelligence quotient
Lucas, A., Morley, R., & Cole, T. J. (1998) · BMJ · doi:10.1136/bmj.317.7171.1481 · Cited by 687
Research works printed but not linked: 2
- [60]Inskip HM Godfrey KM Martin HJ Simmonds SJ Cooper C Sayer AA Southampton Women’s Survey Study Group Size at birth and its relation to muscle strength in young adult women J Intern Med 2007 262 3 368 374 17697158 PMC2062503
- [109]Desai M Byrne CD Zhang J Petry CJ Lucas A Hales CN Programming of hepatic insulin-sensitive enzymes in offspring of rat dams fed a protein-restricted diet Am J Physiol 1997 272 5 Pt 1 G1083 G1090 9176217
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Verklan, M. T. (2014) · The Journal of Perinatal & Neonatal Nursing · doi:10.1097/jpn.0000000000000012 · Cited by 3
Mense, L., Birdir, C., Reichert, J., Schleußner, E., Proquitté, H., Schmitt, J. M., Müller, G., & Rüdiger, M. (2019) · Zeitschrift für Geburtshilfe und Neonatologie · doi:10.1055/a-0998-4532 · Cited by 3
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Кан, Н. Е., Khachatryan, Z. V., Chagovets, V. V., Starodubtseva, N. L., Amiraslanov, A. E. Y., Tyutyunnik, V. L., Анатольевна, Л. Н., & Евгеньевич, Ф. В. (2020) · Biomeditsinskaya Khimiya · doi:10.18097/pbmc20206602174 · Cited by 2
Determinants and measurement of lean body mass in Indian adults
Kulkarni, B. (2014) · Cited by 2
Growth and Development: Physiological Aspects
Hay, W. W. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-375083-9.00139-2 · Cited by 2
Self-citationIntrauterine growth restriction and sugar consumption at two years of age in the BRISA cohort
Aristizábal, L. Y. G., Confortin, S. C., Carneiro, J. R., Ribeiro, C. C. C., Batista, R. F. L., Alves, M. T. S. S. D. B. E., Simões, V. M. F., & da Sílva, A. A. M. (2025) · BMC Pediatrics · doi:10.1186/s12887-025-05448-4 · Cited by 1
Kumar, D., Soni, J. S., & Dave, M. R. (2025) · Advances in Human Biology · doi:10.4103/aihb.aihb_81_25 · Cited by 1
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Dear, T. B., Chang, E. I., Al‐Juboori, S. I., Stremming, J., Wesolowski, S. R., Jonker, S. S., Rozance, P. J., Dobrinskikh, E., & Brown, L. D. (2025) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00044.2025 · Cited by 1
Self-citationZensho, K., Murakami, Y., Takahara, H., Komatsubara, N., Fujiwara, Y., Ohashi, M., Kubota, M., & Mimaki, N. (2025) · Pediatric Research · doi:10.1038/s41390-025-04583-z · Cited by 1
Other Specific Types of Diabetes
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Hay, W. W. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-821848-8.00007-x · Cited by 1
Self-citationRecent Advances in Neonatal Gastroenterology and Neonatal Nutrition
Rao, S., Ravikumara, M., McLeod, G., & Simmer, K. N. (2012) · Neonatal Care · doi:10.5772/33026
Taylor, R. K. (2015) · TigerPrints (Clemson University)
Luna, M. E., Quintero, F. A., Cesani, M. F., Fucini, M. C., Guimarey, L. M., Prio, V., & Oyhenart, E. E. (2016) · Americanae (AECID Library)
Kimball, R. (2016) · ScholarsArchive (Brigham Young University)
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Sozo, F., O’Reilly, M., & Harding, R. (2015) · Stem cell biology and regenerative medicine · doi:10.1007/978-3-319-21082-7_5
Cadaret, C. N. (2017) · Lincoln (University of Nebraska)
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Fontaine, M. A. (2018) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r3dr2pq51
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Reynolds, C. M., Bridge-Comer, P. E., & Vickers, M. H. (2020) · Royal Society of Chemistry eBooks · doi:10.1039/9781839160608-00024
Metabolic risk factors in mothers and metabolic profile of neonates
Jing-ya, W. (2019) · University of Birmingham Institutional Research Archive (University of Birmingham)
Schleußner, E. (2014) · Springer eBooks · doi:10.1007/978-3-662-44369-9_19-1
Analysis of Metabolic Pathways in Intrauterine Growth Restriction
Кан, Н. Е., Khachatryan, Z. V., Chagovets, V. V., Starodubtseva, N. L., Amiraslanov, A. E. Y., Tyutyunnik, V. L., Анатольевна, Л. Н., & Евгеньевич, Ф. В. (2020) · Biochemistry (Moscow) Supplement Series B Biomedical Chemistry · doi:10.1134/s1990750820040071
Wu, Z., Hu, G., Gong, T., Hu, Q., Hong, L., Zhang, Y., & Ao, Z. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.09.29.510071
Gondret, F., Louveau, I., Langendjik, P., & Farmer, C. (2022) · animal · doi:10.1016/j.animal.2022.100691
Amani-Ekhtesar, N., Yaghmaei, P., habibi, A. E., & Karkhaneh, L. (2024) · Physiology and Pharmacology · doi:10.61186/phypha.28.4.409
Cardoso, L. C., Magnabosco, D., Fiúza, A. T. L., Bortolozzo, F. P., Chiarini‐Garcia, H., & de Almeida, F. R. C. L. (2025) · Animal Reproduction Science · doi:10.1016/j.anireprosci.2025.107966
Jacovetti, C., & Regazzi, R. (2026) · Islets · doi:10.1080/19382014.2025.2610590
He, M., Zhao, K., Wei, Q. F., He, M., Yuan, C., Jian, W., & Huang, J. (2026) · International Journal of Women s Health · doi:10.2147/ijwh.s574440
Moutwakil, A., White, A., Wesolowski, S. R., Brown, L. D., & Rozance, P. J. (2026) · Pediatric Research · doi:10.1038/s41390-026-04957-x
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Chastant‐Maillard, S. (2026) · Biology of Reproduction · doi:10.1093/biolre/ioag055
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Hay, W. W. (2026) · Springer eBooks · doi:10.1007/978-3-032-29094-6_2
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Self-citationDai, H., & Xu, H. (2026) · Tissue and Cell · doi:10.1016/j.tice.2026.104071
Metadata
- Authors
- Thorn, S., Rozance, P., Brown, L., & Hay, W.
- Affiliations
- University of Colorado Anschutz (US)
- Venue
- Seminars in Reproductive Medicine
- Publisher
- Georg Thieme Verlag KG
- Published
- 2011-05
- Volume
- 29
- Issue
- 03
- Pages
- 225-236
- ISSN
- 1526-4564 (ISSN-L)
- 1526-8004
- PMC
- PMC3216466
- OpenAlex
- W2059299661
- Cited by
- 153
- References
- 122
- Citations by year
- 2026: 9 · 2025: 11 · 2024: 10 · 2023: 4 · 2022: 12 · 2021: 10 · 2020: 16 · 2019: 17 · 2018: 8 · 2017: 7 · 2016: 13 · 2015: 14 · 2014: 7 · 2013: 9 · 2012: 5
- FWCI
- 6.52
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Seminars in Reproductive Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (K01DK090199)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (K12HD057022, K08HD060688)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Keywords
- fetal growth restriction, fetal brain, insulin resistance, type 2 diabetes, obesity, developmental origins of health and disease, fetal programming, insulin production
- MeSH terms
- Adaptation, Physiological, Adult, Animals, Diabetes Mellitus, Type 2, Female, Fetal Growth Retardation, Humans, Insulin Resistance, Male, Obesity, Pregnancy, Prenatal Exposure Delayed Effects, Fetal Development
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