Chylomicronemia syndrome in pregnancy: a case report of an acute necrotizing pancreatitis
Open accessAbstract
Introduction: Chylomicronemia syndrome (CS) is a rare disorder characterized by a high level of triglycerides in plasma. We present a case of a pregnant woman with a severe acute pancreatitis (AP) affected by a CS. Case: A 38-year-old gravida 2, para 0 with an uneventful course of pregnancy was referred with an AP at 37 0/7 weeks of gestation. This diagnosis was made from a nearby hospital where the chemical analysis showed elevated pancreatic enzymes with significant hypertriglyceridemia. Because of a pathological fetal heart tracing a caesarean delivery was performed. The APGAR score of the female newborn was 5/8/8 at 1, 5 and 10 minutes, respectively. The pH from the umbilical cord were 7.26 (artery) and 7.59 (vein). Once transferred to our intensive care unit a computer tomography scan confirmed an onset of a necrotizing AP. A conservative treatment was tried without success. For this reason a surgical debridement of the infected and necrosic parts was performed. After a long hospitalisation the patient could be dismissed after 2.5 months in good general condition. Discussion: Lipid profile changes in normal pregnancy are characterized by an elevation of total plasma cholesterol and triglyceride levels. This is normally caused by an increased liver synthesis of triglycerides in response to elevated estrogen levels. When a CS is diagnosed the main goal is to maintain fasting triglyceride levels at less than 500 mg/dL to reduce the risk for AP. Conclusion: Practitioners have an important role in evaluating chylomicronemic patients and implementing therapeutic lifestyle and pharmaceutic interventions aimed to reduce the risk for AP.
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This is caused by increased liver synthesis of TGs in response to elevated estrogen levels.
“This is caused by increased liver synthesis of TGs in response to elevated estrogen levels.47”
From Familial chylomicronemia syndrome: Bringing to life dietary recommendations throughout the life span (2018) · cites this paper as [47]
The high TG levels allow the mother to spare glucose for the fetus and allow placental steroidogenesis.
“The high TG levels allow the mother to spare glucose for the fetus and allow placental steroidogenesis.47”
From Familial chylomicronemia syndrome: Bringing to life dietary recommendations throughout the life span (2018) · cites this paper as [47]
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Familial chylomicronemia syndrome: Bringing to life dietary recommendations throughout the life span
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- Authors
- Bolla, D., Schyrba, V., Drack, G., Schöning, A., Stage, A., & Hornung, R.
- Affiliations
- Kantonsspital St. Gallen (CH)
- ORCID
- Venue
- Geburtshilfe und Frauenheilkunde
- Publisher
- Georg Thieme Verlag KG
- Published
- 2012-09-27
- Volume
- 72
- Issue
- 09
- Pages
- 853-855
- ISSN
- 0016-5751 (ISSN-L)
- 1438-8804
- PMC
- PMC4168402
- OpenAlex
- W2040858061
- Cited by
- 3
- References
- 14
- Citations by year
- 2025: 1 · 2019: 1 · 2018: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- de
- Open access
- bronze
- doi.org
- Locations
- Geburtshilfe und Frauenheilkunde (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Health Sciences › Medicine › Surgery › Lymphatic Disorders and Treatments
- Keywords
- chylomicronemia syndrome, acute necrotizing pancreatitis, pregnancy, hypertriglyceridemia, triglyceride elevation, cesarean section, surgical debridement, neonatal acidosis, maternal intensive care
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