Activated Translation Signaling in Placenta from Pregnant Women with Gestational Diabetes Mellitus: Possible Role of Leptin
Open accessAbstract
Placentas from gestational diabetes (GDM) suffer from structural and functional changes including overgrowth. That is why we aimed to study [³H]-leucine incorporation into protein in addition to translation signaling in placenta from GDM. Thus, we investigated the expression of leptin and leptin receptor (LEPR), as well as the activation state of signaling proteins regulating protein synthesis, such as mTOR, S6 Kinase, EIF4E-BP1, EIF4E, and eEF2 by measuring protein phosphorylation by immunoblot. [³H]-Leucine incorporation into protein also was determined in trophoblastic placenta explants from GDM and control pregnancy. We found that leptin and LEPR expression are increased in placentas from GDM and the translation machinery activity as well as [³H]-leucine incorporation into protein were higher in placentas from GDM compared with placentas from control pregnancy. In conclusion, protein synthesis rate is increased in placenta from GDM patients, and this may be due, at least in part, by the activation of translation signaling. The increased expression of leptin and LEPR may contribute to these effects. These results may provide a possible mechanism for the previously observed increase in placenta growth in GDM.
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Placental leptin is thought to facilitate amino acid transport across the placenta, contributing to fetal macrosomia.
“This is also thought to facilitate amino acid transport across the placenta, contributing to fetal macrosomia [101].”
From The Pathophysiology of Gestational Diabetes Mellitus (2018) · cites this paper as [101]
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Pillai, A., Misra, P., Agarwal, D., Vagh, V., Chawla, S., Mukherjee, B., Vashum, Y., & Sibin, M. K. (2026) · Medical Journal Armed Forces India · doi:10.1016/j.mjafi.2026.05.011
da Conceição, Â. I., Dantas, J. V. J. D. B., de Mendonça, C. L., Cajueiro, J. F. D. P., Souto, R. J. C., Pinto, L., Gonçalves, D. N. D. A., de Souza, P. R. E., Afonso, J. A. B., & Soares, P. C. (2026) · Tropical Animal Health and Production · doi:10.1007/s11250-026-05288-z
Diabetes Mellitus: Review of the Common, Rare, and Uncommon (Conceptual and Metaphorical) Types
Pliszka, M., & Szablewski, L. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27219611
- Authors
- Pérez-Pérez, A., Maymó, J., Gambino, Y., Guadix, P., Dueñas, J., Varone, C., & Sánchez-Margalet, V.
- Affiliations
- Departamento de Bioquímica Médica y Biología Molecular, Facultad de Medicina, Hospital Universitario Virgen Macarena, Universidad de Sevilla, Spain
- Universidad de Buenos Aires (AR)
- Hospital Universitario Virgen Macarena (ES)
- Venue
- Hormone and Metabolic Research
- Publisher
- Georg Thieme Verlag KG
- Published
- 2013-02-05
- Volume
- 45
- Issue
- 06
- Pages
- 436-442
- ISSN
- 0018-5043 (ISSN-L)
- 1439-4286
- OpenAlex
- W2027531062
- Cited by
- 57
- References
- 40
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 5 · 2020: 7 · 2019: 4 · 2018: 4 · 2017: 9 · 2016: 2 · 2015: 5 · 2014: 5 · 2013: 1
- FWCI
- 4.86
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Hormone and Metabolic Research (publishedVersion)
- PubMed (publishedVersion)
- CONICET Digital (CONICET) (submittedVersion, cc-by-nc-sa)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Keywords
- gestational diabetes mellitus, placenta, leptin, leptin receptor, protein synthesis, mTOR, S6 kinase, eIF4E, elongation factor 2, leucine incorporation, trophoblast
- MeSH terms
- Adult, Female, Humans, Placenta, Pregnancy, Signal Transduction, Case-Control Studies, Diabetes, Gestational, Leptin, Receptors, Leptin, Young Adult
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