Kinetics of Oxytocin Response to Repeated Restraint Stress and/or Chronic Cold Exposure
Abstract
Recently, several new atypical actions of circulating oxytocin are emerging, which may be of importance for the physiological effects of oxytocin released during stress. However, little information is available on oxytocin response to chronic stress stimuli. The aim of the present study is to deepen the knowledge on oxytocin secretion during chronic and repeated stress. The main hypothesis to be tested was that oxytocin release in response to single and to repeated or chronic stress is of different kinetics. Adult male Sprague-Dawley rats were exposed to 2 different stress stimuli or their combination. Restraint (immobilization) of different duration (10-120 min) and number of repetitions (1 or 7 times) as well as chronic exposure (28 days) to cold temperature were used. Concentrations of oxytocin in plasma and posterior pituitary were measured by a radioimmunoassay. Concentrations of oxytocin in plasma increased significantly in response to both single and repeated immobilization. Acute immobilization caused rapid increase already after 10 min of restraint, while the recovery occurred only after 24 h. Repeated restraint caused delayed onset of increased oxytocin release and a more rapid recovery to prestress levels after 3 h. In conclusion, the results of the present study show that though with a different kinetics, increased oxytocin release is preserved during repeated exposure to an intensive stressor, namely immobilization for 120 min. During repeated exposure to shorter stressors, an adaptation in oxytocin responses may occur. This should be taken into account with respect to cardiovascular and metabolic effects of stress-induced oxytocin.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Elevated concentrations of endogenous oxytocin have been reported following both pleasant experiences such as massage or sexual intercourse, and unpleasant ones such as physical or psychological stress.
“Elevated concentrations of endogenous OXT have been reported following both pleasant experiences such as massage or sexual intercourse (Borrow and Cameron, 2012; Morhenn et al, 2012), and unpleasant ones such as physical or psychological stress (Danevova et al, 2013; Sanders et al, 1990; Taylor et al, 2010).”
From An oxytocin-induced facilitation of neural and emotional responses to social touch correlates inversely with autism traits (2014) · cites this paper as Danevova et al, 2013
Cited by
Sorted by citations
Making room for oxytocin in understanding depression
McQuaid, R. J., McInnis, O. A., Abizaid, A. B., & Anisman, H. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.07.005 · Cited by 172 · see citing works
Scheele, D., Kendrick, K. M., Khouri, C., Kretzer, E., Schläpfer, T. E., Stoffel-Wagner, B., Güntürkün, O., Maier, W., & Hurlemann, R. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.78 · Cited by 171 · see citing works
“Oxytocin and human touch D Scheele et al massage or sexual intercourse (Borrow and Cameron, 2012; Morhenn et al, 2012), and unpleasant ones such as physical or psychological stress (Danevova et al, 2013; Sanders et al, 1990; Taylor et al, 2010).”
BackgroundRelations between plasma oxytocin and cortisol: The stress buffering role of social support
McQuaid, R. J., McInnis, O. A., Paric, A., Al-Yawer, F., Matheson, K., & Anisman, H. (2016) · Neurobiology of Stress · doi:10.1016/j.ynstr.2016.01.001 · Cited by 135 · see citing works
“Although studies in animals have indicated that oxytocin elevations are elicited by acute stressors (Neumann, 2002; Danevova et al., 2013), such effects are less consistently observed in humans.”
BackgroundBlood Pressure Regulation in Stress: Focus on Nitric Oxide-Dependent Mechanisms
Púzserová, A., & Bernátová, I. (2016) · Physiological Research · doi:10.33549/physiolres.933442 · Cited by 73 · see citing works
“Hormones of the posterior pituitary, oxytocin 2016 Stress, Blood Pressure and Nitric Oxide S325 (OT) and vasopressin (VP), represent an important component of the stress response (Jezova et al. 1995, Ondrejcakova et al. 2010, Danevova et al. 2013, Babic et al. 2015).”
BackgroundThe role of oxytocin in familiarization-habituation responses to social novelty
Mattie Tops, A., Huffmeijer, R., Linting, M., Grewen, K., Light, K. C., Koole, S. L., Bakermans‐Kranenburg, M. J., & van IJzendoorn, M. H. (2013) · Frontiers in Psychology · doi:10.3389/fpsyg.2013.00761 · Cited by 52 · see citing works
“Oxytocin may thus be functionally involved in the habituation to social challenge and novelty and, hence, oxytocin responses may occur only as long as there has not been suffi-cient habituation to the social stimulus or context (Danevova et al., 2013).”
BackgroundEndogenous oxytocin exerts anti-nociceptive and anti-inflammatory effects in rats
Nishimura, H., Yoshimura, M., Shimizu, M., Sanada, K., Sonoda, S., Nishimura, K., Baba, K., Ikeda, N., Motojima, Y., Maruyama, T., et al. (2022) · Communications Biology · doi:10.1038/s42003-022-03879-8 · Cited by 34 · see citing works
Camerino, C., Conte, E., Caloiero, R., Fonzino, A., Carratù, M. R., Lograno, M. D., & Tricarico, D. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2017.01101 · Cited by 29 · see citing works
“…stressed rats also BDNF increases in brain and this effect is ameliorated by pre-treatment with citalopram (Garabadu et al., 2015), while plasmatic and hypothalamic concentration of oxytocin increases with different kinetics after repeated exposure to an intensive stressor (Danevova et al., 2013).”
BackgroundJi, H., Liu, N., Li, J., Chen, D., Luo, D., Sun, Q., Liu, Y., Liu, Y., Bu, B., Chen, X., et al. (2019) · Carcinogenesis · doi:10.1093/carcin/bgz064 · Cited by 26 · see citing works
“After exposed to repeated restraint stress, the concentrations of OXT in plasma was significantly increased (14).”
BackgroundEffects of atosiban on stress-related neuroendocrine factors
Babic, S., Pokusa, M., Danevova, V., Ding, S., & Ježová, D. (2015) · Journal of Endocrinology · doi:10.1530/joe-14-0560 · Cited by 22 · see citing works
Self-citationWeber, A. M., Harrison, T. M., Sinnott, L. T., Shoben, A. B., & Steward, D. K. (2018) · Advances in Neonatal Care · doi:10.1097/anc.0000000000000452 · Cited by 17 · see citing works
Yadav, A., & Mishra, R. K. (2022) · Neuroendocrinology · doi:10.1159/000528131 · Cited by 14 · see citing works
Theory of Mind: Towards an Evolutionary Theory
Tsoukalas, I. (2017) · Evolutionary Psychological Science · doi:10.1007/s40806-017-0112-x · Cited by 16 · see citing works
“Similarly, the secretion of oxytocin suppresses avoidance behaviors and accompanies immobilization during courtship and mating in many mammals (McCarthy et al. 1991; Waldherr and Neumann 2007; Borrow and Cameron 2012; Danevova et al. 2013).”
BackgroundInfluentialBarteková, M., Barančı́k, M., Pokusa, M., Prokopova, B., Radošinská, J., Rusnák, A., Breier, A., & Ježová, D. (2015) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2015-0096 · Cited by 6 · see citing works
“Oxytocin belongs to hormones whose concentrations are elevated in blood circulation during acute or chronic stress, and has awide range of physiological activities in the periphery (Danevova et al. 2013; Jezova et al. 1995; Ondrejcakova et al. 2010).”
BackgroundSelf-citationTuman, T. C., YILDIRIM, O., & Tufan, A. E. (2021) · Journal of Surgery and Medicine · doi:10.28982/josam.922612 · Cited by 5 · see citing works
“P a g e | 675 chronic stress exposure, oxytocin level cannot be normalized [51].”
BackgroundOxytocin, Social Interactions and Coping: Implications for Depression
McInnis, O. A. (2016) · doi:10.22215/etd/2016-11454
- Authors
- Danevova, V., Kvetnansky, R., & Jezova, D.
- Affiliations
- Slovak Academy of Sciences (SK)
- Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Slovakia
- Venue
- Hormone and Metabolic Research
- Publisher
- Georg Thieme Verlag KG
- Published
- 2013-07-25
- Volume
- 45
- Issue
- 12
- Pages
- 845-848
- ISSN
- 0018-5043 (ISSN-L)
- 1439-4286
- OpenAlex
- W2314495545
- Cited by
- 19
- References
- 0
- Citations by year
- 2022: 2 · 2021: 1 · 2019: 3 · 2018: 3 · 2017: 1 · 2016: 3 · 2015: 3 · 2014: 2 · 2013: 1
- FWCI
- 4.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hormone and Metabolic Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Council
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- oxytocin, stress response, restraint stress, immobilization, chronic cold exposure, repeated stress, plasma oxytocin, neurohypophysis, stress adaptation, cardiovascular effects of stress
- MeSH terms
- Animals, Cold Temperature, Environmental Exposure, Immobilization, Kinetics, Male, Oxytocin, Stress, Psychological, Rats, Sprague-Dawley, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
